JP5543065B2 - 核酸増幅のためのプライマー、プローブおよび方法 - Google Patents
核酸増幅のためのプライマー、プローブおよび方法 Download PDFInfo
- Publication number
- JP5543065B2 JP5543065B2 JP2007537034A JP2007537034A JP5543065B2 JP 5543065 B2 JP5543065 B2 JP 5543065B2 JP 2007537034 A JP2007537034 A JP 2007537034A JP 2007537034 A JP2007537034 A JP 2007537034A JP 5543065 B2 JP5543065 B2 JP 5543065B2
- Authority
- JP
- Japan
- Prior art keywords
- probe
- pcr
- primer
- amplification
- late
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61965404P | 2004-10-18 | 2004-10-18 | |
| US60/619,654 | 2004-10-18 | ||
| PCT/US2005/037667 WO2006044994A2 (en) | 2004-10-18 | 2005-10-17 | Primers, probes and methods for nucleic acid amplification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000518A Division JP5860484B2 (ja) | 2004-10-18 | 2014-01-06 | 核酸増幅のためのプライマー、プローブおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516612A JP2008516612A (ja) | 2008-05-22 |
| JP2008516612A5 JP2008516612A5 (cg-RX-API-DMAC7.html) | 2012-01-19 |
| JP5543065B2 true JP5543065B2 (ja) | 2014-07-09 |
Family
ID=36203686
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537034A Expired - Lifetime JP5543065B2 (ja) | 2004-10-18 | 2005-10-17 | 核酸増幅のためのプライマー、プローブおよび方法 |
| JP2014000518A Expired - Lifetime JP5860484B2 (ja) | 2004-10-18 | 2014-01-06 | 核酸増幅のためのプライマー、プローブおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000518A Expired - Lifetime JP5860484B2 (ja) | 2004-10-18 | 2014-01-06 | 核酸増幅のためのプライマー、プローブおよび方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7632642B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2351766B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5543065B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR101447405B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101076607B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE494295T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005295298B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0517105B1 (cg-RX-API-DMAC7.html) |
| CA (3) | CA2996947C (cg-RX-API-DMAC7.html) |
| DE (1) | DE602005025791D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1805199T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2359322T3 (cg-RX-API-DMAC7.html) |
| NO (1) | NO20072506L (cg-RX-API-DMAC7.html) |
| PL (1) | PL1805199T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1805199E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2460804C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006044994A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0517105B1 (pt) * | 2004-10-18 | 2015-06-23 | Univ Brandeis | Método para análise de pelo menos um produto de amplificação fita simples de um processo de amplificação de ácido nucléico não-simétrico |
| CN100487432C (zh) * | 2006-06-22 | 2009-05-13 | 上海交通大学 | 采用分子信标对核酸信号进行恒温放大与检测的方法 |
| CN101802224A (zh) | 2007-07-12 | 2010-08-11 | 史密斯探测公司 | 光纤检测系统 |
| US8592182B2 (en) | 2007-10-23 | 2013-11-26 | Stratos Genomics Inc. | High throughput nucleic acid sequencing by spacing |
| US8538733B2 (en) * | 2008-01-25 | 2013-09-17 | Life Technologies Corporation | Methods for the analysis of dissociation melt curve data |
| US20100129796A1 (en) * | 2008-11-24 | 2010-05-27 | Micah Halpern | Dye probe fluorescence resonance energy transfer genotyping |
