US3914250A
(en)
|
1974-08-01 |
1975-10-21 |
American Home Prod |
1,4-Diazepino{8 6,5,4-jk{9 carbazoles
|
CA1258454A
(en)
|
1982-08-10 |
1989-08-15 |
Leo Alig |
Phenethanolamines
|
IT1159765B
(it)
|
1982-09-28 |
1987-03-04 |
Zanussi A Spa Industrie |
Macchina lavabiancheria di tipo modulare
|
ZA848275B
(en)
|
1983-12-28 |
1985-08-28 |
Degussa |
New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
|
MX18467A
(es)
|
1988-11-23 |
1993-07-01 |
Pfizer |
Agentes terapeuticos de quinuclidinas
|
US5232929A
(en)
|
1990-11-28 |
1993-08-03 |
Pfizer Inc. |
3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
|
US5081122A
(en)
|
1990-03-05 |
1992-01-14 |
Sterling Drug Inc. |
Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
|
US5112820A
(en)
|
1990-03-05 |
1992-05-12 |
Sterling Drug Inc. |
Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof
|
US4973587A
(en)
|
1990-03-08 |
1990-11-27 |
Sterling Drug Inc. |
3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method
|
US5013837A
(en)
|
1990-03-08 |
1991-05-07 |
Sterling Drug Inc. |
3-Arylcarbonyl-1H-indole-containing compounds
|
DE69220258T2
(de)
|
1991-02-11 |
1997-12-18 |
Merck Sharp & Dohme |
Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
|
EP0573522B1
(en)
|
1991-03-01 |
1994-12-14 |
Pfizer Inc. |
1-azabicyclo[3.2.2]nonan-3-amine derivatives
|
EP0528495A1
(en)
|
1991-08-20 |
1993-02-24 |
Merck Sharp & Dohme Ltd. |
Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
|
GB9211193D0
(en)
|
1992-05-27 |
1992-07-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
FR2692575B1
(fr)
|
1992-06-23 |
1995-06-30 |
Sanofi Elf |
Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
US5637699A
(en)
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
US5387595A
(en)
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
US5536716A
(en)
|
1992-12-11 |
1996-07-16 |
Merck & Co., Inc. |
Spiro piperidines and homologs which promote release of growth hormone
|
US5292736A
(en)
|
1993-02-26 |
1994-03-08 |
Sterling Winthrop Inc. |
Morpholinoalkylindenes as antiglaucoma agents
|
US5496833A
(en)
|
1993-04-13 |
1996-03-05 |
Merck Sharp & Dohme Limited |
Piperidine tachykinin receptor antagonists
|
KR970707101A
(ko)
|
1994-11-07 |
1997-12-01 |
스피겔 알렌 제이 |
치환된 벤질아민 유도체; 신규한 부류의 신경펩타이드 y1 특이적 리간드(certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands)
|
US5532237A
(en)
|
1995-02-15 |
1996-07-02 |
Merck Frosst Canada, Inc. |
Indole derivatives with affinity for the cannabinoid receptor
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
US5739106A
(en)
|
1995-06-07 |
1998-04-14 |
Rink; Timothy J. |
Appetite regulating compositions
|
FR2741621B1
(fr)
|
1995-11-23 |
1998-02-13 |
Sanofi Sa |
Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
|
AU1328197A
(en)
|
1995-12-01 |
1997-06-19 |
Synaptic Pharmaceutical Corporation |
Aryl sulfonamide and sulfamide derivatives and uses thereof
|
AU7692896A
(en)
|
1995-12-01 |
1997-06-27 |
Novartis Ag |
Quinazolin-2,4-diazirines as NPY receptor antagonist
|
WO1997020820A1
(en)
|
1995-12-01 |
1997-06-12 |
Novartis Ag |
Heteroaryl compounds
|
AU7692996A
(en)
|
1995-12-01 |
1997-06-27 |
Ciba-Geigy Ag |
Receptor antagonists
|
AU7692696A
(en)
|
1995-12-01 |
1997-06-27 |
Novartis Ag |
Heteroaryl derivatives
|
TW432073B
(en)
|
1995-12-28 |
2001-05-01 |
Pfizer |
Pyrazolopyridine compounds
|
WO1997028149A1
(en)
|
1996-02-02 |
1997-08-07 |
Merck & Co., Inc. |
Method for raising hdl cholesterol levels
|
CA2245586A1
(en)
|
1996-02-06 |
1997-08-14 |
Japan Tobacco Inc. |
Novel compounds and pharmaceutical use thereof
|
GB9606805D0
(en)
|
1996-03-30 |
1996-06-05 |
Glaxo Wellcome Inc |
Medicaments
|
CA2273102A1
(en)
|
1996-12-03 |
1998-06-11 |
Banyu Pharmaceutical Co., Ltd. |
Urea derivatives
|
EP0945438B1
(en)
|
1996-12-12 |
2003-03-05 |
Banyu Pharmaceutical Co., Ltd. |
Pyrazole derivatives
|
US6166038A
(en)
|
1996-12-13 |
2000-12-26 |
Banyu Pharmaceutical Co., Ltd. |
Aminopyrazole derivatives
|
CA2274594C
(en)
|
1996-12-16 |
2006-10-10 |
Banyu Pharmaceutical Co., Ltd. |
Aminopyrazole derivatives
|
ES2213892T3
(es)
|
1997-01-21 |
2004-09-01 |
Smithkline Beecham Corporation |
Nuevos moduladores del receptor de canabinoides.
