ES2145971T3 - Procedimiento de preparacion de un cetal derivado de esteroide. - Google Patents
Procedimiento de preparacion de un cetal derivado de esteroide.Info
- Publication number
- ES2145971T3 ES2145971T3 ES96203367T ES96203367T ES2145971T3 ES 2145971 T3 ES2145971 T3 ES 2145971T3 ES 96203367 T ES96203367 T ES 96203367T ES 96203367 T ES96203367 T ES 96203367T ES 2145971 T3 ES2145971 T3 ES 2145971T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- cetal
- steroid
- preparation
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Abstract
LA PRESENTE INVENCION SE RELACIONA CON UN METODO DE PREPARACION DE UN DERIVADO CETAL DE UN ESTEROIDE, DE ACUERDO CON LA FORMULA GENERAL I: DONDE R{SUB,1} ES CH{SUB,3} O C{SUB,2}H{SUB,5}; R{SUB,2} ES OH; R{SUB,3} ES H, CH{SUB,3}; C=CH, CH{SUB,2}HAL, O CH{SUB,2}CN; O R{SUB,2} Y R{SUB,3} UNIDOS SON O; R{SUB,4} ES (2-5C) ALQUILENO; Y HAL ES CL, BR O I, CARACTERIZADO POR QUE EL COMPUESTO DE FORMULA II: DONDE R{SUB,1}, R{SUB,2} Y R{SUB,3} TIENEN LOS SIGNIFICADOS PREVIAMENTE INDICADOS, SE TRATA EN PRESENCIA DE UN ORTOESTER DE FORMULA III: O DE UN ORTOESTER DE FORMULA IV: DONDE R{SUB,4} TIENE EL SIGNIFICADO PREVIAMENTE INDICADO, O UNA MEZCLA DE LOS MISMOS CON UN ALCOHOL DE FORMULA GENERAL HOR{SUB,4}OH, DONDE R{SUB,4} TIENE EL SIGNIFICADO PREVIAMENTE INDICADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1001787 | 1995-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145971T3 true ES2145971T3 (es) | 2000-07-16 |
Family
ID=19761947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96203367T Expired - Lifetime ES2145971T3 (es) | 1995-11-30 | 1996-11-28 | Procedimiento de preparacion de un cetal derivado de esteroide. |
Country Status (25)
Country | Link |
---|---|
US (2) | US5955622A (es) |
EP (1) | EP0776904B1 (es) |
JP (1) | JP3984315B2 (es) |
KR (1) | KR100430312B1 (es) |
CN (1) | CN1152847C (es) |
AR (1) | AR004813A1 (es) |
AT (1) | ATE190314T1 (es) |
AU (1) | AU713688B2 (es) |
CA (1) | CA2191397C (es) |
CZ (1) | CZ293396B6 (es) |
DE (1) | DE69606957T2 (es) |
DK (1) | DK0776904T3 (es) |
ES (1) | ES2145971T3 (es) |
GR (1) | GR3033527T3 (es) |
HU (1) | HUP9603296A3 (es) |
IL (1) | IL119649A (es) |
IN (1) | IN182807B (es) |
MX (1) | MX9605981A (es) |
NO (1) | NO307887B1 (es) |
NZ (1) | NZ299836A (es) |
PL (1) | PL185112B1 (es) |
PT (1) | PT776904E (es) |
RU (1) | RU2165430C2 (es) |
TR (1) | TR199600944A1 (es) |
ZA (1) | ZA969778B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200611909A (en) * | 2004-08-04 | 2006-04-16 | Akzo Nobel Nv | Process for the preparation 2-substituted-derivatives of estrone and estradiol |
TW200613316A (en) | 2004-08-26 | 2006-05-01 | Akzo Nobel Nv | Process for the preparation of estrone and/or estradiol-derivates |
HUP0501132A2 (en) | 2005-12-05 | 2007-06-28 | Richter Gedeon Nyrt | 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production |
ITMI20062504A1 (it) | 2006-12-22 | 2008-06-23 | Antibioticos Spa | Procedimento per la preparazione di 17alfa-cianometil-17beta-idrossi steroidi |
US8673968B2 (en) * | 2009-04-06 | 2014-03-18 | Evestra, Inc. | Progesterone antagonists |
US20130041166A1 (en) | 2010-04-20 | 2013-02-14 | Lupin Limited | Process for the preparation of dienogest substantially free of impurities |
CN101863947A (zh) * | 2010-06-29 | 2010-10-20 | 沈阳药科大学 | 一种地诺孕素的合成方法 |
CN102718828A (zh) * | 2011-03-30 | 2012-10-10 | 西藏海思科药业集团股份有限公司 | 一种地诺孕素的制备方法 |
US9096641B2 (en) | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
CN104497088B (zh) * | 2014-12-30 | 2016-08-24 | 湖南新合新生物医药有限公司 | 19-去甲-4-雄甾烯-3,17-二酮的制备方法 |
CN108997463B (zh) * | 2018-08-09 | 2021-05-14 | 四川理工学院 | 一种雌甾-4,9-二烯-3,17-二酮制备方法 |
CN112409434B (zh) * | 2020-11-27 | 2021-10-26 | 厦门欧瑞捷生物科技有限公司 | 一种去氢孕酮的合成方法 |
