FR2788275B1 - ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique - Google Patents

((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique

Info

Publication number
FR2788275B1
FR2788275B1 FR9900194A FR9900194A FR2788275B1 FR 2788275 B1 FR2788275 B1 FR 2788275B1 FR 9900194 A FR9900194 A FR 9900194A FR 9900194 A FR9900194 A FR 9900194A FR 2788275 B1 FR2788275 B1 FR 2788275B1
Authority
FR
France
Prior art keywords
aminoiminomethyl
amino
therapeutic applications
carboxamides
alkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9900194A
Other languages
English (en)
Other versions
FR2788275A1 (fr
Inventor
Gerard Moinet
Daniel Cravo
Didier Mesangeau
Lilianne Doare
Micheline Kergoat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9900194A priority Critical patent/FR2788275B1/fr
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to HU0200023A priority patent/HUP0200023A3/hu
Priority to PCT/EP1999/010468 priority patent/WO2000042001A1/fr
Priority to IL14422599A priority patent/IL144225A0/xx
Priority to NZ513467A priority patent/NZ513467A/en
Priority to US09/869,957 priority patent/US6518458B1/en
Priority to SI9930505T priority patent/SI1140803T1/xx
Priority to AT99964687T priority patent/ATE252553T1/de
Priority to BR9916858-8A priority patent/BR9916858A/pt
Priority to DE69912315T priority patent/DE69912315T2/de
Priority to CA002359454A priority patent/CA2359454C/fr
Priority to DK99964687T priority patent/DK1140803T3/da
Priority to IDW00200101657A priority patent/ID29586A/id
Priority to CNB998155640A priority patent/CN1182109C/zh
Priority to EEP200100363A priority patent/EE200100363A/xx
Priority to SK984-2001A priority patent/SK285130B6/sk
Priority to ES99964687T priority patent/ES2207325T3/es
Priority to CZ20012482A priority patent/CZ20012482A3/cs
Priority to AU30443/00A priority patent/AU760147B2/en
Priority to EP99964687A priority patent/EP1140803B1/fr
Priority to PT99964687T priority patent/PT1140803E/pt
Priority to JP2000593569A priority patent/JP4567889B2/ja
Priority to KR1020017008794A priority patent/KR100630291B1/ko
Priority to RU2001121195/04A priority patent/RU2236401C2/ru
Priority to ARP000100063A priority patent/AR022221A1/es
Publication of FR2788275A1 publication Critical patent/FR2788275A1/fr
Priority to NO20013420A priority patent/NO20013420L/no
Priority to ZA200106606A priority patent/ZA200106606B/en
Priority to HK02103446.2A priority patent/HK1041689B/zh
Publication of FR2788275B1 publication Critical patent/FR2788275B1/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9900194A 1999-01-11 1999-01-11 ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique Expired - Fee Related FR2788275B1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FR9900194A FR2788275B1 (fr) 1999-01-11 1999-01-11 ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
RU2001121195/04A RU2236401C2 (ru) 1999-01-11 1999-12-30 (аминоиминометил)амино)алканкарбоксидамиды и их применение в терапии
IL14422599A IL144225A0 (en) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy
NZ513467A NZ513467A (en) 1999-01-11 1999-12-30 ((Aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy
US09/869,957 US6518458B1 (en) 1999-01-11 1999-12-30 (Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy
