CN109071545B - 新的吡唑并嘧啶衍生物 - Google Patents

新的吡唑并嘧啶衍生物 Download PDF

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Publication number
CN109071545B
CN109071545B CN201780023855.8A CN201780023855A CN109071545B CN 109071545 B CN109071545 B CN 109071545B CN 201780023855 A CN201780023855 A CN 201780023855A CN 109071545 B CN109071545 B CN 109071545B
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alkyl
hydrogen
halogen atoms
haloalkyl
methyl
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Chinese (zh)
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CN109071545A (zh
Inventor
A.克勒
C.韦尔茨
K.贝恩根
D.库尔克
T.伊尔格
J.克伯林
W.霍伊施
H-G.施瓦茨
U.格根斯
U.埃宾豪斯-金切尔
M.欣克
D.嫩施蒂尔
K.拉明
M.阿当切夫斯基
C.贝姆
N.格里布诺
W.庄
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Lilan Animal Health Care Co ltd
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Bayer Animal Health GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
CN201780023855.8A 2016-04-15 2017-04-10 新的吡唑并嘧啶衍生物 Active CN109071545B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
EP16165572.5 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
CN109071545A CN109071545A (zh) 2018-12-21
CN109071545B true CN109071545B (zh) 2021-08-03

Family

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CN201780023855.8A Active CN109071545B (zh) 2016-04-15 2017-04-10 新的吡唑并嘧啶衍生物

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US (3) US10604525B2 (enExample)
EP (1) EP3442974B8 (enExample)
JP (1) JP7051703B2 (enExample)
KR (1) KR102467347B1 (enExample)
CN (1) CN109071545B (enExample)
AR (1) AR108130A1 (enExample)
AU (1) AU2017251155B2 (enExample)
CA (1) CA3020793C (enExample)
CL (1) CL2018002920A1 (enExample)
CO (1) CO2018010966A2 (enExample)
DO (1) DOP2018000226A (enExample)
ES (1) ES2953467T3 (enExample)
IL (1) IL261885A (enExample)
MX (1) MX389697B (enExample)
PH (1) PH12018550173A1 (enExample)
PL (1) PL3442974T3 (enExample)
RU (1) RU2769448C2 (enExample)
SG (1) SG11201808214TA (enExample)
TW (1) TWI742067B (enExample)
UY (1) UY37201A (enExample)
WO (1) WO2017178416A1 (enExample)
ZA (1) ZA201807656B (enExample)

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TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CN116600807A (zh) * 2020-12-11 2023-08-15 英特维特国际股份有限公司 包含噻吩并吡啶结构的驱虫化合物
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
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US10604525B2 (en) 2020-03-31
JP2019513776A (ja) 2019-05-30
ES2953467T3 (es) 2023-11-13
AU2017251155A1 (en) 2018-10-11
KR102467347B1 (ko) 2022-11-14
JP7051703B2 (ja) 2022-04-11
CL2018002920A1 (es) 2019-02-01
NZ747056A (en) 2025-05-30
PH12018550173A1 (en) 2019-07-15
RU2018140092A (ru) 2020-05-15
TW201803874A (zh) 2018-02-01
US20200239482A1 (en) 2020-07-30
US11001590B2 (en) 2021-05-11
CN109071545A (zh) 2018-12-21
PL3442974T3 (pl) 2023-12-04
CA3020793C (en) 2024-05-21
US20190071447A1 (en) 2019-03-07
TWI742067B (zh) 2021-10-11
EP3442974B1 (en) 2023-06-07
RU2769448C2 (ru) 2022-03-31
KR20180134966A (ko) 2018-12-19
AR108130A1 (es) 2018-07-18
EP3442974B8 (en) 2023-07-12
MX389697B (es) 2025-03-20
WO2017178416A1 (en) 2017-10-19
RU2018140092A3 (enExample) 2020-06-25
IL261885A (en) 2018-10-31
DOP2018000226A (es) 2018-11-15
CO2018010966A2 (es) 2018-10-22
CA3020793A1 (en) 2017-10-19
ZA201807656B (en) 2024-06-26
EP3442974A1 (en) 2019-02-20
UY37201A (es) 2017-11-30
US10934301B2 (en) 2021-03-02
MX2018012544A (es) 2019-01-31
SG11201808214TA (en) 2018-10-30
US20200299299A1 (en) 2020-09-24
EP3442974C0 (en) 2023-06-07
AU2017251155B2 (en) 2021-08-05

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