|
CN1246845A
(zh)
|
1997-02-04 |
2000-03-08 |
纳幕尔杜邦公司 |
杀菌的羧酰胺
|
PT966436E
(pt)
|
1997-02-21 |
2003-03-31 |
Bayer Ag |
Arilsulfonamidas e analogos e sua aplicacao para o tratamento de doencas neurodegenerativas
|
WO1998040356A1
(fr)
|
1997-03-12 |
1998-09-17 |
Banyu Pharmaceutical Co., Ltd. |
Medicaments contenant des derives d'aminopyridine comme ingredient actif
|
JP2001516361A
(ja)
|
1997-03-18 |
2001-09-25 |
スミスクライン・ビーチャム・コーポレイション |
新規カンナビノイド受容体作動薬
|
FR2761265B1
(fr)
|
1997-03-28 |
1999-07-02 |
Sanofi Sa |
Composition pharmaceutique pour l'administration orale d'un derive du n-piperidino-3-pyrazolecarboxamide, de ses sels et de leurs solvates
|
FR2761266B1
(fr)
|
1997-03-28 |
1999-07-02 |
Sanofi Sa |
Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
|
US6258837B1
(en)
|
1997-04-23 |
2001-07-10 |
Banyu Pharmaceutical Co., Ltd. |
Neuropeptide Y receptor antagonist
|
US6001836A
(en)
|
1997-05-28 |
1999-12-14 |
Bristol-Myers Squibb Company |
Dihydropyridine NPY antagonists: cyanoguanidine derivatives
|
KR20010021696A
(ko)
|
1997-07-11 |
2001-03-15 |
미즈노 마사루 |
퀴놀린 화합물 및 그의 의약용도
|
AR016817A1
(es)
|
1997-08-14 |
2001-08-01 |
Smithkline Beecham Plc |
Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
|
WO1999015516A1
(fr)
|
1997-09-25 |
1999-04-01 |
Banyu Pharmaceutical Co., Ltd. |
Nouveaux antagonistes des recepteurs de neuropeptides y
|
WO1999027965A1
(fr)
|
1997-11-28 |
1999-06-10 |
Banyu Pharmaceutical Co., Ltd. |
Agents anti-hyperlipemiques
|
EP1068207A1
(en)
|
1998-04-02 |
2001-01-17 |
Neurogen Corporation |
AMINOALKYL SUBSTITUTED 9H-PYRIDINO 2,3-b]INDOLE AND 9H-PYRIMIDINO 4,5-b]INDOLE DERIVATIVES
|
PT1076644E
(pt)
|
1998-04-29 |
2004-10-29 |
Ortho Mcneil Pharm Inc |
Aminotetralinas substituidas emn como ligandos para o receptor de neuropeptideoy y5 util no tratamento da obesidade e de outras perturbacoes
|
EP1075478B1
(en)
|
1998-05-08 |
2003-04-16 |
SmithKline Beecham plc |
Phenylurea and phenylthio urea derivatives
|
US6329395B1
(en)
|
1998-06-08 |
2001-12-11 |
Schering Corporation |
Neuropeptide Y5 receptor antagonists
|
HN1998000027A
(es)
|
1998-08-19 |
1999-06-02 |
Bayer Ip Gmbh |
Arilsulfonamidas y analagos
|
DE19837627A1
(de)
|
1998-08-19 |
2000-02-24 |
Bayer Ag |
Neue Aminosäureester von Arylsulfonamiden und Analoga
|
US6358951B1
(en)
|
1998-08-21 |
2002-03-19 |
Pfizer Inc. |
Growth hormone secretagogues
|
US6337332B1
(en)
|
1998-09-17 |
2002-01-08 |
Pfizer Inc. |
Neuropeptide Y receptor antagonists
|
WO2000027845A1
(en)
|
1998-11-10 |
2000-05-18 |
Merck & Co., Inc. |
Spiro-indolines as y5 receptor antagonists
|
ES2226785T3
(es)
|
1999-02-12 |
2005-04-01 |
Smithkline Beecham Plc |
Derivados de fenilurea como antagonistas de los receptores de orexina.