CN113861158B (zh) * | 2021-11-22 | 2023-02-10 | 湖南新合新生物医药有限公司 | 一种合成甲基双烯双酮关键中间体的方法 |
CN114409717B (zh) * | 2021-12-17 | 2023-03-17 | 湖南科益新生物医药有限公司 | 替勃龙中间体醚化物和替勃龙的制备方法 |
CN114456223B (zh) * | 2022-01-24 | 2023-07-21 | 湖南科益新生物医药有限公司 | 3-缩酮的合成方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE632347A (es) * | ||||
DE296931C (es) | 1915-11-05 | 1917-03-06 | ||
NL123143C (es) * | 1962-03-06 | |||
NL127071C (es) * | 1964-12-31 | |||
FR2201287A1 (en) * | 1972-09-27 | 1974-04-26 | Roussel Uclaf | Epoxidation using hexafluoroacetone hydroperoxide - for treatment of unsatd. cyclic cpds esp steroids |
DE3113053A1 (de) * | 1981-04-01 | 1982-10-21 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung eines tricyclischen steroid-abbauprodukts |
US4400524A (en) * | 1981-07-28 | 1983-08-23 | The Upjohn Company | Grignard reagents prepared from 5-halopentan-2-one propylene ketals |
DE3208432A1 (de) * | 1982-03-09 | 1983-09-15 | The Upjohn Co., 49001 Kalamazoo, Mich. | Verfahren zur herstellung von 19-norandrostendion, zwischenprodukt des 19-norandrostendions und verfahren zu seiner herstellung |
HU201091B (en) * | 1985-12-26 | 1990-09-28 | Mitsubishi Chem Ind | Process for producing gonatriene derivatives and pharmaceutical compositions comprising same |
NZ232422A (en) * | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
CA2086919C (en) * | 1990-07-09 | 1998-02-24 | Gerhard Teichmuller | Process for the production of unsaturated 17.alpha.-cyanomethyl -17.beta. hydroxy steroids |
CA2100514C (en) * | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
ES2124905T3 (es) * | 1993-08-04 | 1999-02-16 | Akzo Nobel Nv | Esteroides antiglucocorticoides destinados al tratamiento de trastornos de ansiedad. |
-
1996
- 1996-11-19 IL IL11964996A patent/IL119649A/en not_active IP Right Cessation
- 1996-11-20 IN IN2069MA1996 patent/IN182807B/en unknown
- 1996-11-21 ZA ZA969778A patent/ZA969778B/xx unknown
- 1996-11-25 KR KR1019960057104A patent/KR100430312B1/ko not_active IP Right Cessation
- 1996-11-27 CA CA002191397A patent/CA2191397C/en not_active Expired - Fee Related
- 1996-11-27 NZ NZ299836A patent/NZ299836A/en unknown
- 1996-11-27 TR TR96/00944A patent/TR199600944A1/xx unknown
- 1996-11-28 AT AT96203367T patent/ATE190314T1/de not_active IP Right Cessation
- 1996-11-28 ES ES96203367T patent/ES2145971T3/es not_active Expired - Lifetime
- 1996-11-28 DE DE69606957T patent/DE69606957T2/de not_active Expired - Lifetime
- 1996-11-28 EP EP96203367A patent/EP0776904B1/en not_active Expired - Lifetime
- 1996-11-28 PL PL96317248A patent/PL185112B1/pl not_active IP Right Cessation
- 1996-11-28 DK DK96203367T patent/DK0776904T3/da active
- 1996-11-28 PT PT96203367T patent/PT776904E/pt unknown
- 1996-11-28 AU AU74041/96A patent/AU713688B2/en not_active Ceased
- 1996-11-29 AR ARP960105421A patent/AR004813A1/es active IP Right Grant
- 1996-11-29 NO NO965113A patent/NO307887B1/no not_active IP Right Cessation
- 1996-11-29 MX MX9605981A patent/MX9605981A/es not_active IP Right Cessation
- 1996-11-29 JP JP32007996A patent/JP3984315B2/ja not_active Expired - Fee Related
- 1996-11-29 HU HU9603296A patent/HUP9603296A3/hu unknown
- 1996-11-29 RU RU96123242/04A patent/RU2165430C2/ru not_active IP Right Cessation
- 1996-11-29 CZ CZ19963504A patent/CZ293396B6/cs not_active IP Right Cessation
- 1996-11-29 CN CNB961217901A patent/CN1152847C/zh not_active Expired - Lifetime
-
1998
- 1998-08-05 US US09/129,250 patent/US5955622A/en not_active Expired - Lifetime
-
1999
- 1999-01-04 US US09/224,987 patent/US6005124A/en not_active Expired - Fee Related
-
2000
- 2000-05-29 GR GR20000401218T patent/GR3033527T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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