JP2015518721A5 - - Google Patents
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- JP2015518721A5 JP2015518721A5 JP2015513901A JP2015513901A JP2015518721A5 JP 2015518721 A5 JP2015518721 A5 JP 2015518721A5 JP 2015513901 A JP2015513901 A JP 2015513901A JP 2015513901 A JP2015513901 A JP 2015513901A JP 2015518721 A5 JP2015518721 A5 JP 2015518721A5
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- Prior art keywords
- nucleic acid
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- acid molecule
- seq
- base pairs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
- 235000012000 cholesterol Nutrition 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims 26
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 102000039446 nucleic acids Human genes 0.000 claims 26
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 claims 9
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 claims 9
- 230000000295 complement effect Effects 0.000 claims 7
- 108091030071 RNAI Proteins 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000009368 gene silencing by RNA Effects 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical class 0.000 claims 6
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000006698 induction Effects 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 206010023330 Keloid scar Diseases 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 108091092724 Noncoding DNA Proteins 0.000 claims 1
- 108091007412 Piwi-interacting RNA Proteins 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000030279 gene silencing Effects 0.000 claims 1
- 238000012226 gene silencing method Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 description 10
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 10
- 102000000763 Survivin Human genes 0.000 description 9
- 108010002687 Survivin Proteins 0.000 description 9
- 230000000692 anti-sense effect Effects 0.000 description 7
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 108020004459 Small interfering RNA Proteins 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120053950 | 2012-05-22 | ||
| KR10-2012-0053950 | 2012-05-22 | ||
| PCT/KR2013/004463 WO2013176477A1 (ko) | 2012-05-22 | 2013-05-21 | 세포 내 관통능을 가지는 rna 간섭을 유도하는 핵산 분자 및 그 용도 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016250474A Division JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518721A JP2015518721A (ja) | 2015-07-06 |
| JP2015518721A5 true JP2015518721A5 (https=) | 2016-06-23 |
| JP6139671B2 JP6139671B2 (ja) | 2017-05-31 |
Family
ID=49624096
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513901A Active JP6139671B2 (ja) | 2012-05-22 | 2013-05-21 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
| JP2016250474A Active JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
| JP2019031549A Active JP6999590B2 (ja) | 2012-05-22 | 2019-02-25 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016250474A Active JP6629712B2 (ja) | 2012-05-22 | 2016-12-26 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
| JP2019031549A Active JP6999590B2 (ja) | 2012-05-22 | 2019-02-25 | 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10125362B2 (https=) |
| EP (2) | EP3514236A1 (https=) |
| JP (3) | JP6139671B2 (https=) |
| KR (2) | KR101567576B1 (https=) |
| CN (2) | CN108148838A (https=) |
| DK (1) | DK2853597T3 (https=) |
| ES (1) | ES2716818T3 (https=) |
| WO (1) | WO2013176477A1 (https=) |
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| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
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| CN111875265B (zh) | 2015-05-15 | 2023-09-12 | Ａｇｃ株式会社 | 化学增强玻璃 |
| TW201718023A (zh) * | 2015-08-06 | 2017-06-01 | 世代好公司 | 細胞滲透性蛋白質－抗體結合物及使用方法 |
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| WO2020033899A1 (en) | 2018-08-10 | 2020-02-13 | University Of Massachusetts | Modified oligonucleotides targeting snps |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
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| CN109402127B (zh) * | 2018-09-29 | 2021-12-10 | 复旦大学附属眼耳鼻喉科医院 | 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用 |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
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| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
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| AU2022299169A1 (en) | 2021-06-23 | 2024-02-08 | Beth Israel Deaconess Medical Center, Inc. | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
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2013
- 2013-05-21 CN CN201810089022.8A patent/CN108148838A/zh active Pending
- 2013-05-21 JP JP2015513901A patent/JP6139671B2/ja active Active
- 2013-05-21 KR KR1020130057412A patent/KR101567576B1/ko active Active
- 2013-05-21 EP EP18215244.7A patent/EP3514236A1/en active Pending
- 2013-05-21 WO PCT/KR2013/004463 patent/WO2013176477A1/ko not_active Ceased
- 2013-05-21 ES ES13794539T patent/ES2716818T3/es active Active
- 2013-05-21 CN CN201380038984.6A patent/CN104755620B/zh active Active
- 2013-05-21 DK DK13794539.0T patent/DK2853597T3/en active
- 2013-05-21 EP EP13794539.0A patent/EP2853597B1/en active Active
- 2013-05-21 US US14/403,121 patent/US10125362B2/en active Active
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2015
- 2015-09-25 KR KR1020150136206A patent/KR101581655B1/ko active Active
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2016
- 2016-12-26 JP JP2016250474A patent/JP6629712B2/ja active Active
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2018
- 2018-09-19 US US16/135,766 patent/US10883105B2/en active Active
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- 2019-02-25 JP JP2019031549A patent/JP6999590B2/ja active Active
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2020
- 2020-12-03 US US17/110,640 patent/US20210207137A1/en not_active Abandoned
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