JP5349336B2 - Ｒｇｄを含有する組換えゼラチン - Google Patents

Ｒｇｄを含有する組換えゼラチン Download PDF

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Publication number
JP5349336B2
JP5349336B2 JP2009550599A JP2009550599A JP5349336B2 JP 5349336 B2 JP5349336 B2 JP 5349336B2 JP 2009550599 A JP2009550599 A JP 2009550599A JP 2009550599 A JP2009550599 A JP 2009550599A JP 5349336 B2 JP5349336 B2 JP 5349336B2
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gelatin
rgd
cell
cells
amino acids
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Japanese (ja)
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JP2010519252A5 (enExample
JP2010519252A (ja
Inventor
デ・ボーア，アルジョ・リサンダー
ヴァン・ユルク，ヘンドリク
ヴァン・アステン，ペーター・フランシスクス・テレシウス・マリア
ボウストラ，ジャン・バスティアン
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Fujifilm Manufacturing Europe BV
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Fujifilm Manufacturing Europe BV
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Priority claimed from EP07102839A external-priority patent/EP1961414A1/en
Priority claimed from EP07102838A external-priority patent/EP1961411A1/en
Application filed by Fujifilm Manufacturing Europe BV filed Critical Fujifilm Manufacturing Europe BV
Publication of JP2010519252A publication Critical patent/JP2010519252A/ja
Publication of JP2010519252A5 publication Critical patent/JP2010519252A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009550599A 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン Active JP5349336B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07102839A EP1961414A1 (en) 2007-02-21 2007-02-21 A controlled release composition comprising a recombinant gelatin
EP07102838A EP1961411A1 (en) 2007-02-21 2007-02-21 A controlled release composition
EP07102839.3 2007-02-21
EP07102838.5 2007-02-21
EP07116193 2007-09-12
EP07116189 2007-09-12
EP07116193.9 2007-09-12
EP07116189.7 2007-09-12
EP08100556.3 2008-01-16
EP08100556 2008-01-16
PCT/NL2008/050103 WO2008103043A1 (en) 2007-02-21 2008-02-21 Rgd containing recombinant gelatin

Publications (3)

Publication Number Publication Date
JP2010519252A JP2010519252A (ja) 2010-06-03
JP2010519252A5 JP2010519252A5 (enExample) 2011-02-03
JP5349336B2 true JP5349336B2 (ja) 2013-11-20

Family

ID=39503383

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン

Country Status (5)

Country Link
US (5) US8158756B2 (enExample)
EP (4) EP2112999B1 (enExample)
JP (4) JP5349336B2 (enExample)
AT (2) ATE554103T1 (enExample)
WO (4) WO2008103043A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE554103T1 (de) * 2007-02-21 2012-05-15 Fujifilm Mfg Europe Bv Rgd-haltige rekombinante gelatine
JP2011507507A (ja) * 2007-12-21 2011-03-10 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ マルチマー性前駆体のｉｎｖｉｖｏタンパク質分解的プロセシングによる関心対象のタンパク質の分泌収量の改善
WO2009126031A1 (en) * 2008-04-10 2009-10-15 Fujifilm Manufacturing Europe B.V. Recombinant protein enriched in a heparin binding site and/or a heparan sulfate binding site
JP2011526510A (ja) * 2008-07-04 2011-10-13 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ 医療用デバイスのコーティング方法
US20110182960A1 (en) * 2008-10-02 2011-07-28 Elisabeth Marianna Wilhelmina Maria Van Dongen Antimicrobial Coating
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
US20120101040A1 (en) * 2009-05-07 2012-04-26 Fujifilm Corporation angiogenesis inducing agent comprising recombinant gelatin
WO2010143708A1 (ja) * 2009-06-12 2010-12-16 富士フイルム株式会社 新生血管に対する標的化剤
WO2010147109A1 (ja) * 2009-06-15 2010-12-23 富士フイルム株式会社 遺伝子組み換えゼラチン及び塩基性線維芽細胞増殖因子を含む血管新生誘導剤
JP5699077B2 (ja) * 2009-07-30 2015-04-08 富士フイルム株式会社 遺伝子組み換えゼラチンを含む腎臓標的ドラッグデリバリー剤
JP5699078B2 (ja) * 2009-07-30 2015-04-08 富士フイルム株式会社 遺伝子組み換えゼラチンを含む腎臓イメージング剤
CA2773062C (en) 2009-09-04 2017-04-18 Fujifilm Corporation A bone regeneration agent comprising gelatin
JP5737597B2 (ja) * 2009-11-19 2015-06-17 浙江大学 非天然コラーゲン様タンパク質及びその応用
GB0921460D0 (en) 2009-12-08 2010-01-20 Fujifilm Mfg Europe Bv Anti-fibrotic hydrogel compositions
JPWO2011083845A1 (ja) * 2010-01-08 2013-05-16 富士フイルム株式会社 腫瘍部位に対する標的化剤
CN102858381B (zh) * 2010-03-01 2015-09-30 富士胶片株式会社 包括具有生物相容性的聚合物块和细胞的细胞构建体
EP2543398B1 (en) * 2010-03-02 2019-10-16 FUJIFILM Corporation Cell support and bone regeneration material
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
GB201014388D0 (en) 2010-08-31 2010-10-13 Fujifilm Mfg Europe Bv Biocompatible compositions for tissue augmentation
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
JP5847418B2 (ja) 2011-03-30 2016-01-20 富士フイルム株式会社 細胞接着性タンパク質
US20120263681A1 (en) 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP2012244909A (ja) * 2011-05-25 2012-12-13 Nagoya City Univ 組み換え蛋白質の製造方法及び蛋白質の導入方法
JP5990298B2 (ja) * 2011-08-31 2016-09-14 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5876787B2 (ja) * 2011-08-31 2016-03-02 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5808631B2 (ja) * 2011-09-29 2015-11-10 富士フイルム株式会社 血管新生用足場、及び再生医療用の血管の製造方法
GB201119182D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
GB201119173D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
JP5902112B2 (ja) 2012-03-12 2016-04-13 富士フイルム株式会社 骨組織修復材の製造方法
EP2902413B1 (en) 2012-09-26 2019-07-17 FUJIFILM Corporation Polypeptide, scaffold composition, composition for cartilage tissue restoration, composition for cartilage cell culture, and composition for promoting glycosaminoglycan production
CN104902934B (zh) * 2013-01-25 2017-05-10 富士胶片株式会社 移植用人工真皮及其制造方法
EP2962703B1 (en) 2013-02-27 2020-08-19 FUJIFILM Corporation Cell construct for cell transplantation, biocompatible polymer block, and method for producing the same
WO2014141877A1 (ja) 2013-03-12 2014-09-18 富士フイルム株式会社 組織修復材
GB201304947D0 (en) * 2013-03-18 2013-05-01 Cass Anthony E G Biomimetic collagen
CN105611950A (zh) 2013-09-25 2016-05-25 富士胶片株式会社 生物相容性高分子多孔体的制造方法、生物相容性高分子多孔体、生物相容性高分子块体及细胞构建体
WO2015194494A1 (ja) 2014-06-16 2015-12-23 富士フイルム株式会社 脳損傷治療用細胞構造体、その製造方法、及び脳損傷治療剤
JP6455862B2 (ja) 2015-06-25 2019-01-23 学校法人早稲田大学 コラーゲン様構造を有する重合ペプチド及びゲル
CN108025487B (zh) 2015-09-11 2020-01-17 富士胶片株式会社 明胶结构体制造方法及明胶结构体制造系统
WO2017117333A1 (en) 2015-12-30 2017-07-06 Cellular Dynamics International, Inc. Microtissue formation using stem cell-derived human hepatocytes
JP6820912B2 (ja) * 2016-03-28 2021-01-27 富士フイルム株式会社 製剤、製剤用部材およびそれらの製造方法
EP3438246B1 (en) * 2016-03-29 2020-08-26 FUJIFILM Corporation Laminate containing cell sheet, agent for treating cardiac diseases, and film for being laminated on cell sheet
