JP5658570B2 - 毛髪生育に影響を与える組成物 - Google Patents
毛髪生育に影響を与える組成物 Download PDFInfo
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- JP5658570B2 JP5658570B2 JP2010549063A JP2010549063A JP5658570B2 JP 5658570 B2 JP5658570 B2 JP 5658570B2 JP 2010549063 A JP2010549063 A JP 2010549063A JP 2010549063 A JP2010549063 A JP 2010549063A JP 5658570 B2 JP5658570 B2 JP 5658570B2
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- extract
- hair
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- aromatase
- dione
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- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940014903 tadenan Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003530 tetrahydroquinolines Chemical class 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Classifications
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
しかし、エストロゲンもまた毛嚢の生育と周期に関して毛嚢に顕著な影響力を有することが長年知られてきた。即ち、局所的エストロゲン受容体への結合を通した影響である。
過去には、例えば、国際公開WO96/08231Aで考察されているように、アロマターゼ阻害剤を、化粧品上の手段や毛髪生育への影響力のために使用する提案があった。
US 7238 375 B1は、1〜4種の複合体を記載し、ここで複合体1〜3は、脱毛を防ぎ、及び複合体4は、毛髪生育をもたらす。銅イオン、ヤシ抽出物(Serenoa repens)、ピジウム抽出物(Pygeum africanum)、イラクサ抽出物(Urtica dioica)、亜鉛、ビタミンB6及びリノレン酸は、複合体2に属する。
US7105573 B2 及び US2007/0066661 A1は、脱毛及び毛嚢につながる他の疾患を治療するための更なる示唆に関する。
W. Chen他による論文、"Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives"、J Invest Dermatol. Vol. 119、No. 5、Nov 2002、pp. 992-1007は、一般的な皮膚のアンドロゲン代謝を記載し;及びR. HOFFMANN 及び R. HAPPLE、"Current understanding of androgenetic alopecia. Part I: Etiopathogenesis"、Eur J Dermatol. Vol 10、No. 4、June 2000、pp. 319-327はアンドロゲン性脱毛症(AGA)の知識の状態についての一般的概観を与えるが、ここで引用した両論文は、皮膚及び毛髪現象に関する解剖学的領域は複雑な状況にあるという印象を与える。
従って、本発明の目的は、毛髪生育及び毛髪色素沈着に影響を与える改善された組成物を提供することである。
ステロイド性アロマターゼ阻害剤:
4-ヒドロキシアンドロスト-4-エン-3,17-ジオン (フォルメスタン及びレンタロン)、
6-メチレンアンドロストラ-1,4-ジエン-3,17-ジオン(エクゼメスタン)、
10-(2-プロピニル)エストラ-4-エン-3,17-ジオン(MDL 18962)
7-α置換化アンドロステンジオン-誘導体
1,4,6-アンドロスタトリエン-3,17-ジオン (ATD)
10-オキシラン- 及び10-チイラン-置換化アンドロゲン
10-プロパルギルエストラ-4-エン-3,17-ジオン
10-プロパルギルエストラ-4-エン-3,17-プロピオン酸−10-(2-プロピニル)-誘導体
13-レトロ-アンチプロゲスチン
14-α-ヒドロキシ-4-アンドロステン-3,6,17-トリオン (14-α-OHAT)
16- 又は 19-置換化アンドロスト-4-エン
19-(シクロプロピルアミノ)-アンドロスト-4-エン-3,17-ジオン
19-(エチルジチオ)-アンドロスト-4-エン-3,17-ジオン
19-オキシラニル- 及び 19-チイラニル-ステロイド
19-チオメチル- 及び 19-アジド-アンドロステンジオン
1-メチル-アンドロスタ-1,4-ジエン-3,17-ジオン (アタメスタン)
