CO6430439A2 - Agonistas del receptor de esfingosina -1- fosfato - Google Patents
Agonistas del receptor de esfingosina -1- fosfatoInfo
- Publication number
- CO6430439A2 CO6430439A2 CO12027713A CO12027713A CO6430439A2 CO 6430439 A2 CO6430439 A2 CO 6430439A2 CO 12027713 A CO12027713 A CO 12027713A CO 12027713 A CO12027713 A CO 12027713A CO 6430439 A2 CO6430439 A2 CO 6430439A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- phosphate
- receptor agonists
- disclosed
- diseases
- Prior art date
Links
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 title 1
- WWUZIQQURGPMPG-BXDGKWANSA-N (2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol Chemical compound CCCCCCCCCCCCC\C=C/[C@H](O)[C@H](N)CO WWUZIQQURGPMPG-BXDGKWANSA-N 0.000 title 1
- 229910019142 PO4 Inorganic materials 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23205409P | 2009-08-07 | 2009-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6430439A2 true CO6430439A2 (es) | 2012-04-30 |
Family
ID=43029859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12027713A CO6430439A2 (es) | 2009-08-07 | 2012-02-16 | Agonistas del receptor de esfingosina -1- fosfato |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8399451B2 (enExample) |
| EP (1) | EP2462139B1 (enExample) |
| JP (1) | JP5602230B2 (enExample) |
| KR (1) | KR20120108963A (enExample) |
| CN (1) | CN102548989A (enExample) |
| AR (1) | AR077819A1 (enExample) |
| AU (1) | AU2010279354A1 (enExample) |
| BR (1) | BR112012002824A2 (enExample) |
| CA (1) | CA2770194A1 (enExample) |
| CL (1) | CL2012000326A1 (enExample) |
| CO (1) | CO6430439A2 (enExample) |
| EA (1) | EA201270266A1 (enExample) |
| ES (1) | ES2533095T3 (enExample) |
| MX (1) | MX2012001160A (enExample) |
| PE (1) | PE20120732A1 (enExample) |
| SG (1) | SG177691A1 (enExample) |
| TW (1) | TW201109323A (enExample) |
| WO (1) | WO2011017578A1 (enExample) |
| ZA (1) | ZA201200641B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010507619A (ja) * | 2006-10-25 | 2010-03-11 | ノイロサーチ アクティーゼルスカブ | オキサジアゾール及びチアジアゾール化合物並びにニコチン性アセチルコリン受容体調節物質としてのその使用 |
| WO2011133734A1 (en) * | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| CN103124727B (zh) | 2010-07-20 | 2015-03-25 | 百时美施贵宝公司 | 取代的3-苯基-1,2,4-噁二唑化合物 |
| CN103237795B (zh) | 2010-09-24 | 2015-10-21 | 百时美施贵宝公司 | 经取代的噁二唑化合物及其作为s1p1激动剂的用途 |
| EP2635573B1 (en) * | 2010-11-03 | 2014-10-01 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
| US9115054B2 (en) | 2013-02-21 | 2015-08-25 | Bristol-Myers Squibb Company | Tetrahydronaphthalenyl compounds useful as sipi agonists |
| TWI689487B (zh) | 2014-08-20 | 2020-04-01 | 美商必治妥美雅史谷比公司 | 經取代雙環化合物 |
| UY38367A (es) * | 2018-09-13 | 2020-04-30 | Syngenta Participations Ag | Compuestos de azol-amida pesticidamente activos |
| CN114181276A (zh) * | 2021-12-17 | 2022-03-15 | 安徽大学 | 硫酯肽合成方法 |
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| DE4102024A1 (de) | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| TW432061B (en) | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
| US6069143A (en) | 1994-12-20 | 2000-05-30 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
| EP0934265B1 (en) | 1996-08-16 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
| AU2003216054B2 (en) | 2002-01-18 | 2007-01-04 | Merck & Co., Inc. | Selective S1P1/Edg1 receptor agonists |
| JP4709488B2 (ja) | 2002-01-18 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類 |
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| JP2005533058A (ja) | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート |
| AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
