JP5602230B2 - スフィンゴシン−１−リン酸受容体アゴニスト - Google Patents

スフィンゴシン−１−リン酸受容体アゴニスト Download PDF

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Publication number
JP5602230B2
JP5602230B2 JP2012523967A JP2012523967A JP5602230B2 JP 5602230 B2 JP5602230 B2 JP 5602230B2 JP 2012523967 A JP2012523967 A JP 2012523967A JP 2012523967 A JP2012523967 A JP 2012523967A JP 5602230 B2 JP5602230 B2 JP 5602230B2
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JP
Japan
Prior art keywords
phenyl
oxadiazol
trifluoromethyl
ethyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2012523967A
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Japanese (ja)
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JP2013501729A (ja
JP2013501729A5 (enExample
Inventor
ジョン・エル・ギルモア
ジェイムズ・イー・シェペック
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2013501729A5 publication Critical patent/JP2013501729A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2012523967A 2009-08-07 2010-08-06 スフィンゴシン−１−リン酸受容体アゴニスト Expired - Fee Related JP5602230B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23205409P 2009-08-07 2009-08-07
US61/232,054 2009-08-07
PCT/US2010/044627 WO2011017578A1 (en) 2009-08-07 2010-08-06 Sphingosine-1-phosphate receptor agonists

Publications (3)

Publication Number Publication Date
JP2013501729A JP2013501729A (ja) 2013-01-17
JP2013501729A5 JP2013501729A5 (enExample) 2013-08-08
JP5602230B2 true JP5602230B2 (ja) 2014-10-08

Family

ID=43029859

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012523967A Expired - Fee Related JP5602230B2 (ja) 2009-08-07 2010-08-06 スフィンゴシン−１−リン酸受容体アゴニスト

Country Status (19)

Country Link
US (1) US8399451B2 (enExample)
EP (1) EP2462139B1 (enExample)
JP (1) JP5602230B2 (enExample)
KR (1) KR20120108963A (enExample)
CN (1) CN102548989A (enExample)
AR (1) AR077819A1 (enExample)
AU (1) AU2010279354A1 (enExample)
BR (1) BR112012002824A2 (enExample)
CA (1) CA2770194A1 (enExample)
CL (1) CL2012000326A1 (enExample)
CO (1) CO6430439A2 (enExample)
EA (1) EA201270266A1 (enExample)
ES (1) ES2533095T3 (enExample)
MX (1) MX2012001160A (enExample)
PE (1) PE20120732A1 (enExample)
SG (1) SG177691A1 (enExample)
TW (1) TW201109323A (enExample)
WO (1) WO2011017578A1 (enExample)
ZA (1) ZA201200641B (enExample)

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JP5735634B2 (ja) * 2010-04-23 2015-06-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ スフィンゴシン−１−リン酸受容体１アゴニストとしての４−（５−イソオキサゾリルまたは５−ピラゾリル−１，２，４−オキサジアゾール−３−イル）−マンデル酸アミド化合物
JP5788507B2 (ja) 2010-07-20 2015-09-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換３−フェニル−１，２，４−オキサジアゾール化合物
WO2012040532A1 (en) 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
JP2013544811A (ja) * 2010-11-03 2013-12-19 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および血管疾患の治療用のｓ１ｐ１アゴニストとしての複素環式化合物
TWI613182B (zh) 2013-02-21 2018-02-01 必治妥美雅史谷比公司 雙環化合物
UY36274A (es) 2014-08-20 2016-02-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos bicíclicos sustituidos como agonistas selectivos de la actividad del receptor s1p1 acoplado a la proteína g
PY1974248A (es) * 2018-09-13 2020-08-21 Syngenta Participations Ag Compuestos de azol-amida pesticidamente activos
CN114181276A (zh) * 2021-12-17 2022-03-15 安徽大学 硫酯肽合成方法

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Also Published As

Publication number Publication date
ES2533095T3 (es) 2015-04-07
AU2010279354A1 (en) 2012-02-09
AR077819A1 (es) 2011-09-28
PE20120732A1 (es) 2012-06-20
JP2013501729A (ja) 2013-01-17
MX2012001160A (es) 2012-02-13
EP2462139B1 (en) 2015-01-14
CA2770194A1 (en) 2011-02-10
TW201109323A (en) 2011-03-16
KR20120108963A (ko) 2012-10-05
ZA201200641B (en) 2013-06-26
US8399451B2 (en) 2013-03-19
BR112012002824A2 (pt) 2019-09-24
CL2012000326A1 (es) 2012-10-19
EA201270266A1 (ru) 2012-07-30
SG177691A1 (en) 2012-02-28
CO6430439A2 (es) 2012-04-30
WO2011017578A1 (en) 2011-02-10
EP2462139A1 (en) 2012-06-13
US20110190255A1 (en) 2011-08-04
CN102548989A (zh) 2012-07-04

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