|
WO2000047576A1
(en)
|
1999-02-12 |
2000-08-17 |
Smithkline Beecham Plc |
Cinnamide derivatives as orexin-1 receptors antagonists
|
ATE282614T1
(de)
|
1999-02-12 |
2004-12-15 |
Smithkline Beecham Plc |
Phenylharnstoff und phenylthioharnstoffderivate
|
US6340683B1
(en)
|
1999-04-22 |
2002-01-22 |
Synaptic Pharmaceutical Corporation |
Selective NPY (Y5) antagonists (triazines)
|
PT1183245E
(pt)
|
1999-04-22 |
2007-07-12 |
Lundbeck & Co As H |
Antagonistas selectivos de npy (y5)
|
CA2373035A1
(en)
|
1999-05-05 |
2000-11-16 |
Scott Dax |
3a,4,5,9b-tetrahydro-1h-benz[e]indol-2-yl amine-derived neuropeptide y receptors ligands useful in the treatment of obesity and other disorders
|
ATE306481T1
(de)
|
1999-05-12 |
2005-10-15 |
Ortho Mcneil Pharm Inc |
Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen
|
DK1194421T3
(da)
|
1999-06-30 |
2006-02-13 |
Lundbeck & Co As H |
Selektive NPY (Y5) antagonister
|
WO2001007409A1
(en)
|
1999-07-23 |
2001-02-01 |
Astrazeneca Uk Limited |
Carbazole derivatives and their use as neuropeptide y5 receptor ligands
|
JP2003506367A
(ja)
|
1999-07-28 |
2003-02-18 |
オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド |
肥満症および他の障害の処置に有用な神経ペプチドyy5レセプターのリガンドとしてのアミンおよびアミド誘導体
|
US6462053B1
(en)
|
1999-08-20 |
2002-10-08 |
Banyu Pharmaceutical Co., Ltd. |
Spiro compounds
|
TWI279402B
(en)
|
1999-08-20 |
2007-04-21 |
Banyu Pharma Co Ltd |
Spiro compounds having NPY antagonistic activities and agents containing the same
|
CA2383147A1
(en)
|
1999-09-20 |
2001-03-29 |
Takeda Chemical Industries, Ltd. |
Mch antagonists
|
CA2386474A1
(en)
|
1999-09-20 |
2001-03-29 |
Takeda Chemical Industries, Ltd. |
Melanin concentrating hormone antagonist
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
CZ20021089A3
(cs)
|
1999-09-30 |
2002-11-13 |
Neurogen Corporation |
Aminosustituované pyrazolo[1,5-a]-1,5-pyrimidiny a pyrazolo[1,5-a]-1,3,5-triaziny
|
IL148905A0
(en)
|
1999-09-30 |
2002-09-12 |
Neurogen Corp Pfizer Inc |
Certain alkylene diamine-substituted pyrazolo{1,5,-a}-1,5-pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines
|
JP2003510327A
(ja)
|
1999-09-30 |
2003-03-18 |
ニューロジェン・コーポレーション |
特定のアルキレンジアミンで置換された複素環
|
MXPA02006016A
(es)
|
1999-12-16 |
2002-12-05 |
Schering Corp |
Imidazoles sustituidos, antagonistas de los receptores y5 del neuropeptido y.
