JP6640113B2 - 衝撃低減要素を有する自動注入器 - Google Patents
衝撃低減要素を有する自動注入器 Download PDFInfo
- Publication number
- JP6640113B2 JP6640113B2 JP2016566215A JP2016566215A JP6640113B2 JP 6640113 B2 JP6640113 B2 JP 6640113B2 JP 2016566215 A JP2016566215 A JP 2016566215A JP 2016566215 A JP2016566215 A JP 2016566215A JP 6640113 B2 JP6640113 B2 JP 6640113B2
- Authority
- JP
- Japan
- Prior art keywords
- piston
- plunger
- housing
- stopper
- damper mechanism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/06—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using both gas and liquid
- F16F9/08—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using both gas and liquid where gas is in a chamber with a flexible wall
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
- F16F9/103—Devices with one or more members moving linearly to and fro in chambers, any throttling effect being immaterial, i.e. damping by viscous shear effect only
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
- F16F9/14—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect
- F16F9/16—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
- F16F9/14—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect
- F16F9/16—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts
- F16F9/18—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts with a closed cylinder and a piston separating two or more working spaces therein
- F16F9/20—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts with a closed cylinder and a piston separating two or more working spaces therein with the piston-rod extending through both ends of the cylinder, e.g. constant-volume dampers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/32—Details
- F16F9/3207—Constructional features
- F16F9/3228—Constructional features of connections between pistons and piston rods
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/32—Details
- F16F9/34—Special valve constructions; Shape or construction of throttling passages
- F16F9/348—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/32—Details
- F16F9/34—Special valve constructions; Shape or construction of throttling passages
- F16F9/348—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body
- F16F9/3481—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body characterised by shape or construction of throttling passages in piston
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
- F16F9/32—Details
- F16F9/36—Special sealings, including sealings or guides for piston-rods
- F16F9/361—Sealings of the bellows-type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461990063P | 2014-05-07 | 2014-05-07 | |
| US61/990,063 | 2014-05-07 | ||
| PCT/US2015/029485 WO2015171777A1 (en) | 2014-05-07 | 2015-05-06 | Autoinjector with shock reducing elements |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019232375A Division JP7123898B2 (ja) | 2014-05-07 | 2019-12-24 | 衝撃低減要素を有する自動注入器 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518791A JP2017518791A (ja) | 2017-07-13 |
| JP2017518791A5 JP2017518791A5 (enExample) | 2018-05-31 |
| JP6640113B2 true JP6640113B2 (ja) | 2020-02-05 |
Family
ID=53200314
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016566215A Active JP6640113B2 (ja) | 2014-05-07 | 2015-05-06 | 衝撃低減要素を有する自動注入器 |
| JP2019232375A Active JP7123898B2 (ja) | 2014-05-07 | 2019-12-24 | 衝撃低減要素を有する自動注入器 |
| JP2022075795A Active JP7487257B2 (ja) | 2014-05-07 | 2022-05-02 | 衝撃低減要素を有する自動注入器 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019232375A Active JP7123898B2 (ja) | 2014-05-07 | 2019-12-24 | 衝撃低減要素を有する自動注入器 |
| JP2022075795A Active JP7487257B2 (ja) | 2014-05-07 | 2022-05-02 | 衝撃低減要素を有する自動注入器 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10722655B2 (enExample) |
| EP (2) | EP3785749B1 (enExample) |