2,2-ジメチル-4-ヒドロキシ-4-アンドロステン-3,17-ジオン
3-α-メトキシアンドロスト-4-エン-6,17-ジオン
3-β-ヒドロキシアンドロスト-4-エン-6-オン-誘導体
3-オキソ-17 β-カルボキシアミド-ステロイドの3-デオキシアンドロゲン-19-酸素化物誘導体
4-(フェニルチオ)-4-アンドロステン-3,17-ジオン
4-(チオ置換化)-4-アンドロステン-3,17-ジオン
4-アセトキシ-4-アンドロステン-3,17-ジオン
4-アミノアンドロステンジオン
4-アンドロステン-3,6,17-トリオン
4-ヒドロキシアンドロステンジオン(4-OHA)
4-メトキシ-4-アンドロステン-3,17-ジオン
4-酸素化アンドロスト-5-エン-17-オン及びこれらの 7-オキソ誘導体
4-アンドロステン-3,17-ジオンの4-チオ置換化誘導体
4-チオ置換化-4-アンドロステン-3,17-ジオン-誘導体
5-α-ジヒドロノレチンドロン (ノレチンドロンの代謝物)
5-α-還元化 C19-ステロイド
C-3 及び/又は C-6にカルボニル官能基性を持つ又は持たない5-α-アンドロスタン-17-オン
6-α-フルオロテストステロン
6-β-プロピニル置換化ステロイド
6,7-アジリジニルステロイド及び関係化合物
δ1,4,6-アンドロゲンの6-アルキル類縁体
6-アルキル- 及び 6-アリルアンドロスト-4-エン3,17-ジオン
7 α- 及び7-β-アリール脂肪族置換化アンドロスト-4-エン-3,17-ジオンの
6-アルキルアンドロスト-4-エン-3,17-ジオン
6-アルキルアンドロスト-4,6-ジエン-3,17-ジオン 及び これらの1,4,6-トリエン類縁体
6-アルキル-置換化アンドロゲン
1,4-ジエン-、4,6-ジエン- or 1,4,6-トリエン構造による6-フェニル脂肪族-置換化C19-ステロイド
6-ブロモアンドロステンジオン
6-ヒドロキシイミノアンドロステンジオン
6-メチレンアンドロスタ-1,4-ジエン-3,17-ジオン(FCE 24304)
6-メチレンアンドロスタ-1,4-ジエン-3,17-ジオン (FCE 24304)
6-フェニル脂肪族-置換化アンドロスト-4-エン-3,17-ジオン
6-置換化アンドロスト-4-エン-類縁体
7-α-(4'-アミノ)フェニルチオ-4-アンドロステン-3,17-ジオン
7-α-置換化アンドロスタ-1,4-ジエン-3,17-ジオン
7-α-置換化アンドロステンジオン
7-α-(4'-アミノ)フェニルチオ-4-アンドロステン-3,17-ジオン
7-α-アリール脂肪族アンドロスタ−1,4-ジエン-3,17-ジオン
7-α-置換化アンドロステンジオン
7-置換化4,6-アンドロスタジオン-3,17-ジオン
7-置換化ステロイド
アンドロスト-4-エン-3,6-ジオン誘導体
アンドロスト-5-エン-7,17-ジオン 19-ノル- 及び 5-β−6-β-エポキシ誘導体
アンドロスト-4-エン-3,6,17-トリオンのA-又は B-環置換化誘導体
A-環架橋化ステロイド
ブロモアセトキシ-4-アンドロステン-3-オン
δ-1,4,6-アンドロゲン
δ-4,6-アンドロゲン
エピマー化6-ヒドロパーオキシアンドロステンジオン
エストラ-4-エン-3,17-ジオン(MDL 18 962),
エストラ-4-エン-3,6,17-トリオン
フラボノイド
RU486
6-[(4-クロロフェニル)(1H-1,2,4-トリアゾール-1-イル)-メチル]-1-メチル-1H-ベンゾトリアゾール (ボラゾール)、
2,2'-[5-(1H-1,2,4-トリアゾール-1-イル メチル)-1,3-フェニレン]ビス(2-メチルプロプリオニトリル) (アリミデクス)、
4-[1-(シアノフェニル)-1-(1,2,4-トリアゾリル)メチル]ベンゾニトリル(レトロゾール),
{4-(5,6,7,8-テトラヒドロ-イミダゾ-[1,5a]-ピリジン-5-イル) ベンゾニトリル モノヒドロクロリド(ファドロゾール)
ピリドグルテチミド (ログレチミド)
アミノグルテチミド
1,2-イミダゾリルメチルシクロペンタノール-誘導体
1-[(ベンゾフラン-2-イル)フェニルメチル-トリアゾール 及び-テトラゾール
1-[ベンゾフラン-2-イル]-フェニルメチル]-イミダゾール (置換型)
N,N-ジ置換化-5-アミノピリミジン-誘導体の1-(ベンゾフラン-2-イルメチル)イミダゾール
1-イミダゾリル(アルキル)−置換化 ジ−及びテトラヒドロキノリン
1-ペンチル-3-(4-アミノフェニル)ピロリジン-2,5-ジオン
1-フェニル-3-アザビシクロ[3.1.0]ヘキサン-2,4-ジオン
1-フェニル-3-アザビシクロ[3.1.0]ヘキサン-2,4-ジオン及び類縁体
3-アルキル化3-(4-アミノフェニル)ピペリジン-2,6-ジオン
3-シクロアルキル-置換化3-(4-アミノフェニル)ピペリジン-2,6-ジオン
3-エチル-3-(4-ピリジル)ピペリジン-2,6- 及び 5-アルキル誘導体
3-エチル-3-(4-ピリジル)ピペリジン-2,6-ジオン-類縁体
4-アミノ-4H-1,2,4-トリアゾール-誘導体
