ES2182327T3 - Derivados de (imidazol-5-il)metil-2-quinlinona como inhibidores de la proliferacion de celulas de musculos lisos. - Google Patents
Derivados de (imidazol-5-il)metil-2-quinlinona como inhibidores de la proliferacion de celulas de musculos lisos.Info
- Publication number
- ES2182327T3 ES2182327T3 ES98928332T ES98928332T ES2182327T3 ES 2182327 T3 ES2182327 T3 ES 2182327T3 ES 98928332 T ES98928332 T ES 98928332T ES 98928332 T ES98928332 T ES 98928332T ES 2182327 T3 ES2182327 T3 ES 2182327T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- alkyl
- sup
- amino
- alkyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000035755 proliferation Effects 0.000 title abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- -1 4,4-dimethyl -oxazolyl Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- XOCUXOWLYLLJLV-UHFFFAOYSA-N [O].[S] Chemical group [O].[S] XOCUXOWLYLLJLV-UHFFFAOYSA-N 0.000 abstract 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere al empleo de compuestos de fórmula (I) en los que la línea de puntos representa un enlace opcional; X es oxigeno azufre; R{sup, 1} es H, alquilo C{sub, 1-12}, Ar{sup,1}, Ar{sup,2} alquilo -C{sub, 1-6}, quinolinil alquilo C{sub, 1-6}, piridinil C{sub, 1-6} alquilo, hidroxi alquilo C{sub, 1-6}, C{sub, 1-6} alcoxilo, alquilo C{sub, 1-6}, mono- o di(alquil C{sub, 1-6})amino alquilo C{sub, 1-6}, amino alquilo C{sub, 1-6}, o un radical de la fórmula -Alq {suo,1}-C(=O)-R{sup,9}, -Alq {sup,1}-S(O)-R{sup, 9}, o -Arq{sup,1}-S(O){sub,2}-R{sup, 9}; R{sup, 2}, R{sup, 3} y R{sup, 17}, cada uno independientemente son H, hidroxi, halo, ciano, alquilo C{sub, 1-6}, C{sub, 1-6} alcoxilo, hidorxi- alquiloxi C{sub, 1-6}, alquiloxi C{sub, 1-6}, amino alquiloxi C{sub, 1-6}, mono-o di(alquil C{sub, 1-6})amino alquiloxi C{sub, 1-6}, Ar{sup,1}, Ar{sup,2} alquilo C{sub, 1-6}, Ar{sup,2} oxi, Ar{sup,2}, alquiloxi C{sub, 1-6}, hidroxicarbonilo, alquiloxicarbonilo C{sub, 1-6}, trihalometilo, trihalometoxi, alquenilo C{sub, 2-6}, R{sup, 4} y R{sup, 5} cada uno independinetemente son H, Ar{sup,1}, alquilo C{sub, 1-6}, hidoroxi- alquilo C{sub, 1-6}, alquiloxi C{sub, 1-6}, alquilo C{sub, 1-6}, alquiloxi C{sub, 1-6}, alquiltio C{sub, 1-6}, amino, hidorcarbonilo, alquiloxicarbonilo C{sub, 1-6}, alquil C{sub, 1-6} S(O) alquilo C{sub, 1-6} o alquil C{sub, 1-6} S(O){sub,2} alquilo C{sub, 1-6}; R{sup,6} y R{sup,7} cada uno independientemente son H, halo, ciano, C{sub, 1-6} alquilo, 4,4-dimetil -oxazolilo, C{sub, 1-6}alquiloxilo o Ar{sup,2}oxy; R{sup,8} es H, C{sub, 1-6} alquilo, ciano, hidroxicarbonilo, C{sub, 1-6} alquiloxicarbonilo, C{sub, 1-6} alquilcarbonilo, C{sub, 1-6} alquilo, cianoC{sub, 1-6} alquilo, C{sub, 1-6} alquiloxicarbonil C{sub, 1-6} alquilo, alcoxi C{sub, 1-6} alquilo, hidroxi C{sub, 1-6} alquilo, amino C1-6 alquilo, mono-o di(C{sub, 1-6}alquil)amino C{sub, 1-6}alquilo, imidazolilo, halo, alquilo C{sub,1-6}, alcoxi C{sub,1-6} alquilo C{sub,1-6}, aminocarbonil alquilo C{sub,1-6} o u radical de fórmula -O-R{sup, 10}, -S-R{sup, 10}, -N-R{sup, 11}, O{sup, 12}; R{sup, 17} es H, halo, ciano, alquilo C{sub, 1-6}, alquiloxicarbonilo C{sub, 1-6}, Ar{sup,1}; R{sup, 18} es H, alquilo C{sub, 1-6}, alcoxilo o halo C{sub, 1-6}; R{sup, 19} es H o alquilo C{sub, 1-6} para la fabricación de un medicamento que inhibe la proliferación de células de músculo liso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4737697P | 1997-06-02 | 1997-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182327T3 true ES2182327T3 (es) | 2003-03-01 |
Family
ID=21948611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98928332T Expired - Lifetime ES2182327T3 (es) | 1997-06-02 | 1998-05-25 | Derivados de (imidazol-5-il)metil-2-quinlinona como inhibidores de la proliferacion de celulas de musculos lisos. |
Country Status (22)
Country | Link |
---|---|
US (4) | US6365600B1 (es) |
EP (1) | EP0988038B1 (es) |
JP (1) | JP4209472B2 (es) |
KR (1) | KR100517832B1 (es) |
CN (2) | CN1231215C (es) |
AT (1) | ATE222104T1 (es) |
AU (1) | AU740603B2 (es) |
BR (1) | BR9810423A (es) |
CA (1) | CA2290992C (es) |
DE (1) | DE69807222T2 (es) |
DK (1) | DK0988038T3 (es) |
ES (1) | ES2182327T3 (es) |
HK (2) | HK1025046A1 (es) |
ID (1) | ID24675A (es) |
IL (1) | IL133212A (es) |
NO (1) | NO318834B1 (es) |
NZ (1) | NZ501401A (es) |
PT (1) | PT988038E (es) |
RU (1) | RU2209066C2 (es) |
TR (1) | TR199902923T2 (es) |
WO (1) | WO1998055124A1 (es) |
ZA (1) | ZA984700B (es) |
Families Citing this family (100)
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ES2212580T3 (es) * | 1998-07-06 | 2004-07-16 | Janssen Pharmaceutica N.V. | Inhibidores de la proteina farnesil-transferasa para el tratamiento de artropatias. |
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SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
US5049403A (en) | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
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US5863904A (en) | 1995-09-26 | 1999-01-26 | The University Of Michigan | Methods for treating cancers and restenosis with P21 |
TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
EP1162201B1 (en) * | 1995-12-08 | 2006-03-29 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives |
WO1998055124A1 (en) | 1997-06-02 | 1998-12-10 | Janssen Pharmaceutica N.V. | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
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