HUP0200023A2 - ((Amino-imino-metil)-amino)-alkán-karboxamidok és gyógyászati alkalmazásuk és eljárás a vegyületek előállítására - Google Patents
((Amino-imino-metil)-amino)-alkán-karboxamidok és gyógyászati alkalmazásuk és eljárás a vegyületek előállításáraInfo
- Publication number
- HUP0200023A2 HUP0200023A2 HU0200023A HUP0200023A HUP0200023A2 HU P0200023 A2 HUP0200023 A2 HU P0200023A2 HU 0200023 A HU0200023 A HU 0200023A HU P0200023 A HUP0200023 A HU P0200023A HU P0200023 A2 HUP0200023 A2 HU P0200023A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- group
- meaning
- general formula
- carbon atoms
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 (aminoiminomethyl)amino Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány tárgya hatóanyagként (I) általános képletű vegyületettartalmazó gyógyszerkészítmény, ahol R1, R2, R3 és A jelentése azalábbiakban megadott. Az (I) általános képletben R1 jelentésehidrogénatom, adott esetben szubsztituált 1-20 szénatomos alkicsoport;R2 és R3 jelentése egymástól függetlenül hidrogénatom vagy adottesetben szubsztituált 3-8 szénatomos cikloalkilcsoport, egy vagy többheteroatomot mégpedig nitrogén-, oxigén- és/vagy kénatomot tartalmazóés adott esetben szubsztituált 3-8 szénatomos heterocikloalkilcsoport;adott esetben szubsztituált 6-14 szénatomos arilcsoport, A jelentése -CH2-, -CH2-CH2- vagy -CHR4- csoport, ahol R4 jelentése azonos az R2 ésR3 jelentésében megadotakkal. A készítményeket inzulin rezisztenciaszindrómával kapcsolatos patológia kezelésére lehet használni. Atalálmány kiterjed a vegyületek előállítására is. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900194A FR2788275B1 (fr) | 1999-01-11 | 1999-01-11 | ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0200023A2 true HUP0200023A2 (hu) | 2002-05-29 |
| HUP0200023A3 HUP0200023A3 (en) | 2003-04-28 |
Family
ID=9540749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0200023A HUP0200023A3 (en) | 1999-01-11 | 1999-12-30 | ((aminoiminomethyl)amino) alkanecarboxamides and their applications in therapy and process for their preparation |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6518458B1 (hu) |
| EP (1) | EP1140803B1 (hu) |
| JP (1) | JP4567889B2 (hu) |
| KR (1) | KR100630291B1 (hu) |
| CN (1) | CN1182109C (hu) |
| AR (1) | AR022221A1 (hu) |
| AT (1) | ATE252553T1 (hu) |
| AU (1) | AU760147B2 (hu) |
| BR (1) | BR9916858A (hu) |
| CA (1) | CA2359454C (hu) |
| CZ (1) | CZ20012482A3 (hu) |
| DE (1) | DE69912315T2 (hu) |
| DK (1) | DK1140803T3 (hu) |
| EE (1) | EE200100363A (hu) |
| ES (1) | ES2207325T3 (hu) |
| FR (1) | FR2788275B1 (hu) |
| HK (1) | HK1041689B (hu) |
| HU (1) | HUP0200023A3 (hu) |
| ID (1) | ID29586A (hu) |
| IL (1) | IL144225A0 (hu) |
| NO (1) | NO20013420L (hu) |
| NZ (1) | NZ513467A (hu) |
| PT (1) | PT1140803E (hu) |
| RU (1) | RU2236401C2 (hu) |
| SK (1) | SK285130B6 (hu) |
| WO (1) | WO2000042001A1 (hu) |
| ZA (1) | ZA200106606B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105152A2 (en) | 2004-05-05 | 2005-11-10 | Atugen Ag | Lipids, lipid complexes and use thereof |
| WO2006069782A2 (en) | 2004-12-27 | 2006-07-06 | Silence Therapeutics Ag. | Lipid complexes coated with peg and their use |
| TW200808705A (en) * | 2006-06-15 | 2008-02-16 | Sanofi Aventis | Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics |
| RU2553561C2 (ru) * | 2006-07-21 | 2015-06-20 | Сайленс Терапьютикс Аг | Средства ингибирования экспрессии протеинкиназы 3 |
| EP2269980A4 (de) * | 2008-12-24 | 2011-05-18 | Vertex Closed Joint Stock Company | Creatinamide, verfahren zu ihrer herstellung und wirkstoff zur ausführung einer neuroprotektiven aktion |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1153424A (en) * | 1965-04-15 | 1969-05-29 | Horlicks Ltd | Pharmaceutical Compositions |
| US5654451B1 (en) * | 1993-01-14 | 2000-02-22 | Magainin Pharma | Amino acids and peptides having modified c-terminals and modified n-terminals |
| JPH0841008A (ja) * | 1994-07-29 | 1996-02-13 | Ono Pharmaceut Co Ltd | 一酸化窒素合成酵素阻害剤 |
| CA2217550A1 (en) * | 1996-10-22 | 1998-04-22 | F. Hoffmann-La Roche Ag | Cationic lipids for gene therapy |
| US6395713B1 (en) * | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| DE19748697A1 (de) * | 1997-11-04 | 1999-05-06 | Basf Ag | Verfahren zur Herstellung von substituierten Guanidinderivaten |
-
1999
- 1999-01-11 FR FR9900194A patent/FR2788275B1/fr not_active Expired - Fee Related
- 1999-12-30 NZ NZ513467A patent/NZ513467A/en unknown
- 1999-12-30 JP JP2000593569A patent/JP4567889B2/ja not_active Expired - Fee Related
- 1999-12-30 PT PT99964687T patent/PT1140803E/pt unknown
- 1999-12-30 CA CA002359454A patent/CA2359454C/en not_active Expired - Fee Related
- 1999-12-30 CN CNB998155640A patent/CN1182109C/zh not_active Expired - Fee Related
- 1999-12-30 KR KR1020017008794A patent/KR100630291B1/ko not_active IP Right Cessation
- 1999-12-30 EP EP99964687A patent/EP1140803B1/en not_active Expired - Lifetime
- 1999-12-30 IL IL14422599A patent/IL144225A0/xx unknown
- 1999-12-30 DE DE69912315T patent/DE69912315T2/de not_active Expired - Lifetime
- 1999-12-30 SK SK984-2001A patent/SK285130B6/sk not_active IP Right Cessation
- 1999-12-30 AU AU30443/00A patent/AU760147B2/en not_active Ceased
- 1999-12-30 RU RU2001121195/04A patent/RU2236401C2/ru not_active IP Right Cessation
- 1999-12-30 WO PCT/EP1999/010468 patent/WO2000042001A1/en active IP Right Grant
- 1999-12-30 HU HU0200023A patent/HUP0200023A3/hu unknown
- 1999-12-30 BR BR9916858-8A patent/BR9916858A/pt not_active Application Discontinuation
- 1999-12-30 ES ES99964687T patent/ES2207325T3/es not_active Expired - Lifetime
- 1999-12-30 AT AT99964687T patent/ATE252553T1/de not_active IP Right Cessation
- 1999-12-30 DK DK99964687T patent/DK1140803T3/da active
- 1999-12-30 EE EEP200100363A patent/EE200100363A/xx unknown
- 1999-12-30 ID IDW00200101657A patent/ID29586A/id unknown
- 1999-12-30 CZ CZ20012482A patent/CZ20012482A3/cs unknown
- 1999-12-30 US US09/869,957 patent/US6518458B1/en not_active Expired - Lifetime
-
2000
- 2000-01-07 AR ARP000100063A patent/AR022221A1/es unknown
-
2001
- 2001-07-10 NO NO20013420A patent/NO20013420L/no not_active Application Discontinuation
- 2001-08-10 ZA ZA200106606A patent/ZA200106606B/en unknown
-
2002
- 2002-05-07 HK HK02103446.2A patent/HK1041689B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |