JP2018518163A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018518163A5 JP2018518163A5 JP2017559861A JP2017559861A JP2018518163A5 JP 2018518163 A5 JP2018518163 A5 JP 2018518163A5 JP 2017559861 A JP2017559861 A JP 2017559861A JP 2017559861 A JP2017559861 A JP 2017559861A JP 2018518163 A5 JP2018518163 A5 JP 2018518163A5
- Authority
- JP
- Japan
- Prior art keywords
- lytic bacteriophage
- repeat
- spacer
- lytic
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001515965 unidentified phage Species 0.000 claims 22
- 230000002101 lytic effect Effects 0.000 claims 21
- 125000006850 spacer group Chemical group 0.000 claims 10
- 230000001580 bacterial effect Effects 0.000 claims 7
- 241000894007 species Species 0.000 claims 7
- 108091033409 CRISPR Proteins 0.000 claims 4
- 238000010354 CRISPR gene editing Methods 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022054902A JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175749P | 2015-06-15 | 2015-06-15 | |
| US62/175,749 | 2015-06-15 | ||
| PCT/US2016/037493 WO2016205276A1 (en) | 2015-06-15 | 2016-06-15 | Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022054902A Division JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518163A JP2018518163A (ja) | 2018-07-12 |
| JP2018518163A5 true JP2018518163A5 (https=) | 2019-07-18 |
| JP7051438B2 JP7051438B2 (ja) | 2022-04-11 |
Family
ID=57546192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559861A Active JP7051438B2 (ja) | 2015-06-15 | 2016-06-15 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2022054902A Active JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2023084331A Pending JP2023109907A (ja) | 2015-06-15 | 2023-05-23 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022054902A Active JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2023084331A Pending JP2023109907A (ja) | 2015-06-15 | 2023-05-23 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11155823B2 (https=) |
| EP (2) | EP3307872B1 (https=) |
| JP (3) | JP7051438B2 (https=) |
| KR (2) | KR102468240B1 (https=) |
| CN (2) | CN107922918B (https=) |
| AU (2) | AU2016280002B2 (https=) |
| CA (1) | CA2983874C (https=) |
| DK (1) | DK3307872T3 (https=) |
| ES (1) | ES2960226T3 (https=) |
| FI (1) | FI3307872T3 (https=) |
| WO (1) | WO2016205276A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2015066119A1 (en) | 2013-10-30 | 2015-05-07 | North Carolina State University | Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US11439712B2 (en) | 2014-04-08 | 2022-09-13 | North Carolina State University | Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3633032A3 (en) | 2014-08-28 | 2020-07-29 | North Carolina State University | Novel cas9 proteins and guiding features for dna targeting and genome editing |
| CN107667173A (zh) | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| KR20220139447A (ko) | 2015-05-29 | 2022-10-14 | 노쓰 캐롤라이나 스테이트 유니버시티 | 크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법 |
| KR102468240B1 (ko) | 2015-06-15 | 2022-11-17 | 노쓰 캐롤라이나 스테이트 유니버시티 | 핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물 |
| WO2017058751A1 (en) | 2015-09-28 | 2017-04-06 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| EP3368687B1 (en) * | 2015-10-27 | 2021-09-29 | The Broad Institute, Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| US11311582B2 (en) | 2015-11-19 | 2022-04-26 | Locus Biosciences, Inc. | Bacteriophage compositions and methods of use thereof |
| US11542466B2 (en) | 2015-12-22 | 2023-01-03 | North Carolina State University | Methods and compositions for delivery of CRISPR based antimicrobials |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018146206A1 (en) * | 2017-02-10 | 2018-08-16 | Eth Zurich | Rebooting of synthetic bacteriophage genome in l-form bacteria |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111051510A (zh) * | 2017-06-25 | 2020-04-21 | 斯尼普技术有限公司 | 改变微生物群体和修饰微生物群 |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| GB201712733D0 (en) | 2017-08-08 | 2017-09-20 | Snipr Tech Ltd | Methods & cells |
