JP6948333B2 - Ror−ガンマのモジュレータとしてのベンズイミダゾール誘導体 - Google Patents
Ror−ガンマのモジュレータとしてのベンズイミダゾール誘導体 Download PDFInfo
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- JP6948333B2 JP6948333B2 JP2018539070A JP2018539070A JP6948333B2 JP 6948333 B2 JP6948333 B2 JP 6948333B2 JP 2018539070 A JP2018539070 A JP 2018539070A JP 2018539070 A JP2018539070 A JP 2018539070A JP 6948333 B2 JP6948333 B2 JP 6948333B2
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- methyl
- benzo
- imidazole
- carboxamide
- dioxol
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- 0 CCNIN*(C(*)=*c1c2)c1ccc2C(*1(CC1)C1(C2C1CC2)C1NC=C(*)CC1)=O Chemical compound CCNIN*(C(*)=*c1c2)c1ccc2C(*1(CC1)C1(C2C1CC2)C1NC=C(*)CC1)=O 0.000 description 22
- UZBMBVRBBQZLNS-UHFFFAOYSA-N CCCc1ccc(CN)nc1 Chemical compound CCCc1ccc(CN)nc1 UZBMBVRBBQZLNS-UHFFFAOYSA-N 0.000 description 1
- SYRTXLUSQIHZRE-UHFFFAOYSA-N CCSc(cc1)cnc1Br Chemical compound CCSc(cc1)cnc1Br SYRTXLUSQIHZRE-UHFFFAOYSA-N 0.000 description 1
- MONNZRQOALFXBM-UHFFFAOYSA-N CCSc1ccc(CNSC(C)(C)C)nc1 Chemical compound CCSc1ccc(CNSC(C)(C)C)nc1 MONNZRQOALFXBM-UHFFFAOYSA-N 0.000 description 1
- NYGDMPXFJMTHTG-UHFFFAOYSA-N CCc1cccc2c1[nH]cn2 Chemical compound CCc1cccc2c1[nH]cn2 NYGDMPXFJMTHTG-UHFFFAOYSA-N 0.000 description 1
- QGBUVGVUZSPYJN-HSKKLARCSA-N COC(CS/C(/C=C)=C/C=C/C#N)=O Chemical compound COC(CS/C(/C=C)=C/C=C/C#N)=O QGBUVGVUZSPYJN-HSKKLARCSA-N 0.000 description 1
- DMFYWDMSMVJSPD-UHFFFAOYSA-N COC(c(cc1)cc(N)c1NCc(cccc1O2)c1OC2(F)F)=O Chemical compound COC(c(cc1)cc(N)c1NCc(cccc1O2)c1OC2(F)F)=O DMFYWDMSMVJSPD-UHFFFAOYSA-N 0.000 description 1
- UODINHBLNPPDPD-UHFFFAOYSA-N Fc(cc1)cnc1Br Chemical compound Fc(cc1)cnc1Br UODINHBLNPPDPD-UHFFFAOYSA-N 0.000 description 1
- PZAYKWCWHGXQEQ-UHFFFAOYSA-N NC(CC=C1)c2c1[o]cc2 Chemical compound NC(CC=C1)c2c1[o]cc2 PZAYKWCWHGXQEQ-UHFFFAOYSA-N 0.000 description 1
- VCDLDEQYVBRTDN-UHFFFAOYSA-N NCC(CC1)CCN1S(CC(N)=O)(=O)=O Chemical compound NCC(CC1)CCN1S(CC(N)=O)(=O)=O VCDLDEQYVBRTDN-UHFFFAOYSA-N 0.000 description 1
- OPLLEJQGWXBXAT-UHFFFAOYSA-N OC(c(cc1)cc2c1[n](Cc1cccc(O3)c1OC3(F)F)c(C(F)(F)F)n2)=O Chemical compound OC(c(cc1)cc2c1[n](Cc1cccc(O3)c1OC3(F)F)c(C(F)(F)F)n2)=O OPLLEJQGWXBXAT-UHFFFAOYSA-N 0.000 description 1
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| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| HRP20210745T1 (hr) | 2015-05-15 | 2021-06-25 | Aurigene Discovery Technologies Limited | Supstituirani spojevi tetrahidrokinolinona kao ror gama modulatori |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| CN108463458B (zh) | 2015-11-20 | 2022-02-01 | 生命医药有限责任公司 | ROR-γ的调节剂 |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