4-シクロヘキシルアニリン
アミノグルテチミド
ベンズイミダゾール- 及び イミダゾール-化合物
δ-1,4-ビスノルコラジエン酸
δ-1-テストステロン
ピロリドン酸及びピペリドン酸イミダゾリル-1,3,5-トリアジンのイミダゾール誘導体
MR 20492 及びMR 20494 (2種のインドリジノン誘導体)
ピリジル-置換化 インダノン、インダン及び テトラリン
トリアジン誘導体SEF19
置換化ピリジン
テストロラクトン
8-ブロモ-サイクリックアデノシン一リン酸
FR901537
ヘキサメチルメラミン誘導体(SAE9)
レトロゾール(CGS 20267)
メフロキン
MPV-2213ad
N-n-オクタノイルノルニコチン及び更なるノルニコチン誘導体
Org 33201
R 76713 及び R 76713
セスキターペネラクトン
SH 489
TAN-931
甲状腺ホルモン
タバコアルカロイド誘導体
YM511
Chromolaena odoratum(シャムウィード)、coconut oil(ココナッツ油)、Cuban king palm(ダイオウヤシ)(Roystonea regia)、Pygeum africanum(ピジウム属のアフリカプルーン)、Serenoa repens(セレノアレペンス、ノコギリヤシ)、Cucurbita pepo(ペポカボチャ、一般名ズッキーニ)、Albizia lebbeck(ビルマネムノキ、樹皮)、Roystonea regia (ダイオウヤシ、果実)、Ruta graveolens(ヘンルーダ)、Azadirachta indica(インドセンダン、葉)、Momordica charantia (ゴーヤ、種子)、Ganoderma lucidum(マンネンタケ)、Echinacea purpurea(エキナセア・プルプレア)、Belamcanda chinensis(カラスオウギ)、Citrus aurantium(ダイダイ、シトレスオウレンチウム)、Echinacea purpurea(エキナセア・プルプレア)、Silybum marianum (オオヒレアザミ)、milk thistle(マリアアザミ))、Crotalaria juncea(サンヘンプ)、Pygeum africanum(アフリカプルーン)、pumpkin seed oil(カボチャ種油)、crimson clover (ベニバナツメクサ、特にフラボノイドに富む成分 ; Trifoleum pratense(アカクローバ)) 、Pinus (マツ属、イタリアカサマツ)、spruce (スプルース、Picea(トウヒ属のコニファ))、rye(ライ麦、花粉抽出物)、soya ダイズ、Pygeum africanum(アフリカプルーン)、Hypoxis rooperi (キンバイササ、根)、stinging nettle(イアラクサ、Urtica dioica(ユーカリ))、Cordia multispicata(カチャバツノキ属の1種、ブラジル産、トリテルぺノイド抽出物)、Myricae cortex (ヨウバイヒ、Myrica rubra(ヤマモモ)、Myricaceae(ヤマモモ科)樹皮から)、Pygeum africanum (アフリカプルーン、アフリカプラムからの樹皮抽出物Tadenan(タデナン))、Azadirachta indica(センダン)、Sophora flavescens(クララ)、Hibiscus rosa-sinesis(ハイビスカス)、Dalbergia cochinchinensis(シタン)、Fructus psoraleae(ソラレアエ フルクタス)、Striga orobanchioides(ストライガ・オロバンキ(根寄生植物)、及び Vitex negundo(ホソバタイワンニンジンボク、種子から)。
以下の実施例1〜8において、毛髪生育に影響力のあるチンキ剤の調製のために与えられた成分(活性成分及び活性成分の混合物のそれぞれに)は、男性及び女性に対してそれぞれ適用される。
実施例1
水 14.24%、ジメチルイソソルバイド 10%、ノコゴリヤシ果実抽出物 0.99%、4 -ヒドロキシ−アンドロステンジオン 0.6%、セイヨウイラクサ(イラクサ) 抽出物1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール0.02%、PCA(ピロリドンカルボン酸)亜鉛 0.2%、ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン0.2%、サリチル酸トリデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブオイル不鹸化物 0.4%、ビオチン 0.2%、尿素0.25%、PEG-40 水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール(70%)。
水14.24%、ジメチルイソソルバイド 10%、ノコギリヤシ果実抽出物0.99%、アセトキシアンドロステンジオン 0.6%、セイヨウイラクサ(イラクサ) 抽出物 1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素0.25%、PEG-40水素化ヒマシ油 0.05%、プロピレングリコール0.05%、乳酸 0.05%、及び残りは変性アルコール (70%)。
