JP6916783B2 - 免疫調節剤として有用な化合物 - Google Patents
免疫調節剤として有用な化合物 Download PDFInfo
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- JP6916783B2 JP6916783B2 JP2018519301A JP2018519301A JP6916783B2 JP 6916783 B2 JP6916783 B2 JP 6916783B2 JP 2018519301 A JP2018519301 A JP 2018519301A JP 2018519301 A JP2018519301 A JP 2018519301A JP 6916783 B2 JP6916783 B2 JP 6916783B2
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- methoxy
- chloro
- methyl
- biphenyl
- amino
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- WRFHSRZKYYBXRR-BYYXFNHRSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 WRFHSRZKYYBXRR-BYYXFNHRSA-N 0.000 description 1
- ILJRCYPUUHCMFB-AUZZNGNRSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CC2(CO)C(O)=O)c1Cl Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CC2(CO)C(O)=O)c1Cl ILJRCYPUUHCMFB-AUZZNGNRSA-N 0.000 description 1
- KXDXZSWBCDBUQV-HMIRPBQQSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CCC2)C[C@H]2O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CCC2)C[C@H]2O)c1 KXDXZSWBCDBUQV-HMIRPBQQSA-N 0.000 description 1
- BRSVYIOXUZFYEL-QNGWXLTQSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2O)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2O)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 BRSVYIOXUZFYEL-QNGWXLTQSA-N 0.000 description 1
- NRIVRUNOOXECMJ-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CNC(CO)CO)cc2Cl)cccc1-c1cccc(NC(c2ncccc2CO)=O)c1C Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CNC(CO)CO)cc2Cl)cccc1-c1cccc(NC(c2ncccc2CO)=O)c1C NRIVRUNOOXECMJ-UHFFFAOYSA-N 0.000 description 1
- QVTPURFKWDNZNE-RYCFQHDISA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cc(OCC(N(CC2)C[C@H]2O)=O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cc(OCC(N(CC2)C[C@H]2O)=O)ccc1 QVTPURFKWDNZNE-RYCFQHDISA-N 0.000 description 1
- BSIUOHOAFJTSTG-PSXMRANNSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(OC)=O)O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(OC)=O)O)c1 BSIUOHOAFJTSTG-PSXMRANNSA-N 0.000 description 1
- DVYMCZNVDMGVOJ-UUWRZZSWSA-N Cc1c(COc2cc(OCc3cncc(C(N)=O)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(O)=O)O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C(N)=O)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(O)=O)O)c1 DVYMCZNVDMGVOJ-UUWRZZSWSA-N 0.000 description 1
- MMTNPBFKACADCT-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(C=O)cc2Cl)cccc1-c1cc(OCCCCl)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(C=O)cc2Cl)cccc1-c1cc(OCCCCl)ccc1 MMTNPBFKACADCT-UHFFFAOYSA-N 0.000 description 1
- ZMKOTIDIZAPPQD-XLWWBGEVSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 ZMKOTIDIZAPPQD-XLWWBGEVSA-N 0.000 description 1
- MAOFSUQNDQHIJV-XLWWBGEVSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 MAOFSUQNDQHIJV-XLWWBGEVSA-N 0.000 description 1
- PRNFTNDZZIUYDW-UHFFFAOYSA-N Cc1cc(Br)c(C)c(COc2cc(O)c(C=O)cc2Cl)c1 Chemical compound Cc1cc(Br)c(C)c(COc2cc(O)c(C=O)cc2Cl)c1 PRNFTNDZZIUYDW-UHFFFAOYSA-N 0.000 description 1
- CIVYPGRFVKVBAR-PGUFJCEWSA-N Cc1ccc(COc(c(CNC(CO)(CO)CO)c2)cc(OCc3cccc(-c4cccc(OCCCN(CC5)C[C@@H]5O)c4C)c3C)c2Cl)cc1C Chemical compound Cc1ccc(COc(c(CNC(CO)(CO)CO)c2)cc(OCc3cccc(-c4cccc(OCCCN(CC5)C[C@@H]5O)c4C)c3C)c2Cl)cc1C CIVYPGRFVKVBAR-PGUFJCEWSA-N 0.000 description 1
- FBSWLFXZDATTHB-UUWRZZSWSA-N Cc1cccc(C)c1COc(cc1OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4O)ccc3)ccc2)c(CNC(CO)(CO)CO)cc1Cl Chemical compound Cc1cccc(C)c1COc(cc1OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4O)ccc3)ccc2)c(CNC(CO)(CO)CO)cc1Cl FBSWLFXZDATTHB-UUWRZZSWSA-N 0.000 description 1
