PT988038E - Derivados (imidazol-5-il)metil-2-quinolinona como inibidores da proliferacao de celulas dos musculos lisos - Google Patents

Derivados (imidazol-5-il)metil-2-quinolinona como inibidores da proliferacao de celulas dos musculos lisos

Info

Publication number
PT988038E
PT988038E PT98928332T PT98928332T PT988038E PT 988038 E PT988038 E PT 988038E PT 98928332 T PT98928332 T PT 98928332T PT 98928332 T PT98928332 T PT 98928332T PT 988038 E PT988038 E PT 988038E
Authority
PT
Portugal
Prior art keywords
sub
sup
alkyl
alkyloxy
hydrogen
Prior art date
Application number
PT98928332T
Other languages
English (en)
Inventor
David William End
Michael J Zelesko
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT988038E publication Critical patent/PT988038E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT98928332T 1997-06-02 1998-05-25 Derivados (imidazol-5-il)metil-2-quinolinona como inibidores da proliferacao de celulas dos musculos lisos PT988038E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4737697P 1997-06-02 1997-06-02

Publications (1)

Publication Number Publication Date
PT988038E true PT988038E (pt) 2002-12-31

Family

ID=21948611

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98928332T PT988038E (pt) 1997-06-02 1998-05-25 Derivados (imidazol-5-il)metil-2-quinolinona como inibidores da proliferacao de celulas dos musculos lisos

Country Status (22)

Country Link
US (4) US6365600B1 (pt)
EP (1) EP0988038B1 (pt)
JP (1) JP4209472B2 (pt)
KR (1) KR100517832B1 (pt)
CN (2) CN100525766C (pt)
AT (1) ATE222104T1 (pt)
AU (1) AU740603B2 (pt)
BR (1) BR9810423A (pt)
CA (1) CA2290992C (pt)
DE (1) DE69807222T2 (pt)
DK (1) DK0988038T3 (pt)
ES (1) ES2182327T3 (pt)
HK (2) HK1025046A1 (pt)
ID (1) ID24675A (pt)
IL (1) IL133212A (pt)
NO (1) NO318834B1 (pt)
NZ (1) NZ501401A (pt)
PT (1) PT988038E (pt)
RU (1) RU2209066C2 (pt)
TR (1) TR199902923T2 (pt)
WO (1) WO1998055124A1 (pt)
ZA (1) ZA984700B (pt)

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Also Published As

Publication number Publication date
HK1025046A1 (en) 2000-11-03
AU8020798A (en) 1998-12-21
RU2209066C2 (ru) 2003-07-27
US6743805B2 (en) 2004-06-01
ID24675A (id) 2000-07-27
CN100525766C (zh) 2009-08-12
JP2002503235A (ja) 2002-01-29
DK0988038T3 (da) 2002-12-02
CN1231215C (zh) 2005-12-14
EP0988038B1 (en) 2002-08-14
ATE222104T1 (de) 2002-08-15
IL133212A (en) 2005-12-18
US6734194B2 (en) 2004-05-11
US20020091138A1 (en) 2002-07-11
US6365600B1 (en) 2002-04-02
BR9810423A (pt) 2000-10-03
AU740603B2 (en) 2001-11-08
US20030229118A1 (en) 2003-12-11
DE69807222T2 (de) 2003-04-17
ZA984700B (en) 1999-12-01
HK1088820A1 (en) 2006-11-17
CA2290992C (en) 2008-02-12
DE69807222D1 (de) 2002-09-19
CA2290992A1 (en) 1998-12-10
KR100517832B1 (ko) 2005-09-30
US20040198771A1 (en) 2004-10-07
TR199902923T2 (xx) 2000-11-21
NO995883L (no) 2000-02-02
WO1998055124A1 (en) 1998-12-10
IL133212A0 (en) 2001-03-19
NO995883D0 (no) 1999-12-01
KR20010012782A (ko) 2001-02-26
EP0988038A1 (en) 2000-03-29
JP4209472B2 (ja) 2009-01-14
ES2182327T3 (es) 2003-03-01
NZ501401A (en) 2002-03-28
CN1762355A (zh) 2006-04-26
CN1265585A (zh) 2000-09-06
NO318834B1 (no) 2005-05-09
US7253183B2 (en) 2007-08-07

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