CN109071545B - 新的吡唑并嘧啶衍生物 - Google Patents

新的吡唑并嘧啶衍生物 Download PDF

Info

Publication number
CN109071545B
CN109071545B CN201780023855.8A CN201780023855A CN109071545B CN 109071545 B CN109071545 B CN 109071545B CN 201780023855 A CN201780023855 A CN 201780023855A CN 109071545 B CN109071545 B CN 109071545B
Authority
CN
China
Prior art keywords
alkyl
hydrogen
halogen atoms
haloalkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780023855.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN109071545A (zh
Inventor
A.克勒
C.韦尔茨
K.贝恩根
D.库尔克
T.伊尔格
J.克伯林
W.霍伊施
H-G.施瓦茨
U.格根斯
U.埃宾豪斯-金切尔
M.欣克
D.嫩施蒂尔
K.拉明
M.阿当切夫斯基
C.贝姆
N.格里布诺
W.庄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilan Animal Health Care Co ltd
Original Assignee
Bayer Animal Health GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health GmbH filed Critical Bayer Animal Health GmbH
Publication of CN109071545A publication Critical patent/CN109071545A/zh
Application granted granted Critical
Publication of CN109071545B publication Critical patent/CN109071545B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
CN201780023855.8A 2016-04-15 2017-04-10 新的吡唑并嘧啶衍生物 Active CN109071545B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
EP16165572.5 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
CN109071545A CN109071545A (zh) 2018-12-21
CN109071545B true CN109071545B (zh) 2021-08-03

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780023855.8A Active CN109071545B (zh) 2016-04-15 2017-04-10 新的吡唑并嘧啶衍生物

Country Status (22)

Country Link
US (3) US10604525B2 (enExample)
EP (1) EP3442974B8 (enExample)
JP (1) JP7051703B2 (enExample)
KR (1) KR102467347B1 (enExample)
CN (1) CN109071545B (enExample)
AR (1) AR108130A1 (enExample)
AU (1) AU2017251155B2 (enExample)
CA (1) CA3020793C (enExample)
CL (1) CL2018002920A1 (enExample)
CO (1) CO2018010966A2 (enExample)
DO (1) DOP2018000226A (enExample)
ES (1) ES2953467T3 (enExample)
IL (1) IL261885A (enExample)
MX (1) MX389697B (enExample)
PH (1) PH12018550173A1 (enExample)
PL (1) PL3442974T3 (enExample)
RU (1) RU2769448C2 (enExample)
SG (1) SG11201808214TA (enExample)
TW (1) TWI742067B (enExample)
UY (1) UY37201A (enExample)
WO (1) WO2017178416A1 (enExample)
ZA (1) ZA201807656B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
CA3018802A1 (en) 2016-04-15 2017-10-19 Abbvie Inc. Bromodomain inhibitors
ES2953467T3 (es) 2016-04-15 2023-11-13 Elanco Animal Health Gmbh Derivados de pirazolopirimidina
US11672800B2 (en) 2017-04-21 2023-06-13 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
WO2018197401A1 (en) 2017-04-27 2018-11-01 Bayer Animal Health Gmbh New bicyclic pyrazole derivatives
JP2020533376A (ja) 2017-09-15 2020-11-19 アドゥロ バイオテック，インク． ピラゾロピリミジノン化合物およびその使用
KR20250065422A (ko) 2017-12-15 2025-05-12 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
SG11202010024UA (en) * 2018-05-09 2020-11-27 Bayer Animal Health Gmbh New quinoline derivatives
WO2020014068A1 (en) 2018-07-09 2020-01-16 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds
EP3643711A1 (en) * 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
NZ777370A (en) * 2018-12-18 2024-11-29 Elanco Tiergesundheit Ag Bicyclic derivatives
PL3897842T3 (pl) * 2018-12-18 2025-05-19 Elanco Tiergesundheit Ag Pochodne bicykliczne
CA3133100A1 (en) * 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
US12448391B2 (en) 2019-06-07 2025-10-21 Elanco Tiergesundheit Ag Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CA3164098A1 (en) * 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
WO2021122906A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising azaindoles structure
AU2021278889A1 (en) * 2020-05-29 2023-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelmintic heterocyclic compounds
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
JP2023553269A (ja) 2020-11-18 2023-12-21 エランコ・ティアゲゾンタイト・アーゲー イヌ糸状虫感染症を治療するためのｎ－（２，３－ジヒドロ－１，４－ベンゾオキサジン－４－イル）－３－イソプロピル－７－（２，３，５－トリフルオロフェニル）ベンゾ－チオフェン－２－カルボキサミド誘導体及び類似化合物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
US20240043446A1 (en) * 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100343255C (zh) * 2002-04-23 2007-10-17 盐野义制药株式会社 吡唑并[1,5－a]嘧啶衍生物和含有该衍生物的NAD(P)H氧化酶抑制剂
CN101535313A (zh) * 2006-10-30 2009-09-16 诺瓦提斯公司 作为蛋白激酶调节剂的3-氨基羰基取代的稠合的吡唑衍生物
WO2016012485A1 (en) * 2014-07-25 2016-01-28 Bayer Animal Health Gmbh Compounds for use in anthelminthic treatment

