JP5957526B2 - チロシンキナーゼとしての６−置換３−（キノリン−６−イルチオ）−［１，２，４］トリアゾロ［４，３−ａ］ピラジン - Google Patents
チロシンキナーゼとしての６−置換３−（キノリン−６−イルチオ）−［１，２，４］トリアゾロ［４，３−ａ］ピラジン Download PDFInfo
- Publication number
- JP5957526B2 JP5957526B2 JP2014530361A JP2014530361A JP5957526B2 JP 5957526 B2 JP5957526 B2 JP 5957526B2 JP 2014530361 A JP2014530361 A JP 2014530361A JP 2014530361 A JP2014530361 A JP 2014530361A JP 5957526 B2 JP5957526 B2 JP 5957526B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- triazolo
- quinolin
- pyrazol
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PHJFHVDRXLVFAQ-UHFFFAOYSA-N CN1CCN(Cc2cc(cc(cc3)O)c3nc2)CC1 Chemical compound CN1CCN(Cc2cc(cc(cc3)O)c3nc2)CC1 PHJFHVDRXLVFAQ-UHFFFAOYSA-N 0.000 description 2
- 0 *c1c[n]2c(Sc(cc3)cc4c3ncc(*)c4)nnc2c(*)c1 Chemical compound *c1c[n]2c(Sc(cc3)cc4c3ncc(*)c4)nnc2c(*)c1 0.000 description 1
- QKLMSBGPZMYOMF-UHFFFAOYSA-N Brc1cnc(ccc(OCc2ccccc2)c2)c2c1 Chemical compound Brc1cnc(ccc(OCc2ccccc2)c2)c2c1 QKLMSBGPZMYOMF-UHFFFAOYSA-N 0.000 description 1
- YFCXQUJKPIVRBF-STBIYBPSSA-N C/C(/c(cc1)n[n]2c1nnc2Cc(cc1)cc2c1ncc(N1CCN(C)CC1)c2)=N\OCCO Chemical compound C/C(/c(cc1)n[n]2c1nnc2Cc(cc1)cc2c1ncc(N1CCN(C)CC1)c2)=N\OCCO YFCXQUJKPIVRBF-STBIYBPSSA-N 0.000 description 1
- XDYZXDIUGARRDS-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c1cc2cc(C(C)=C)ccc2nc1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1cc2cc(C(C)=C)ccc2nc1)=O XDYZXDIUGARRDS-UHFFFAOYSA-N 0.000 description 1
- IHPJCGNNOPYJQG-UHFFFAOYSA-N CCN(CC1)CCN1c1cnc(ccc([O](C2)C2=C)c2)c2c1 Chemical compound CCN(CC1)CCN1c1cnc(ccc([O](C2)C2=C)c2)c2c1 IHPJCGNNOPYJQG-UHFFFAOYSA-N 0.000 description 1
- TXIOGJHPPVXTOY-UHFFFAOYSA-N CCN1CCN(C)CC1 Chemical compound CCN1CCN(C)CC1 TXIOGJHPPVXTOY-UHFFFAOYSA-N 0.000 description 1
- RMWXBDPPMFXPDI-UHFFFAOYSA-N CN1CCN(Cc2cc3cc(OCc4ccccc4)ccc3nc2)CC1 Chemical compound CN1CCN(Cc2cc3cc(OCc4ccccc4)ccc3nc2)CC1 RMWXBDPPMFXPDI-UHFFFAOYSA-N 0.000 description 1
- IQIXNLSBPCWCMG-CYBMUJFWSA-N C[C@H](C=C)c1ccc2ncc(N3CCOCC3)cc2c1 Chemical compound C[C@H](C=C)c1ccc2ncc(N3CCOCC3)cc2c1 IQIXNLSBPCWCMG-CYBMUJFWSA-N 0.000 description 1
- QWEPGYACBQWDFQ-UHFFFAOYSA-N Oc1cc2cc(N(CC3)CCN3C3CCCCC3)cnc2cc1 Chemical compound Oc1cc2cc(N(CC3)CCN3C3CCCCC3)cnc2cc1 QWEPGYACBQWDFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011079695 | 2011-09-15 | ||
| CNPCT/CN2011/079695 | 2011-09-15 | ||
| CN2012079055 | 2012-07-23 | ||
| CNPCT/CN2012/079055 | 2012-07-23 | ||
| PCT/IB2012/054775 WO2013038362A1 (en) | 2011-09-15 | 2012-09-13 | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526499A JP2014526499A (ja) | 2014-10-06 |
| JP2014526499A5 JP2014526499A5 (https=) | 2015-11-05 |
| JP5957526B2 true JP5957526B2 (ja) | 2016-07-27 |
Family
ID=46981017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530361A Expired - Fee Related JP5957526B2 (ja) | 2011-09-15 | 2012-09-13 | チロシンキナーゼとしての６−置換３−（キノリン−６−イルチオ）−［１，２，４］トリアゾロ［４，３−ａ］ピラジン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9062045B2 (https=) |
| EP (1) | EP2755976B1 (https=) |
| JP (1) | JP5957526B2 (https=) |
| KR (1) | KR20140077916A (https=) |
| AR (1) | AR087868A1 (https=) |
| AU (1) | AU2012310168B2 (https=) |
| BR (1) | BR112014006223A8 (https=) |
| CA (1) | CA2848809A1 (https=) |
| EA (1) | EA026655B1 (https=) |
| ES (1) | ES2691650T3 (https=) |
| MX (1) | MX339302B (https=) |
| TW (1) | TW201319067A (https=) |
| UY (1) | UY34329A (https=) |
| WO (1) | WO2013038362A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014180182A1 (zh) * | 2013-05-10 | 2014-11-13 | 江苏豪森药业股份有限公司 | [1,2,4]三唑并[4,3-a]吡啶类衍生物，其制备方法或其在医药上的应用 |
| AU2014302595B2 (en) | 2013-06-24 | 2018-08-02 | Amgen Inc. | Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines |
| GB201321742D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| WO2016015653A1 (zh) * | 2014-08-01 | 2016-02-04 | 江苏豪森药业股份有限公司 | C-Met抑制剂结晶型游离碱或其结晶型酸式盐及其制备方法和应用 |
| WO2017049711A1 (zh) | 2015-09-24 | 2017-03-30 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
| CN106883250B (zh) * | 2015-12-15 | 2021-05-18 | 江苏豪森药业集团有限公司 | C-Met酪氨酸激酶抑制剂的制备方法 |
| KR102709679B1 (ko) | 2018-04-25 | 2024-09-26 | 바이엘 악티엔게젤샤프트 | 살충제로서의 신규 헤테로아릴-트리아졸 및 헤테로아릴-테트라졸 화합물 |
| CN118561817A (zh) | 2019-07-23 | 2024-08-30 | 拜耳公司 | 作为农药的新的杂芳基-三唑化合物 |
| BR112022000942A2 (pt) | 2019-07-23 | 2022-05-17 | Bayer Ag | Compostos de heteroaril-triazol como pesticidas |
| CN111440174B (zh) * | 2020-04-02 | 2021-07-09 | 广州医科大学 | 一种吡啶酰胺类化合物及其制备方法与应用 |
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- 2012-09-13 EA EA201490630A patent/EA026655B1/ru not_active IP Right Cessation
- 2012-09-13 US US13/613,291 patent/US9062045B2/en active Active
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- 2012-09-13 MX MX2014003194A patent/MX339302B/es active IP Right Grant
- 2012-09-13 WO PCT/IB2012/054775 patent/WO2013038362A1/en not_active Ceased
- 2012-09-13 BR BR112014006223A patent/BR112014006223A8/pt not_active IP Right Cessation
- 2012-09-13 KR KR1020147009795A patent/KR20140077916A/ko not_active Withdrawn
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| Publication number | Publication date |
|---|---|
| AU2012310168B2 (en) | 2015-07-16 |
| EA201490630A1 (ru) | 2014-08-29 |
| UY34329A (es) | 2013-04-30 |
| BR112014006223A2 (pt) | 2017-04-11 |
| AU2012310168A1 (en) | 2014-05-01 |
| EP2755976A1 (en) | 2014-07-23 |
| ES2691650T3 (es) | 2018-11-28 |
| MX339302B (es) | 2016-05-19 |
| WO2013038362A1 (en) | 2013-03-21 |
| MX2014003194A (es) | 2015-03-19 |
| US20130245002A1 (en) | 2013-09-19 |
| US9474762B2 (en) | 2016-10-25 |
| JP2014526499A (ja) | 2014-10-06 |
| CA2848809A1 (en) | 2013-03-21 |
| TW201319067A (zh) | 2013-05-16 |
| KR20140077916A (ko) | 2014-06-24 |
| BR112014006223A8 (pt) | 2018-01-09 |
| AR087868A1 (es) | 2014-04-23 |
| EA026655B1 (ru) | 2017-05-31 |
| US20150250799A1 (en) | 2015-09-10 |
| EP2755976B1 (en) | 2018-07-18 |
| US9062045B2 (en) | 2015-06-23 |
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