SI9930505T SI1140803T1 (en) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy
CZ20012482A CZ20012482A3 (cs) 1999-01-11 1999-12-30 Deriváty ((aminoiminomethyl)amino)alkankarboxamidu a jejich pouľití v terapii
BR9916858-8A BR9916858A (pt) 1999-01-11 1999-12-30 ((aminoiminometil)amino)alcanocarboxamidas e asaplicações das mesmas em terapia
DE69912315T DE69912315T2 (de) 1999-01-11 1999-12-30 ((aminoiminomethyl)amino) alkanecarboxamide und deren therapeutische verwendungen
CA002359454A CA2359454C (fr) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides et leurs utilisations therapeutiques
DK99964687T DK1140803T3 (da) 1999-01-11 1999-12-30 ((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi
IDW00200101657A ID29586A (id) 1999-01-11 1999-12-30 ((aminoiminometil)amino) alkanakarboksamida-((aminoiminometil)amino) alkanakarboksamida dan aplikasi-aplikasinya dalam terapi
CNB998155640A CN1182109C (zh) 1999-01-11 1999-12-30 ((氨基亚氨基甲基)氨基)链烷羧酰胺及其在治疗中的应用
EEP200100363A EE200100363A (et) 1999-01-11 1999-12-30 ((Aminoiminometüül)amino)alkaankarboksamiidid ja nende kasutamine ravis
HU0200023A HUP0200023A3 (en) 1999-01-11 1999-12-30 ((aminoiminomethyl)amino) alkanecarboxamides and their applications in therapy and process for their preparation
SK984-2001A SK285130B6 (sk) 1999-01-11 1999-12-30 Farmaceutický prostriedok obsahujúci derivát [(aminoiminometyl)amino]alkánkarboxamidu, tento derivát a spôsob jeho prípravy a použitie tohto derivátua prostriedku
AT99964687T ATE252553T1 (de) 1999-01-11 1999-12-30 ((aminoiminomethyl)amino) alkanecarboxamide und deren therapeutische verwendungen
AU30443/00A AU760147B2 (en) 1999-01-11 1999-12-30 ((Aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy
EP99964687A EP1140803B1 (fr) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides et leurs utilisations therapeutiques
PT99964687T PT1140803E (pt) 1999-01-11 1999-12-30 (aminoiminometil)amino)alcanocarboxamidas e suas aplicacoes em terapia
JP2000593569A JP4567889B2 (ja) 1999-01-11 1999-12-30 （（アミノイミノメチル）アミノ）アルカンカルボキシアミドおよび治療におけるその適用
KR1020017008794A KR100630291B1 (ko) 1999-01-11 1999-12-30 ((아미노이미노메틸)아미노)알칸카르복스아미드 및 이의치료법에서의 용도
PCT/EP1999/010468 WO2000042001A1 (fr) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides et leurs utilisations therapeutiques
ES99964687T ES2207325T3 (es) 1999-01-11 1999-12-30 ((aminoiminomethil) amino) alcanocarboxamidas y sus aplicaciones terapeuticas.
ARP000100063A AR022221A1 (es) 1999-01-11 2000-01-07 Composiciones que comprenden [(aminoiminometil)-amino]-alcanocarboxamidas en calidad de principio activo; [(aminoiminometil)-amino]-alcanocarboxamidas paraestas composiciones, y procedimiento para preparar dichas [(aminoiminometil)-amino]-alcanocarboxamidas
NO20013420A NO20013420L (no) 1999-01-11 2001-07-10 ((Aminoiminometyl)amino)alkankarboksamider og deres anvendelser innen terapi
ZA200106606A ZA200106606B (en) 1999-01-11 2001-08-10 (Aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy.
HK02103446.2A HK1041689B (zh) 1999-01-11 2002-05-07 ((氨基亞氨基甲基)氨基)鏈烷羧酰胺及其在治療中的應用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900194A FR2788275B1 (fr) 1999-01-11 1999-01-11 ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
FR2788275A1 FR2788275A1 (fr) 2000-07-13
FR2788275B1 true FR2788275B1 (fr) 2002-06-14