- RIFQKLPIDWXDME-IWWXRALLSA-N N=C(c1cc(COc(c(CNC[C@@H](CO)O)c2)cc(OCc(cccc3-c4cccc(OCCCN(CC5)C[C@@H]5O)c4Cl)c3Cl)c2Cl)cnc1)N(CC1)C[C@@H]1O Chemical compound N=C(c1cc(COc(c(CNC[C@@H](CO)O)c2)cc(OCc(cccc3-c4cccc(OCCCN(CC5)C[C@@H]5O)c4Cl)c3Cl)c2Cl)cnc1)N(CC1)C[C@@H]1O RIFQKLPIDWXDME-IWWXRALLSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N N[C@@H](CO)C(O)=O Chemical compound N[C@@H](CO)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105705489B (zh) | 2013-09-04 | 2019-04-26 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| TW201718581A (zh) | 2015-10-19 | 2017-06-01 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
| CA3005727A1 (en) | 2015-11-19 | 2017-05-26 | Incyte Corporation | Substituted 2-methylbiphenyl-3-yl heterocyclic compounds and pharmaceutical compositions thereof useful as immunomodulators |
| CR20180374A (es) | 2015-12-22 | 2018-10-16 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| MA44860A (fr) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CA3028685A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2018005374A1 (en) | 2016-06-27 | 2018-01-04 | Chemocentryx, Inc. | Immunomodulator compounds |
| AU2017294231B2 (en) * | 2016-07-05 | 2021-09-09 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
| JP7168551B2 (ja) * | 2016-07-08 | 2022-11-09 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な1,3-ジヒドロキシフェニル誘導体 |
| WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| KR20210118240A (ko) | 2016-10-14 | 2021-09-29 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| JP7106572B2 (ja) | 2016-12-20 | 2022-07-26 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な化合物 |
| SG10202106743QA (en) | 2016-12-22 | 2021-08-30 | Incyte Corp | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| JP7303108B2 (ja) | 2016-12-22 | 2023-07-04 | インサイト・コーポレイション | 免疫調節剤としての二環式複素芳香環化合物 |
| CR20190318A (es) | 2016-12-22 | 2019-10-21 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US20180179201A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| WO2018124766A2 (ko) | 2016-12-28 | 2018-07-05 | 주식회사 녹십자랩셀 | 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포 |
| US10654815B2 (en) * | 2016-12-29 | 2020-05-19 | Shenzhen Chipscreen Biosciences Co., Ltd. | Urea compound and preparation method and application thereof |
| EP3601258B1 (en) | 2017-03-27 | 2023-08-30 | Bristol-Myers Squibb Company | Substituted isoquionline derivatives as immunomudulators |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
| WO2019008156A1 (en) * | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
| EP3658522B1 (en) * | 2017-07-28 | 2021-12-22 | ChemoCentryx, Inc. | Immunomodulator compounds |
| ES2926540T3 (es) | 2017-08-08 | 2022-10-26 | Chemocentryx Inc | Inmunomoduladores macrocíclicos |
| CN109678796B (zh) * | 2017-10-19 | 2023-01-10 | 上海长森药业有限公司 | Pd-1/pd-l1小分子抑制剂及其制备方法和用途 |
| WO2019098682A1 (ko) | 2017-11-14 | 2019-05-23 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| KR102162289B1 (ko) * | 2017-11-28 | 2020-10-06 | 충남대학교 산학협력단 | Golga2 유전자 넉아웃 폐 섬유화 마우스 모델 |
| KR102162283B1 (ko) * | 2017-11-28 | 2020-10-06 | 충남대학교 산학협력단 | Golga2 유전자 넉아웃 간 섬유화 마우스 모델 |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN109956898B (zh) * | 2017-12-22 | 2021-03-26 | 上海海雁医药科技有限公司 | 免疫调节剂及其制法与医药上的用途 |
| SG11202005962YA (en) | 2017-12-29 | 2020-07-29 | Guangzhou Maxinovel Pharmaceuticals Co Ltd | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application |
