JP2015128433A5 - - Google Patents

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Publication number
JP2015128433A5
JP2015128433A5 JP2015030813A JP2015030813A JP2015128433A5 JP 2015128433 A5 JP2015128433 A5 JP 2015128433A5 JP 2015030813 A JP2015030813 A JP 2015030813A JP 2015030813 A JP2015030813 A JP 2015030813A JP 2015128433 A5 JP2015128433 A5 JP 2015128433A5
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JP
Japan
Prior art keywords
seq
set forth
sequence set
nucleotide sequence
stretch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015030813A
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English (en)
Japanese (ja)
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JP2015128433A (ja
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Publication of JP2015128433A publication Critical patent/JP2015128433A/ja
Publication of JP2015128433A5 publication Critical patent/JP2015128433A5/ja
Pending legal-status Critical Current

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JP2015030813A 2006-07-21 2015-02-19 プロテインキナーゼ3の発現を阻害するための手段 Pending JP2015128433A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06015262.6 2006-07-21
EP06015262 2006-07-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2013034653A Division JP2013172714A (ja) 2006-07-21 2013-02-25 プロテインキナーゼ3の発現を阻害するための手段

Publications (2)

Publication Number Publication Date
JP2015128433A JP2015128433A (ja) 2015-07-16
JP2015128433A5 true JP2015128433A5 (https=) 2015-08-27

Family

ID=38663298

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009519879A Pending JP2009544281A (ja) 2006-07-21 2007-07-20 プロテインキナーゼ3の発現を阻害するための手段
JP2013034653A Ceased JP2013172714A (ja) 2006-07-21 2013-02-25 プロテインキナーゼ3の発現を阻害するための手段
JP2015030813A Pending JP2015128433A (ja) 2006-07-21 2015-02-19 プロテインキナーゼ3の発現を阻害するための手段

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2009519879A Pending JP2009544281A (ja) 2006-07-21 2007-07-20 プロテインキナーゼ3の発現を阻害するための手段
JP2013034653A Ceased JP2013172714A (ja) 2006-07-21 2013-02-25 プロテインキナーゼ3の発現を阻害するための手段

Country Status (12)

Country Link
US (1) US8232256B2 (https=)
EP (2) EP2049658A2 (https=)
JP (3) JP2009544281A (https=)
KR (1) KR101670085B1 (https=)
CN (3) CN101490253A (https=)
AU (1) AU2007276388A1 (https=)
BR (1) BRPI0714875A2 (https=)
CA (1) CA2658550C (https=)
HK (1) HK1208701A1 (https=)
MX (1) MX2009000654A (https=)
RU (1) RU2553561C2 (https=)
WO (1) WO2008009477A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001264317A1 (en) * 2000-06-20 2002-01-02 Koken Co., Ltd. Preparations for oligonucleotide transfer
EP1407787B1 (en) * 2001-06-20 2009-04-29 Dainippon Sumitomo Pharma Co., Ltd. Method of promoting nucleic acid transfer
PT1536827E (pt) * 2002-08-14 2009-03-20 Silence Therapeutics Ag Utilização de proteína cinase n beta
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
KR101670085B1 (ko) 2006-07-21 2016-10-28 사일런스 테라퓨틱스 게엠베하 단백질 키나아제 3의 발현을 억제하기 위한 수단
JPWO2010110314A1 (ja) * 2009-03-27 2012-10-04 協和発酵キリン株式会社 核酸を含有する肺高血圧症治療剤
EP2382994A1 (en) * 2010-04-26 2011-11-02 Maurizio Victor Cattaneo Ligand targeted nanocapsules for the delivery of RNAi and other agents
JP2015521041A (ja) 2012-05-16 2015-07-27 サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Pkn3阻害剤投与のためのバイオマーカーとしてのvegfr1の使用
WO2016083623A1 (en) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Means for the treatment of pre-eclampsia
CA3043768A1 (en) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes for delivery of therapeutic agents
RU2698199C1 (ru) * 2018-05-18 2019-08-23 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт общей патологии и патофизиологии" Средство для подавления экспрессии генов, связанных с накоплением холестерина макрофагами человека
CN120682233B (zh) * 2025-08-25 2025-12-12 浙江大学 Pkn3激酶抑制剂、药物组合物及pkn3激酶抑制剂的制备方法和应用