| CN107447044A (zh) * | 2017-08-09 | 2017-12-08 | 华子昂 | 一种检测大肠杆菌λ噬菌体全基因组碱基修饰单倍型的方法 |
| CN107365804B (zh) * | 2017-08-13 | 2019-12-20 | 中国人民解放军疾病预防控制所 | 一种使用温和噬菌体载体包装CRISPR-Cas9系统的方法 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN108300732A (zh) * | 2018-02-23 | 2018-07-20 | 上海交通大学 | 一种高转化率运动发酵单胞菌及其构建方法和应用 |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| AU2019246043B2 (en) * | 2018-03-25 | 2024-07-04 | Snipr Biome Aps. | Treating and preventing microbial infections |
| CA3099316A1 (en) * | 2018-05-04 | 2019-11-07 | Locus Biosciences, Inc. | Methods and compositions for killing a target bacterium |
| CN112236517A (zh) * | 2018-05-22 | 2021-01-15 | 学校法人自治医科大学 | 抗菌噬菌体、治疗用组合物、杀菌剂、食品、细菌鉴别试剂盒、治疗用组合物制造方法、细菌去除方法、细菌鉴别方法及动物治疗方法 |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12227776B2 (en) | 2018-06-13 | 2025-02-18 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US10227576B1 (en) | 2018-06-13 | 2019-03-12 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020072250A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression |
| US12264330B2 (en) | 2018-10-01 | 2025-04-01 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for killing target cells |
| WO2020072253A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for screening for variant cells |
| WO2020072248A1 (en) * | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system |
| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020163655A1 (en) * | 2019-02-06 | 2020-08-13 | Fred Hutchinson Cancer Research Center | Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN114981408A (zh) * | 2019-11-06 | 2022-08-30 | 洛可斯生物科学公司 | Crispr cas系统和溶原性模块 |
| CN114981418A (zh) * | 2019-11-06 | 2022-08-30 | 洛可斯生物科学公司 | 包含crispr-cas系统的噬菌体组合物及其使用方法 |
| US11584781B2 (en) | 2019-12-30 | 2023-02-21 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| US11746352B2 (en) * | 2019-12-30 | 2023-09-05 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| US12098372B2 (en) | 2019-12-30 | 2024-09-24 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| GB202007943D0 (en) | 2020-05-27 | 2020-07-08 | Snipr Biome Aps | Products & methods |
| AU2021373795A1 (en) * | 2020-11-05 | 2023-06-22 | Locus Biosciences, Inc. | Phage compositions for pseudomonas comprising crispr-cas systems and methods of use thereof |
| EP4247942A4 (en) * | 2020-11-05 | 2025-04-02 | Locus Biosciences, Inc. | Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof |
| US20240309391A1 (en) * | 2021-07-15 | 2024-09-19 | North Carolina State University | Compositions, methods, and systems for enhanced dna transformation in bacteria |
| WO2023111286A1 (en) | 2021-12-17 | 2023-06-22 | Snipr Biome Aps | Nucleic acid delivery methods and compositions |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| KR20250060133A (ko) | 2023-10-24 | 2025-05-07 | 중앙대학교 산학협력단 | CRISPR-Cas 탑재 박테리오파지 및 이의 용도 |
| WO2025208072A1 (en) * | 2024-03-29 | 2025-10-02 | The General Hospital Corporation | Methods and materials for treating disorders related to bacterial infections |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4723202A (en) | 1987-04-02 | 1988-02-02 | The Garrett Corporation | Converter-fed AC machine without damper winding |
| IL128933A0 (en) | 1999-03-11 | 2000-02-17 | Mango Computers Ltd | A system for convertinog high-level computer languages into specific low-level languages of digital signal processors |
| US6361634B1 (en) | 2000-04-05 | 2002-03-26 | Kimberly-Clark Worldwide, Inc. | Multiple stage coating of elastic strands with adhesive |
| AU2002365188A1 (en) * | 2001-11-07 | 2003-07-30 | Musc Foundation For Research Development | Nucleic acid delivery and expression |
| US7919277B2 (en) | 2004-04-28 | 2011-04-05 | Danisco A/S | Detection and typing of bacterial strains |
