KR20180100697A - Ror-감마의 조절제로서의 벤즈이미다졸 유도체 - Google Patents
Ror-감마의 조절제로서의 벤즈이미다졸 유도체 Download PDFInfo
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- KR20180100697A KR20180100697A KR1020187024271A KR20187024271A KR20180100697A KR 20180100697 A KR20180100697 A KR 20180100697A KR 1020187024271 A KR1020187024271 A KR 1020187024271A KR 20187024271 A KR20187024271 A KR 20187024271A KR 20180100697 A KR20180100697 A KR 20180100697A
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- 0 CC(*CC(*)c(cc1)pcc1O)C(C(C1)C=CC2=C1*=C(*)S2CIc1c2OC(*)(N)Oc2ccc1)=O Chemical compound CC(*CC(*)c(cc1)pcc1O)C(C(C1)C=CC2=C1*=C(*)S2CIc1c2OC(*)(N)Oc2ccc1)=O 0.000 description 15
- NGXGMPWCNLTJQI-UHFFFAOYSA-N CC(C)(C)OC(NC(C(CC1)CCN1/S(/C)=C(\C)/O)C(OC)=O)=O Chemical compound CC(C)(C)OC(NC(C(CC1)CCN1/S(/C)=C(\C)/O)C(OC)=O)=O NGXGMPWCNLTJQI-UHFFFAOYSA-N 0.000 description 1
- PCAQJVBYPKVZSP-UHFFFAOYSA-N CC(C)(C)OC(NC(CO)C(CC1)CCN1S(C)(=O)=O)=O Chemical compound CC(C)(C)OC(NC(CO)C(CC1)CCN1S(C)(=O)=O)=O PCAQJVBYPKVZSP-UHFFFAOYSA-N 0.000 description 1
- JPKABPHRXUGGJL-LBPRGKRZSA-N CC(C)(C)OC(N[C@@H](CC(OC)=O)c(cc1)ccc1Br)=O Chemical compound CC(C)(C)OC(N[C@@H](CC(OC)=O)c(cc1)ccc1Br)=O JPKABPHRXUGGJL-LBPRGKRZSA-N 0.000 description 1
- XRKRWBOJZQIJHT-UHFFFAOYSA-N CCCS(c(cc1)ccc1C#N)(=O)=O Chemical compound CCCS(c(cc1)ccc1C#N)(=O)=O XRKRWBOJZQIJHT-UHFFFAOYSA-N 0.000 description 1
- GWNVEZCWRGNXON-UHFFFAOYSA-N CCCS(c1ccc(CN)cc1)(=O)=O Chemical compound CCCS(c1ccc(CN)cc1)(=O)=O GWNVEZCWRGNXON-UHFFFAOYSA-N 0.000 description 1
- PENAHQPTHCKJFR-UHFFFAOYSA-N CCCSc(cc1)ccc1C#N Chemical compound CCCSc(cc1)ccc1C#N PENAHQPTHCKJFR-UHFFFAOYSA-N 0.000 description 1
- OSKBHWZCZQZMJR-UHFFFAOYSA-N CCS(CC)c1ccc(C(CO)N)cc1 Chemical compound CCS(CC)c1ccc(C(CO)N)cc1 OSKBHWZCZQZMJR-UHFFFAOYSA-N 0.000 description 1
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- QSQMYQCRSIJXEF-UHFFFAOYSA-N CS(N(CC1)CCC1C(CO)N)(=O)=O Chemical compound CS(N(CC1)CCC1C(CO)N)(=O)=O QSQMYQCRSIJXEF-UHFFFAOYSA-N 0.000 description 1
- CUWXLJOCFGCIIG-UHFFFAOYSA-N FC(c1nc(cc(cc2)Br)c2[n]1Cc(cccc1O2)c1OC2(F)F)(F)F Chemical compound FC(c1nc(cc(cc2)Br)c2[n]1Cc(cccc1O2)c1OC2(F)F)(F)F CUWXLJOCFGCIIG-UHFFFAOYSA-N 0.000 description 1
- AEKVBBNGWBBYLL-UHFFFAOYSA-N N#Cc(cc1)ccc1F Chemical compound N#Cc(cc1)ccc1F AEKVBBNGWBBYLL-UHFFFAOYSA-N 0.000 description 1
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| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| CU24487B1 (es) | 2015-05-15 | 2020-11-30 | Aurigene Discovery Tech Ltd | Compuestos de tetrahidroquinolinona sustituidos como moduladores de gamma ror |
| ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
| EP3868750A1 (en) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
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| CN112745268B (zh) * | 2019-10-31 | 2022-09-16 | 江苏恒瑞医药股份有限公司 | 苯并咪唑衍生物的晶型及制备方法 |
| TW202136237A (zh) | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
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2017
- 2017-01-26 TW TW111104096A patent/TW202220968A/zh unknown
- 2017-01-26 TW TW106103216A patent/TWI757266B/zh not_active IP Right Cessation
- 2017-01-27 KR KR1020187024271A patent/KR20180100697A/ko not_active Withdrawn
- 2017-01-27 AU AU2017212577A patent/AU2017212577B2/en not_active Ceased
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- 2017-01-27 MA MA055328A patent/MA55328A/fr unknown
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- 2017-01-27 EP EP21184347.9A patent/EP3939974A1/en not_active Withdrawn
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- 2017-01-27 MA MA045646A patent/MA45646A/fr unknown
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2018
- 2018-07-28 SA SA518392101A patent/SA518392101B1/ar unknown
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2020
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2021
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| WO2017132432A8 (en) | 2017-08-31 |
| TW202220968A (zh) | 2022-06-01 |
| EP3408268A1 (en) | 2018-12-05 |
| TWI757266B (zh) | 2022-03-11 |
| EP3408268B1 (en) | 2021-08-04 |
| CN109071509A (zh) | 2018-12-21 |
| JP2019503385A (ja) | 2019-02-07 |
| CN114230523A (zh) | 2022-03-25 |
| AU2017212577B2 (en) | 2021-05-13 |
| RU2018127360A (ru) | 2020-03-02 |
| AU2017212577A1 (en) | 2018-08-02 |
| MX2018009257A (es) | 2018-11-09 |
| RU2018127360A3 (enExample) | 2020-04-06 |
| TW201734001A (zh) | 2017-10-01 |
| UY37098A (es) | 2017-08-31 |
| JP6948333B2 (ja) | 2021-10-13 |
| EP3408268B8 (en) | 2023-12-06 |
| MX381313B (es) | 2025-03-12 |
| RU2760366C2 (ru) | 2021-11-24 |
| MA55328A (fr) | 2022-01-19 |
| EP3939974A1 (en) | 2022-01-19 |
| CN109071509B (zh) | 2021-11-30 |
| CA3011838A1 (en) | 2017-08-03 |
| SA518392101B1 (ar) | 2022-03-16 |
| RU2021133444A (ru) | 2021-11-29 |
| US20210094940A1 (en) | 2021-04-01 |
| US10829481B2 (en) | 2020-11-10 |
| WO2017132432A1 (en) | 2017-08-03 |
| MA45646A (fr) | 2021-03-24 |
| BR112018015273A2 (pt) | 2018-12-18 |
| JP2021193131A (ja) | 2021-12-23 |
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