ES2165407T3 - Compuestos beta-carbolina inhibidores de tromboxano sintasa. - Google Patents

Compuestos beta-carbolina inhibidores de tromboxano sintasa.

Info

Publication number
ES2165407T3
ES2165407T3 ES95300396T ES95300396T ES2165407T3 ES 2165407 T3 ES2165407 T3 ES 2165407T3 ES 95300396 T ES95300396 T ES 95300396T ES 95300396 T ES95300396 T ES 95300396T ES 2165407 T3 ES2165407 T3 ES 2165407T3
Authority
ES
Spain
Prior art keywords
tromboxan
beta
sintasa
carboline compounds
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95300396T
Other languages
English (en)
Inventor
Joseph Anthony Jakubowski
Alan David Palkowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2165407T3 publication Critical patent/ES2165407T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN DERIVADOS DEL TIPO DE BETA-CARBOLINA FUNCIONAL DEL ACIDO EFECTIVOS COMO INHIBIDORES DE LA SINTASA DE TROMBOXANO, QUE TIENEN LA FORMULA (I) EN LA QUE R1 Y R2 SON RADICALES MONOVALENTES, (LA)- ES UN GRUPO DE ENLACE DE ENTRE 4 Y 8 ATOMOS DE CADENA, Y A ES UN GRUPO ACIDICO.
ES95300396T 1994-01-24 1995-01-23 Compuestos beta-carbolina inhibidores de tromboxano sintasa. Expired - Lifetime ES2165407T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18563494A 1994-01-24 1994-01-24

Publications (1)

Publication Number Publication Date
ES2165407T3 true ES2165407T3 (es) 2002-03-16

Family

ID=22681809

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95300396T Expired - Lifetime ES2165407T3 (es) 1994-01-24 1995-01-23 Compuestos beta-carbolina inhibidores de tromboxano sintasa.

Country Status (6)

Country Link
US (1) US5604236A (es)
EP (1) EP0667347B1 (es)
JP (1) JPH07206862A (es)
CA (1) CA2140722A1 (es)
DE (1) DE69523961T2 (es)
ES (1) ES2165407T3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1023067T4 (da) * 1997-10-17 2011-12-12 Ark Therapeutics Ltd Anvendelse af inhibitorer af renin-angiotensin-systemet til behandling af hypoxi eller svækket metabolisk funktion
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
NZ521386A (en) 2000-03-15 2004-06-25 Aventis Pharma Gmbh Substituted beta-carbolines with lkB-kinase inhibiting activity
KR20070086079A (ko) * 2004-11-13 2007-08-27 메타프로테오믹스, 엘엘씨 사이클로옥시게나제-2의 억제를 나타내는 조성물
DE102007009264A1 (de) * 2007-02-26 2008-08-28 Ellneuroxx Ltd. 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen
CA2785233C (en) 2009-12-28 2018-10-09 Audiocure Pharma Gmbh .beta.-carbolines for treatment of hearing damages and vertigo
TWI648272B (zh) 2013-06-25 2019-01-21 美商必治妥美雅史谷比公司 經取代之四氫咔唑及咔唑甲醯胺化合物
CN105473573B (zh) 2013-06-25 2018-03-16 百时美施贵宝公司 用作激酶抑制剂的咔唑甲酰胺化合物
SI3461821T1 (sl) 2014-10-24 2020-09-30 Bristol-Myers Squibb Company Spojine indol karboksamida, uporabne kot kinazni inhibitorji
AU2015335783B2 (en) 2014-10-24 2019-10-03 Bristol-Myers Squibb Company Tricyclic atropisomer compounds
TN2017000158A1 (en) 2014-10-24 2018-10-19 Bristol Myers Squibb Co Carbazole derivatives
EP3318563A1 (en) 2016-11-07 2018-05-09 Sanofi Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2850501A (en) * 1956-07-30 1958-09-02 Searle & Co Basic esters of 9-pyrid (3, 4-b) indole alkanoic acid
US3015660A (en) * 1959-11-12 1962-01-02 Searle & Co 9-carboxyalkyl-9-pyrid[3, 4-b] indole piperazides
GB2111050B (en) * 1981-11-19 1985-09-11 Ciba Geigy Ag N-substituted-2-pyridylindoles
JPS6045580A (ja) * 1983-08-22 1985-03-12 Kaken Pharmaceut Co Ltd β−カルボリン誘導体
JPS6058990A (ja) * 1983-09-12 1985-04-05 Kaken Pharmaceut Co Ltd β−カルボリン誘導体
JPS60112791A (ja) * 1983-11-25 1985-06-19 Kaken Pharmaceut Co Ltd カンチン誘導体
JPS60132984A (ja) * 1983-12-22 1985-07-16 Kaken Pharmaceut Co Ltd β−カルボリン誘導体
DE3535928A1 (de) * 1985-10-04 1987-04-09 Schering Ag Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0380155A1 (en) * 1989-01-19 1990-08-01 Duphar International Research B.V 8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate

Also Published As

Publication number Publication date
DE69523961T2 (de) 2002-07-04
CA2140722A1 (en) 1995-07-25
DE69523961D1 (de) 2002-01-03
EP0667347A1 (en) 1995-08-16
JPH07206862A (ja) 1995-08-08
US5604236A (en) 1997-02-18
EP0667347B1 (en) 2001-11-21

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