WO2017170342A1 (ja) * 2016-03-29 2017-10-05 富士フイルム株式会社 細胞シート包埋剤、細胞シート含有組成物およびキット
WO2017200039A1 (ja) * 2016-05-19 2017-11-23 富士フイルム株式会社 細胞培養方法、培地及び培地キット
CN109219587B (zh) 2016-05-30 2021-09-14 富士胶片株式会社 磷酸钙成型体的制造方法、磷酸钙成型体及移植用材料
EP3470206B1 (en) 2016-06-08 2020-10-07 FUJIFILM Corporation Method for producing gelatin formed body and gelatin formed body
JP6865265B2 (ja) * 2017-03-02 2021-04-28 富士フイルム株式会社 細胞塊または細胞構造体の包埋剤、細胞塊または細胞構造体含有組成物およびキット
WO2018169061A1 (ja) 2017-03-16 2018-09-20 富士フイルム株式会社 巨核球と血小板とを分離する方法および巨核球と血小板とを分離するための器具
JP6964313B2 (ja) 2017-03-17 2021-11-10 富士フイルム株式会社 細胞構造体の製造方法
JPWO2018207923A1 (ja) * 2017-05-12 2020-03-12 富士フイルム株式会社 間葉系幹細胞の製造方法、およびその応用
EP3646899B1 (en) 2017-06-30 2024-07-31 FUJIFILM Corporation Lysosomal storage disease treatment agent
WO2019044991A1 (ja) 2017-08-30 2019-03-07 富士フイルム株式会社 血管新生剤およびその製造方法
EP3677287B1 (en) 2017-08-30 2024-05-29 FUJIFILM Corporation Cell transplantation device and method for manufacturing same
JPWO2019087650A1 (ja) * 2017-11-06 2020-11-12 富士フイルム株式会社 真珠養殖用材料及びコーティング用組成物
EP3708656A4 (en) 2017-11-10 2020-11-25 FUJIFILM Corporation METHOD OF PRODUCTION OF INSULIN-PRODUCING CELLS FROM MESENCHYMATIC STEM CELLS, INSULIN-PRODUCING CELLS, CELL STRUCTURE, AND PHARMACEUTICAL COMPOSITION
WO2019151205A1 (ja) * 2018-01-30 2019-08-08 富士フイルム株式会社 フィブリン組成物、再生医療用基材、フィブリン組成物の製造方法およびキット
JP7216735B2 (ja) * 2018-09-03 2023-02-01 富士フイルム株式会社 ゲル形成キット、ゲルおよびゲルの製造方法
CN121605944A (zh) * 2018-10-12 2026-03-06 富士胶片株式会社 珍珠养殖用材料、插核方法及珍珠养殖用材料组合物
EP4005597A4 (en) 2019-07-26 2022-11-30 FUJIFILM Corporation BIOGRAFT MATERIAL
WO2021039610A1 (ja) 2019-08-23 2021-03-04 富士フイルム株式会社 ミクロカプセルと細胞構造体とを含む組成物
EP4159916A4 (en) 2020-05-25 2023-09-06 FUJIFILM Corporation Composition, sheet-shaped molded body, artificial leather, and sheet-shaped molded body production method
GB2596525A (en) * 2020-06-26 2022-01-05 Fujifilm Corp Modified gelatins
CN117098967A (zh) 2021-03-24 2023-11-21 富士胶片株式会社 加热处理装置及加热处理物的制造方法
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JP7333121B2 (ja) 2021-08-02 2023-08-24 株式会社Rainbow 幹細胞を非凍結で保存または輸送するための方法
WO2023053710A1 (ja) 2021-09-30 2023-04-06 富士フイルム株式会社 組織修復材キット及び組織修復方法
JPWO2023188492A1 (enExample) 2022-03-30 2023-10-05
WO2024253122A1 (ja) 2023-06-06 2024-12-12 富士フイルム株式会社 遺伝子組換え酵母、目的タンパク質の製造方法、キットおよび遺伝子組換え酵母の製造方法
WO2025122874A1 (en) * 2023-12-08 2025-06-12 Bolt Threads, Inc. Recombinant silk polypeptides and compositions made thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US241032A (en) * 1881-05-03 Machine for making curved lead pipe
US68013A (en) * 1867-08-20 Es ait t aeeaft
US196496A (en) * 1877-10-23 Improvement in elevator-cups
US119170A (en) * 1871-09-19 Improvement in harvester-cutters
US114078A (en) * 1871-04-25 Improvement in valves and steam-chests for engines
US4034A (en) * 1845-05-07 Improvement in machines for breaking and cleaning hemp
US177492A (en) * 1876-05-16 Improvement in anchors
US28243A (en) * 1860-05-08 williams
US147690A (en) * 1874-02-17 Improvement in belt-fastenings
US121609A (en) * 1871-12-05 Improvement in tremolos for reed organs
US58703A (en) * 1866-10-09 Improved mop-head
US204551A (en) * 1878-06-04 Improvement in bee-hives
US229264A (en) * 1880-06-29 Recovering soda from spent liquors after treating vegetable fiber
US9580A (en) * 1853-02-08 Improvement in gas-meters
US190153A (en) * 1877-05-01 Improvement in processes of making shoes
US107666A (en) * 1870-09-27 Improvement in rollers for sewing-machines
US143568A (en) * 1873-10-14 Improvement in stays for ships sails
US31501A (en) * 1861-02-19 Fracture apparatus
US251719A (en) * 1882-01-03 Crucible
US24361A (en) * 1859-06-07 Jacob j
US64074A (en) * 1867-04-23 Thesraphic oo
US147501A (en) * 1874-02-17 Improvement in eooklnq-stoves
US106410A (en) * 1870-08-16 William f
US7991A (en) * 1851-03-18 Of beehives
US274957A (en) * 1883-04-03 Punch for nut-machines
US24346A (en) * 1859-06-07 Lock attachment
US113910A (en) * 1871-04-18 Improvement in door-locks
US167446A (en) * 1875-09-07 Improvement in refrigerators
US237663A (en) * 1881-02-08 Hydrocarbon-gas generator
US208141A (en) * 1878-09-17 Improvement in harvester guard-fingers