| JP (3) | JP6640113B2 (enExample) |
| KR (1) | KR102496507B1 (enExample) |
| CN (1) | CN106413779B (enExample) |
| AU (1) | AU2015256082C1 (enExample) |
| BR (1) | BR112016025852B1 (enExample) |
| CA (2) | CA3193070A1 (enExample) |
| ES (1) | ES3072073T3 (enExample) |
| IL (1) | IL247935B (enExample) |
| MX (1) | MX388536B (enExample) |
| SG (2) | SG11201609219QA (enExample) |
| WO (1) | WO2015171777A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016163642A (ja) * | 2015-03-06 | 2016-09-08 | 大成化工株式会社 | 針付きバレル及びこれを備えたシリンジ |
| FR3036966B1 (fr) * | 2015-06-05 | 2021-10-01 | Aptar France Sas | Autoinjecteur |
| JP2018535046A (ja) * | 2015-11-27 | 2018-11-29 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 自動注射器 |
| JOP20170042B1 (ar) | 2016-02-12 | 2022-09-15 | Amgen Inc | وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه |
| WO2017160799A1 (en) * | 2016-03-15 | 2017-09-21 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
| EP3439715B1 (en) | 2016-04-08 | 2021-03-10 | Amgen Inc. | Drug delivery device |
| US10549044B2 (en) * | 2016-06-09 | 2020-02-04 | Becton, Dickinson And Company | Spacer assembly for drug delivery system |
| US20180015224A1 (en) | 2016-07-13 | 2018-01-18 | California Institute Of Technology | Dampers and Methods for Performing Measurements in an Autoinjector |
| GB2553770A (en) * | 2016-09-09 | 2018-03-21 | Owen Mumford Ltd | Injection device |
| EP3534989A1 (en) | 2016-11-01 | 2019-09-11 | Sanofi-Aventis Deutschland GmbH | Feedback mechanism for an injection device |
| EP3348294A1 (en) * | 2017-01-13 | 2018-07-18 | Carebay Europe Ltd. | Medicament delivery device |
| WO2018136398A1 (en) * | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
| MA49447A (fr) * | 2017-06-22 | 2020-04-29 | Amgen Inc | Réduction des impacts/chocs d'activation d'un dispositif |
| EP3740266A4 (en) | 2018-01-19 | 2021-10-13 | Birya Biotech, Inc. | TOOL FOR MAINTENANCE OF AN AUTOMATIC INJECTOR |
| JP7324774B2 (ja) * | 2018-04-19 | 2023-08-10 | サノフイ | 注射デバイス用のショックアブソーバ |
| CN112292167B (zh) | 2018-04-19 | 2023-01-20 | 赛诺菲 | 注射装置中的力减小 |
| WO2020072577A1 (en) | 2018-10-02 | 2020-04-09 | Amgen Inc. | Injection systems for drug delivery with internal force transmission |
| JP7719714B2 (ja) * | 2018-10-15 | 2025-08-06 | アムジエン・インコーポレーテツド | ダンピング機構を有する薬物送達装置 |
| WO2020091956A1 (en) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| MA54057A (fr) | 2018-11-01 | 2022-02-09 | Amgen Inc | Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament |
| PE20240329A1 (es) | 2019-06-05 | 2024-02-27 | Regeneron Pharma | Dispositivos y metodos para administracion de dosis de precision |
| CN114728134A (zh) | 2019-09-25 | 2022-07-08 | 杨森制药公司 | 药物施用系统的互连 |
| BR112022005850A2 (pt) * | 2019-09-30 | 2022-06-21 | Amgen Inc | Dispositivo de administração de fármaco |
| JP7425883B2 (ja) * | 2020-09-11 | 2024-01-31 | 富士フイルム株式会社 | 濃縮デバイス、検体液の濃縮方法、検体液の検査方法、及び、検査キット |
| JP7075977B2 (ja) * | 2020-10-09 | 2022-05-26 | 成田空港給油施設株式会社 | シリンジ |
| JP7887184B2 (ja) * | 2021-02-12 | 2026-07-09 | アルタヴィズ,リミティッド・ライアビリティ・カンパニー | 外部動力式シリンジドライバおよびこれを使用するシステムおよび方法 |
| US11311666B1 (en) | 2021-02-18 | 2022-04-26 | Fresenius Kabi Deutschland Gmbh | Modular wearable medicament delivery device and method of use thereof |
| US11464902B1 (en) | 2021-02-18 | 2022-10-11 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with compressible reservoir and method of use thereof |
| US11872369B1 (en) | 2021-02-18 | 2024-01-16 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof |
| US11497847B1 (en) | 2021-02-19 | 2022-11-15 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive substrate |
| US11607505B1 (en) | 2021-02-19 | 2023-03-21 | Fresenius Kabi Deutschland Gmbh | Wearable injector with sterility sensors |