| WO2019023207A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibitors of rorϒ |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
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| AU2019262169B2 (en) * | 2018-05-03 | 2024-05-02 | Jiangsu Hengrui Medicine Co., Ltd. | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORy) and pharmaceutical uses thereof |
| CN110483437B (zh) * | 2018-05-14 | 2022-12-06 | 嘉兴维眸生物科技有限公司 | 一种含五元环的化合物及其制备和应用 |
| CN112601745B (zh) * | 2018-10-24 | 2023-06-27 | 上海和誉生物医药科技有限公司 | 一种氮杂芳基酰胺衍生物及其制备方法和应用 |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
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| CN112745268B (zh) * | 2019-10-31 | 2022-09-16 | 江苏恒瑞医药股份有限公司 | 苯并咪唑衍生物的晶型及制备方法 |
| US20220411380A1 (en) * | 2019-10-31 | 2022-12-29 | Jiangsu Hengrui Medicine Co., Ltd. | ACID ADDITION SALT OF RORy REGULATOR |
| TW202136237A (zh) | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
| CN111333552B (zh) * | 2020-04-09 | 2021-07-20 | 广州安岩仁医药科技有限公司 | β-苯并氨基酸类化合物的合成方法 |
| CN111606868B (zh) * | 2020-06-23 | 2023-02-17 | 温州大学新材料与产业技术研究院 | 一种双齿噁唑啉手性配体的制备方法 |
| CN113912563B (zh) * | 2020-07-10 | 2025-05-27 | 中国科学院广州生物医药与健康研究院 | 一种苯并五元氮杂环化合物及其应用 |
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| CN118265545A (zh) * | 2021-10-04 | 2024-06-28 | 博尔特生物治疗药物有限公司 | 不对称双苯并咪唑sting激动剂免疫缀合物及其用途 |
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| EP3408268B1 (en) | 2021-08-04 |
| CN114230523A (zh) | 2022-03-25 |
| JP2021193131A (ja) | 2021-12-23 |
| US20190352286A1 (en) | 2019-11-21 |
| RU2018127360A (ru) | 2020-03-02 |
| RU2760366C2 (ru) | 2021-11-24 |
| KR20180100697A (ko) | 2018-09-11 |
| EP3408268A1 (en) | 2018-12-05 |
| TW201734001A (zh) | 2017-10-01 |
| TWI757266B (zh) | 2022-03-11 |
| MX2018009257A (es) | 2018-11-09 |
| MA45646A (fr) | 2021-03-24 |
| MX381313B (es) | 2025-03-12 |
| UY37098A (es) | 2017-08-31 |
| AU2017212577A1 (en) | 2018-08-02 |
| RU2018127360A3 (enExample) | 2020-04-06 |
| US10829481B2 (en) | 2020-11-10 |
| TW202220968A (zh) | 2022-06-01 |
| BR112018015273A2 (pt) | 2018-12-18 |
| MA55328A (fr) | 2022-01-19 |
| EP3408268B8 (en) | 2023-12-06 |
| CN109071509B (zh) | 2021-11-30 |
| US20210094940A1 (en) | 2021-04-01 |
| EP3939974A1 (en) | 2022-01-19 |
| CA3011838A1 (en) | 2017-08-03 |
| CN109071509A (zh) | 2018-12-21 |
| WO2017132432A1 (en) | 2017-08-03 |
| WO2017132432A8 (en) | 2017-08-31 |
| RU2021133444A (ru) | 2021-11-29 |
| JP2019503385A (ja) | 2019-02-07 |
| AU2017212577B2 (en) | 2021-05-13 |
| SA518392101B1 (ar) | 2022-03-16 |
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