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する2′修飾オリゴヌクレオチド
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5777153A (en) 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6020526A (en) 1995-07-21 2000-02-01 Genta, Incorporated Amide-based cationic lipids
DE59708838D1 (de) 1996-08-30 2003-01-09 Jens Peter Fuerste Spiegelselektion und spiegelevolution von nucleinsäuren
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US5989912A (en) 1996-11-21 1999-11-23 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
CA2217550A1 (en) 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
US6358523B1 (en) 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
EP0975332A1 (en) 1997-04-04 2000-02-02 Valentis Inc. Improved methods of delivery using cationic lipids and helper lipids
AU7490098A (en) 1997-05-15 1998-12-08 Genzyme Corporation Cationic amphiphile formulations
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
WO1999004819A1 (en) 1997-07-24 1999-02-04 Inex Pharmaceuticals Corporation Liposomal compositions for the delivery of nucleic acid catalysts
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
CA2315256A1 (en) 1997-12-16 1999-06-24 Valentis, Inc. Needle-free injection of formulated nucleic acid molecules
EP1071753A2 (en) 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
US6150345A (en) 1998-08-10 2000-11-21 Regents Of The University Of California Methods for promoting survival of myelin producing cells
FR2788275B1 (fr) 1999-01-11 2002-06-14 Lipha ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7015040B2 (en) 1999-02-26 2006-03-21 Mirus Bio Corporation Intravascular delivery of nucleic acid
DE60040274D1 (de) 1999-03-10 2008-10-30 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
WO2000073469A2 (en) 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
EP1064944A1 (en) 1999-06-25 2001-01-03 Schering Aktiengesellschaft Protein kinase N inhibitor comprising Fasudil
BR0012624B1 (pt) 1999-07-15 2011-08-09 métodos para a preparação de agentes terapêuticos envolvidos por lipìdeos.
US6133032A (en) 1999-09-09 2000-10-17 Isis Pharmaceutical Inc. Antisense modulation of PI3 kinase p110 beta expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
KR20020097198A (ko) 2000-03-17 2002-12-31 베니텍 오스트레일리아 리미티드 유전자 사일런싱
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
AU5454801A (en) 2000-04-20 2001-11-07 Univ British Columbia Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers
ATE354350T1 (de) 2000-10-25 2007-03-15 Univ British Columbia Lipidformulierungen zur zielgerichteten abgabe
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
US6394713B1 (en) * 2001-03-05 2002-05-28 Phillip E. Yates, Sr. Drill guide apparatus
WO2003070910A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20030135033A1 (en) 2002-01-04 2003-07-17 Anke Klippel-Giese Compounds and methods for the identification and/ or validation of a target
AU2003219817B2 (en) 2002-02-20 2006-08-31 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis C virus
DE60310944T3 (de) 2002-08-05 2017-08-03 Silence Therapeutics Gmbh Weitere neue formen von interferierende rns moleküle
TR201816291T4 (tr) * 2002-08-05 2018-11-21 Silence Therapeutics Gmbh Müdahaleci rna moleküllerinin ilave yeni biçimleri.
US20040156816A1 (en) 2002-08-06 2004-08-12 David Anderson Lipid-drug complexes in reversed liquid and liquid crystalline phases
EP1393742A1 (en) 2002-08-14 2004-03-03 atugen AG Use of protein kinase N beta
PT1536827E (pt) 2002-08-14 2009-03-20 Silence Therapeutics Ag Utilização de proteína cinase n beta
US7635770B2 (en) 2002-11-14 2009-12-22 Dharmacon, Inc. siRNA targeting protein kinase N-3 (PKN-3)
ES2321841T3 (es) 2003-08-26 2009-06-12 Smithkline Beecham Corporation Copolimeros heterofuncionales de glicerol y polietilenglicol, sus conjugados y composiciones.
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
MXPA06012722A (es) 2004-05-05 2007-02-14 Atugen Ag Lipidos, complejos de lipido y su uso.
JP2008520600A (ja) 2004-11-19 2008-06-19 ノヴォソム アクチェンゲゼルシャフト 局所投与のための医薬組成物におけるまたはそれに関する改善
WO2006074546A1 (en) 2005-01-13 2006-07-20 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
KR101670085B1 (ko) 2006-07-21 2016-10-28 사일런스 테라퓨틱스 게엠베하 단백질 키나아제 3의 발현을 억제하기 위한 수단
RU2360967C1 (ru) * 2007-10-01 2009-07-10 Химический факультет Московского государственного университета имени М.В.Ломоносова Биокатализатор на основе иммобилизованных клеток бактерий для разложения метилфосфоновой кислоты и ее эфиров

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