JP5761997B2 - ヒトｏｘ４０受容体に対する結合分子 - Google Patents

ヒトｏｘ４０受容体に対する結合分子 Download PDF

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Publication number
JP5761997B2
JP5761997B2 JP2010538157A JP2010538157A JP5761997B2 JP 5761997 B2 JP5761997 B2 JP 5761997B2 JP 2010538157 A JP2010538157 A JP 2010538157A JP 2010538157 A JP2010538157 A JP 2010538157A JP 5761997 B2 JP5761997 B2 JP 5761997B2
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antibody
human
ox40r
cells
binding molecule
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JP2011505836A (ja
Inventor
ジン・ミン
ヤンリー・ウー
ローリー・フランシス・フィン
バレット・リチャード・シエレ
ウェイ・リヤオ
ロナルド・ポール・グラデュー
アルヴィンド・ラージパル
ティモシー・ジョウゼフ・パラダイス
ペーター・ブラームス
ブリジット・デヴォークス
イー・ウー
クリストファー・トイ
ハイディー・エヌ・レブランク
ハイチュン・フアーン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
JP2010538157A 2007-12-14 2008-12-11 ヒトｏｘ４０受容体に対する結合分子 Expired - Fee Related JP5761997B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1394707P 2007-12-14 2007-12-14
US61/013,947 2007-12-14
PCT/US2008/086417 WO2009079335A1 (en) 2007-12-14 2008-12-11 Binding molecules to the human ox40 receptor

Related Child Applications (1)

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JP2014222800A Division JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子

Publications (2)

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JP2011505836A JP2011505836A (ja) 2011-03-03
JP5761997B2 true JP5761997B2 (ja) 2015-08-12

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JP2010538157A Expired - Fee Related JP5761997B2 (ja) 2007-12-14 2008-12-11 ヒトｏｘ４０受容体に対する結合分子
JP2014222800A Expired - Fee Related JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子
JP2017008103A Expired - Fee Related JP6420379B2 (ja) 2007-12-14 2017-01-20 ヒトｏｘ４０受容体に対する結合分子
JP2018191343A Pending JP2019030313A (ja) 2007-12-14 2018-10-10 ヒトｏｘ４０受容体に対する結合分子

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JP2014222800A Expired - Fee Related JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子
JP2017008103A Expired - Fee Related JP6420379B2 (ja) 2007-12-14 2017-01-20 ヒトｏｘ４０受容体に対する結合分子
JP2018191343A Pending JP2019030313A (ja) 2007-12-14 2018-10-10 ヒトｏｘ４０受容体に対する結合分子

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US (7) US7960515B2 (enExample)
EP (4) EP2242771B1 (enExample)
JP (4) JP5761997B2 (enExample)
KR (2) KR101577843B1 (enExample)
CN (1) CN101918447B (enExample)
AR (2) AR069681A1 (enExample)
AU (1) AU2008338591B8 (enExample)
BR (1) BRPI0820875B1 (enExample)
CA (2) CA2707773C (enExample)
CL (1) CL2008003706A1 (enExample)
CO (1) CO6280541A2 (enExample)
DK (3) DK2242771T3 (enExample)
ES (3) ES2628093T3 (enExample)
HR (1) HRP20141188T8 (enExample)
HU (1) HUE032735T2 (enExample)
IL (3) IL206297A (enExample)
MX (1) MX2010006466A (enExample)
PA (1) PA8807601A1 (enExample)
PE (1) PE20091269A1 (enExample)
PH (1) PH12015500806B1 (enExample)
PL (2) PL2242771T3 (enExample)
PT (3) PT2594590E (enExample)
RU (1) RU2010129045A (enExample)
SG (2) SG10201604770VA (enExample)
SI (3) SI2594590T1 (enExample)
TW (1) TW200932268A (enExample)
UY (1) UY31533A1 (enExample)
WO (1) WO2009079335A1 (enExample)
ZA (1) ZA201003579B (enExample)

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* Cited by examiner, † Cited by third party
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CA2707773A1 (en) 2009-06-25
CN101918447B (zh) 2014-06-11
IL206297A0 (en) 2010-12-30
AU2008338591B8 (en) 2014-02-20
SI2851374T1 (sl) 2017-08-31
PE20091269A1 (es) 2009-09-09
US9028824B2 (en) 2015-05-12
BRPI0820875B1 (pt) 2021-10-19
TW200932268A (en) 2009-08-01
EP2242771B1 (en) 2013-07-17
AU2008338591A1 (en) 2009-06-25
US20090214560A1 (en) 2009-08-27
US20110206681A1 (en) 2011-08-25
PT2594590E (pt) 2015-01-14
US20220002428A1 (en) 2022-01-06
DK2594590T3 (en) 2015-01-12
IL206297A (en) 2016-06-30
US20180057600A1 (en) 2018-03-01
US9840562B2 (en) 2017-12-12
IL239674A (en) 2017-08-31
KR20150061041A (ko) 2015-06-03
EP2594590B1 (en) 2014-11-12
DK2851374T3 (en) 2017-06-19
US20190135932A1 (en) 2019-05-09
EP3239178A1 (en) 2017-11-01
IL245876A0 (en) 2016-07-31
ES2628093T3 (es) 2017-08-01
US8236930B2 (en) 2012-08-07
SG10201604770VA (en) 2016-08-30
ES2425269T3 (es) 2013-10-14
AR109355A2 (es) 2018-11-21
SI2594590T1 (sl) 2015-03-31
CA2707773C (en) 2017-01-10
HUE032735T2 (en) 2017-10-30
SG186656A1 (en) 2013-01-30
EP2594590A1 (en) 2013-05-22
PL2242771T3 (pl) 2013-12-31
CN101918447A (zh) 2010-12-15
US20120225086A1 (en) 2012-09-06
KR20100102657A (ko) 2010-09-24
WO2009079335A1 (en) 2009-06-25
JP2011505836A (ja) 2011-03-03
RU2010129045A (ru) 2012-01-20
AU2008338591B2 (en) 2014-01-23
US7960515B2 (en) 2011-06-14
IL245876A (en) 2017-08-31
KR101577843B1 (ko) 2015-12-16
US20150218279A1 (en) 2015-08-06
EP2851374B1 (en) 2017-05-03
JP2015110558A (ja) 2015-06-18
PH12015500806B1 (en) 2015-12-02
CA2949772A1 (en) 2009-06-25
EP2242771A1 (en) 2010-10-27
PA8807601A1 (es) 2009-09-17
SI2242771T1 (sl) 2013-09-30
JP6420379B2 (ja) 2018-11-07

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