Family

ID=9540749

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9900194A Expired - Fee Related FR2788275B1 (fr) 1999-01-11 1999-01-11 ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique

Country Status (27)

Country Link
US (1) US6518458B1 (fr)
EP (1) EP1140803B1 (fr)
JP (1) JP4567889B2 (fr)
KR (1) KR100630291B1 (fr)
CN (1) CN1182109C (fr)
AR (1) AR022221A1 (fr)
AT (1) ATE252553T1 (fr)
AU (1) AU760147B2 (fr)
BR (1) BR9916858A (fr)
CA (1) CA2359454C (fr)
CZ (1) CZ20012482A3 (fr)
DE (1) DE69912315T2 (fr)
DK (1) DK1140803T3 (fr)
EE (1) EE200100363A (fr)
ES (1) ES2207325T3 (fr)
FR (1) FR2788275B1 (fr)
HK (1) HK1041689B (fr)
HU (1) HUP0200023A3 (fr)
ID (1) ID29586A (fr)
IL (1) IL144225A0 (fr)
NO (1) NO20013420L (fr)
NZ (1) NZ513467A (fr)
PT (1) PT1140803E (fr)
RU (1) RU2236401C2 (fr)
SK (1) SK285130B6 (fr)
WO (1) WO2000042001A1 (fr)
ZA (1) ZA200106606B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1968714B (zh) 2004-05-05 2013-10-16 赛伦斯治疗公司 脂质、脂质复合物及其应用
EP1830888B1 (fr) 2004-12-27 2015-08-05 Silence Therapeutics GmbH Complexes lipidiques revetus et leur utilisation
TW200808705A (en) * 2006-06-15 2008-02-16 Sanofi Aventis Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics
EP2546337A1 (fr) * 2006-07-21 2013-01-16 Silence Therapeutics AG Procédé et appareil dans un système de télécommunication
WO2010074591A1 (fr) * 2008-12-24 2010-07-01 Закрытое Акционерное Общество "Beptekc" Amides de créatine, procédé de production, et produit possédant une action neuroprotectrice

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1153424A (en) * 1965-04-15 1969-05-29 Horlicks Ltd Pharmaceutical Compositions
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
JPH0841008A (ja) * 1994-07-29 1996-02-13 Ono Pharmaceut Co Ltd 一酸化窒素合成酵素阻害剤
CA2217550A1 (fr) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Lipides cationiques pour therapie genique
US6395713B1 (en) * 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
DE19748697A1 (de) * 1997-11-04 1999-05-06 Basf Ag Verfahren zur Herstellung von substituierten Guanidinderivaten

Also Published As

Publication number Publication date
NZ513467A (en) 2003-08-29
ES2207325T3 (es) 2004-05-16
AU760147B2 (en) 2003-05-08
ATE252553T1 (de) 2003-11-15
ZA200106606B (en) 2002-11-11
JP2002534496A (ja) 2002-10-15
WO2000042001A1 (fr) 2000-07-20
DK1140803T3 (da) 2003-12-22
DE69912315D1 (de) 2003-11-27
HUP0200023A2 (hu) 2002-05-29
NO20013420D0 (no) 2001-07-10
DE69912315T2 (de) 2004-08-05
AU3044300A (en) 2000-08-01
IL144225A0 (en) 2002-05-23
CZ20012482A3 (cs) 2001-10-17
ID29586A (id) 2001-09-06
RU2236401C2 (ru) 2004-09-20
SK285130B6 (sk) 2006-07-07
EP1140803B1 (fr) 2003-10-22
NO20013420L (no) 2001-07-10
HK1041689A1 (en) 2002-07-19
KR20010089822A (ko) 2001-10-08
JP4567889B2 (ja) 2010-10-20
HUP0200023A3 (en) 2003-04-28
CA2359454A1 (fr) 2000-07-20
EE200100363A (et) 2002-10-15
BR9916858A (pt) 2001-12-04
SK9842001A3 (en) 2001-12-03
US6518458B1 (en) 2003-02-11
CN1182109C (zh) 2004-12-29
KR100630291B1 (ko) 2006-09-29
AR022221A1 (es) 2002-09-04
CA2359454C (fr) 2009-10-27
FR2788275A1 (fr) 2000-07-13
HK1041689B (zh) 2005-09-02
EP1140803A1 (fr) 2001-10-10
PT1140803E (pt) 2004-03-31
CN1333747A (zh) 2002-01-30

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Effective date: 20140930