JP5406039B2 - タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体 - Google Patents

タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体 Download PDF

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JP5406039B2
JP5406039B2 JP2009542940A JP2009542940A JP5406039B2 JP 5406039 B2 JP5406039 B2 JP 5406039B2 JP 2009542940 A JP2009542940 A JP 2009542940A JP 2009542940 A JP2009542940 A JP 2009542940A JP 5406039 B2 JP5406039 B2 JP 5406039B2
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JP2010514676A5 (cg-RX-API-DMAC10.html
JP2010514676A (ja
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マイケル・モーティモア
スティーブン・クリントン・ヤング
サイモン・ロバート・ロリー・エバリット
ロナルド・クネフテル
ジョアン・ルイーズ・ピンダー
アリステア・ピーター・ラザフォード
スティーブン・デュラント
ガイ・ブレンチリー
ジャン・ダミアン・シャリエール
マイケル・オドネル
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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JP2009542940A 2006-12-21 2007-12-21 タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体 Expired - Fee Related JP5406039B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US87630706P 2006-12-21 2006-12-21
US60/876,307 2006-12-21
US92229107P 2007-04-06 2007-04-06
US60/922,291 2007-04-06
US94770707P 2007-07-03 2007-07-03
US60/947,707 2007-07-03
US98901407P 2007-11-19 2007-11-19
US60/989,014 2007-11-19
PCT/US2007/026190 WO2008079346A1 (en) 2006-12-21 2007-12-21 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors

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JP2013227246A Division JP2014051516A (ja) 2006-12-21 2013-10-31 タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体

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JP2010514676A JP2010514676A (ja) 2010-05-06
JP2010514676A5 JP2010514676A5 (cg-RX-API-DMAC10.html) 2011-06-30
JP5406039B2 true JP5406039B2 (ja) 2014-02-05

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JP2013227246A Pending JP2014051516A (ja) 2006-12-21 2013-10-31 タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体

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US (3) US8247421B2 (cg-RX-API-DMAC10.html)
EP (2) EP2815750A1 (cg-RX-API-DMAC10.html)
JP (2) JP5406039B2 (cg-RX-API-DMAC10.html)
KR (1) KR20090091350A (cg-RX-API-DMAC10.html)
CN (1) CN101678022A (cg-RX-API-DMAC10.html)
AR (1) AR064675A1 (cg-RX-API-DMAC10.html)
AU (1) AU2007338754A1 (cg-RX-API-DMAC10.html)
CA (1) CA2673472A1 (cg-RX-API-DMAC10.html)
MX (1) MX2009006700A (cg-RX-API-DMAC10.html)
NO (1) NO20092668L (cg-RX-API-DMAC10.html)
NZ (1) NZ577798A (cg-RX-API-DMAC10.html)
TW (1) TW200838517A (cg-RX-API-DMAC10.html)
WO (1) WO2008079346A1 (cg-RX-API-DMAC10.html)

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AR064675A1 (es) 2009-04-15
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