| US9856522B2 (en) | 2008-12-30 | 2018-01-02 | Stmicroelectronics S.R.L. | Method, microreactor and apparatus for carrying out real-time nucleic acid amplification |
| FR2940805B1 (fr) * | 2009-01-05 | 2015-10-16 | Biomerieux Sa | Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede |
| JP5423006B2 (ja) * | 2009-01-20 | 2014-02-19 | ソニー株式会社 | プライマー評価方法、プライマー評価プログラム及びリアルタイムpcr装置 |
| US8039215B2 (en) * | 2009-03-10 | 2011-10-18 | Roche Molecular Systems, Inc. | Multiplex quantitative nucleic acid amplification and melting assay |
| EP2406394B1 (en) | 2009-03-12 | 2014-01-08 | Brandeis University | Reagents and methods for pcr |
| US8674080B2 (en) | 2009-04-09 | 2014-03-18 | Roche Molecular Systems, Inc. | Dye composition for liquid transfer control |
| FI20095514A0 (fi) * | 2009-05-07 | 2009-05-07 | Expression Analytics Oy | Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi |
| DE102009026651A1 (de) * | 2009-06-02 | 2011-02-17 | Großmann, Kay, Dr. rer. nat. (Chemie) | Verfahren und Messvorrichtung zur qualitativen und quantitativen Analyse von Körperflüssigkeiten |
| AR077840A1 (es) | 2009-08-11 | 2011-09-28 | Univ Brandeis | Ensayos de deteccion e identificacion de especies y tipos de staphylococcus |
| AR077841A1 (es) * | 2009-08-11 | 2011-09-28 | Univ Brandeis | Metodos kits y composiciones de deteccion de acido nucleico a multiples temperaturas, con sonda unica |
| US8853373B2 (en) * | 2009-08-14 | 2014-10-07 | Hitachi, Ltd. | Method and reagent for gene sequence analysis |
| EP2491144B1 (en) | 2009-10-21 | 2015-09-30 | Brandeis University | Methods for analyzing single-stranded nucleic acid sequences |
| CN102712955A (zh) * | 2009-11-03 | 2012-10-03 | Htg分子诊断有限公司 | 定量核酸酶保护测序(qNPS) |
| SG185543A1 (en) * | 2010-05-14 | 2012-12-28 | Fluidigm Corp | Assays for the detection of genotype, mutations, and/or aneuploidy |
| IT1405994B1 (it) * | 2010-06-22 | 2014-02-06 | Euroclone Spa | Metodo ad elevata sensibilita' per rilevare un acido nucleico target in un campione |
| US20120058481A1 (en) * | 2010-08-20 | 2012-03-08 | Life Technologies Corporation | Quantitative Real Time PCR Assay Using FRET Dual-Labeled Primers |
| WO2012033875A2 (en) | 2010-09-08 | 2012-03-15 | Brandeis University | Compositions and methods for nucleic acid based diagnostic assays for variable sequence targets |
| IN2013MN00522A (cg-RX-API-DMAC7.html) | 2010-09-24 | 2015-05-29 | Univ Leland Stanford Junior | |
| WO2012048207A2 (en) * | 2010-10-07 | 2012-04-12 | Brandeis University | Compositions and methods for nucleic acid based diagnostic assays |
| GB201017978D0 (en) | 2010-10-25 | 2010-12-08 | Oxitec Ltd | Multiplex amplification and detection |
| ES2689257T3 (es) | 2010-11-10 | 2018-11-12 | Brandeis University | Kit para la detección e identificación de micobacterias |
| US9637790B2 (en) | 2010-12-03 | 2017-05-02 | Brandeis University | Detecting mutations in DNA |
| US20140004504A1 (en) * | 2010-12-10 | 2014-01-02 | Brandeis University | Compositions and methods for the detection and analysis of african swine fever virus |
| EP3181704B1 (en) | 2010-12-27 | 2021-01-27 | Abbott Molecular Inc. | Quantitating high titer samples by digital pcr |
| WO2012095748A2 (en) * | 2011-01-14 | 2012-07-19 | Smiths Detection - Watford Limited | Single tube quantitative polymerase chain reaction (pcr) |