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
RU15525U1 (ru) 2000-07-04 2000-10-20 Федеральный научно-производственный центр закрытое акционерное общество "Научно-производственный концерн (объединение) "ЭНЕРГИЯ" Электродвигатель постоянного тока
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
EA009517B1 (ru) * 2003-06-27 2008-02-28 Байер Кропсайенс Аг Пиразолопиримидины
US20070037828A1 (en) 2003-06-27 2007-02-15 Olaf Gebauer Pyrazolopyrimidines
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
WO2006043635A1 (ja) 2004-10-20 2006-04-27 Kumiai Chemical Industry Co., Ltd. ３－トリアゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤
WO2007040280A1 (ja) 2005-10-06 2007-04-12 Nippon Soda Co., Ltd. 環状アミン化合物および有害生物防除剤
EP2102211A2 (en) * 2006-11-20 2009-09-23 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
JP5372763B2 (ja) 2007-09-28 2013-12-18 協和発酵キリン株式会社 皮膚疾患の予防及び／または治療剤
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US8007468B2 (en) 2009-07-13 2011-08-30 Navilyst Medical, Inc. Method to secure an elastic component in a valve
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
MX363956B (es) 2010-08-31 2019-04-09 Meiji Seika Pharma Co Ltd Star Agente de control de plagas.
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
AU2013252946A1 (en) 2012-04-27 2014-12-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
ES2626360T3 (es) 2012-03-30 2017-07-24 Basf Se Compuestos de piridinilideno tiocarbonilo N-sustituidos y su uso para combatir plagas de animales
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
JP6482466B2 (ja) 2012-11-03 2019-03-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
EP3057429A4 (en) 2013-10-17 2017-08-09 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
WO2015058028A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
ES2953467T3 (es) 2016-04-15 2023-11-13 Elanco Animal Health Gmbh Derivados de pirazolopirimidina

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100343255C (zh) * 2002-04-23 2007-10-17 盐野义制药株式会社 吡唑并[1,5－a]嘧啶衍生物和含有该衍生物的NAD(P)H氧化酶抑制剂
CN101535313A (zh) * 2006-10-30 2009-09-16 诺瓦提斯公司 作为蛋白激酶调节剂的3-氨基羰基取代的稠合的吡唑衍生物
WO2016012485A1 (en) * 2014-07-25 2016-01-28 Bayer Animal Health Gmbh Compounds for use in anthelminthic treatment