| US11426523B1 (en) | 2021-02-19 | 2022-08-30 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a removable cartridge |
| US11633537B1 (en) | 2021-02-19 | 2023-04-25 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a pre-filled cartridge |
| US11406755B1 (en) | 2021-02-19 | 2022-08-09 | Fresenius Kabi Deutschland Gmbh | Sensing fluid flow irregularities in an on-body injector |
| US11344682B1 (en) | 2021-02-19 | 2022-05-31 | Fresenius Kabi Deutschland Gmbh | Drug supply cartridge with visual use indicator and delivery devices that use the same |
| US11413394B1 (en) | 2021-02-19 | 2022-08-16 | Fresenius Kabi Deutschland Gmbh | Display for wearable drug delivery device |
| JPWO2022191136A1 (enExample) * | 2021-03-12 | 2022-09-15 | ||
| JP2024510668A (ja) * | 2021-03-25 | 2024-03-08 | アムジエン・インコーポレーテツド | 薬物送達デバイス |
| US11529459B1 (en) | 2021-04-30 | 2022-12-20 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive module |
| US11504470B1 (en) | 2021-04-30 | 2022-11-22 | Fresenius Kabi Deutschland Gmbh | Deformable drug reservoir for wearable drug delivery device |
| US11351300B1 (en) | 2021-04-30 | 2022-06-07 | Fresenius Kabl Deutschland GmbH | Drug dispensing system with replaceable drug supply cartridges |
| US11419976B1 (en) | 2021-04-30 | 2022-08-23 | Fresenius Kabi Deutschland Gmbh | Wearable drug delivery device with pressurized fluid dispensing |
| US11717608B1 (en) | 2021-05-03 | 2023-08-08 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including an adhesive pad |
| US11484646B1 (en) | 2021-05-04 | 2022-11-01 | Fresenius Kabi Deutschland Gmbh | Sealing systems for a reservoir of an on-body injector |
| US12649031B2 (en) | 2021-09-08 | 2026-06-09 | Regeneron Pharmaceuticals, Inc. | Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation |
| JP7903808B2 (ja) * | 2022-05-02 | 2026-08-12 | コスメディ製薬株式会社 | マイクロニードル用アプリケータ |
| CN217409470U (zh) * | 2022-05-11 | 2022-09-13 | 苏州嘉树医疗科技有限公司 | 适用于液体容器的助推机构 |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| CN119746211B (zh) * | 2024-12-29 | 2025-12-12 | 深圳市美好创亿医疗科技股份有限公司 | 延时机构及注射装置 |
| US12420017B1 (en) * | 2025-02-26 | 2025-09-23 | Genzyme Corporation | Damping device for a medicament delivery device |
Family Cites Families (227)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE537349A (enExample) | ||||
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| AU646822B2 (en) | 1989-10-13 | 1994-03-10 | Kirin-Amgen Inc. | Erythropoietin isoforms |
| US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
| US5318156A (en) | 1992-12-15 | 1994-06-07 | Honeywell Inc. | Rigid volume viscous damper |
| IL110669A (en) | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
| AU3272695A (en) | 1994-08-12 | 1996-03-07 | Immunomedics Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| GB9504878D0 (en) | 1995-03-10 | 1995-04-26 | Weston Medical Ltd | Viscously coupled actuator |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US6391633B1 (en) | 1997-07-23 | 2002-05-21 | Roche Diagnostics Gmbh | Production of erythropoietin by endogenous gene activation |
| US6090078A (en) * | 1997-09-30 | 2000-07-18 | Becton, Dickinson And Company | Dampening devices and methods for needle retracting safety vascular access devices |
| US6030086A (en) | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
| US6310078B1 (en) | 1998-04-20 | 2001-10-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as erythropoietin mimetics |
| DE19821933C1 (de) | 1998-05-15 | 1999-11-11 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
| DK1088084T3 (da) | 1998-06-15 | 2007-01-29 | Gtc Biotherapeutics Inc | Erythropoietin analog-humant serumalbumin fusionsprotein |