| WO2012151111A1 (en) | 2011-05-04 | 2012-11-08 | Htg Molecular Diagnostics, Inc. | Quantitative nuclease protection assay (qnpa) and sequencing (qnps) improvements |
| US20150031024A1 (en) * | 2011-07-30 | 2015-01-29 | The Regents Of The University Of California | Enzymatic preparation of 10 base to 50 kb double-strand dna reagent for sequencing with a nanopore-polymerase sequencing device |
| US20130052650A1 (en) | 2011-08-29 | 2013-02-28 | Thermo Fisher Scientific Inc. | Dye blends |
| CN102321765B (zh) * | 2011-09-08 | 2014-04-02 | 厦门基科生物科技有限公司 | 一种实时荧光pcr方法及用途 |
| CA2849023C (en) | 2011-09-15 | 2022-07-19 | David A. Shafer | Probe:antiprobe compositions for high specificity dna or rna detection |
| CN104024433B (zh) * | 2011-10-31 | 2016-11-16 | 爱科来株式会社 | 基因丰度的测定方法 |
| CN107326085B (zh) | 2012-02-03 | 2022-05-03 | 加州理工学院 | 多路生化测定中信号的编码和解码 |
| EP2820157B1 (en) | 2012-03-02 | 2019-05-01 | Winthrop-University Hospital | Method for using probe based pcr detection to measure the levels of circulating demethylated beta cell derived dna as a measure of beta cell loss in diabetes |
| CN102643910B (zh) * | 2012-04-10 | 2014-10-15 | 中国人民解放军第三军医大学第一附属医院 | 非对称多色荧光发夹探针链反应在病原菌检测中的应用 |
| WO2014022827A1 (en) * | 2012-08-03 | 2014-02-06 | California Institute Of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
| EP2895627A4 (en) * | 2012-09-17 | 2016-06-29 | Univ Brandeis | COMBINATION OF DSDNA BINDING DYES AND PROBES FOR CHARACTERIZING SSDNA SEQUENCES |
| US20160186267A1 (en) * | 2013-02-21 | 2016-06-30 | Toma Biosciences, Inc. | Methods, compositions, and kits for nucleic acid analysis |
| US11254977B2 (en) | 2013-03-12 | 2022-02-22 | Life Technologies Corporation | Universal reporter-based genotyping methods and materials |
| EP3666903B1 (en) * | 2013-08-12 | 2025-12-31 | Bio-Rad Laboratories, Inc. | AMPLIFICATION REPORTER GENE CONTAINING OLIGOMERS WITH BASIC PAIRINGS |
| WO2015047186A1 (en) * | 2013-09-30 | 2015-04-02 | Di Wu | Methods to profile molecular complexes by using proximity bar-coding |
| WO2015086604A1 (en) * | 2013-12-11 | 2015-06-18 | Qiagen Gmbh | Nucleic acid detection and quantification |
| US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
| WO2015147370A1 (en) | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
| GB201411567D0 (en) | 2014-06-30 | 2014-08-13 | Epistem Ltd | Quantification methods |
| US20170247745A1 (en) * | 2014-09-12 | 2017-08-31 | Click Diagnostics, Inc. | Multiplex optical detection |
| ES2994737T3 (en) | 2014-10-10 | 2025-01-30 | Univ Rutgers | Polymerase chain reaction primers and probes for mycobacterium tuberculosis |
| WO2016093620A1 (en) | 2014-12-09 | 2016-06-16 | Seegene, Inc. | Differentiation of signals for target nucleic acid sequences |
| CA2971200A1 (en) * | 2014-12-19 | 2016-06-23 | Brandeis University | Mispriming prevention reagents |
| ES2898103T3 (es) | 2014-12-31 | 2022-03-03 | Visby Medical Inc | Dispositivos para pruebas de diagnóstico molecular |
| US10913944B2 (en) * | 2015-01-12 | 2021-02-09 | Life Technologies Corporation | Methods, systems and compositions thereof for nucleic acid library quality control and quantification |
| EP3353697B1 (en) * | 2015-09-24 | 2025-11-05 | Seegene, Inc. | Multiple dataset analysis for determining the presence or absence of target analyte |