水 14.33%、ジメチルイソソルバイド 10%、ノコギリヤシ果実抽出物 1%、ダイズステロール 0.5%、セイヨウイラクサ(イラクサ) 抽出物1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物0.2%、パルミチン酸レチニル0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物0.2%、ウスベニアオイ (コモンマロウ) 抽出物0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40 水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール (70%).
水 14.33%、ジメチルイソソルバイド 10%、ノコギリヤシ果実抽出物 1%、ハクサイ(アブラナ) ステロール 0.5%、セイヨウイラクサ(イラクサ) 抽出物 1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残り変性アルコール (70%)。
実施例5
水14.33%、ジメチルイソソルバイド 10%、4-ヒドロキシ−アンドロステンジオン 0.7%、ノコギリヤシ果実抽出物 0.8%、セイヨウイラクサ(イラクサ) 抽出物 1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40 水酸化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール(70%)。
水 14.33%、ジメチルイソソルバイド 19%、アセトキシアンドロステンジオン 0.7%、ノコギリヤシ果実抽出物 0.8%、セイヨウイラクサ(イラクサ) 抽出物 1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40 水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール (70%)。
水 14.23%、ジメチルイソソルバイド 10%、ダイズステロール 1%、ノコギリヤシ果実抽出物 0.6%、セイヨウイラクサ(イラクサ) 抽出物 1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%、ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリドデシル 0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40 水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール (70%)。
水 14.23%、ジメチルイソソルバイド 10%、ハクサイ(アブラナ) ステロール 1%、ノコギリヤシ果実抽出物 0.6%、セイヨウイラクサ(イラクサ) 抽出物1%、ツシラ・ファルファラ(フキタンポポ)葉抽出物 0.2%、パルミチン酸レチニル 0.05%、トコフェロール 0.02%、PCA亜鉛 0.2%,ツクシ抽出物 0.2%、ウスベニアオイ (コモンマロウ) 抽出物 0.4%、シスチニルジコハク酸2ナトリウム 0.2%、ピロクトンオラミン 0.2%、サリチル酸トリデシル0.2%、ナイアシンアミド 0.1%、ハマメリス=ウィッチヘーゼル抽出物 0.4%、オリーブ油不鹸化物 0.4%、ビオチン 0.2%、尿素 0.25%、PEG-40水素化ヒマシ油 0.05%、プロピレングリコール 0.05%、乳酸 0.05%、及び残りは変性アルコール (70%)。
体毛除去:
実施例9
ジメチルイソソルバイド 6%、アボガド油 4%、オクチルドデカノール 3.9%、サリチル酸トリデシル 2%、乳酸C12〜13 アルキル 2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ジステアリン酸ポリグリセリル-3 メチルグルコース 1.9%,(アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー0.85%、ノコギリヤシ果実抽出物 0.9%、ハクサイ(アブラナ) ステロール 0.5%、ダイズステロール 0.5%、酢酸トコフェリル 0.9%、トコフェロール 0.0175%、カプリロイルグリシン 0.1%、トリベヘニン 0.9%、グリセリン 0.9552%、キシリトール 0.9%、ソルビトール0.9%、パルマチン 0.0024%、ココグルコシド 0.052%、エチルヘキシルグリセリン 0.3%、乳酸 0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン 0.028%、アスコルビン酸パルミチン酸エステル 0.0175%、アンモニア 0.0175%、フェノキシエタノール 0.8%、キサンタンガム 0.1%、及び残りは水 (66.7423%).
ジメチルイソソルバイド 6%、アボカド油 4%、オクチルドデカノール 3.9%、サリチル酸トリデシル 2%、乳酸C12〜13アルキル 2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ステアリン酸ポリグリセリル-3 メチルグルコース1.9%、(アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー 0.85%、ノコギリヤシ果実抽出物 0.9%、アセトキシアンドロステンジオン 0.5%、酢酸トコフェリル0.9%、トコフェロール 0.0175%、カプリロイルグリシン 0.1%、トリベヘニン 0.9%、グリセリン 0.9552%、キシリトール 0.9%、ソルビトール 0.9%、パルマチン 0.024%、ココグルコシド 0.052%、エチルヘキシルグリセリン 0.3%、乳酸 0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン 0.028%、アスコルビン酸パルミチン酸エステル0.0175%、アンモニア 0.0175%、フェノキシエタノール0.8%、キサンタンガム 0.1%、及び残りは水 (67.2423%).
ジメチルイソソルバイド6%、アボガド油 4%、オクチルドデカノール 3.9%、サリチル酸トリデシル2%、乳酸C12〜13 アルキル 2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ジステアリン酸ポリグリセリル-3 メチルグルコース 1.9%、(アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー 0.85%、ノコギリヤシ果実抽出物 0.9%、4-ヒドロキシアンドロステンジオン 0.5%、酢酸トコフェリル0.9%、トコフェロール 0.0175%、カプリロイルグリシン 0.1%、トリベヘニン 0.9%、グリセリン0.9552、キシリトール 0.9%、ソルビトール0.9%、パルマチン 0.024%、ココグルコシド0.052%、エチルヘキシルグリセリン0.3%、乳酸0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン0.028%、アスコルビン酸パルミチン酸エステル 0.0175%、アンモニア 0.0175%、フェノキシエタノール 0.8%、キサンタンガム 0.1%、及び残りは水 (67.2423%).