| US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| US7798993B2 (en) * | 1998-07-29 | 2010-09-21 | Becton, Dickinson And Company | Single use syringe |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| DE69935345T3 (de) | 1998-10-23 | 2018-03-01 | Amgen Inc. | Methoden und zusammensetzungen zur prävention und behandlung der anämie |
| SE9803662D0 (sv) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | Autoinjector |
| ES2639020T3 (es) | 1998-11-27 | 2017-10-25 | Ucb Pharma S.A. | Composiciones y métodos para incrementar la mineralización de la substancia ósea |
| EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
| EP1169352A4 (en) | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
| US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| ATE308354T1 (de) | 1999-04-16 | 2005-11-15 | Becton Dickinson Co | Stiftförmiger injektor mit merkmalen zur automatischen substanzkombination |
| US6171286B1 (en) * | 1999-04-20 | 2001-01-09 | James R. Gross | Self-aligning syringe plunger |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| AU1099601A (en) | 1999-10-22 | 2001-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules derived from rat brain and programmed cell death models |
| US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| JP4810042B2 (ja) | 2000-01-21 | 2011-11-09 | バイオヴェックス リミテッド | ヘルペスウイルス株 |
| AUPQ599700A0 (en) | 2000-03-03 | 2000-03-23 | Super Internet Site System Pty Ltd | On-line geographical directory |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU5551601A (en) | 2000-04-21 | 2001-11-07 | Amgen Inc | Methods and compositions for the prevention and treatment of anemia |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| GB2366705B (en) | 2000-08-29 | 2004-07-14 | Motorola Inc | Communications system, communications unit and method of operation |
| US20030191291A1 (en) | 2000-09-08 | 2003-10-09 | Kochendoerfer Gerd G. | Synthetic erythropoiesis stimulating proteins |
| US7271689B1 (en) | 2000-11-22 | 2007-09-18 | Fonar Corporation | Magnet structure |
| EP1345628B1 (en) | 2000-12-20 | 2011-04-13 | F. Hoffmann-La Roche AG | Conjugates of erythropoietin (epo) with polyethylene glycol (peg) |
| NZ527302A (en) | 2001-01-05 | 2006-10-27 | Abgenix Inc | Antibodies to insulin-like growth factor I receptor |
| JP2005503127A (ja) | 2001-04-04 | 2005-02-03 | ジェンオディセ | エリスロポエチン遺伝子の新規ポリヌクレオチド及びポリペプチド |
| HU229910B1 (hu) | 2001-05-11 | 2014-12-29 | Amgen Inc Thousand Oaks | A TALL-1-hez kötõdõ peptidek és rokon molekulák |
| TR201809678T4 (tr) | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| US6900292B2 (en) | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| KR100911951B1 (ko) | 2001-08-23 | 2009-08-13 | 젠맵 에이/에스 | 인터루킨 15 (il-15)에 대하여 특이적인 인간 항체 |
| US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| GB0125506D0 (en) * | 2001-10-24 | 2001-12-12 | Weston Medical Ltd | Needle free injection method and apparatus |
| WO2003055526A2 (en) | 2001-12-21 | 2003-07-10 | Maxygen Aps | Erythropoietin conjugates |
| ES2283759T3 (es) | 2002-01-18 | 2007-11-01 | Pierre Fabre Medicament | Anticuerpos anti-igf-ir y sus aplicaciones. |
| US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| GB0202252D0 (en) | 2002-01-31 | 2002-03-20 | Oxford Biomedica Ltd | Anemia |
| EP1470232A1 (en) | 2002-01-31 | 2004-10-27 | Oxford Biomedica (UK) Limited | Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia |
| ATE363541T1 (de) | 2002-03-26 | 2007-06-15 | Lek Tovarna Farmacevtskih | Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen |
| WO2003084477A2 (en) | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
| KR100954975B1 (ko) | 2002-03-29 | 2010-04-30 | 구미아이 가가쿠 고교 가부시키가이샤 | 아세토락테이트 합성효소를 암호화하는 유전자 |
| WO2003094858A2 (en) | 2002-05-13 | 2003-11-20 | Modigenetech Ltd. | Ctp-extended erythropoietin |
| GB0211294D0 (en) * | 2002-05-17 | 2002-06-26 | Owen Mumford Ltd | Improvements relating to injection devices |