| WO2017087942A1 (en) | 2015-11-20 | 2017-05-26 | Brandeis University | Amplifying and detecting rna and dna sequences comprising high levels of intramolecular hybridization |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| WO2017209563A1 (en) * | 2016-06-02 | 2017-12-07 | Seegene, Inc. . | Method for detecting a target analyte in a sample using a signal change-amount data set |
| EP3478857A1 (en) | 2016-06-29 | 2019-05-08 | Click Diagnostics, Inc. | Devices and methods for the detection of molecules using a flow cell |
| WO2018190814A1 (en) * | 2017-04-11 | 2018-10-18 | Nugen Technologies, Inc. | Library quantitation and qualification |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| US20190093155A1 (en) * | 2017-05-25 | 2019-03-28 | Roche Molecular Systems, Inc. | Multiplex Nucleic Acid Amplification Assay |
| KR102380264B1 (ko) * | 2017-08-31 | 2022-03-29 | 주식회사 씨젠 | 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가 |
| MX2020004783A (es) | 2017-11-09 | 2020-08-13 | Visby Medical Inc | Dispositivo portatil para el diagnostico molecular y metodos para la deteccion de virus objetivo. |
| CN108570495A (zh) * | 2018-01-15 | 2018-09-25 | 新开源博畅(武汉)生物科技有限公司 | 一种hla高分辨基因位点的快速扩增诊断试剂盒及扩增方法 |
| CN108624664B (zh) * | 2018-01-16 | 2020-08-28 | 武汉菲思特生物科技有限公司 | 一种急性肝损伤的早期诊断标志物的快速扩增方法 |
| CA3088250A1 (en) * | 2018-01-22 | 2019-07-25 | Luminex Corporation | Methods and compositions for discrete melt analysis |
| US12454720B2 (en) | 2018-04-17 | 2025-10-28 | ChromaCode, Inc. | Methods and systems for multiplex analysis |
| WO2019203623A1 (en) * | 2018-04-20 | 2019-10-24 | Seegene, Inc. . | Method and apparatus for detecting a plurality of target nucleic acid sequences in sample |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| KR20210081335A (ko) | 2018-09-03 | 2021-07-01 | 비스비 메디컬, 인코포레이티드 | 항생제 감수성 시험을 위한 장치 및 방법 |
| CN109321672B (zh) * | 2018-10-30 | 2021-07-06 | 中国农业大学 | 核苷酸组合物、试剂盒及检测方法 |
| US12263478B2 (en) | 2019-04-28 | 2025-04-01 | Visby Medical, Inc. | Molecular diagnostic devices with digital detection capability and wireless connectivity |
| WO2021011850A2 (en) * | 2019-07-17 | 2021-01-21 | Chao Chien Chung | Amplification assay for the detection of anaplasma phagocytophilum |
| CN110568175A (zh) * | 2019-09-06 | 2019-12-13 | 成都理工大学 | 一种基于核酸染料诱导纳米金快速聚集检测dna的方法 |
| PL4034674T3 (pl) | 2019-09-23 | 2025-08-04 | Universiteit Gent | Sonda i sposób genotypowania str |
| EP4085149A4 (en) | 2020-01-03 | 2024-03-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
| US20230242971A1 (en) * | 2020-05-08 | 2023-08-03 | Roche Sequencing Solutions, Inc. | Removal of excess oligonucleotides from a reation mixture |
| CN111961717B (zh) * | 2020-08-28 | 2023-08-01 | 南方医科大学 | 单管同时检测缺失型和非缺失型α-地中海贫血基因的荧光PCR试剂盒 |
| CN111909990B (zh) * | 2020-08-28 | 2023-11-28 | 亚能生物技术(深圳)有限公司 | 单管同时检测基因的缺失突变和点突变的荧光pcr检测方法 |
| US20230068047A1 (en) * | 2021-08-19 | 2023-03-02 | Luminex Corporation | Digital amplification assay analysis method |
| CN119173642A (zh) * | 2022-06-20 | 2024-12-20 | 株式会社日立高新技术 | 引物、dna检测方法和dna检测试剂盒 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5756285A (en) * | 1991-09-27 | 1998-05-26 | Amersham Life Science, Inc. | DNA cycle sequencing |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5716784A (en) * | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
| EP0892808B1 (en) | 1996-04-12 | 2008-05-14 | PHRI Properties, Inc. | Detection probes, kits and assays |