|
WO2001053288A1
(fr)
|
2000-01-20 |
2001-07-26 |
Eisai Co., Ltd. |
Nouveaux composes de piperidine et medicaments contenant ces composes
|
AU2001228325A1
(en)
|
2000-02-01 |
2001-08-14 |
Novo-Nordisk A/S |
Use of compounds for the regulation of food intake
|
US6653304B2
(en)
|
2000-02-11 |
2003-11-25 |
Bristol-Myers Squibb Co. |
Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
|
CA2400659A1
(en)
|
2000-02-22 |
2001-08-30 |
Banyu Pharmaceutical Co., Ltd. |
Novel imidazoline compounds
|
US6531478B2
(en)
|
2000-02-24 |
2003-03-11 |
Cheryl P. Kordik |
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
|
FR2805810B1
(fr)
|
2000-03-03 |
2002-04-26 |
Aventis Pharma Sa |
Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation
|
FR2805817B1
(fr)
|
2000-03-03 |
2002-04-26 |
Aventis Pharma Sa |
Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
|
FR2805818B1
(fr)
|
2000-03-03 |
2002-04-26 |
Aventis Pharma Sa |
Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
|
EP1132389A1
(en)
|
2000-03-06 |
2001-09-12 |
Vernalis Research Limited |
New aza-indolyl derivatives for the treatment of obesity
|
ES2234840T3
(es)
|
2000-03-14 |
2005-07-01 |
Actelion Pharmaceuticals Ltd. |
Derivados de 1,2,3,4- tetrahidroisoquinolina.
|
EP1142886A1
(en)
|
2000-04-07 |
2001-10-10 |
Aventis Pharma Deutschland GmbH |
Percyquinnin, a process for its production and its use as a pharmaceutical
|
ATE479429T1
(de)
|
2000-04-28 |
2010-09-15 |
Takeda Pharmaceutical |
Antagonisten des melanin-konzentrierenden hormons
|
GB0010757D0
(en)
|
2000-05-05 |
2000-06-28 |
Astrazeneca Ab |
Chemical compounds
|
GB0011013D0
(en)
|
2000-05-09 |
2000-06-28 |
Astrazeneca Ab |
Chemical compounds
|
US6479482B2
(en)
|
2000-05-10 |
2002-11-12 |
Bristol-Myers Squibb Company |
Alkylamine derivatives of dihydropyridine NPY antagonists
|
US6432960B2
(en)
|
2000-05-10 |
2002-08-13 |
Bristol-Myers Squibb Company |
Squarate derivatives of dihydropyridine NPY antagonists
|
US6444675B2
(en)
|
2000-05-10 |
2002-09-03 |
Bristol-Myers Squibb Company |
4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists
|
EP1280777B1
(en)
|
2000-05-11 |
2005-11-23 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline analogs useful as growth hormone secretagogues
|
EP1288202A4
(en)
|
2000-05-11 |
2003-07-02 |
Banyu Pharma Co Ltd |
N-ACYLTETRAHYDROISOQUINOLINE DERIVATIVES
|
EP1283199A4
(en)
|
2000-05-16 |
2003-12-17 |
Takeda Chemical Industries Ltd |
MELANIN CONCENTRATION HORMONE ANTAGONIST
|
EP1286697A2
(en)
|
2000-05-17 |
2003-03-05 |
Eli Lilly And Company |
Method for selectively inhibiting ghrelin action
|
US6391881B2
(en)
|
2000-05-19 |
2002-05-21 |
Bristol-Myers Squibb Company |
Thiourea derivatives of dihydropyridine NPY antagonists
|
SE0001899D0
(sv)
|
2000-05-22 |
2000-05-22 |
Pharmacia & Upjohn Ab |
New compounds
|
PT1289955E
(pt)
|
2000-06-16 |
2005-08-31 |
Smithkline Beecham Plc |
Piperidinas para utilizacao como antagonistas dos receptores da orexina
|
EP1299362A4
(en)
|
2000-07-05 |
2004-11-03 |
Synaptic Pharma Corp |
SELECTIVE RECEPTOR ANTAGONISTS OF MELANINE CONCENTRATING HORMON-1 (MCH1) AND THEIR USE
|
EP1366030A2
(en)
|
2000-07-06 |
2003-12-03 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands
|
JP2004504406A
(ja)
|
2000-07-24 |
2004-02-12 |
アーダナ バイオサイエンス リミテッド |
グレリンアンタゴニスト
|
KR100539139B1
(ko)
|
2000-07-31 |
2005-12-26 |
에프. 호프만-라 로슈 아게 |
피페라진 유도체
|
US20020165223A1
(en)
|
2000-09-14 |
2002-11-07 |
Greenlee William J. |
Substituted urea neuropeptide Y Y5 receptor antagonists
|
CA2419388A1
(en)
|
2000-10-13 |
2002-04-25 |
Eli Lilly And Company |
Substituted dipeptides as growth hormone secretagogues
|
KR100545435B1
(ko)
|
2000-10-16 |
2006-01-24 |
에프. 호프만-라 로슈 아게 |
인돌린 유도체 및 5-ht2 수용체 리간드로서의 이들의 용도
|
WO2002036596A2
(en)
|
2000-11-03 |
2002-05-10 |
Wyeth |
CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
|
EP1335907B1
(en)
|
2000-11-20 |
2010-06-09 |
Biovitrum AB (publ) |
Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
|
DE60139021D1
(de)
|
2000-11-20 |
2009-07-30 |
Biovitrum Ab Publ |
Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
|
ATE286897T1
(de)
|
2000-11-28 |
2005-01-15 |
Smithkline Beecham Plc |
Morpholinderivate als antagonisten an orexinrezeptoren
|
US20050033048A1
(en)
|
2000-12-12 |
2005-02-10 |
Rajagopal Bakthavatchalam |
Spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-piperidines
|
GB0030710D0
(en)
|
2000-12-15 |
2001-01-31 |
Hoffmann La Roche |
Piperazine derivatives
|
IL156157A0
(en)
|
2000-12-21 |
2003-12-23 |
Schering Corp |
Heteroaryl urea neuropeptide y y5 receptor antagonists
|
CA2431953A1
(en)
|
2000-12-22 |
2002-07-04 |
Schering Corporation |
Piperidine mch antagonists and their use in the treatment of obesity
|
WO2002051232A2
(en)
|
2000-12-27 |
2002-07-04 |
Actelion Pharmaceuticals Ltd. |
Novel benzazepines and related heterocyclic derivatives
|
CA2432085C
(en)
|
2000-12-27 |
2009-02-24 |
F. Hoffmann-La Roche Ag |
Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
|
KR20030074774A
(ko)
|
2001-02-02 |
2003-09-19 |
다케다 야쿠힌 고교 가부시키가이샤 |
접합 헤테로시클릭 화합물
|
WO2002076929A1
(en)
|
2001-03-21 |
2002-10-03 |
Pharmacopeia, Inc. |
Aryl and biaryl compounds having mch modulatory activity
|
US6900329B2
(en)
|
2001-03-21 |
2005-05-31 |
Schering Corporation |
MCH antagonists and their use in the treatment of obesity
|
PL363751A1
(en)
|
2001-03-22 |
2004-11-29 |
Solvay Pharmaceuticals B.V. |
4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
|
US6573287B2
(en)
|
2001-04-12 |
2003-06-03 |
Bristo-Myers Squibb Company |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
|
WO2002083134A1
(en)
|
2001-04-12 |
2002-10-24 |
Pharmacopeia, Inc. |
Aryl and biaryl piperidines used as mch antagonists
|
CZ20032990A3
(cs)
|
2001-05-05 |
2004-04-14 |
Smithkline Beecham P. L. C. |
N-aroylové cyklické aminy
|
JP2004534026A
(ja)
|
2001-05-05 |
2004-11-11 |
スミスクライン ビーチャム パブリック リミテッド カンパニー |
オレキシン受容体アンタゴニストとしてのn−アロイルサイクリックアミン誘導体
|
FR2824825B1
(fr)
|
2001-05-15 |
2005-05-06 |
Servier Lab |
Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
WO2002094825A1
(fr)
|
2001-05-22 |
2002-11-28 |
Banyu Pharmaceutical Co., Ltd. |
Nouveau derive de spiropiperidine
|
EP1389189A2
(en)
|
2001-05-22 |
2004-02-18 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
|
ES2257555T3
(es)
|
2001-06-20 |
2006-08-01 |
MERCK & CO., INC. |
Inhibidores de dipeptidilpeptidasa para el tratamiento de la diabetes.
