TW201317228A - ２－吡啶氧基－４－腈食慾素受體拮抗劑 - Google Patents

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Publication number

TW201317228A

TW201317228A TW101138514A TW101138514A TW201317228A TW 201317228 A TW201317228 A TW 201317228A TW 101138514 A TW101138514 A TW 101138514A TW 101138514 A TW101138514 A TW 101138514A TW 201317228 A TW201317228 A TW 201317228A

Authority

TW

Taiwan

Prior art keywords

oxy

carbonyl

pyridine

carbonitrile

methyl

Prior art date

2011-10-19

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• 150000001875 compounds Chemical class 0.000 claims abstract description 179
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
• 238000011282 treatment Methods 0.000 claims abstract description 17
• 230000002265 prevention Effects 0.000 claims abstract description 7
• -1 4-cyanopyridin-2-yl Chemical group 0.000 claims description 78
• 150000003839 salts Chemical class 0.000 claims description 53
• 125000000217 alkyl group Chemical group 0.000 claims description 39
• 239000003814 drug Substances 0.000 claims description 30
• 229910052736 halogen Inorganic materials 0.000 claims description 23
• 150000002367 halogens Chemical class 0.000 claims description 23
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
• 125000001424 substituent group Chemical group 0.000 claims description 17
• 125000001072 heteroaryl group Chemical group 0.000 claims description 15
• 239000001257 hydrogen Substances 0.000 claims description 14
• 229910052739 hydrogen Inorganic materials 0.000 claims description 14
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 12
• 125000000623 heterocyclic group Chemical group 0.000 claims description 12
• 239000000460 chlorine Substances 0.000 claims description 11
• 125000004076 pyridyl group Chemical group 0.000 claims description 10
• 208000019116 sleep disease Diseases 0.000 claims description 10
• 125000002971 oxazolyl group Chemical group 0.000 claims description 8
• 208000008589 Obesity Diseases 0.000 claims description 7
• 125000002883 imidazolyl group Chemical group 0.000 claims description 7
• 238000004519 manufacturing process Methods 0.000 claims description 7
• 235000020824 obesity Nutrition 0.000 claims description 7
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 7
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 7
• 125000001425 triazolyl group Chemical group 0.000 claims description 7
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
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• 125000003342 alkenyl group Chemical group 0.000 claims description 6
• 125000000304 alkynyl group Chemical group 0.000 claims description 6
• 229910052801 chlorine Inorganic materials 0.000 claims description 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
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• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
• 125000001041 indolyl group Chemical group 0.000 claims description 5
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• 239000011737 fluorine Substances 0.000 claims description 4
• 229910052731 fluorine Inorganic materials 0.000 claims description 4
• 125000001786 isothiazolyl group Chemical group 0.000 claims description 4
• 125000001624 naphthyl group Chemical group 0.000 claims description 4
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 4
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 4
• 125000000335 thiazolyl group Chemical group 0.000 claims description 4
• 125000001544 thienyl group Chemical group 0.000 claims description 4
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• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
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