| CA2591550C (en) * | 1996-06-04 | 2009-04-28 | University Of Utah Research Foundation | Monitoring hybridization during pcr |
| US5935791A (en) * | 1997-09-23 | 1999-08-10 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
| GB9725197D0 (en) | 1997-11-29 | 1998-01-28 | Secr Defence | Detection system |
| US6140054A (en) * | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
| US6277607B1 (en) | 1999-05-24 | 2001-08-21 | Sanjay Tyagi | High specificity primers, amplification methods and kits |
| WO2001013086A2 (en) | 1999-08-13 | 2001-02-22 | Brandeis University | Detection of nucleic acids |
| US6472156B1 (en) | 1999-08-30 | 2002-10-29 | The University Of Utah | Homogeneous multiplex hybridization analysis by color and Tm |
| US7662550B1 (en) | 1999-10-22 | 2010-02-16 | Phri Properties, Inc. | Assays for short sequence variants |
| US20030082550A1 (en) * | 2000-09-08 | 2003-05-01 | Hans-Ulrich Thomann | Mutations of the cyclooxygenase-2 gene |
| US7267945B2 (en) * | 2001-03-26 | 2007-09-11 | Applera Corporation | Methods of determining the presence of polynucleotides employing amplification |
| GB0112868D0 (en) * | 2001-05-25 | 2001-07-18 | Secr Defence | Detection system |
| JP2005514003A (ja) * | 2001-06-08 | 2005-05-19 | シャンハイ メンデル ディーエヌエー センター シーオー., エルティーディー | 高いプライミング特異性を有するdnaの低温サイクル伸長 |
| US20030108906A1 (en) * | 2001-07-27 | 2003-06-12 | Brooksbank Robert Alan | Identification and use of molecules implicated in pain |
| WO2003040397A2 (en) * | 2001-10-25 | 2003-05-15 | Gorilla Genomics, Inc. | Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons |
| WO2003045233A1 (en) | 2001-11-21 | 2003-06-05 | Optiscan Biomedical Corporation | Method and apparatus for improving the accuracy of alternative site analyte concentration measurements |
| US7198897B2 (en) * | 2001-12-19 | 2007-04-03 | Brandeis University | Late-PCR |
| JP2004024035A (ja) * | 2002-06-21 | 2004-01-29 | Tosoh Corp | 核酸の検出方法 |
| ATE378425T1 (de) * | 2002-09-02 | 2007-11-15 | Toyo Boseki | Verfahren zu identifizierung von nukleotid- polymorphismen unter verwendung von resonanzenergietransfer |
| WO2004048516A2 (en) * | 2002-11-22 | 2004-06-10 | North Shore-Long Island Jewish Research Institute | Elf3 gene compositions and methods |
| US20040175704A1 (en) * | 2003-03-06 | 2004-09-09 | Stratagene | Compositions and methods for polynucleotide sequence detection |
| CA2548205C (en) * | 2003-12-03 | 2017-06-27 | Abbott Laboratories | Double stranded linear nucleic acid probe and uses thereof |
| ES2741546T3 (es) * | 2004-03-31 | 2020-02-11 | Massachusetts Gen Hospital | Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico |
| BRPI0517105B1 (pt) * | 2004-10-18 | 2015-06-23 | Univ Brandeis | Método para análise de pelo menos um produto de amplificação fita simples de um processo de amplificação de ácido nucléico não-simétrico |
-
2005
- 2005-10-17 BR BRPI0517105-9A patent/BRPI0517105B1/pt not_active IP Right Cessation
- 2005-10-17 PT PT05810422T patent/PT1805199E/pt unknown
- 2005-10-17 KR KR1020137025318A patent/KR101447405B1/ko not_active Expired - Fee Related
- 2005-10-17 CA CA2996947A patent/CA2996947C/en not_active Expired - Fee Related
- 2005-10-17 DK DK05810422.5T patent/DK1805199T3/da active
- 2005-10-17 CN CN200580042622XA patent/CN101076607B/zh not_active Expired - Lifetime