| MXPA04011624A (es) | 2002-05-24 | 2005-03-07 | Schering Corp | Anticuerpo neutralizante humano anti-igfr. |
| DE10226537A1 (de) | 2002-06-14 | 2004-01-08 | Peter Eichhorst | Preinjektionseinrichtung |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7241733B2 (en) | 2002-06-28 | 2007-07-10 | Centocor, Inc. | Mammalian EPO mimetic CH1 deleted mimetibodies, compositions, methods and uses |
| WO2004002417A2 (en) | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
| WO2004009627A1 (en) | 2002-07-19 | 2004-01-29 | Cangene Corporation | Pegylated erythropoietic compounds |
| AU2003257994A1 (en) * | 2002-07-31 | 2004-02-16 | Alza Corporation | Injection device providing automatic needle retraction |
| TW200413406A (en) | 2002-08-26 | 2004-08-01 | Kirin Brewery | Peptides and drugs containing the same |
| MXPA05002514A (es) | 2002-09-06 | 2005-05-27 | Amgen Inc | Anticuerpo monoclonal anti-il-1r1 humano terapeutico. |
| WO2005025606A1 (en) | 2003-09-09 | 2005-03-24 | Warren Pharmaceuticals, Inc. | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| MXPA05002594A (es) | 2002-09-11 | 2005-05-27 | Fresenius Kabi Gmbh | Derivados de polipeptidos con hidroxialquilalmidon, especialmente derivados de eritropoyetina con hidroxialquilalmidon. |
| US9486581B2 (en) | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| US7396913B2 (en) | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
| TWI320716B (en) | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
| US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
| WO2004034988A2 (en) | 2002-10-16 | 2004-04-29 | Amgen Inc. | Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors |
| US20040091961A1 (en) | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
| US6939319B1 (en) | 2002-11-20 | 2005-09-06 | Conrad Anstead | Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections |
| GB2396816A (en) * | 2002-12-17 | 2004-07-07 | Pa Consulting Services | Injection device |
| EP1589901A4 (en) * | 2002-12-20 | 2006-08-09 | Generipharm Inc | INTRAKUTANE INJECTION |
| AU2003301195B2 (en) | 2002-12-20 | 2010-01-07 | Amgen Inc. | Binding agents which inhibit myostatin |
| BRPI0408317A (pt) | 2003-03-14 | 2006-03-07 | Pharmacia Corp | anticorpos do receptor de igf-i para o tratamento de cáncer |
| CA2519113C (en) | 2003-04-02 | 2012-06-05 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
| US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
| EP2365001A3 (en) | 2003-05-01 | 2012-03-28 | Imclone LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| PL1625156T3 (pl) | 2003-05-12 | 2013-03-29 | Affymax Inc | Peptydy wiążące się do receptora erytropoetyny |
| KR101163683B1 (ko) | 2003-05-12 | 2012-07-10 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 신규의 펩티드 |
| JP2007530440A (ja) | 2003-05-12 | 2007-11-01 | アフィーマックス・インコーポレイテッド | 新規ポリ(エチレングリコール)修飾化合物およびその用途 |
| US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
| JP2005016719A (ja) * | 2003-05-30 | 2005-01-20 | Thk Co Ltd | 制振材料及びこの制振材料を組み込んだ運動案内装置 |
| WO2004108667A2 (en) | 2003-05-30 | 2004-12-16 | Centocor, Inc. | Formation of novel erythropoietin conjugates using transglutaminase |
| WO2005001136A1 (en) | 2003-06-04 | 2005-01-06 | Irm Llc | Methods and compositions for modulating erythropoietin expression |
| AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| UA97086C2 (uk) | 2003-07-15 | 2012-01-10 | Емджен, Інк. | Виділене людське антитіло, яке специфічно зв'язується з фактором росту нервової тканини (ngf) |
| EA015363B1 (ru) | 2003-07-18 | 2011-06-30 | Эмджен Инк. | Агенты, специфически связывающие фактор роста гепатоцитов, и их применение |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| GB0317511D0 (en) | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| JP2007512001A (ja) | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Epoミメティックペプチドおよび融合タンパク質 |
| IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
| US20060127404A1 (en) | 2003-09-30 | 2006-06-15 | Chichi Huang | Hinge core mimetibodies, compositions, methods and uses |
| UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
| UA93653C2 (ru) | 2003-11-07 | 2011-03-10 | Иммунекс Корпорейшн | Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r) |
| AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| NZ547168A (en) | 2003-11-24 | 2010-05-28 | Biogenerix Ag | Glycopegylated erythropoietin |
| WO2005058967A2 (en) | 2003-12-16 | 2005-06-30 | Pierre Fabre Medicament | Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof |
| EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
| EP1699920A4 (en) | 2003-12-31 | 2008-05-28 | Centocor Inc | NEW RECOMBINANT PROTEINS WITH FREE N-TERMINAL THIOL |
| EP1699821B1 (en) | 2003-12-31 | 2012-06-20 | Merck Patent GmbH | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| CN101912325A (zh) | 2004-01-12 | 2010-12-15 | i科学外科公司 | 一种输送粘性材料的注射器 |
| US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
| WO2005070451A1 (en) | 2004-01-22 | 2005-08-04 | Zafena Aktiebolag | Pharmaceutical composition comprising non-glycosylated erythropoietin |
| WO2005084711A1 (en) | 2004-03-02 | 2005-09-15 | Chengdu Institute Of Biological Products | A pegylated recombinant erythropoietin that has in vivo activity |
| TW200603818A (en) | 2004-03-11 | 2006-02-01 | Fresenius Kabi De Gmbh | Conjugates of hydroxyethyl starch and erythropoietin |
| CA2560889A1 (en) | 2004-03-23 | 2005-10-13 | Sanjay D. Khare | Monoclonal antibodies specific for human ox40l (cd 134l) |
| US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
| CA2563874A1 (en) | 2004-04-23 | 2005-11-03 | Cambridge Antibody Technology Limited | Erythropoietin protein variants |
| GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
| GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
| EP1781697B1 (en) | 2004-07-07 | 2009-04-22 | H.Lundbeck A/S | Novel carbamylated epo and method for its production |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US20060073563A1 (en) | 2004-09-02 | 2006-04-06 | Xencor, Inc. | Erythropoietin derivatives with altered immunogenicity |
| EP1814616A1 (en) | 2004-11-04 | 2007-08-08 | Sid Technologies Llc | Automatic injector |
| AU2005303887A1 (en) | 2004-11-10 | 2006-05-18 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| WO2006081171A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
| WO2006079064A1 (en) | 2005-01-24 | 2006-07-27 | Antares Pharma, Inc. | Prefilled needle assisted jet injector |
| GB2424838B (en) | 2005-04-06 | 2011-02-23 | Cilag Ag Int | Injection device (adaptable drive) |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| DE102005025424A1 (de) | 2005-06-02 | 2006-12-07 | Tecpharma Licensing Ag | Injektionsvorrichtung mit einem Drehfederantrieb |
| CA2678008C (en) | 2005-06-17 | 2013-07-30 | Imclone Systems Incorporated | Methods of treating a secondary bone tumor with anti-pdgfralpha antibodies |
| WO2007000328A1 (en) | 2005-06-27 | 2007-01-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof |
| DK1915398T3 (en) | 2005-07-18 | 2016-07-04 | Amgen Inc | Humane anti-B7RP1 neutraliserende antistoffer |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| DE102005038933A1 (de) * | 2005-08-17 | 2007-02-22 | L + N Plast Vertriebs Gmbh | Autoinjektionsgerät |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| GB0603683D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
| CN103255162A (zh) | 2006-05-19 | 2013-08-21 | 格利科菲公司 | 促红细胞生成素组合物 |
| FR2905273B1 (fr) * | 2006-09-06 | 2009-04-03 | Becton Dickinson France Soc Pa | Dispositif d'injection automatique avec moyen de temporisation. |
| CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
| EP3738626B1 (de) | 2006-09-15 | 2022-08-10 | Ypsomed AG | Injektionsgerät mit verbessertem förderelement |
| CA2667869A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| CA2667894A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| WO2008133647A2 (en) | 2006-11-07 | 2008-11-06 | Merck & Co., Inc. | Antagonists of pcsk9 |
| WO2008057457A2 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| AR064333A1 (es) | 2006-12-14 | 2009-04-01 | Schering Corp | Anticuerpo anti-tslp de diseno |
| ES2657483T3 (es) * | 2007-03-09 | 2018-03-05 | Eli Lilly And Company | Mecanismo de retardo para un dispositivo de inyección automática |
| AR066042A1 (es) | 2007-04-13 | 2009-07-22 | Novartis Ag | Moleculas y metodos para modular la proteina convertasa-subtilisina /quexina tipo 9 (pcsk9) |
| KR20100034015A (ko) | 2007-06-20 | 2010-03-31 | 아이알엠 엘엘씨 | 알레르기 질환 치료를 위한 방법 및 조성물 |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| CN102232088A (zh) | 2007-10-26 | 2011-11-02 | 先灵公司 | 用于治疗脂类和胆固醇疾病的抗pcsk9及方法 |
| AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| GB0802351D0 (en) | 2008-02-08 | 2008-03-12 | Owen Mumford Ltd | Injection devices |
| WO2009141219A1 (en) * | 2008-05-20 | 2009-11-26 | Shl Group Ab | Device for a medicament delivery device |
| KR101382346B1 (ko) * | 2008-05-23 | 2014-04-08 | 현대자동차 주식회사 | 차량용 쇽 업소버 |
| DE102008044852A1 (de) | 2008-08-28 | 2010-03-04 | Schaeffler Kg | Dämpfungsvorrichtung, insbesondere für Spannvorrichtungen von Zugmitteltrieben an oder in Verbrennungskraftmaschinen |
| TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Pcsk9拮抗劑類 |
| CN102264417B (zh) | 2008-10-29 | 2014-01-01 | Shl集团有限责任公司 | 注射装置 |
| EP2355867B1 (en) | 2008-12-12 | 2014-07-16 | SHL Group AB | Medicament delivery device |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| EP2218473B1 (de) | 2009-02-11 | 2011-08-17 | Nils Leuzinger | Injektionsvorrichtung mit Druckdämpfung für die Injektion eines Fluids |
| DE202009001836U1 (de) | 2009-02-13 | 2009-06-25 | Dieter Hölzle Technik-Projekte GmbH | Elektromechanische Injektionsvorrichtung |
| GB0913136D0 (en) | 2009-07-28 | 2009-09-02 | Ucb Pharma Sa | Auto-injector |
| US20120219558A1 (en) | 2009-09-25 | 2012-08-30 | Yan Ni | Antagonists of pcsk9 |
| CA2777698A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Ax1 and ax189 pcsk9 antagonists and variants |
| AU2010313324A1 (en) | 2009-10-30 | 2012-04-12 | Merck Sharp & Dohme Corp. | AX213 and AX132 PCSK9 antagonists and variants |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| WO2011096907A1 (en) | 2010-02-08 | 2011-08-11 | Insu Teknik Makina Sanayi Ve Ticaret Anonim Sirketi | Easy to produce, single piece valve body and piston body for shock absorbers |
| WO2011101378A1 (en) * | 2010-02-18 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Finger guard for an injection device |
| US9248245B2 (en) * | 2010-02-18 | 2016-02-02 | Sanofi-Aventis Deutschlannd GMBH | Auto-injector |
| EP2364741A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Interlock mechanism for defining an operation sequence of an auto-injector |
| EP2364740A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Arrangement for transferring a translation of a drive means to a plunger |
| EP2364739A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Re-usable autoinjector |
| NZ602220A (en) | 2010-03-11 | 2014-10-31 | Rinat Neuroscience Corp | Antibodies with ph dependent antigen binding |
| EP2399627A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| EP2399631A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector with injection damper |
| US9233209B2 (en) * | 2010-08-27 | 2016-01-12 | Novo Nordisk A/S | Medical injection device |
