JP5368792B2 - 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達 - Google Patents
複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達 Download PDFInfo
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- JP5368792B2 JP5368792B2 JP2008524272A JP2008524272A JP5368792B2 JP 5368792 B2 JP5368792 B2 JP 5368792B2 JP 2008524272 A JP2008524272 A JP 2008524272A JP 2008524272 A JP2008524272 A JP 2008524272A JP 5368792 B2 JP5368792 B2 JP 5368792B2
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- 0 CCCC(CCC)C(N*)=O Chemical compound CCCC(CCC)C(N*)=O 0.000 description 2
- OMOMUFTZPTXCHP-UHFFFAOYSA-N CCCC(CCC)C(N)=O Chemical compound CCCC(CCC)C(N)=O OMOMUFTZPTXCHP-UHFFFAOYSA-N 0.000 description 1
- BZVPMSKCPUPVSB-UHFFFAOYSA-N Cc1cc(C(N2)=Cc3ncccc3C2=O)cc(C)c1O Chemical compound Cc1cc(C(N2)=Cc3ncccc3C2=O)cc(C)c1O BZVPMSKCPUPVSB-UHFFFAOYSA-N 0.000 description 1
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
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- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70403505P | 2005-07-29 | 2005-07-29 | |
| US60/704,035 | 2005-07-29 | ||
| PCT/US2006/029827 WO2007016525A2 (en) | 2005-07-29 | 2006-07-28 | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502970A JP2009502970A (ja) | 2009-01-29 |
| JP2009502970A5 JP2009502970A5 (enExample) | 2009-09-10 |
| JP5368792B2 true JP5368792B2 (ja) | 2013-12-18 |
Family
ID=37421024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524272A Expired - Fee Related JP5368792B2 (ja) | 2005-07-29 | 2006-07-28 | 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8410109B2 (enExample) |
| EP (2) | EP2314295B1 (enExample) |
| JP (1) | JP5368792B2 (enExample) |
| KR (1) | KR101431279B1 (enExample) |
| CN (1) | CN101365446B (enExample) |
| AU (1) | AU2006275514B2 (enExample) |
| CA (1) | CA2617213C (enExample) |
| NZ (1) | NZ566180A (enExample) |
| WO (1) | WO2007016525A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006045010A2 (en) | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| WO2008092231A1 (en) | 2007-02-01 | 2008-08-07 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| AU2008282261A1 (en) * | 2007-07-31 | 2009-02-05 | Limerick Biopharma, Inc. | Phosphorylated pyrone analogs and methods |
| PL2346837T3 (pl) | 2008-06-26 | 2015-07-31 | Resverlogix Corp | Sposoby wytwarzania pochodnych chinazolinonu |
| EP2324022A1 (de) * | 2008-08-05 | 2011-05-25 | Boehringer Ingelheim International GmbH | Substituierte naphthyridine und ihre verwendung als arzneimittel |
| US20100092534A1 (en) * | 2008-10-10 | 2010-04-15 | Medtronic Vascular, Inc. | Combination Local Delivery Using a Stent |
| US8952021B2 (en) | 2009-01-08 | 2015-02-10 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| EP2408454B1 (en) | 2009-03-18 | 2024-07-24 | Resverlogix Corp. | Novel anti-inflammatory agents |
| CN102458405B (zh) * | 2009-04-22 | 2017-06-23 | 雷斯韦洛吉克斯公司 | 新抗炎剂 |
| DK2533637T3 (da) | 2010-02-12 | 2014-05-19 | N30 Pharmaceuticals Inc | Chromoninhibitorer af S-nitrosoglutathionreduktase |
| PL2533638T3 (pl) * | 2010-02-12 | 2016-08-31 | Nivalis Therapeutics Inc | Nowe inhibitory reduktazy S-nitrozoglutationowej |
| CA2803665C (en) | 2010-06-28 | 2019-03-05 | Dieter Dorsch | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
| SMT201800065T1 (it) | 2010-08-18 | 2018-03-08 | Samumed Llc | Dichetoni e idrossichetoni come attivatori della via di segnalazione della catechina |