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| AU2004251146A1 (en) | 2003-05-19 | 2005-01-06 | Irm, Llc | Immunosuppressant compounds and compositions |
| ATE537825T1 (de) | 2003-05-19 | 2012-01-15 | Irm Llc | Immunosuppressive verbindungen und zusammensetzungen |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
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| BRPI0612028A2 (pt) | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
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| EP2046766A1 (en) | 2006-08-01 | 2009-04-15 | Praecis Pharmaceuticals Incorporated | Agonists of the sphingosine- 1- phosphate receptor (slp) |
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| PL2291080T3 (pl) | 2008-05-14 | 2015-12-31 | Scripps Research Inst | Nowe modulatory receptorów sfingozyno-1-fosforanu |
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| EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
| CN102361869A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 在治疗自身免疫性疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物 |
| JP2012515789A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | スフィンゴシン−１−リン酸アゴニストとしてのピラゾール−１，２，４−オキサジアゾール誘導体 |
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| JP5669363B2 (ja) | 2009-03-31 | 2015-02-12 | 昭和電工株式会社 | 樹脂組成物及びこれで処理された紙又は繊維加工品 |
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-
2010
- 2010-08-05 US US12/850,892 patent/US8399451B2/en active Active
- 2010-08-06 TW TW099126390A patent/TW201109323A/zh unknown
- 2010-08-06 SG SG2012003430A patent/SG177691A1/en unknown
- 2010-08-06 KR KR1020127005901A patent/KR20120108963A/ko not_active Withdrawn
- 2010-08-06 EP EP10742067.1A patent/EP2462139B1/en not_active Not-in-force
- 2010-08-06 MX MX2012001160A patent/MX2012001160A/es not_active Application Discontinuation
- 2010-08-06 BR BR112012002824A patent/BR112012002824A2/pt not_active IP Right Cessation
- 2010-08-06 PE PE2012000174A patent/PE20120732A1/es not_active Application Discontinuation
- 2010-08-06 JP JP2012523967A patent/JP5602230B2/ja not_active Expired - Fee Related
- 2010-08-06 AR ARP100102904A patent/AR077819A1/es not_active Application Discontinuation
- 2010-08-06 CA CA2770194A patent/CA2770194A1/en not_active Abandoned
- 2010-08-06 CN CN2010800453726A patent/CN102548989A/zh active Pending
- 2010-08-06 AU AU2010279354A patent/AU2010279354A1/en not_active Abandoned
- 2010-08-06 ES ES10742067.1T patent/ES2533095T3/es active Active
- 2010-08-06 WO PCT/US2010/044627 patent/WO2011017578A1/en not_active Ceased
- 2010-08-06 EA EA201270266A patent/EA201270266A1/ru unknown
-
2012
- 2012-01-24 ZA ZA2012/00641A patent/ZA201200641B/en unknown
- 2012-02-07 CL CL2012000326A patent/CL2012000326A1/es unknown
- 2012-02-16 CO CO12027713A patent/CO6430439A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120108963A (ko) | 2012-10-05 |
| JP2013501729A (ja) | 2013-01-17 |
| CA2770194A1 (en) | 2011-02-10 |
| AR077819A1 (es) | 2011-09-28 |
| US8399451B2 (en) | 2013-03-19 |
| EP2462139A1 (en) | 2012-06-13 |
| PE20120732A1 (es) | 2012-06-20 |
| SG177691A1 (en) | 2012-02-28 |
| ES2533095T3 (es) | 2015-04-07 |
| BR112012002824A2 (pt) | 2019-09-24 |
| MX2012001160A (es) | 2012-02-13 |
| ZA201200641B (en) | 2013-06-26 |
| US20110190255A1 (en) | 2011-08-04 |
| EP2462139B1 (en) | 2015-01-14 |
| CL2012000326A1 (es) | 2012-10-19 |
| EA201270266A1 (ru) | 2012-07-30 |
| AU2010279354A1 (en) | 2012-02-09 |
| TW201109323A (en) | 2011-03-16 |
| JP5602230B2 (ja) | 2014-10-08 |
| CN102548989A (zh) | 2012-07-04 |
| WO2011017578A1 (en) | 2011-02-10 |
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