JP6625551B2 - Ｆｇｆｒキナーゼ調節剤として有用なキノキサリン誘導体 - Google Patents

Ｆｇｆｒキナーゼ調節剤として有用なキノキサリン誘導体 Download PDF

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JP6625551B2
JP6625551B2 JP2016558669A JP2016558669A JP6625551B2 JP 6625551 B2 JP6625551 B2 JP 6625551B2 JP 2016558669 A JP2016558669 A JP 2016558669A JP 2016558669 A JP2016558669 A JP 2016558669A JP 6625551 B2 JP6625551 B2 JP 6625551B2
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cancer
compound
formula
alkyl
compounds
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JP2017511311A (ja
JP2017511311A5 (https=
Inventor
ウィム、フェレメレン
スティーブン、アナ、ホスティン
フィリップ、アルベール、セリーヌ、キュイケン
ラッセル、マーク、ジョーンズ
ディエゴ、フェルナンド、ドメニコ、ブロッジーニ
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016558669A 2014-03-26 2015-03-26 Ｆｇｆｒキナーゼ調節剤として有用なキノキサリン誘導体 Active JP6625551B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14161820.7 2014-03-26
EP14161820 2014-03-26
PCT/EP2015/056507 WO2015144803A1 (en) 2014-03-26 2015-03-26 Quinoxaline derivatives useful as fgfr kinase modulators

Publications (3)

Publication Number Publication Date
JP2017511311A JP2017511311A (ja) 2017-04-20
JP2017511311A5 JP2017511311A5 (https=) 2018-05-10
JP6625551B2 true JP6625551B2 (ja) 2019-12-25

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JP2016558669A Active JP6625551B2 (ja) 2014-03-26 2015-03-26 Ｆｇｆｒキナーゼ調節剤として有用なキノキサリン誘導体

Country Status (38)

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US (2) US9902714B2 (https=)
EP (1) EP3122742B1 (https=)
JP (1) JP6625551B2 (https=)
KR (1) KR102469506B1 (https=)
CN (1) CN106459010B (https=)
AP (1) AP2016009536A0 (https=)
AR (1) AR099854A1 (https=)
AU (1) AU2015238300C1 (https=)
BR (1) BR112016022060B1 (https=)
CA (1) CA2943683A1 (https=)
CL (1) CL2016002382A1 (https=)
CR (1) CR20160501A (https=)
CY (1) CY1120969T1 (https=)
DK (1) DK3122742T3 (https=)
EA (1) EA032145B1 (https=)
ES (1) ES2702450T3 (https=)
HR (1) HRP20182073T1 (https=)
HU (1) HUE041738T2 (https=)
IL (1) IL247658B (https=)
JO (1) JO3512B1 (https=)
LT (1) LT3122742T (https=)
MA (1) MA39783B1 (https=)
MX (1) MX380829B (https=)
MY (1) MY194074A (https=)
NI (1) NI201600144A (https=)
NZ (1) NZ724907A (https=)
PH (1) PH12016501898B1 (https=)
PL (1) PL3122742T3 (https=)
PT (1) PT3122742T (https=)
RS (1) RS58088B1 (https=)
SG (1) SG11201607961QA (https=)
SI (1) SI3122742T1 (https=)
SM (1) SMT201800670T1 (https=)
TR (1) TR201819138T4 (https=)
TW (1) TWI686391B (https=)
UA (1) UA117958C2 (https=)
WO (1) WO2015144803A1 (https=)
ZA (1) ZA201606942B (https=)

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