| US11414418B2 (en) | 2018-01-23 | 2022-08-16 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CN110092779B (zh) * | 2018-01-29 | 2022-07-12 | 广州丹康医药生物有限公司 | 一种取代的苯基化合物及其应用 |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| JP7387616B2 (ja) | 2018-02-22 | 2023-11-28 | ケモセントリックス,インコーポレイティド | Pd-l1アンタゴニストとしてのインダン-アミン |
| EP3759109B1 (en) | 2018-02-26 | 2023-08-30 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds as hbv replication inhibitors |
| WO2019169123A1 (en) | 2018-03-01 | 2019-09-06 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2019174533A1 (zh) * | 2018-03-13 | 2019-09-19 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| EP4212529B1 (en) | 2018-03-30 | 2025-01-29 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3774883A1 (en) | 2018-04-05 | 2021-02-17 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| EP4520328A3 (en) | 2018-05-11 | 2025-04-16 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3810109B1 (en) | 2018-05-31 | 2024-08-07 | Peloton Therapeutics, Inc. | Compounds and compositions for inhibiting cd73 |
| WO2019230919A1 (ja) | 2018-05-31 | 2019-12-05 | 小野薬品工業株式会社 | 免疫チェックポイント阻害薬の有効性判定バイオマーカー |
| TWI809427B (zh) | 2018-07-13 | 2023-07-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
| CN110872275A (zh) * | 2018-08-31 | 2020-03-10 | 深圳微芯生物科技股份有限公司 | 作为免疫调节剂的联苯化合物及其用途 |
| TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
| EP3870566A1 (en) | 2018-10-24 | 2021-09-01 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| ES2979163T3 (es) | 2018-10-31 | 2024-09-24 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de HPK1 |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP3875458A4 (en) | 2018-11-02 | 2022-08-24 | Shanghai Maxinovel Pharmaceuticals Co., Ltd. | DIPHENYLIKE COMPOUNDS, INTERMEDIATE PRODUCTS THEREOF, PREPARATION PROCESS THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USES THEREOF |
| CN109438263A (zh) * | 2018-11-28 | 2019-03-08 | 南方医科大学 | 一种含取代联苯的萘及其应用 |
| CA3129011C (en) | 2019-03-07 | 2023-12-19 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| US12318403B2 (en) | 2019-03-07 | 2025-06-03 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′-cyclic dinucleotides and prodrugs thereof |
| JP2022526960A (ja) | 2019-03-28 | 2022-05-27 | ブリストル-マイヤーズ スクイブ カンパニー | 腫瘍を処置する方法 |
| EP3946625A1 (en) | 2019-03-28 | 2022-02-09 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN111747927B (zh) * | 2019-03-29 | 2023-08-18 | 广州丹康医药生物有限公司 | 作为免疫调节剂的化合物及其应用 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| US20210386721A1 (en) * | 2019-05-10 | 2021-12-16 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Substituted phenylpropenyl pyridine derivatives, their preparation and pharmaceutical applications |
| CN114340633B (zh) | 2019-05-15 | 2025-12-30 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的三芳基化合物 |
| CN111978287A (zh) * | 2019-05-23 | 2020-11-24 | 中国科学院上海有机化学研究所 | 一类免疫检查点小分子抑制剂及其制备方法和用途 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| KR20220016157A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 국재화 시그너쳐 및 조합 요법 |
| CN114127315A (zh) | 2019-05-30 | 2022-03-01 | 百时美施贵宝公司 | 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法 |
| WO2020243563A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Multi-tumor gene signatures for suitability to immuno-oncology therapy |
| WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
| CN111808086B (zh) * | 2019-06-17 | 2021-12-14 | 上海海雁医药科技有限公司 | 杂环取代的苯乙烯基-4-苯基吡啶衍生物及其制法与医药上的用途 |
| CA3139242A1 (en) | 2019-06-20 | 2020-12-24 | Viengkham Malathong | Compounds for treatment of pd-l1 diseases |