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5002769A (en) 1987-03-13 1991-03-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for the sustained-release of chlorhexidine
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
AU630643B2 (en) * 1988-11-09 1992-11-05 Protein Polymers Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
IL95500A (en) * 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
AU675056B2 (en) * 1991-11-12 1997-01-23 Protein Polymer Technologies, Inc. High molecular weight collagen-like protein polymers
DE4140192C2 (de) 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen
DE4210334A1 (de) 1992-03-30 1993-10-07 Stoess & Co Gelatine Biologisch abbaubares, wasserresistentes Polymer-Material
IL105529A0 (en) 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5512474A (en) 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
ATE203913T1 (de) * 1993-05-31 2001-08-15 Kaken Pharma Co Ltd Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
IL109539A0 (en) * 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
EP0986408B1 (en) 1997-06-03 2005-05-11 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
NL1007908C2 (nl) 1997-12-24 1999-06-25 Fuji Photo Film Bv Zilverhalide-emulsies met recombinant collageen die geschikt zijn voor fotografische toediening alsmede de bereiding daarvan.
US6150081A (en) * 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US20050147690A1 (en) 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US20030007991A1 (en) 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
EP1014176B1 (en) 1998-12-23 2009-04-29 FUJIFILM Manufacturing Europe B.V. Silver halide emulsions containing recombinant gelatin-like proteins
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
HK1046004B (en) 1999-11-12 2013-11-08 Fibrogen, Inc. Recombinant gelatins
US20030118598A1 (en) 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
EP1238675A1 (en) 2001-03-06 2002-09-11 Fuji Photo Film B.V. Recombinant gelatin-like proteins for use as plasma expanders
US20060024346A1 (en) 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
US20070196496A1 (en) * 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US7670839B2 (en) 2002-12-23 2010-03-02 Fuji Film Manufacturing Europe B.V. Process for coating cell-culture support
US20060147501A1 (en) 2003-02-28 2006-07-06 Hillas Patrick J Collagen compositions and biomaterials
JP4459543B2 (ja) 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
EP1862476B1 (en) 2003-03-28 2009-12-23 Fuji Film Manufacturing Europe B.V. RGD-enriched gelatine-like proteins for preventing tissue adhesion
US20050058703A1 (en) * 2003-08-01 2005-03-17 Chang Robert C. Gelatin capsules
JP2007501223A (ja) * 2003-08-05 2007-01-25 フジ フォト フィルム ビー．ブイ． 安定剤としての組換え又は合成ゼラチンのワクチン中の使用
WO2005011740A1 (en) * 2003-08-05 2005-02-10 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
US7229634B2 (en) * 2004-01-23 2007-06-12 California Institute Of Technology Engineered proteins, and methods of making and using
JP2005211477A (ja) 2004-01-30 2005-08-11 Gunze Ltd 再生医療用支持体
EP1723974A4 (en) 2004-02-25 2010-09-01 Ihara & Company Ltd COLLAGENGEL AND METHOD FOR ITS MANUFACTURE
US20070190153A1 (en) 2004-03-05 2007-08-16 Jonathan Farber Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
AU2005259789A1 (en) * 2004-06-30 2006-01-12 Covalon Technologies Inc. Non-adhesive hydrogels
US20060024361A1 (en) 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
CN101060821A (zh) * 2004-09-21 2007-10-24 麻省理工学院 梯度支架及其制备方法
CA2580357C (en) 2004-09-30 2014-01-28 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
DE602006015289D1 (de) * 2005-02-23 2010-08-19 Fujifilm Mfg Europe Bv Nicht-glycosylierte rekombinante collagen-ähnliche polypeptide
EP1863466B1 (en) * 2005-03-03 2017-08-09 Takasago International Corporation (USA) Synergistic salivation components
EP1801122A1 (en) 2005-12-23 2007-06-27 FUJIFILM Manufacturing Europe B.V. Recombinant gelatin particles for cell adhesion
ATE554103T1 (de) * 2007-02-21 2012-05-15 Fujifilm Mfg Europe Bv Rgd-haltige rekombinante gelatine

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