JP6139671B2 - 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 - Google Patents
細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 Download PDFInfo
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- JP6139671B2 JP6139671B2 JP2015513901A JP2015513901A JP6139671B2 JP 6139671 B2 JP6139671 B2 JP 6139671B2 JP 2015513901 A JP2015513901 A JP 2015513901A JP 2015513901 A JP2015513901 A JP 2015513901A JP 6139671 B2 JP6139671 B2 JP 6139671B2
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- C12N2320/32—Special delivery means, e.g. tissue-specific
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120053950 | 2012-05-22 | ||
| KR10-2012-0053950 | 2012-05-22 | ||
| PCT/KR2013/004463 WO2013176477A1 (ko) | 2012-05-22 | 2013-05-21 | 세포 내 관통능을 가지는 rna 간섭을 유도하는 핵산 분자 및 그 용도 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016250474A Division JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518721A JP2015518721A (ja) | 2015-07-06 |
| JP2015518721A5 JP2015518721A5 (https=) | 2016-06-23 |
| JP6139671B2 true JP6139671B2 (ja) | 2017-05-31 |
Family
ID=49624096
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513901A Active JP6139671B2 (ja) | 2012-05-22 | 2013-05-21 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
| JP2016250474A Active JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
| JP2019031549A Active JP6999590B2 (ja) | 2012-05-22 | 2019-02-25 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016250474A Active JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
| JP2019031549A Active JP6999590B2 (ja) | 2012-05-22 | 2019-02-25 | 細胞内貫通能を持ってrna干渉を誘導する核酸分子およびその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10125362B2 (https=) |
| EP (2) | EP3514236A1 (https=) |
| JP (3) | JP6139671B2 (https=) |
| KR (2) | KR101567576B1 (https=) |
| CN (2) | CN108148838A (https=) |
| DK (1) | DK2853597T3 (https=) |
| ES (1) | ES2716818T3 (https=) |
| WO (1) | WO2013176477A1 (https=) |
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| DK2631291T3 (da) | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
| CN108148838A (zh) | 2012-05-22 | 2018-06-12 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及用途 |
| EP3046585B1 (en) | 2013-09-17 | 2021-08-25 | Bolt Threads, Inc. | Methods and compositions for synthesizing improved silk fibers |
| KR102279110B1 (ko) * | 2014-04-30 | 2021-07-20 | 올릭스 주식회사 | LasiRNA를 유효성분으로 포함하는 피부 미백용 조성물 |
| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
| SMT202000454T1 (it) | 2015-04-03 | 2020-11-10 | Univ Massachusetts | Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina |
| CN111875265B (zh) | 2015-05-15 | 2023-09-12 | Agc株式会社 | 化学增强玻璃 |
| TW201718023A (zh) * | 2015-08-06 | 2017-06-01 | 世代好公司 | 細胞滲透性蛋白質-抗體結合物及使用方法 |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| EP4454637A3 (en) | 2015-11-16 | 2025-01-08 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| CA3022877A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb |
| KR102825946B1 (ko) | 2016-02-02 | 2025-06-27 | 올릭스 주식회사 | IL4Rα, TRPA1, 또는 F2RL1을 표적화하는 RNA 복합체를 사용한 아토피 피부염 및 천식의 치료 |
| WO2017178883A2 (en) * | 2016-04-11 | 2017-10-19 | Olix Pharmaceuticals, Inc. | Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
| KR102321426B1 (ko) * | 2017-02-21 | 2021-11-05 | 올릭스 주식회사 | 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | 2テイル自己デリバリー型siRNAおよび関連方法 |
| KR20190037166A (ko) * | 2017-09-28 | 2019-04-05 | 올릭스 주식회사 | 결합 조직 성장 인자를 표적으로 하는 rna 복합체를 함유하는 노인성 황반변성의 예방 또는 치료용 약학 조성물 |
| IL274611B2 (en) * | 2017-11-13 | 2024-10-01 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of a target gene comprising phosphorodithioate linkages |
| MX2020004897A (es) | 2017-11-13 | 2020-10-05 | Silence Therapeutics Gmbh | Acidos nucleicos para inhibir la expresion de lpa en una celula. |
| WO2020033899A1 (en) | 2018-08-10 | 2020-02-13 | University Of Massachusetts | Modified oligonucleotides targeting snps |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | O-メチルリッチ完全安定化オリゴヌクレオチド |
| WO2020069055A1 (en) * | 2018-09-28 | 2020-04-02 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| CN109402127B (zh) * | 2018-09-29 | 2021-12-10 | 复旦大学附属眼耳鼻喉科医院 | 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用 |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| KR102321425B1 (ko) * | 2019-01-18 | 2021-11-04 | 올릭스 주식회사 | NRL(Neural retina leucine zipper)의 발현을 억제하는 비대칭 siRNA |
| US20220380774A1 (en) * | 2019-05-20 | 2022-12-01 | Olix Pharmaceuticals, Inc. | Asymmetric sirna inhibiting expression of pd-1 |
| MX2022001710A (es) | 2019-08-09 | 2022-05-10 | Univ Massachusetts | Oligonucleótidos modificados químicamente dirigidos a los snp. |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| KR102757180B1 (ko) * | 2019-11-22 | 2025-01-21 | (주)바이오니아 | Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
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| CN114807127A (zh) * | 2021-01-19 | 2022-07-29 | 陈璞 | 用于结缔组织生长因子的小干扰rna及其应用 |
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| KR101581655B9 (ko) | 2015-12-31 |
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| US20190002881A1 (en) | 2019-01-03 |
| US10125362B2 (en) | 2018-11-13 |
| US20210207137A1 (en) | 2021-07-08 |
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| EP2853597B1 (en) | 2018-12-26 |
| CN104755620A (zh) | 2015-07-01 |
| US20150111948A1 (en) | 2015-04-23 |
| WO2013176477A1 (ko) | 2013-11-28 |
| EP2853597A1 (en) | 2015-04-01 |
| KR20150118061A (ko) | 2015-10-21 |
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