| CN114206338B (zh) | 2019-07-10 | 2025-12-12 | 凯莫森特里克斯股份有限公司 | 作为pd-l1抑制剂的二氢化茚类 |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| AU2020327251A1 (en) | 2019-08-05 | 2022-03-03 | National Cancer Center Japan | Biomarker for accessing efficacy of immune checkpoint inhibitor |
| WO2021030162A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| US20220296619A1 (en) | 2019-08-19 | 2022-09-22 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| US20220348653A1 (en) | 2019-09-22 | 2022-11-03 | Bristol-Myers Squibb Company | Quantitative Spatial Profiling for LAG-3 Antagonist Therapy |
| CN112574183B (zh) * | 2019-09-29 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种pd-1抑制剂及其制备方法和用途 |
| CR20220190A (es) | 2019-09-30 | 2022-06-15 | Incyte Corp | Compuestos de pirido [3,2-d] primidina como inmunomoduladores |
| IL315295A (en) | 2019-09-30 | 2024-10-01 | Gilead Sciences Inc | Hbv vaccines and methods treating hbv |
| JP7642625B2 (ja) * | 2019-10-04 | 2025-03-10 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な化合物 |
| US11713307B2 (en) | 2019-10-16 | 2023-08-01 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases |
| PH12022550877A1 (en) | 2019-10-16 | 2023-03-27 | Chemocentryx Inc | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| CN115942973A (zh) | 2019-11-08 | 2023-04-07 | 百时美施贵宝公司 | 用于黑色素瘤的lag-3拮抗剂疗法 |
| EP4058461A1 (en) | 2019-11-11 | 2022-09-21 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| CN116057068A (zh) | 2019-12-06 | 2023-05-02 | 精密生物科学公司 | 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶 |
| AU2020418006A1 (en) | 2020-01-03 | 2022-08-25 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Biphenyl derivative inhibitor, preparation method therefor and use thereof |
| CN111187172B (zh) * | 2020-01-20 | 2021-10-29 | 中国药科大学 | 硝基苯醚类化合物、其制备方法和药物组合物与用途 |
| CN111205196B (zh) * | 2020-03-04 | 2021-04-02 | 中国科学院昆明植物研究所 | 一种苯酚类ab环结构化合物及其制备方法和应用 |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| US20230141284A1 (en) | 2020-04-10 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Cancer therapeutic method |
| CN111320606B (zh) * | 2020-04-10 | 2021-07-27 | 安徽实特医药科技有限公司 | 苯联吡唑并环类衍生物及其在抗肿瘤药物中的应用 |
| EP4134134A4 (en) | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONISTIC COMPOUND |
| CN111559981B (zh) * | 2020-04-15 | 2023-08-01 | 杭州庆正鸿科技有限公司 | 一种联苯-嘧啶偶联物及其制备方法和应用 |
| KR20230041654A (ko) | 2020-05-05 | 2023-03-24 | 테온 테라퓨틱스, 인크. | 칸나비노이드 수용체 유형 2 (cb2) 조정제 및 그의 용도 |
| CA3193421A1 (en) | 2020-08-28 | 2022-03-03 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
| US20230303700A1 (en) | 2020-08-31 | 2023-09-28 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| TW202214568A (zh) * | 2020-09-09 | 2022-04-16 | 大陸商廣州再極醫藥科技有限公司 | 芳香乙烯類化合物、其製備方法、中間體、藥物組合物及其應用 |
| CN114276328B (zh) * | 2020-09-28 | 2023-09-01 | 北京康辰药业股份有限公司 | 作为小分子免疫抑制剂的化合物、其制备方法及其应用 |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| PE20231438A1 (es) | 2020-11-06 | 2023-09-14 | Incyte Corp | Proceso para hacer un inhibidor de pd-1/pd-l1 y sales y formas cristalinas del mismo |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| CN112834643B (zh) * | 2020-12-31 | 2022-03-18 | 郑州原理生物科技有限公司 | 测定2,6-二羟基-4-甲基吡啶及2,6-二羟基-3-氰基-4-甲基吡啶的方法 |
| WO2022199578A1 (zh) * | 2021-03-22 | 2022-09-29 | 南京明德新药研发有限公司 | 氟代乙烯基联苯衍生物及其应用 |
| AU2022246593A1 (en) | 2021-03-29 | 2023-10-12 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
| CN113135895A (zh) * | 2021-04-30 | 2021-07-20 | 中国药科大学 | 一种新型联苯类衍生物及其制备方法与医药用途 |
| TW202348237A (zh) | 2021-05-13 | 2023-12-16 | 美商基利科學股份有限公司 | TLR8調節化合物及抗HBV siRNA療法之組合 |
