JP6456143B2 - カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物 - Google Patents

カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物 Download PDF

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JP6456143B2
JP6456143B2 JP2014547135A JP2014547135A JP6456143B2 JP 6456143 B2 JP6456143 B2 JP 6456143B2 JP 2014547135 A JP2014547135 A JP 2014547135A JP 2014547135 A JP2014547135 A JP 2014547135A JP 6456143 B2 JP6456143 B2 JP 6456143B2
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compound
reaction
mixture
product
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JP2015500335A5 (enExample
JP2015500335A (ja
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ルッソ，ドメニコ
アルノ キス，ラズロ
アルノ キス，ラズロ
ブルーノ ライス ワノン，ジョルジュ
ブルーノ ライス ワノン，ジョルジュ
アレクサンダー リーマス，デヴィッド
アレクサンダー リーマス，デヴィッド
エスゼニー，ティボル
ジメルマン，アクセル
シュルメル，ビョルン
クライス，ミカエル
ロイター，クラウス
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ノヴィファーマ，エス．アー．
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Priority claimed from GBGB1121413.7A external-priority patent/GB201121413D0/en
Priority claimed from GBGB1201758.8A external-priority patent/GB201201758D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014547135A 2011-12-13 2012-12-12 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物 Active JP6456143B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161570141P 2011-12-13 2011-12-13
GB1121413.7 2011-12-13
GBGB1121413.7A GB201121413D0 (en) 2011-12-13 2011-12-13 Chemical compounds and processes
US61/570,141 2011-12-13
US201261593625P 2012-02-01 2012-02-01
US61/593,625 2012-02-01
GB1201758.8 2012-02-01
GBGB1201758.8A GB201201758D0 (en) 2012-02-01 2012-02-01 Chemical compounds and processes
US201261718589P 2012-10-25 2012-10-25
US61/718,589 2012-10-25
PCT/PT2012/000048 WO2013089573A1 (en) 2011-12-13 2012-12-12 Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor

Related Child Applications (1)

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JP2017207738A Division JP6721558B2 (ja) 2011-12-13 2017-10-27 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物

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JP2015500335A JP2015500335A (ja) 2015-01-05
JP2015500335A5 JP2015500335A5 (enExample) 2016-02-12
JP6456143B2 true JP6456143B2 (ja) 2019-01-23

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JP2014547135A Active JP6456143B2 (ja) 2011-12-13 2012-12-12 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物
JP2017207738A Active JP6721558B2 (ja) 2011-12-13 2017-10-27 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物
JP2019214566A Withdrawn JP2020059729A (ja) 2011-12-13 2019-11-27 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物

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JP2017207738A Active JP6721558B2 (ja) 2011-12-13 2017-10-27 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物
JP2019214566A Withdrawn JP2020059729A (ja) 2011-12-13 2019-11-27 カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物

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US (2) US9126988B2 (enExample)
EP (2) EP2791134B1 (enExample)
JP (3) JP6456143B2 (enExample)
BR (1) BR112014014341A2 (enExample)
CA (2) CA3088684C (enExample)
CY (1) CY1122580T1 (enExample)
DK (1) DK2791134T3 (enExample)
ES (2) ES2758659T3 (enExample)
HR (1) HRP20192133T8 (enExample)
HU (1) HUE047856T2 (enExample)
PL (1) PL2791134T3 (enExample)
PT (2) PT2791134T (enExample)
RS (1) RS59666B1 (enExample)
SI (1) SI2791134T1 (enExample)
WO (1) WO2013089573A1 (enExample)

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CN113292489B (zh) * 2021-06-16 2022-08-30 泓博智源(开原)药业有限公司 二氯代二烷基烟腈的制备方法
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JP2026524539A (ja) 2023-07-11 2026-07-22 テイ・セラピューティクス・リミテッド Ｐｔｃリードスルー剤としてのナフチリジン又はピリドピリミジン核を含む化合物
CN119775271A (zh) * 2024-12-31 2025-04-08 南京海纳医药科技股份有限公司 一种奥吡卡朋粗品的精制方法
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CA2858025C (en) 2020-09-22
CY1122580T1 (el) 2021-01-27
WO2013089573A1 (en) 2013-06-20
JP2015500335A (ja) 2015-01-05
SI2791134T1 (sl) 2020-01-31
RS59666B1 (sr) 2020-01-31
PT2791134T (pt) 2019-12-18
EP3604299B1 (en) 2023-07-26
HRP20192133T8 (hr) 2021-02-19
PT3604299T (pt) 2023-10-31
US20140350057A1 (en) 2014-11-27
JP6721558B2 (ja) 2020-07-15
EP2791134A1 (en) 2014-10-22
CA3088684A1 (en) 2013-06-20
US9126988B2 (en) 2015-09-08
EP2791134B1 (en) 2019-09-25
HUE047856T2 (hu) 2020-05-28
PL2791134T3 (pl) 2020-03-31
CA2858025A1 (en) 2013-06-20
US9630955B2 (en) 2017-04-25
ES2960805T3 (es) 2024-03-06
BR112014014341A2 (pt) 2017-08-22
US20160009700A1 (en) 2016-01-14
ES2758659T3 (es) 2020-05-06
HRP20192133T1 (hr) 2020-02-21
CA3088684C (en) 2021-10-26
DK2791134T3 (da) 2019-12-09
JP2020059729A (ja) 2020-04-16
EP3604299A1 (en) 2020-02-05
JP2018052949A (ja) 2018-04-05

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