実施例12
ジメチルイソソルバイド 6%、アボガド油 4.5%,オクチルドデカノール 4.4%、サリチル酸トリデシル2%、乳酸C12〜13アルキル 2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ジステアリン酸ポリグリセリル-3 メチルグルコース 1.9%、ハクサイ(アブラナ) ステロール 0.5%、ダイズステロール 0.48%、ノコギリヤシ果実抽出物 0.9%、カプリロイルグリシン0.1%、トリベヘニン 0.9%、グリセリン 0.9552%、キシリトール 0.9%、ソルビトール 0.9%、(アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー 1.25%、パルマチン 0.024%、ココグルコシド 0.052%、酢酸トコフェリル 0.9%、トコフェロール 0.0175%、エチルヘキシルグリセリン 0.3%、乳酸 0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン 0.028%、アスコルビン酸パルミチン酸エステル 0.0175%、アンモニア 0.0175%、フェノキシエタノール 0.8%、キサンタンガム 0.1%、及び残りは水(65.3407%)。
ジメチルソルバイド 6%、アボガド油 4.5%、オクチルドデカノール 4.4%、サリチル酸トリデシル2%、乳酸C12〜13 アルキル2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ジステアリン酸ポリグリセリル-3 メチルグルコース1.9%、アセトキシアンドロステンジオン0.68、ノコギリヤシ果実抽出物 0.9%、カプリロイルグリシン 0.1%、トリベヘニン 0.9%、グリセリン 0.9552%、キシリトール0.9%、ソルビトール 0.9%、(アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー1.25%、パルマチン 0.024%、ココグルコシド0.52%、酢酸トコフェリル0.9%、トコフェロール 0.0175%、エチルヘキシルグリセリン 0.3%、乳酸 0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン 0.028%、アスコルビン酸パルミチン酸エステル 0.0175%、アンモニア 0.0175%、フェノキシエタノール 0.8%、キサンタンガム 0.1%、及び残りは水 (65.6407%)。
ジメチルイソソルバイド 6%、アボガド油 4.5%、オクチルドデカノール 4.4%、サリチル酸トリデシル 2%、乳酸C12〜13アルキル 2%、イソノナン酸セテアリル 2%、カプリリル・カプリン酸トリグリセリド 1.9476%、ジステアリン酸ポリグリセリル-3 メチルグルコース 1.9%、4 - ヒドロキシアンドロステンジオン0.68%、ノコギリヤシ果実抽出物 0.9%、カプリロイルグリシン 0.1%、トリベヘニン 0.9%、グリセリン 0.9552%、キシリトール 0.9%、ソルビトール 0.9%、アクリロイルジメチルタウリン酸アンモニウム/VP)コポリマー 1.25%、パルマチン0.024%、ココグリコシド 0.052%、酢酸トコフェリル 0.9%、トコフェロール 0.0175%、エチルヘキシルグリセリン 0.3%、乳酸 0.12%、ラウリン酸ソルビタン 0.09%、ポロクサマー 407 0.5%、ナイロン-12 0.06%、レシチン 0.028%、アスコルビン酸パルミチン酸エステル 0.0175%、アンモニア 0.0175%、フェノキシエタノール 0.8%、キサンタンガム 0.1%、及び残りは水 (65.6407%)
応用実施例1
遺伝的脱毛症の女性及び男性の頭髪への影響
重い遺伝的脱毛症をもつ40〜60歳の10名の女性、及び34〜64歳の12名の男性に、以下の活性成分の組合せローション調製物を適用した:
女性には、実施例6(n=4)及び実施例5(n=6)の組成物のローション。
男性には、実施例2(n=12)の組成物のローション。
その結果、3ヶ月後に、全ての男性及び女性が、毛髪生育におけるポジティブな影響(毛髪量)及び毛髪の密集性の増加を示した。非常に顕著な毛髪生育(毛髪量)の増加に加えて、6ヶ月後に、毛髪の密集性がかなり増加した。驚くべきことに、ほとんど全ての女性(n=9)及び男性(n=10)が、毛髪の再色素沈着を示し、従って、本来の毛髪色への復帰を示した。
女性における脚の毛の成長に対する応用:
脚に濃い毛の成長を示す女性(n=35)に、6ヶ月間、実施例10(n=15)又は実施例11(n=20)の組成物のクリームを与えた。
診察は、30日間隔の診察時点を含む180日間行った。結果は驚くべきものであった。30日後に、毛の量及び密集性の減少が検知された。180日後に、診察領域当たりの毛の量は、89%減少し、残った毛のほぼ70%において、完全な脱色素沈着が生じ、かつ女性の95%以上において、残った毛の密集性が減少し、非常に微細になった。この結果は、両クリーム調製物について同様であり、従って、両クリームは同じ生物学的有効性を示した。
女性の顎及び上唇における顔の毛(ドイツ語では"女性の髭")に対する応用:
所謂"女性の顎及び上唇における顔の毛"を有する6人の女性に、実施例13の組成物を含むクリームを適用したところ、同じ効果が観察された。
Claims (12)
- 毛髪の色素沈着を維持し、若しくは毛髪の再色素沈着を誘発するための、又は女性の体毛について、毛の成長を減少させ若しくは脱毛させ、並びに男性及び女性の体毛について、脱色素沈着のための、化粧品用組成物であって、
(i)化学的に合成されたアロマターゼ阻害剤及びアロマターゼ阻害性を示すナタネの抽出物からなる群から選択された少なくとも1種のアロマターゼ阻害剤、及び
(ii)5αレダクターゼI型及び/又はII型阻害剤並びにアンドロゲン受容体遮断剤からなる群から選択される1種又はそれ以上の活性成分物質を含む少なくとも1種の植物抽出物であって、ノコギリヤシ(ノコギリヤシ果実)、カボチャ種、イラクサ、チュウゴクイチイ、クロカンラン、コウサンフウ、及び/又はサンビロートの抽出物である植物抽出物
の組み合わせであることを特徴とする組成物。 - 前記成分(ii)が、5αレダクターゼI型及び/又はII型阻害剤並びにアンドロゲン受容体遮断剤の活性成分の混合物を含む植物抽出物を含む請求項1に記載の組成物。
- 前記アロマターゼ阻害剤が、更に5αレダクターゼを阻害する性質を有する請求項1又は2に記載の組成物。
- 前記成分(i)が、ダイズ及びナタネの抽出物若しくはナタネの抽出物のみであるか、又は化学的に合成されたアロマターゼ阻害剤のみである請求項1に記載の組成物。
- 前記成分(i)が、ダイズ及びナタネの抽出物若しくはナタネの抽出物と化学的に合成されたアロマターゼ阻害剤とを組み合わせたものである請求項1に記載の組成物。
- 前記植物抽出物がノコギリヤシの抽出物であって、該ノコギリヤシの抽出物が、ノコギリヤシ果実のエタノール抽出物である請求項1〜5のいずれか一項に記載の組成物。
- 前記成分(ii)の植物抽出物が、フィトステロール及び/又はフラボノイドに富む抽出物である請求項1〜6いずれか一項に記載の記載の組成物。
- 前記成分(i)の化学的に合成されたアロマターゼ阻害剤が、アロマターゼと共有結合することによりアロマターゼを阻害する請求項1〜7のいずれか一項に記載の組成物。
- 前記化学的に合成されたアロマターゼ阻害剤が、4−ヒドロキシ−アンドロステン−ジオン又はその4−カルボン酸エステル誘導体である請求項1〜8のいずれか一項に記載の組成物。
- 前記4−カルボン酸エステル誘導体が、4−アセトキシ−アンドロステン−ジオンである請求項9に記載の組成物。
- 成分(i)及び(ii)の他に、銅その他の毒性金属を含む活性物質を含まず、但し、適切な担体、賦形剤又は添加物を含んでもよい請求項1〜10のいずれか一項に記載の組成物。
- 局所的な応用に適するように処方された請求項1〜11のいずれか一項に記載の組成物。
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2009
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Also Published As
Publication number | Publication date |
---|---|
US20110117218A1 (en) | 2011-05-19 |
US11324711B2 (en) | 2022-05-10 |
JP2015028044A (ja) | 2015-02-12 |
EP2262471A2 (de) | 2010-12-22 |
EP2262471B1 (de) | 2015-10-28 |
WO2009109402A8 (de) | 2011-01-06 |
BRPI0908792B1 (pt) | 2019-02-26 |
RU2010140915A (ru) | 2012-04-20 |
CA2717806C (en) | 2017-01-03 |
JP2011514345A (ja) | 2011-05-06 |
WO2009109402A2 (de) | 2009-09-11 |
US20130142890A1 (en) | 2013-06-06 |
US11974977B2 (en) | 2024-05-07 |
US11052059B2 (en) | 2021-07-06 |
CA2717806A1 (en) | 2009-09-11 |
DE102008012988A1 (de) | 2009-09-10 |
HUE026198T2 (en) | 2016-05-30 |
PL2262471T3 (pl) | 2016-03-31 |
WO2009109402A3 (de) | 2010-10-21 |
CN101969921A (zh) | 2011-02-09 |
ES2558806T3 (es) | 2016-02-08 |
US20210290579A1 (en) | 2021-09-23 |
BRPI0908792A2 (pt) | 2015-07-21 |
RU2491914C2 (ru) | 2013-09-10 |
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