BR9810423A - Derivados de (imidazol-5-il)metil-2-quinolinona como inibidores da proliferação das células do músculo liso - Google Patents
Derivados de (imidazol-5-il)metil-2-quinolinona como inibidores da proliferação das células do músculo lisoInfo
- Publication number
- BR9810423A BR9810423A BR9810423-3A BR9810423A BR9810423A BR 9810423 A BR9810423 A BR 9810423A BR 9810423 A BR9810423 A BR 9810423A BR 9810423 A BR9810423 A BR 9810423A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- alkyloxy
- hydrogen
- alkyloxycarbonyl
- halo
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 2
- AVGQUILLCRPWKH-UHFFFAOYSA-N 4-(1h-imidazol-5-yl)-3-methyl-1h-quinolin-2-one Chemical class C12=CC=CC=C2NC(=O)C(C)=C1C1=CN=CN1 AVGQUILLCRPWKH-UHFFFAOYSA-N 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 31
- 125000003545 alkoxy group Chemical group 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- -1 amino, hydroxycarbonyl Chemical group 0.000 abstract 3
- 230000035755 proliferation Effects 0.000 abstract 2
- POYSUXIHCXBJPN-UHFFFAOYSA-N 3-Methyl-quinolin-2-ol Chemical class C1=CC=C2NC(=O)C(C)=CC2=C1 POYSUXIHCXBJPN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE (IMIDAZOL-5-IL)METIL-2-QUINOLINONA COMO INIBIDORES DA PROLIFERAçãO DAS CéLULAS DO MúSCULO LISO"<D>. A invenção compreende o uso de compostos da fórmula (I) em que a linha pontilhada representa uma ligação opcional; X é oxigênio ou enxofre; R¹ é hidrogênio, C~ 1-12~ alquila, Ar¹, Ar² C~ 1-6~ alquila, quinolinil C~ 1-6~ alquila, piridil, C~1-6~ alquila, hidróxi C~ 1-6~ alquila, C~ 1-6~ alquilóxi C~ 1-6~ alquila, mono- ou di(C~1-6~ alquil) amino C~ 1-6~alquila, amino C~ 1-6~ alquila; ou um radical de fórmula -Alk¹-C(=O)-R^ 9^, -Alk¹-S(O)-R^ 9^ ou -Alk¹-S(O~ 2~)-R^ 9^; R², R³ e R^ 16^ são cada um independentemente hidrogênio, hidróxi, halo, ciano, C~ 1-6~ alquila, C~ 1-6~ alquilóxi, hidróxi C~ 1-6~ alquilóxi, C~ 1-6~ alquilóxi C~ 1-6~ alquilóxi, amino C~ 1-6~ alquilóxi, mono- ou di(C~ 1-6~ alquil) amino C~ 1-6~ alquilóxi, Ar¹, Ar² C~ 1-6~ alquila, Ar²óxi, Ar² C~ 1-6~ alquilóxi, hidroxicarbonila, C~ 1-6~ alquiloxicarbonila, trialometila, trialometóxi, C~ 2-6~ alquenila; R^ 4^ e R^ 5^ são cada um independentemente hidrogênio, halo, Ar¹, C~ 1-6~ alquila, hidróxi C~ 1-6~ alquila, C~ 1-6~ alquilóxi C~ 1-6~ alquila, C~ 1-6~ alquiolóxi, C~ 1-6~ alquiltio, amino, hidroxicarbonila, C~ 1-6~ alquiloxicarbonila, C~ 1-6~ alquil S(O) C~ 1-6~ alquila ou C~ 1-6~ alquil S(O)~ 2~ C~ 1-6~ alquila; R^ 6^ e R^ 7^ são cada um independetemente hidrogênio, halo, ciano, C~ 1-6~ alquila, 4,4-dimetiloxazolila C~ 1-6~ alquilóxi, ou Ar²óxi; R^ 8^ é hidrogênio, C~ 1-6~ alquila, ciano, hidroxicarbonila, C~ 1-6~ alquiloxicarbonila, C~ 1-6~ alquilcarbonil C~ 1-6~ alquila, ciano C~ 1-6~ alquila, C~ 1-6~ alquiloxicarbonil C~ 1-6~ alquila, carbóxi C~ 1-6~ alquila, hidróxi C~ 1-6~ alquila, amino C~ 1-6~ alquila, mono- ou di(C~ 1-6~ alquil) amino C~ 1-6~ alquila, imidazolila, halo C~ 1-6~ alquila, C~ 1-6~ alquilóxi C~ 1-6~ alquila, aminocarbonil C~ 1-6~ alquila ou um radical de fórmula -O-R^ 10^, -S-R^ 10^, N-R^ 11^O^ 12^; R^ 17^ é hidrogênio, halo, ciano, C~ 1-6~ alquila, C~ 1-6~ alquiloxicarbonila, Ar¹; R^ 18^ é hidrogênio, C~ 1-6~ alquila, C~ 1-6~ alquilóxi ou halo; R^ 19^ é hidrogênio ou C~ 1-6~ alquila; para a fabricação de um medicamento para a inibição da proliferação das células do músculo liso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4737697P | 1997-06-02 | 1997-06-02 | |
PCT/EP1998/003182 WO1998055124A1 (en) | 1997-06-02 | 1998-05-25 | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810423A true BR9810423A (pt) | 2000-10-03 |
Family
ID=21948611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810423-3A BR9810423A (pt) | 1997-06-02 | 1998-05-25 | Derivados de (imidazol-5-il)metil-2-quinolinona como inibidores da proliferação das células do músculo liso |
Country Status (22)
Country | Link |
---|---|
US (4) | US6365600B1 (pt) |
EP (1) | EP0988038B1 (pt) |
JP (1) | JP4209472B2 (pt) |
KR (1) | KR100517832B1 (pt) |
CN (2) | CN1231215C (pt) |
AT (1) | ATE222104T1 (pt) |
AU (1) | AU740603B2 (pt) |
BR (1) | BR9810423A (pt) |
CA (1) | CA2290992C (pt) |
DE (1) | DE69807222T2 (pt) |
DK (1) | DK0988038T3 (pt) |
ES (1) | ES2182327T3 (pt) |
HK (2) | HK1025046A1 (pt) |
ID (1) | ID24675A (pt) |
IL (1) | IL133212A (pt) |
NO (1) | NO318834B1 (pt) |
NZ (1) | NZ501401A (pt) |
PT (1) | PT988038E (pt) |
RU (1) | RU2209066C2 (pt) |
TR (1) | TR199902923T2 (pt) |
WO (1) | WO1998055124A1 (pt) |
ZA (1) | ZA984700B (pt) |
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