Also Published As

Publication number Publication date
DOP2018000226A (es) 2018-11-15
US20200239482A1 (en) 2020-07-30
CL2018002920A1 (es) 2019-02-01
ZA201807656B (en) 2024-06-26
KR20180134966A (ko) 2018-12-19
RU2018140092A (ru) 2020-05-15
SG11201808214TA (en) 2018-10-30
US11001590B2 (en) 2021-05-11
EP3442974C0 (en) 2023-06-07
AR108130A1 (es) 2018-07-18
AU2017251155B2 (en) 2021-08-05
AU2017251155A1 (en) 2018-10-11
TW201803874A (zh) 2018-02-01
EP3442974B1 (en) 2023-06-07
US10934301B2 (en) 2021-03-02
EP3442974B8 (en) 2023-07-12
JP7051703B2 (ja) 2022-04-11
EP3442974A1 (en) 2019-02-20
RU2769448C2 (ru) 2022-03-31
PH12018550173A1 (en) 2019-07-15
CA3020793A1 (en) 2017-10-19
IL261885A (en) 2018-10-31
MX389697B (es) 2025-03-20
KR102467347B1 (ko) 2022-11-14
PL3442974T3 (pl) 2023-12-04
US10604525B2 (en) 2020-03-31
NZ747056A (en) 2025-05-30
CO2018010966A2 (es) 2018-10-22
US20190071447A1 (en) 2019-03-07
CA3020793C (en) 2024-05-21
JP2019513776A (ja) 2019-05-30
TWI742067B (zh) 2021-10-11
RU2018140092A3 (enExample) 2020-06-25
WO2017178416A1 (en) 2017-10-19
UY37201A (es) 2017-11-30
US20200299299A1 (en) 2020-09-24
CN109071545A (zh) 2018-12-21
MX2018012544A (es) 2019-01-31
ES2953467T3 (es) 2023-11-13

Similar Documents

Publication Publication Date Title
CN109071545B (zh) 新的吡唑并嘧啶衍生物
US10889573B2 (en) Anthelmintic quinoline-3-carboxamide derivatives
AU2018257582B2 (en) New bicyclic pyrazole derivatives
CN114423749B (zh) 异喹啉衍生物及其用于治疗寄生虫感染的用途
CN119409690A (zh) 新型驱虫化合物
KR20200036909A (ko) 연충에 의한 감염을 치료하기 위한 퀴놀린 유도체
CN112074514A (zh) 新的喹啉衍生物
RU2839897C2 (ru) Новые производные изохинолина
HK40002140A (en) Pyrazolopyrimidine derivatives
HK40016708A (en) New bicyclic pyrazole derivatives
HK40010021A (en) New anthelmintic quinoline-3-carboxamide derivatives

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40002140

Country of ref document: HK

CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: A. Keller

Inventor after: U. Ebenhaus kincher

Inventor after: M. Hink

Inventor after: D. Nenstier

Inventor after: K. Lamine

Inventor after: M. Adanchevsky

Inventor after: C. Bem

Inventor after: N. Gribno

Inventor after: W.Zhuang

Inventor after: C. wells

Inventor after: K. Baingen

Inventor after: D. Kurk

Inventor after: T. Ilga

Inventor after: J. Kebolin

Inventor after: W. Hoish

Inventor after: H-G. Schwartz

Inventor after: U. gross

Inventor before: A. Keller

Inventor before: U. Ebenhaus kincher

Inventor before: M. Hink

Inventor before: D. Nenstier

Inventor before: K. Lamine

Inventor before: M. Adanchevsky

Inventor before: C. Bem

Inventor before: C. wells

Inventor before: K. Baingen

Inventor before: D. Kurk

Inventor before: T. Ilga

Inventor before: J. Kebolin

Inventor before: W. Hoish

Inventor before: H-G. Schwartz

Inventor before: U. gross

GR01 Patent grant
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: Germany's Rhine River Monheim

Patentee after: Lilan animal health care Co.,Ltd.

Country or region after: Germany

Address before: Leverkusen, Germany

Patentee before: BAYER ANIMAL HEALTH GmbH

Country or region before: Germany

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 40002140

Country of ref document: HK