JP5947906B2 - ２−ピリジルオキシ−４−ニトリルオレキシン受容体アンタゴニスト - Google Patents
２−ピリジルオキシ−４−ニトリルオレキシン受容体アンタゴニスト Download PDFInfo
- Publication number
- JP5947906B2 JP5947906B2 JP2014537157A JP2014537157A JP5947906B2 JP 5947906 B2 JP5947906 B2 JP 5947906B2 JP 2014537157 A JP2014537157 A JP 2014537157A JP 2014537157 A JP2014537157 A JP 2014537157A JP 5947906 B2 JP5947906 B2 JP 5947906B2
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- carbonitrile
- pyridine
- carbonyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548883P | 2011-10-19 | 2011-10-19 | |
| US61/548,883 | 2011-10-19 | ||
| PCT/US2012/060479 WO2013059222A1 (en) | 2011-10-19 | 2012-10-17 | 2-pyridyloxy-4-nitrile orexin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532624A JP2014532624A (ja) | 2014-12-08 |
| JP5947906B2 true JP5947906B2 (ja) | 2016-07-06 |
Family
ID=47116466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537157A Expired - Fee Related JP5947906B2 (ja) | 2011-10-19 | 2012-10-17 | ２−ピリジルオキシ−４−ニトリルオレキシン受容体アンタゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9156819B2 (enExample) |
| EP (1) | EP2768823B1 (enExample) |
| JP (1) | JP5947906B2 (enExample) |
| CN (1) | CN103874695B (enExample) |
| AR (1) | AR088352A1 (enExample) |
| AU (1) | AU2012326275B2 (enExample) |
| BR (1) | BR112014009486A2 (enExample) |
| CA (1) | CA2852425C (enExample) |
| IN (1) | IN2014CN02515A (enExample) |
| TW (1) | TW201317228A (enExample) |
| WO (1) | WO2013059222A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| RU2014136339A (ru) | 2012-02-07 | 2016-03-27 | Иолас Терапьютикс, Инк. | Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов |
| EP2908812A4 (en) * | 2012-10-16 | 2016-04-20 | Merck Sharp & Dohme | 2-pyridyloxy, 3-ESTER-4-NITRILOREXIN receptor antagonists |
| US9546152B2 (en) * | 2012-10-23 | 2017-01-17 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists |
| EP2925321A4 (en) * | 2012-11-27 | 2016-04-27 | Merck Sharp & Dohme | 2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists |
| US9556145B2 (en) * | 2012-12-20 | 2017-01-31 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ester orexin receptor antagonists |
| US9765057B2 (en) * | 2012-12-20 | 2017-09-19 | Merck Sharp & Dohme Corp. | 3-ester-4 substituted orexin receptor antagonists |
| WO2014099698A1 (en) * | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists |
| TW201444821A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代之哌啶化合物及其作為食慾素受體調節劑之用途 |
| TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途 |
| TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
| US9725434B2 (en) * | 2013-04-23 | 2017-08-08 | Merck Sharp & Dohme Corp. | Hydroxy-substituted orexin receptor antagonists |
| WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2015018029A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2015088865A1 (en) | 2013-12-09 | 2015-06-18 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-methyl orexin receptor antagonists |
| US9975876B2 (en) | 2013-12-09 | 2018-05-22 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists |
| US9617246B2 (en) | 2013-12-18 | 2017-04-11 | Merck Sharp & Dohme Corp. | Thioether-piperidinyl orexin receptor antagonists |
| US9676751B2 (en) | 2013-12-20 | 2017-06-13 | Merck Sharp & Dohme Corp. | 2-amino-3-ester-pyridl orexin receptor antagonists |
| AU2015226679B2 (en) * | 2014-03-06 | 2017-05-25 | Shanghai Haiyan Pharmaceutical Technology Co. Ltd | Piperidine derivatives as orexin receptor antagonist |
| EP3180332B1 (en) | 2014-08-13 | 2021-10-27 | Eolas Therapeutics Inc. | Difluoropyrrolidines as orexin receptor modulators |
| WO2016040789A1 (en) | 2014-09-11 | 2016-03-17 | Janssen Pharmaceutica Nv | Substituted 2-azabicycles and their use as orexin receptor modulators |
| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2016065586A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole and tetrazole orexin receptor antagonists |
| WO2016065584A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| WO2016065585A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine isoxazole and isothiazole orexin receptor antagonists |
| WO2016065587A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole orexin receptor antagonists |
| US20190083508A1 (en) * | 2014-11-24 | 2019-03-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Use of ox1r antagonists for the treatment of inflammatory bowel diseases |
| WO2016085784A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| WO2016085783A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| WO2016086358A1 (en) * | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Hydroxymethyl piperidine orexin receptor antagonists |
| US9938276B2 (en) | 2014-12-19 | 2018-04-10 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
| WO2016100162A2 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
| WO2016095205A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Heteroaryl orexin receptor antagonists |
| US10011595B2 (en) | 2014-12-19 | 2018-07-03 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016095204A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor antagonists |
| WO2016101118A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
| WO2016101119A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Fused heteroaryl derivatives as orexin receptor antagonists |
| WO2017088759A1 (en) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF |
| KR102738491B1 (ko) | 2016-02-12 | 2024-12-03 | 아스트라제네카 아베 | 오렉신 수용체 조정제로서의 할로-치환된 피페리딘 |
| US20190151304A1 (en) | 2016-05-10 | 2019-05-23 | Inserm (Institut National De La Santé Et De La Rechercjae Médicale | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory |
| MY202221A (en) | 2017-08-03 | 2024-04-17 | Takeda Pharmaceuticals Co | Heterocyclic compound and use thereof |
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- 2012-10-17 JP JP2014537157A patent/JP5947906B2/ja not_active Expired - Fee Related
- 2012-10-17 WO PCT/US2012/060479 patent/WO2013059222A1/en not_active Ceased
- 2012-10-17 IN IN2515CHN2014 patent/IN2014CN02515A/en unknown
- 2012-10-17 US US13/653,454 patent/US9156819B2/en active Active
- 2012-10-17 AU AU2012326275A patent/AU2012326275B2/en not_active Ceased
- 2012-10-17 CN CN201280051319.6A patent/CN103874695B/zh not_active Expired - Fee Related
- 2012-10-17 EP EP12780370.8A patent/EP2768823B1/en active Active
- 2012-10-17 BR BR112014009486A patent/BR112014009486A2/pt not_active Application Discontinuation
- 2012-10-18 TW TW101138514A patent/TW201317228A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR088352A1 (es) | 2014-05-28 |
| CA2852425A1 (en) | 2013-04-25 |
| CN103874695B (zh) | 2017-12-15 |
| JP2014532624A (ja) | 2014-12-08 |
| WO2013059222A1 (en) | 2013-04-25 |
| BR112014009486A2 (pt) | 2017-05-09 |
| AU2012326275B2 (en) | 2016-12-01 |
| EP2768823B1 (en) | 2017-09-06 |
| IN2014CN02515A (enExample) | 2015-07-31 |
| CA2852425C (en) | 2019-11-12 |
| EP2768823A1 (en) | 2014-08-27 |
| AU2012326275A1 (en) | 2014-04-17 |
| CN103874695A (zh) | 2014-06-18 |
| US20130102619A1 (en) | 2013-04-25 |
| TW201317228A (zh) | 2013-05-01 |
| US9156819B2 (en) | 2015-10-13 |
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