| CA3222752A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| KR20240019283A (ko) | 2021-06-11 | 2024-02-14 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 저해제와 항암제의 병용 |
| CN117480155A (zh) | 2021-06-23 | 2024-01-30 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| EP4359413A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| WO2023034530A1 (en) | 2021-09-02 | 2023-03-09 | Teon Therapeutics, Inc. | Methods of improving growth and function of immune cells |
| CA3224890A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| CN114085184B (zh) * | 2021-11-17 | 2023-08-29 | 中山大学 | 含环丙烷结构的联苯类衍生物及其制备方法和应用 |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| CN114181144B (zh) * | 2021-12-06 | 2023-04-04 | 浙江工业大学 | 一种氟代联苯甲基间苯二酚醚类衍生物、其制备方法和应用 |
| EP4444423A1 (en) | 2021-12-06 | 2024-10-16 | Helmholtz-Zentrum Dresden - Rossendorf e.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
| JP2025503962A (ja) | 2022-01-26 | 2025-02-06 | ブリストル-マイヤーズ スクイブ カンパニー | 肝細胞がんのための併用療法 |
| US20230326022A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures |
| WO2024015372A1 (en) | 2022-07-14 | 2024-01-18 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| WO2024043227A1 (ja) | 2022-08-23 | 2024-02-29 | 小野薬品工業株式会社 | 二重特異性抗体 |
| CN115368277B (zh) * | 2022-09-15 | 2024-03-29 | 华侨大学 | 一种含异羟肟酸结构的联苯类化合物及其应用 |
| WO2024088036A1 (zh) * | 2022-10-26 | 2024-05-02 | 西安新通药物研究股份有限公司 | 一种非对称性联苯衍生物及其制备方法与医药用途 |
| KR20250123912A (ko) | 2022-12-21 | 2025-08-18 | 브리스톨-마이어스 스큅 컴퍼니 | 폐암에 대한 병용 요법 |
| KR20250150141A (ko) | 2023-02-23 | 2025-10-17 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 피리도피리미딘 유도체 및 이의 용도 |
| WO2024183756A1 (zh) * | 2023-03-07 | 2024-09-12 | 上海再极医药科技有限公司 | 一种含苯环类化合物及其制备方法和应用 |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240243A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with bulevirtide and an inhibitory nucleic acid targeting hepatitis b virus |
| WO2025245489A1 (en) | 2024-05-24 | 2025-11-27 | Bristol-Myers Squibb Company | Treatment of tumors in subjects having fgl-1 positive samples |
| CN119504834B (zh) * | 2024-11-21 | 2025-10-17 | 南开大学 | 一种以含硅基团为疏水标签的pd-l1蛋白降解剂及其制备方法、药物组合物和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| JPWO2004007439A1 (ja) | 2002-07-10 | 2005-11-10 | 住友製薬株式会社 | ビアリール誘導体 |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| WO2004080377A2 (en) | 2003-03-11 | 2004-09-23 | Neurosearch A/S | Kcnq channel modulating compounds and their pharmaceutical use |
| JP2005179281A (ja) | 2003-12-19 | 2005-07-07 | Sumitomo Pharmaceut Co Ltd | ビフェニル化合物 |
| BRPI0418148A (pt) * | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | 3−(4−ベンジルオキシフェニル)プロパン酸誘導体 |
| WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| JP2009505973A (ja) | 2005-08-09 | 2009-02-12 | アステランド ユーケイ リミテッド | Ep2受容体アゴニスト |
| TW200815377A (en) * | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| EP2139843B1 (en) | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| WO2011082400A2 (en) * | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| CN105705489B (zh) | 2013-09-04 | 2019-04-26 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| ES2727329T3 (es) * | 2013-12-17 | 2019-10-15 | Lilly Co Eli | Compuestos de ácido dimetilbenzoico |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| JP7168551B2 (ja) | 2016-07-08 | 2022-11-09 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な1,3-ジヒドロキシフェニル誘導体 |
| US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
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