|
ES2259800T3
(es)
|
1990-06-11 |
2006-10-16 |
Gilead Sciences, Inc. |
Procedimientos de uso de ligandos de acido nucleico.
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
JP3131222B2
(ja)
|
1991-12-24 |
2001-01-31 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ギャップを有する2′修飾オリゴヌクレオチド
|
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
|
US5504103A
(en)
|
1993-08-25 |
1996-04-02 |
Eli Lilly And Company |
Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
|
|
US5777153A
(en)
|
1994-07-08 |
1998-07-07 |
Gilead Sciences, Inc. |
Cationic lipids
|
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US6020526A
(en)
|
1995-07-21 |
2000-02-01 |
Genta, Incorporated |
Amide-based cationic lipids
|
|
DE59708838D1
(de)
|
1996-08-30 |
2003-01-09 |
Jens Peter Fuerste |
Spiegelselektion und spiegelevolution von nucleinsäuren
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US5989912A
(en)
|
1996-11-21 |
1999-11-23 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
CA2217550A1
(en)
|
1996-10-22 |
1998-04-22 |
F. Hoffmann-La Roche Ag |
Cationic lipids for gene therapy
|
|
US6358523B1
(en)
|
1996-12-06 |
2002-03-19 |
The Regents Of The University Of California |
Macromolecule-lipid complexes and methods for making and regulating
|
|
US6001311A
(en)
|
1997-02-05 |
1999-12-14 |
Protogene Laboratories, Inc. |
Apparatus for diverse chemical synthesis using two-dimensional array
|
|
EP0975332A1
(en)
|
1997-04-04 |
2000-02-02 |
Valentis Inc. |
Improved methods of delivery using cationic lipids and helper lipids
|
|
AU7490098A
(en)
|
1997-05-15 |
1998-12-08 |
Genzyme Corporation |
Cationic amphiphile formulations
|
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
WO1999004819A1
(en)
|
1997-07-24 |
1999-02-04 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for the delivery of nucleic acid catalysts
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
CA2315256A1
(en)
|
1997-12-16 |
1999-06-24 |
Valentis, Inc. |
Needle-free injection of formulated nucleic acid molecules
|
|
EP1071753A2
(en)
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
US6150345A
(en)
|
1998-08-10 |
2000-11-21 |
Regents Of The University Of California |
Methods for promoting survival of myelin producing cells
|
|
FR2788275B1
(fr)
|
1999-01-11 |
2002-06-14 |
Lipha |
((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
US7015040B2
(en)
|
1999-02-26 |
2006-03-21 |
Mirus Bio Corporation |
Intravascular delivery of nucleic acid
|
|
DE60040274D1
(de)
|
1999-03-10 |
2008-10-30 |
Phogen Ltd |
Verabreichung von nukleinsäuren und proteinen an zellen
|
|
WO2000073469A2
(en)
|
1999-05-28 |
2000-12-07 |
Sugen, Inc. |
Protein kinases
|
|
EP1064944A1
(en)
|
1999-06-25 |
2001-01-03 |
Schering Aktiengesellschaft |
Protein kinase N inhibitor comprising Fasudil
|
|
BR0012624B1
(pt)
|
1999-07-15 |
2011-08-09 |
|
métodos para a preparação de agentes terapêuticos envolvidos por lipìdeos.
|
|
US6133032A
(en)
|
1999-09-09 |
2000-10-17 |
Isis Pharmaceutical Inc. |
Antisense modulation of PI3 kinase p110 beta expression
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
KR20020097198A
(ko)
|
2000-03-17 |
2002-12-31 |
베니텍 오스트레일리아 리미티드 |
유전자 사일런싱
|
|
ES2336887T5
(es)
|
2000-03-30 |
2019-03-06 |
Whitehead Inst Biomedical Res |
Mediadores de interferencia por ARN específicos de secuencias de ARN
|
|
AU5454801A
(en)
|
2000-04-20 |
2001-11-07 |
Univ British Columbia |
Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers
|
|
ATE354350T1
(de)
|
2000-10-25 |
2007-03-15 |
Univ British Columbia |
Lipidformulierungen zur zielgerichteten abgabe
|
|
CA2429814C
(en)
|
2000-12-01 |
2014-02-18 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
US6394713B1
(en)
*
|
2001-03-05 |
2002-05-28 |
Phillip E. Yates, Sr. |
Drill guide apparatus
|
|
WO2003070910A2
(en)
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Incorporated |
INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20030135033A1
(en)
|
2002-01-04 |
2003-07-17 |
Anke Klippel-Giese |
Compounds and methods for the identification and/ or validation of a target
|
|
AU2003219817B2
(en)
|
2002-02-20 |
2006-08-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus
|
|
DE60310944T3
(de)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Weitere neue formen von interferierende rns moleküle
|
|
TR201816291T4
(tr)
*
|
2002-08-05 |
2018-11-21 |
Silence Therapeutics Gmbh |
Müdahaleci rna moleküllerinin ilave yeni biçimleri.
|
|
US20040156816A1
(en)
|
2002-08-06 |
2004-08-12 |
David Anderson |
Lipid-drug complexes in reversed liquid and liquid crystalline phases
|
|
EP1393742A1
(en)
|
2002-08-14 |
2004-03-03 |
atugen AG |
Use of protein kinase N beta
|
|
PT1536827E
(pt)
|
2002-08-14 |
2009-03-20 |
Silence Therapeutics Ag |
Utilização de proteína cinase n beta
|
|
US7635770B2
(en)
|
2002-11-14 |
2009-12-22 |
Dharmacon, Inc. |
siRNA targeting protein kinase N-3 (PKN-3)
|
|
ES2321841T3
(es)
|
2003-08-26 |
2009-06-12 |
Smithkline Beecham Corporation |
Copolimeros heterofuncionales de glicerol y polietilenglicol, sus conjugados y composiciones.
|
|
WO2006069782A2
(en)
|
2004-12-27 |
2006-07-06 |
Silence Therapeutics Ag. |
Lipid complexes coated with peg and their use
|
|
MXPA06012722A
(es)
|
2004-05-05 |
2007-02-14 |
Atugen Ag |
Lipidos, complejos de lipido y su uso.
|
|
JP2008520600A
(ja)
|
2004-11-19 |
2008-06-19 |
ノヴォソム アクチェンゲゼルシャフト |
局所投与のための医薬組成物におけるまたはそれに関する改善
|
|
WO2006074546A1
(en)
|
2005-01-13 |
2006-07-20 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
KR101670085B1
(ko)
|
2006-07-21 |
2016-10-28 |
사일런스 테라퓨틱스 게엠베하 |
단백질 키나아제 3의 발현을 억제하기 위한 수단
|
|
RU2360967C1
(ru)
*
|
2007-10-01 |
2009-07-10 |
Химический факультет Московского государственного университета имени М.В.Ломоносова |
Биокатализатор на основе иммобилизованных клеток бактерий для разложения метилфосфоновой кислоты и ее эфиров
|