| EP2438939A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Arrangement for coupling a plunger to either a syringe or a stopper |
| WO2012054438A1 (en) | 2010-10-22 | 2012-04-26 | Schering Corporation | Anti-pcsk9 |
| EP2468337A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Back-end device for an auto-injector and auto-injector |
| EP2468341A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| CN103261230A (zh) | 2010-12-22 | 2013-08-21 | 霍夫曼-拉罗奇有限公司 | 抗pcsk9抗体及使用方法 |
| GB2487235A (en) | 2011-01-17 | 2012-07-18 | Owen Mumford Ltd | Injection device with pneumatic damping of the drive mechanism |
| US9084849B2 (en) * | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| CA2825778A1 (en) | 2011-01-28 | 2012-08-02 | Sanofi | Pharmaceutical compositions comprising human antibodies to pcsk9 |
| MX2013009258A (es) | 2011-02-11 | 2013-10-17 | Novartis Ag | Antagonistas de pcsk9. |
| US9956345B2 (en) | 2011-04-21 | 2018-05-01 | Abbvie Inc. | Wearable automatic injection device for controlled administration of therapeutic agents |
| JOP20200043A1 (ar) | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| EP2854898B1 (en) | 2012-05-31 | 2019-07-10 | SHL Medical AG | Medicament delivery device with delayed feedback mechanism |
| EP2716316A1 (en) * | 2012-10-04 | 2014-04-09 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device with damping mechanism |
| US20140114248A1 (en) * | 2012-10-24 | 2014-04-24 | Nuance Designs, LLC | Power pack for an autoinjector |
| EP3907237A1 (en) | 2012-12-20 | 2021-11-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| US8591463B1 (en) * | 2013-03-08 | 2013-11-26 | Teva Pharmaceutical Industries Ltd. | Re-useable injector device for syringe |
| SG11201507524TA (en) | 2013-03-14 | 2015-10-29 | Amgen Inc | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| US20140274874A1 (en) | 2013-03-14 | 2014-09-18 | Amgen Inc. | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| EA201591482A1 (ru) | 2013-03-14 | 2016-01-29 | Эли Лилли Энд Компани | Механизм задержки, подходящий для компактного автоматического инъекционного устройства |
| US9402716B2 (en) * | 2013-03-15 | 2016-08-02 | Abbott Medical Optics Inc. | Intraocular lens inserter and system and method regarding same |
| EP2781230B2 (de) | 2013-03-22 | 2025-05-14 | Ypsomed AG | Substanzabgabevorrichtung mit Signalvorrichtung |
| AR095807A1 (es) | 2013-04-10 | 2015-11-11 | Sanofi Sa | Mecanismo de control de velocidad de dispensación y dispositivo de inyección |
| EP2988799B1 (en) | 2013-04-23 | 2019-02-27 | E3D Agricultural Cooperative Association Ltd. | Automatic injection device for administration of high viscosity medication |
| US20140350517A1 (en) * | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Injection device with stress protection |
| JP2016519976A (ja) | 2013-06-03 | 2016-07-11 | ノボ・ノルデイスク・エー/エス | 医療用注射装置 |
| US10213559B2 (en) | 2013-10-16 | 2019-02-26 | Novo Nordisk A/S | Drug delivery device with brake mechanism |
| CN105722539B (zh) * | 2013-11-13 | 2021-01-15 | 豪夫迈·罗氏有限公司 | 辅助式手动注射装置和方法 |
| US20180015224A1 (en) * | 2016-07-13 | 2018-01-18 | California Institute Of Technology | Dampers and Methods for Performing Measurements in an Autoinjector |
| EP3534989A1 (en) * | 2016-11-01 | 2019-09-11 | Sanofi-Aventis Deutschland GmbH | Feedback mechanism for an injection device |
| MA49447A (fr) * | 2017-06-22 | 2020-04-29 | Amgen Inc | Réduction des impacts/chocs d'activation d'un dispositif |
| JP7324774B2 (ja) * | 2018-04-19 | 2023-08-10 | サノフイ | 注射デバイス用のショックアブソーバ |
| US11504485B1 (en) * | 2021-08-18 | 2022-11-22 | Cellular Vehicles, Inc. | Cellular therapy infusion devices, systems, and methods for use |
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