| RU2599144C2 (ru) | 2010-10-08 | 2016-10-10 | Нивалис Терапьютикс,Инк. | Новые замещенные хинолиновые соединения как ингибиторы s-нитрозоглутатион-редуктазы |
| EP2651223A4 (en) | 2010-12-16 | 2015-07-22 | Nivalis Therapeutics Inc | NOVEL BICYCLIC AROMATIC COMPOUNDS SUBSTITUTED AS INHIBITORS OF S-NITROSOGLUTATHION REDUCTASE |
| US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
| RS58911B1 (sr) | 2011-11-01 | 2019-08-30 | Resverlogix Corp | Oralne formulacije sa trenutnim otpuštanjem za supstituisane hinazolinone |
| KR101401253B1 (ko) * | 2012-03-06 | 2014-05-29 | 연세대학교 산학협력단 | Pcsk9 발현 억제를 통한 저밀도지단백 수용체 증가 유도용 조성물 |
| MX346147B (es) | 2012-03-07 | 2017-03-09 | Inst Of Cancer Research: Royal Cancer Hospital (The) | Compuestos de 3-aril-5-substituido-isoquinolin-1-ona y su uso terapeutico. |
| MX358514B (es) | 2012-03-23 | 2018-08-24 | Ptc Therapeutics Inc | Compuestos para tratar la atrofia muscular espinal. |
| US20130281397A1 (en) * | 2012-04-19 | 2013-10-24 | Rvx Therapeutics Inc. | Treatment of diseases by epigenetic regulation |
| AU2013333575B2 (en) | 2012-10-15 | 2015-07-16 | Resverlogix Corp. | Compounds useful in the synthesis of benzamide compounds |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| MX2015007921A (es) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
| ES2709824T3 (es) | 2013-02-22 | 2019-04-17 | Samumed Llc | Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina |
| KR102307566B1 (ko) | 2013-06-21 | 2021-10-05 | 제니쓰 에피제네틱스 리미티드 | 신규한 바이사이클릭 브로모도메인 억제제 |
| US9662311B2 (en) | 2013-06-21 | 2017-05-30 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
| US9855271B2 (en) | 2013-07-31 | 2018-01-02 | Zenith Epigenetics Ltd. | Quinazolinones as bromodomain inhibitors |
| US9611223B2 (en) | 2013-09-11 | 2017-04-04 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| SMT201900709T1 (it) | 2014-08-20 | 2020-01-14 | Samumed Llc | Gamma-dichetoni per trattamento e prevenzione di pelle in invecchiamento e rughe |
| CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| EP3227281A4 (en) | 2014-12-01 | 2018-05-30 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| EP3233846A4 (en) | 2014-12-17 | 2018-07-18 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
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- 2006-07-28 WO PCT/US2006/029827 patent/WO2007016525A2/en not_active Ceased
- 2006-07-28 US US11/990,162 patent/US8410109B2/en not_active Expired - Fee Related
- 2006-07-28 EP EP10191972.8A patent/EP2314295B1/en not_active Not-in-force
- 2006-07-28 EP EP06800576A patent/EP1909788A2/en not_active Withdrawn
- 2006-07-28 CN CN2006800342341A patent/CN101365446B/zh not_active Expired - Fee Related
- 2006-07-28 JP JP2008524272A patent/JP5368792B2/ja not_active Expired - Fee Related
- 2006-07-28 KR KR1020087005148A patent/KR101431279B1/ko not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101365446B (zh) | 2013-05-22 |
| EP2314295A1 (en) | 2011-04-27 |
| KR101431279B1 (ko) | 2014-08-20 |
| AU2006275514A1 (en) | 2007-02-08 |
| US8410109B2 (en) | 2013-04-02 |
| JP2009502970A (ja) | 2009-01-29 |
| EP2314295B1 (en) | 2015-01-28 |
| NZ566180A (en) | 2011-04-29 |
| WO2007016525A2 (en) | 2007-02-08 |
| AU2006275514B2 (en) | 2012-04-05 |
| US20090029987A1 (en) | 2009-01-29 |
| KR20080034180A (ko) | 2008-04-18 |
| WO2007016525A3 (en) | 2007-05-31 |
| CA2617213C (en) | 2014-01-28 |
| EP1909788A2 (en) | 2008-04-16 |
| CA2617213A1 (en) | 2007-02-08 |
| CN101365446A (zh) | 2009-02-11 |
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