| WO2006113709A2 (en) | 2005-04-15 | 2006-10-26 | Del Monte Fresh Produce Company | Plant promoters, terminators, genes, vectors and related transformed plants |
| ES2398918T3 (es) | 2005-08-26 | 2013-03-22 | Dupont Nutrition Biosciences Aps | Un método y una ordenación para soportar verticalmente elementos de resistencia eléctrica pendientes |
| PL2018441T3 (pl) * | 2006-05-19 | 2012-03-30 | Dupont Nutrition Biosci Aps | Mikroorganizmy znakowane i sposoby znakowania |
| AU2008223544B2 (en) | 2007-03-02 | 2014-06-05 | Dupont Nutrition Biosciences Aps | Cultures with improved phage resistance |
| MX337838B (es) | 2008-11-07 | 2016-03-22 | Dupont Nutrition Biosci Aps | Secuencias de repetidos palindromicos cortos regularmente intercalados agrupados de bifidobacterias. |
| WO2010075424A2 (en) | 2008-12-22 | 2010-07-01 | The Regents Of University Of California | Compositions and methods for downregulating prokaryotic genes |
| CN103261213A (zh) | 2010-10-20 | 2013-08-21 | 杜邦营养生物科学有限公司 | 乳球菌CRISPR-Cas序列 |
| WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| WO2013000023A1 (en) * | 2011-06-29 | 2013-01-03 | Affinity Biosciences Pty Ltd | Method of protein display |
| GB201122458D0 (en) * | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| CN104540382A (zh) | 2012-06-12 | 2015-04-22 | 弗·哈夫曼-拉罗切有限公司 | 用于产生条件性敲除等位基因的方法和组合物 |
| WO2013188638A2 (en) | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| HK1207111A1 (en) | 2012-08-03 | 2016-01-22 | 加利福尼亚大学董事会 | Methods and compositions for controlling gene expression by rna processing |
| EP4357457B1 (en) | 2012-10-23 | 2024-10-16 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US20150315576A1 (en) | 2012-11-01 | 2015-11-05 | Massachusetts Institute Of Technology | Genetic device for the controlled destruction of dna |
| EP3363902B1 (en) | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| WO2014093479A1 (en) | 2012-12-11 | 2014-06-19 | Montana State University | Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation |
| DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| CA2894684A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| AU2013359262C1 (en) | 2012-12-12 | 2021-05-13 | Massachusetts Institute Of Technology | CRISPR-Cas component systems, methods and compositions for sequence manipulation |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CA2895155C (en) | 2012-12-17 | 2021-07-06 | President And Fellows Of Harvard College | Rna-guided human genome engineering |
| LT2943579T (lt) | 2013-01-10 | 2018-11-12 | Dharmacon, Inc. | Molekulių bibliotekos ir molekulių generavimo būdai |
| EP3919505B1 (en) | 2013-01-16 | 2023-08-30 | Emory University | Uses of cas9-nucleic acid complexes |
| US10660943B2 (en) | 2013-02-07 | 2020-05-26 | The Rockefeller University | Sequence specific antimicrobials |
| MX374090B (es) | 2013-03-14 | 2025-03-05 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos al ácido nucleico. |
| US20140273235A1 (en) | 2013-03-15 | 2014-09-18 | Regents Of The University Of Minnesota | ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| AU2014227653B2 (en) | 2013-03-15 | 2017-04-20 | The General Hospital Corporation | Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing |
| WO2014186686A2 (en) | 2013-05-17 | 2014-11-20 | Two Blades Foundation | Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| US20160122774A1 (en) | 2013-05-29 | 2016-05-05 | Cellectis | A method for producing precise dna cleavage using cas9 nickase activity |
| WO2014191128A1 (en) | 2013-05-29 | 2014-12-04 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| US9982277B2 (en) | 2013-06-11 | 2018-05-29 | The Regents Of The University Of California | Methods and compositions for target DNA modification |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| WO2014204724A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| CA3109801C (en) | 2013-08-22 | 2024-01-09 | Andrew Cigan | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
| WO2015034872A2 (en) * | 2013-09-05 | 2015-03-12 | Massachusetts Institute Of Technology | Tuning microbial populations with programmable nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| EP3418379B1 (en) | 2013-09-18 | 2020-12-09 | Kymab Limited | Methods, cells & organisms |
| US20150098954A1 (en) | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
| EP3060656A1 (en) | 2013-10-24 | 2016-08-31 | Yeda Research and Development Co., Ltd. | Polynucleotides encoding brex system polypeptides and methods of using same |
| WO2015066119A1 (en) | 2013-10-30 | 2015-05-07 | North Carolina State University | Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri |
| US20150132263A1 (en) | 2013-11-11 | 2015-05-14 | Radiant Genomics, Inc. | Compositions and methods for targeted gene disruption in prokaryotes |
| EP3760719A1 (en) | 2013-11-18 | 2021-01-06 | CRISPR Therapeutics AG | Crispr-cas system materials and methods |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| JP6793547B2 (ja) | 2013-12-12 | 2020-12-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物 |
| US9994831B2 (en) | 2013-12-12 | 2018-06-12 | The Regents Of The University Of California | Methods and compositions for modifying a single stranded target nucleic acid |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
| JP2017503514A (ja) | 2014-01-24 | 2017-02-02 | ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ | Ｃａｓ９ターゲッティングをガイドする配列に関する方法および組成物 |
| WO2015116686A1 (en) | 2014-01-29 | 2015-08-06 | Agilent Technologies, Inc. | Cas9-based isothermal method of detection of specific dna sequence |
| PL3102722T3 (pl) | 2014-02-04 | 2021-03-08 | Jumpcode Genomics, Inc. | Frakcjonowanie genomu |
| CA2942915A1 (en) | 2014-03-20 | 2015-09-24 | Universite Laval | Crispr-based methods and products for increasing frataxin levels and uses thereof |
| WO2015148680A1 (en) | 2014-03-25 | 2015-10-01 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
| WO2015153791A1 (en) | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2) |
| WO2015153889A2 (en) | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| EP3126503A1 (en) | 2014-04-03 | 2017-02-08 | Massachusetts Institute Of Technology | Methods and compositions for the production of guide rna |
| US11439712B2 (en) | 2014-04-08 | 2022-09-13 | North Carolina State University | Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes |
| EP3132025B1 (en) | 2014-04-14 | 2023-08-30 | Maxcyte, Inc. | Methods and compositions for modifying genomic dna |
| WO2015159068A1 (en) | 2014-04-14 | 2015-10-22 | Nemesis Bioscience Ltd | Therapeutic |
| GB201406968D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Deletion mutants |
| GB201406970D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Targeted mutations |
| WO2015189693A1 (en) | 2014-06-12 | 2015-12-17 | King Abdullah University Of Science And Technology | Targeted viral-mediated plant genome editing using crispr/cas9 |
| WO2015200555A2 (en) | 2014-06-25 | 2015-12-30 | Caribou Biosciences, Inc. | Rna modification to engineer cas9 activity |
| EP3633032A3 (en) | 2014-08-28 | 2020-07-29 | North Carolina State University | Novel cas9 proteins and guiding features for dna targeting and genome editing |
| WO2016084088A1 (en) * | 2014-11-26 | 2016-06-02 | Ramot At Tel-Aviv University Ltd. | Targeted elimination of bacterial genes |
| WO2016135559A2 (en) | 2015-02-23 | 2016-09-01 | Crispr Therapeutics Ag | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| CN107667173A (zh) | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| KR20220139447A (ko) | 2015-05-29 | 2022-10-14 | 노쓰 캐롤라이나 스테이트 유니버시티 | 크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법 |
| KR102468240B1 (ko) | 2015-06-15 | 2022-11-17 | 노쓰 캐롤라이나 스테이트 유니버시티 | 핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물 |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| US10301613B2 (en) | 2015-09-15 | 2019-05-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Targeted remodeling of prokaryotic genomes using CRISPR-nickases |
| EP3353309A4 (en) | 2015-09-25 | 2019-04-10 | Tarveda Therapeutics, Inc. | COMPOSITIONS AND METHOD FOR GENERIC EDITING |
| WO2017058751A1 (en) | 2015-09-28 | 2017-04-06 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| EP4089175A1 (en) | 2015-10-13 | 2022-11-16 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| US11542466B2 (en) | 2015-12-22 | 2023-01-03 | North Carolina State University | Methods and compositions for delivery of CRISPR based antimicrobials |
| WO2017147507A1 (en) | 2016-02-24 | 2017-08-31 | Xycrobe Therapeutics, Inc. | Skin probiotic formulation |
| EP3630975B1 (en) | 2017-05-26 | 2025-11-19 | North Carolina State University | Altered guide rnas for modulating cas9 activity and methods of use |
-
2016
- 2016-06-15 KR KR1020187001223A patent/KR102468240B1/ko active Active
- 2016-06-15 CN CN201680031757.4A patent/CN107922918B/zh active Active
- 2016-06-15 JP JP2017559861A patent/JP7051438B2/ja active Active
- 2016-06-15 CA CA2983874A patent/CA2983874C/en active Active
- 2016-06-15 EP EP16812275.2A patent/EP3307872B1/en active Active
- 2016-06-15 FI FIEP16812275.2T patent/FI3307872T3/fi active
- 2016-06-15 KR KR1020227039777A patent/KR102902492B1/ko active Active
- 2016-06-15 US US15/735,028 patent/US11155823B2/en active Active
- 2016-06-15 ES ES16812275T patent/ES2960226T3/es active Active
- 2016-06-15 WO PCT/US2016/037493 patent/WO2016205276A1/en not_active Ceased
- 2016-06-15 AU AU2016280002A patent/AU2016280002B2/en active Active
- 2016-06-15 EP EP23192508.2A patent/EP4299754A3/en active Pending
- 2016-06-15 DK DK16812275.2T patent/DK3307872T3/da active
- 2016-06-15 CN CN202211231313.9A patent/CN115537421A/zh active Pending
-
2021
- 2021-09-10 US US17/471,776 patent/US12606834B2/en active Active
-
2022
- 2022-03-30 JP JP2022054902A patent/JP7290368B2/ja active Active
- 2022-06-28 AU AU2022204576A patent/AU2022204576B2/en active Active
-
2023
- 2023-05-23 JP JP2023084331A patent/JP2023109907A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018518163A5 (https=) | ||
| Rodriguez-Campos et al. | Overview and phylogeny of Mycobacterium tuberculosis complex organisms: implications for diagnostics and legislation of bovine tuberculosis | |
| Underwood et al. | Biology and diseases of ruminants (sheep, goats, and cattle) | |
| JP2016537341A5 (https=) | ||
| FI3307872T3 (fi) | Menetelmiä ja koostumuksia nukleiinihappojen ja rna-pohjaisten antimikrobien tehokkaaseen antamiseen | |
| BR112019003327A2 (pt) | nucleases manipuladas de alvo específico | |
| JP2015133993A5 (https=) | ||
| RU2018117360A (ru) | Сконструированные нуклеиновые кислоты, нацеленные на нуклеиновую кислоту | |
| WO2015126766A8 (en) | Methods and compositions for dna profiling | |
| RU2016123086A (ru) | Способы и композиции для лечения болезни хантингтона | |
| WO2015196128A3 (en) | Alternative nucleic acid molecules and uses thereof | |
| JP2016537982A5 (https=) | ||
| JP2012223202A5 (https=) | ||
| MX374553B (es) | Derivado de ácido nucleico que tiene actividad inmunoestimuladora. | |
| EP3277743A4 (en) | HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS THEREWITH | |
| CN109963944A (zh) | 体外敲除T细胞中靶基因的方法以及该方法中使用的crRNA | |
| CN116134150A (zh) | 病原体特异性核酸片段及其应用 | |
| JP2017532044A5 (https=) | ||
| EP3773609A4 (en) | DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES MODIFIED WITH Tm-INCREASING NUCLEOTIDES | |
| JP2021525105A5 (https=) | ||
| WO2020139152A8 (en) | Gene therapy dna vector and its application | |
| JP2018534946A5 (https=) | ||
| WO2020036654A3 (en) | Highly knotted molecular topologies from single-stranded nucleic acids | |
| PH12019502063A1 (en) | Nucleic acid derivative having immunostimulatory activity | |
| CO2021006938A2 (es) | Agente de corte de adn |