- 2005-10-17 EP EP10187807.2A patent/EP2351766B1/en not_active Expired - Lifetime
- 2005-10-17 DE DE602005025791T patent/DE602005025791D1/de not_active Expired - Lifetime
- 2005-10-17 ES ES05810422T patent/ES2359322T3/es not_active Expired - Lifetime
- 2005-10-17 US US11/252,433 patent/US7632642B2/en not_active Expired - Lifetime
- 2005-10-17 KR KR1020137002325A patent/KR101347951B1/ko not_active Expired - Fee Related
- 2005-10-17 RU RU2007118545/10A patent/RU2460804C2/ru not_active IP Right Cessation
- 2005-10-17 AT AT05810422T patent/ATE494295T1/de active
- 2005-10-17 ES ES14195859.5T patent/ES2668467T3/es not_active Expired - Lifetime
- 2005-10-17 CA CA2584569A patent/CA2584569C/en not_active Expired - Fee Related
- 2005-10-17 PL PL05810422T patent/PL1805199T3/pl unknown
- 2005-10-17 EP EP05810422A patent/EP1805199B1/en not_active Expired - Lifetime
- 2005-10-17 JP JP2007537034A patent/JP5543065B2/ja not_active Expired - Lifetime
- 2005-10-17 KR KR1020077011244A patent/KR101424812B1/ko not_active Expired - Fee Related
- 2005-10-17 AU AU2005295298A patent/AU2005295298B2/en not_active Ceased
- 2005-10-17 ES ES10187807.2T patent/ES2529204T3/es not_active Expired - Lifetime
- 2005-10-17 WO PCT/US2005/037667 patent/WO2006044994A2/en not_active Ceased
- 2005-10-17 EP EP14195859.5A patent/EP2927238B1/en not_active Expired - Lifetime
- 2005-10-17 CA CA2855748A patent/CA2855748C/en not_active Expired - Fee Related
-
2007
- 2007-05-15 NO NO20072506A patent/NO20072506L/no not_active Application Discontinuation
-
2008
- 2008-11-10 US US12/292,038 patent/US20120040352A1/en not_active Abandoned
-
2012
- 2012-08-01 US US13/564,528 patent/US9745624B2/en not_active Expired - Lifetime
-
2014
- 2014-01-06 JP JP2014000518A patent/JP5860484B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5543065B2 (ja) | 核酸増幅のためのプライマー、プローブおよび方法 | |
| KR102358734B1 (ko) | 상이한 검출 온도를 이용한 타겟 핵산 서열의 검출 | |
| US7348141B2 (en) | Hybridization beacon and method of rapid sequence detection and discrimination | |
| JP6688318B2 (ja) | 多重侵入切断アッセイ | |
| US8748590B2 (en) | Oligonucleotides for detection test of polymorphism of EGFR exon 19 and use therof | |
| EP1641939A2 (en) | Methods of nucleic acid analysis | |
| HK1106251B (en) | Methods for nucleic acid amplification |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080812 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110524 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110817 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110824 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111124 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20111124 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120626 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120918 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120925 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121226 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130903 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140106 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20140217 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20140310 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140415 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140508 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5543065 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |