MX389697B - Nuevos derivados de pirazolopirimidina. - Google Patents

Nuevos derivados de pirazolopirimidina.

Info

Publication number
MX389697B
MX389697B MX2018012544A MX2018012544A MX389697B MX 389697 B MX389697 B MX 389697B MX 2018012544 A MX2018012544 A MX 2018012544A MX 2018012544 A MX2018012544 A MX 2018012544A MX 389697 B MX389697 B MX 389697B
Authority
MX
Mexico
Prior art keywords
sup
compounds
pyrazolopyrimidine derivatives
preparing
pharmaceutical compositions
Prior art date
Application number
MX2018012544A
Other languages
English (en)
Spanish (es)
Other versions
MX2018012544A (es
Inventor
Adeline Köhler
Claudia Böhm
Claudia Welz
Daniel Kulke
Dirk Nennstiel
Hans-Georg Schwarz
Johannes Köbberling
Kirsten Börngen
Klaus Raming
Maike Hink
Martin Adamczewski
Nils Griebenow
Thomas Ilg
Ulrich Ebbinghaus-Kintscher
Ulrich Görgens
Walter Hübsch
Wei Zhuang
Original Assignee
Elanco Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Animal Health Gmbh filed Critical Elanco Animal Health Gmbh
Publication of MX2018012544A publication Critical patent/MX2018012544A/es
Publication of MX389697B publication Critical patent/MX389697B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
MX2018012544A 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina. MX389697B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
MX2018012544A MX2018012544A (es) 2019-01-31
MX389697B true MX389697B (es) 2025-03-20

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012544A MX389697B (es) 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina.

Country Status (22)

Country Link
US (3) US10604525B2 (enExample)
EP (1) EP3442974B8 (enExample)
JP (1) JP7051703B2 (enExample)
KR (1) KR102467347B1 (enExample)
CN (1) CN109071545B (enExample)
AR (1) AR108130A1 (enExample)
AU (1) AU2017251155B2 (enExample)
CA (1) CA3020793C (enExample)
CL (1) CL2018002920A1 (enExample)
CO (1) CO2018010966A2 (enExample)
DO (1) DOP2018000226A (enExample)
ES (1) ES2953467T3 (enExample)
IL (1) IL261885A (enExample)
MX (1) MX389697B (enExample)
PH (1) PH12018550173A1 (enExample)
PL (1) PL3442974T3 (enExample)
RU (1) RU2769448C2 (enExample)
SG (1) SG11201808214TA (enExample)
TW (1) TWI742067B (enExample)
UY (1) UY37201A (enExample)
WO (1) WO2017178416A1 (enExample)
ZA (1) ZA201807656B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
KR102467347B1 (ko) * 2016-04-15 2022-11-14 바이엘 애니멀 헬스 게엠베하 피라졸로피리미딘 유도체
ES2793239T3 (es) 2016-04-15 2020-11-13 Abbvie Inc Inhibidores del bromodominio
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
WO2018197401A1 (en) * 2017-04-27 2018-11-01 Bayer Animal Health Gmbh New bicyclic pyrazole derivatives
WO2019055750A1 (en) 2017-09-15 2019-03-21 Aduro Biotech, Inc. PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF
CN119157876A (zh) 2017-12-15 2024-12-20 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
JP7403472B2 (ja) 2018-05-09 2023-12-22 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規キノリン誘導体
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
CN113490527B (zh) * 2018-12-18 2024-10-25 瑞士伊兰科动物保健有限公司 双环衍生物
AR116909A1 (es) * 2018-12-18 2021-06-23 Elanco Tiergesundheit Ag Derivados bicíclicos
JP7637630B2 (ja) 2019-03-19 2025-02-28 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
BR112021024726A2 (pt) 2019-06-07 2022-01-18 Elanco Tiergesundheit Ag Novos derivados bicíclicos
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
EP4077281A1 (en) * 2019-12-18 2022-10-26 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
EP4077322A1 (en) * 2019-12-18 2022-10-26 Intervet International B.V. Anthelmintic compounds comprising azaindoles structure
PH12022553222A1 (en) * 2020-05-29 2024-02-12 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic heterocyclic compounds
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
CA3202092A1 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag Bicyclic derivatives
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CN116600807A (zh) * 2020-12-11 2023-08-15 英特维特国际股份有限公司 包含噻吩并吡啶结构的驱虫化合物
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos
EP4694887A1 (en) 2023-04-14 2026-02-18 Elanco Animal Health GmbH Long-term prevention and/or treatment of a disease by slo-1 inhibitors
IL326231A (en) 2023-08-02 2026-03-01 Intervet Int Bv Carboxamide-4-quinoline compounds with anthelmintic activity
CN119139315B (zh) * 2024-09-23 2026-03-10 大连大学 D724-0491在制备治疗乳腺癌药物中的应用
WO2026078157A2 (en) 2024-10-10 2026-04-16 Elanco Animal Health Gmbh Slo-1 modulators for prevention and/or treatment of a disease

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
RU15525U1 (ru) 2000-07-04 2000-10-20 Федеральный научно-производственный центр закрытое акционерное общество "Научно-производственный концерн (объединение) "ЭНЕРГИЯ" Электродвигатель постоянного тока
KR20040097375A (ko) * 2002-04-23 2004-11-17 시오노기 앤드 컴파니, 리미티드 피라졸로[1, 5-에이]피리미딘 유도체 및 이를 함유한엔에이디(피)에이취 산화효소 저해제
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
AU2004251845A1 (en) 2003-06-27 2005-01-06 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidines
EA009517B1 (ru) * 2003-06-27 2008-02-28 Байер Кропсайенс Аг Пиразолопиримидины
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
CA2581725C (en) 2004-10-20 2013-01-08 Kumiai Chemical Industry Co., Ltd. 3-triazolylphenyl sulfide derivative, and insecticide, miticide and nematicide containing it as an active ingredient
NZ567127A (en) 2005-10-06 2010-04-30 Nippon Soda Co Bridged cyclic amine compound and pest control agent
EP1918291A1 (en) * 2006-10-30 2008-05-07 Novartis AG 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
CA2670083A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
US8729264B2 (en) 2007-09-28 2014-05-20 Kyowa Hakko Kirin Co., Ltd. Agent for prevention and/or treatment of skin diseases
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US8007468B2 (en) 2009-07-13 2011-08-30 Navilyst Medical, Inc. Method to secure an elastic component in a valve
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
PL2984930T3 (pl) 2010-08-31 2019-03-29 Meiji Seika Pharma Co., Ltd. Środek do zwalczania szkodników
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
ES2626360T3 (es) 2012-03-30 2017-07-24 Basf Se Compuestos de piridinilideno tiocarbonilo N-sustituidos y su uso para combatir plagas de animales
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
RU2627654C2 (ru) 2012-04-27 2017-08-09 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и относящиеся к ним способы
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
JP6482466B2 (ja) 2012-11-03 2019-03-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
WO2014158644A1 (en) 2013-03-13 2014-10-02 Dow Agrosciences Llc Process for the preparation of triaryl rhamnose carbamates
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
CN105636440A (zh) 2013-10-17 2016-06-01 美国陶氏益农公司 制备杀虫化合物的方法
EP3057430A4 (en) 2013-10-17 2017-09-13 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
UY36196A (es) * 2014-07-25 2016-02-29 Bayer Animal Health Gmbh Compuestos para usar en el tratamiento antihelmíntico
KR102467347B1 (ko) * 2016-04-15 2022-11-14 바이엘 애니멀 헬스 게엠베하 피라졸로피리미딘 유도체

Also Published As

Publication number Publication date
US10604525B2 (en) 2020-03-31
JP2019513776A (ja) 2019-05-30
ES2953467T3 (es) 2023-11-13
AU2017251155A1 (en) 2018-10-11
KR102467347B1 (ko) 2022-11-14
JP7051703B2 (ja) 2022-04-11
CL2018002920A1 (es) 2019-02-01
NZ747056A (en) 2025-05-30
PH12018550173A1 (en) 2019-07-15
RU2018140092A (ru) 2020-05-15
TW201803874A (zh) 2018-02-01
US20200239482A1 (en) 2020-07-30
US11001590B2 (en) 2021-05-11
CN109071545A (zh) 2018-12-21
PL3442974T3 (pl) 2023-12-04
CA3020793C (en) 2024-05-21
US20190071447A1 (en) 2019-03-07
TWI742067B (zh) 2021-10-11
EP3442974B1 (en) 2023-06-07
RU2769448C2 (ru) 2022-03-31
KR20180134966A (ko) 2018-12-19
AR108130A1 (es) 2018-07-18
EP3442974B8 (en) 2023-07-12
WO2017178416A1 (en) 2017-10-19
RU2018140092A3 (enExample) 2020-06-25
IL261885A (en) 2018-10-31
DOP2018000226A (es) 2018-11-15
CO2018010966A2 (es) 2018-10-22
CA3020793A1 (en) 2017-10-19
ZA201807656B (en) 2024-06-26
EP3442974A1 (en) 2019-02-20
UY37201A (es) 2017-11-30
US10934301B2 (en) 2021-03-02
MX2018012544A (es) 2019-01-31
SG11201808214TA (en) 2018-10-30
US20200299299A1 (en) 2020-09-24
CN109071545B (zh) 2021-08-03
EP3442974C0 (en) 2023-06-07
AU2017251155B2 (en) 2021-08-05

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