|
CA2450579A1
(en)
|
2001-06-20 |
2003-01-03 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
GB0115517D0
(en)
|
2001-06-25 |
2001-08-15 |
Ferring Bv |
Novel antidiabetic agents
|
ATE370943T1
(de)
|
2001-06-27 |
2007-09-15 |
Smithkline Beecham Corp |
Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
|
WO2003002530A2
(en)
|
2001-06-27 |
2003-01-09 |
Smithkline Beecham Corporation |
Pyrrolidines as dipeptidyl peptidase inhibitors
|
EP1862457B1
(en)
|
2001-06-27 |
2010-01-20 |
SmithKline Beecham Corporation |
Fluoropyrrolidines as dipeptidyl peptidase inhibitors
|
CN1688599A
(zh)
|
2001-06-27 |
2005-10-26 |
前体生物药物股份有限公司 |
二肽基肽酶iv抑制剂的新用途
|
GB0115862D0
(en)
|
2001-06-28 |
2001-08-22 |
Smithkline Beecham Plc |
Compounds
|
BR0210609A
(pt)
*
|
2001-06-28 |
2004-07-20 |
Smithkline Beecham Plc |
Derivados de amina cìclica n-aroila como antagonistas do receptor da orexina
|
JP2005502624A
(ja)
|
2001-07-03 |
2005-01-27 |
ノボ ノルディスク アクティーゼルスカブ |
糖尿病を治療するための、dpp−ivを阻害するプリン誘導体
|
EA005934B1
(ru)
|
2001-07-05 |
2005-08-25 |
Х. Лундбекк А/С |
Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
AU2002319627A1
(en)
|
2001-07-20 |
2003-03-03 |
Merck And Co., Inc. |
Substituted imidazoles as cannabinoid receptor modulators
|
BRPI0104510B8
(pt)
|
2001-07-27 |
2021-05-25 |
Embrapa Pesquisa Agropecuaria |
peptídeos antibióticos da família das phylloseptinas isolados da secreção da pele de phylloseptina hypocondrialis e composição antimicrobiana relacionada
|
WO2003014083A1
(fr)
|
2001-08-07 |
2003-02-20 |
Banyu Pharmaceutical Co., Ltd. |
Composes spiro
|
GB0124463D0
(en)
|
2001-10-11 |
2001-12-05 |
Smithkline Beecham Plc |
Compounds
|
GB0126292D0
(en)
|
2001-11-01 |
2002-01-02 |
Smithkline Beecham Plc |
Compounds
|
GB0127145D0
(en)
|
2001-11-10 |
2002-01-02 |
Smithkline Beecham |
Compounds
|
GB0130341D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
GB0130393D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
GB0130335D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
JP2005320249A
(ja)
|
2002-05-01 |
2005-11-17 |
Banyu Pharmaceut Co Ltd |
2−アミノピラジン誘導体の製造方法
|
TWI283241B
(en)
|
2002-05-29 |
2007-07-01 |
Tanabe Seiyaku Co |
Novel piperidine compound
|
AR040241A1
(es)
|
2002-06-10 |
2005-03-23 |
Merck & Co Inc |
Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
JP4498922B2
(ja)
|
2002-07-09 |
2010-07-07 |
アクテリオン ファーマシューティカルズ リミテッド |
7,8,9,10−テトラヒドロ−6H−アゼピノ、6,7,8,9−テトラヒドロ−ピリドおよび2,3−ジヒドロ−2H−ピロロ[2,1−b]−キナゾリノン誘導体
|
DE60309481T2
(de)
|
2002-09-18 |
2007-06-21 |
Glaxo Group Ltd., Greenford |
Cyclische n-aroylamine als orexinrezeptorantagonisten
|
US6869966B2
(en)
|
2002-09-30 |
2005-03-22 |
Banyu Pharmaceutical Co., Ltd. |
N-substituted-2-oxodihydropyridine derivatives
|
WO2004033445A1
(en)
|
2002-10-08 |
2004-04-22 |
Merck Frosst Canada & Co. |
4-amino-azepan-3-one compounds as cathepsin k inhibitors useful in the treatment of osteoporosis
|
BR0315115A
(pt)
|
2002-10-11 |
2005-08-16 |
Actelion Pharmaceuticals Ltd |
Compostos, composições farmacêuticas, método para tratar ou prevenir doenças ou distúrbios em que se requer um antagonista de receptores de orexina humana, processo para a fabricação de composições farmacêuticas, e, uso de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
|
GB0225938D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
GB0225884D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
MY134457A
(en)
|
2002-11-22 |
2007-12-31 |
Merck & Co Inc |
Substituted amides
|
AU2003299648A1
(en)
|
2002-12-12 |
2004-06-30 |
Janssen Pharmaceutica, N.V. |
Substituted 4-phenyl-(1,3)-dioxanes
|
JO2397B1
(en)
|
2002-12-20 |
2007-06-17 |
ميرك شارب اند دوم كوربوريشن |
Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
|
CL2004000553A1
(es)
|
2003-03-20 |
2005-02-04 |
Actelion Pharmaceuticals Ltd |
Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
|
WO2004085403A1
(en)
|
2003-03-26 |
2004-10-07 |
Actelion Pharmaceuticals Ltd |
Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists
|
JO2355B1
(en)
|
2003-04-15 |
2006-12-12 |
ميرك شارب اند دوم كوربوريشن |
Hereditary calcitonin polypeptide receptor antagonists
|
CN1780820A
(zh)
|
2003-04-28 |
2006-05-31 |
埃科特莱茵药品有限公司 |
作为阿立新受体拮抗剂的喹喔啉-3-酮衍生物
|
WO2005000809A1
(en)
|
2003-06-11 |
2005-01-06 |
Merck & Co., Inc. |
Substituted 3-alkyl and 3-alkenyl azetidine derivatives
|
HUP0304101A3
(en)
|
2003-12-22 |
2008-10-28 |
Sanofi Aventis |
Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
HUP0400405A3
(en)
|
2004-02-10 |
2009-03-30 |
Sanofi Synthelabo |
Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
WO2005118548A1
(en)
|
2004-03-01 |
2005-12-15 |
Actelion Pharmaceuticals Ltd |
Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
|
WO2006067224A2
(en)
|
2004-12-23 |
2006-06-29 |
Biovitrum Ab (Publ) |
Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists
|
DE102004062544A1
(de)
|
2004-12-24 |
2006-07-06 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue substituierte Pyrrolidinone, deren Herstellung und deren Verewendung als Arzneimittel
|
WO2006110626A1
(en)
|
2005-04-12 |
2006-10-19 |
Merck & Co., Inc. |
Amidopropoxyphenyl orexin receptor antagonists
|
TW200716594A
(en)
*
|
2005-04-18 |
2007-05-01 |
Neurogen Corp |
Substituted heteroaryl CB1 antagonists
|
WO2006117669A1
(en)
|
2005-05-03 |
2006-11-09 |
Pfizer Inc. |
Amide resorcinol compounds
|
WO2006127550A1
(en)
|
2005-05-23 |
2006-11-30 |
Merck & Co., Inc. |
Proline bis-amide orexin receptor antagonists
|
CA2617324A1
(en)
|
2005-08-04 |
2007-02-15 |
Merck & Co., Inc. |
Aminoethane sulfonamide orexin receptor antagonists
|
AU2006282955A1
(en)
|
2005-08-26 |
2007-03-01 |
Merck & Co., Inc. |
Diazaspirodecane orexin receptor antagonists
|
TWI329641B
(en)
*
|
2005-08-31 |
2010-09-01 |
Otsuka Pharma Co Ltd |
(benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
|
JP2009516742A
(ja)
|
2005-11-22 |
2009-04-23 |
メルク エンド カムパニー インコーポレーテッド |
インドールオレキシン受容体アンタゴニスト
|
WO2007126934A2
(en)
|
2006-03-29 |
2007-11-08 |
Merck & Co., Inc. |
Amidoethylthioether orexin receptor antagonists
|
JP2009531447A
(ja)
|
2006-03-29 |
2009-09-03 |
メルク エンド カムパニー インコーポレーテッド |
ジアゼパンオレキシン受容体アンタゴニスト
|
US8003654B2
(en)
|
2006-04-11 |
2011-08-23 |
Actelion Pharmaceuticals Ltd. |
N-glycinsulfonamide derivatives and uses as orexin receptor antagonists
|
CA2647077A1
(en)
|
2006-04-26 |
2007-11-01 |
Actelion Pharmaceuticals Ltd |
Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
|
SI2049529T1
(sl)
|
2006-07-14 |
2010-11-30 |
Merck Sharp & Dohme |
Substituiran diazepan oreksin receptor antagonist
|
CA2657623A1
(en)
|
2006-07-14 |
2008-01-17 |
Merck & Co., Inc. |
Bridged diazepan orexin receptor antagonists
|
AU2007272795A1
(en)
|
2006-07-14 |
2008-01-17 |
Merck & Co., Inc. |
2-substituted proline bis-amide orexin receptor antagonists
|
WO2008020405A2
(en)
|
2006-08-15 |
2008-02-21 |
Actelion Pharmaceuticals Ltd |
Azetidine compounds as orexin receptor antagonists
|
ES2339822T3
(es)
|
2006-08-28 |
2010-05-25 |
Actelion Pharmaceuticals Ltd. |
Derivados de 1,4,5,6,7,8-hexahidro-1,2,5-triaza-azuleno como antagonistas del receptor de orexina.
|
CN101522618A
(zh)
|
2006-09-29 |
2009-09-02 |
埃科特莱茵药品有限公司 |
3-氮杂-双环[3.1.0]己烷衍生物
|
WO2008065626A2
(en)
*
|
2006-12-01 |
2008-06-05 |
Actelion Pharmaceuticals Ltd |
3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors
|
PE20081229A1
(es)
|
2006-12-01 |
2008-08-28 |
Merck & Co Inc |
Antagonistas de receptor de orexina de diazepam sustituido
|
CA2679817A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Merck & Co., Inc. |
Bipyridine carboxamide orexin receptor antagonists
|
NZ580887A
(en)
|
2007-05-23 |
2012-03-30 |
Merck Sharp & Dohme |
Pyridyl piperidine orexin receptor antagonists
|
US8003797B2
(en)
*
|
2007-08-09 |
2011-08-23 |
Merck Sharp & Dohme Corp. |
Pyridine carboxamide orexin receptor antagonists
|
WO2009080533A1
(en)
*
|
2007-12-21 |
2009-07-02 |
F. Hoffmann-La Roche Ag |
Heteroaryl derivatives as orexin receptor antagonists
|
AR070221A1
(es)
*
|
2008-01-23 |
2010-03-25 |
Astrazeneca Ab |
Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
|
WO2009133522A1
(en)
*
|
2008-04-30 |
2009-11-05 |
Actelion Pharmaceuticals Ltd |
Piperidine and pyrrolidine compounds
|
AU2009249306B8
(en)
|
2008-05-22 |
2013-07-25 |
Merck Canada Inc. |
Process for the preparation of an orexin receptor antagonist
|
US8357700B2
(en)
|
2008-10-21 |
2013-01-22 |
Merck Sharp & Dohme Corp. |
2,3-disubstituted piperidine orexin receptor antagonists
|
EP2349270B1
(en)
|
2008-10-21 |
2015-09-09 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted morpholine orexin receptor antagonists
|
US8710076B2
(en)
|
2008-10-21 |
2014-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted piperidine orexin receptor antagonists
|
CA2739915A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted piperidine orexin receptor antagonists
|
CA2739919A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,4-disubstituted pyrrolidine orexin receptor antagonists
|
JP2012506379A
(ja)
|
2008-10-21 |
2012-03-15 |
メルク・シャープ・エンド・ドーム・コーポレイション |
二置換アゼパンオレキシン受容体アンタゴニスト
|
WO2010051236A1
(en)
*
|
2008-10-30 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Isonicotinamide orexin receptor antagonists
|
JP2012507539A
(ja)
*
|
2008-10-30 |
2012-03-29 |
メルク・シャープ・エンド・ドーム・コーポレイション |
2,5−二置換フェニルカルボキサミド・オレキシン受容体アンタゴニスト
|
GB0823467D0
(en)
|
2008-12-23 |
2009-01-28 |
Glaxo Group Ltd |
Novel Compounds
|
WO2011023578A1
(en)
|
2009-08-24 |
2011-03-03 |
Glaxo Group Limited |
5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder
|
WO2014066196A1
(en)
*
|
2012-10-23 |
2014-05-01 |
Merck Sharp & Dohme Corp. |
2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
|