JP5340302B2 - キグシを含む加味雙和湯を有効成分として含有する二日酔い解消用組成物 - Google Patents
キグシを含む加味雙和湯を有効成分として含有する二日酔い解消用組成物 Download PDFInfo
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- JP5340302B2 JP5340302B2 JP2010535873A JP2010535873A JP5340302B2 JP 5340302 B2 JP5340302 B2 JP 5340302B2 JP 2010535873 A JP2010535873 A JP 2010535873A JP 2010535873 A JP2010535873 A JP 2010535873A JP 5340302 B2 JP5340302 B2 JP 5340302B2
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Description
本発明は、白芍薬10重量部に対し、キグシ10〜15重量部、熟地黄6〜17重量部、黄耆6〜17重量部、当帰6〜17重量部、センキュウ6〜17重量部、肉桂3〜14重量部、甘草3〜14重量部、生姜2〜14重量部及び大棗4〜8重量部を混合して熱水抽出した、キグシを含む加味雙和湯を含有する二日酔い解消用組成物を提供する。
さらに、本発明は、白芍薬10重量部に対し、熟地黄6〜17重量部、黄耆6〜17重量部、当帰6〜17重量部、センキュウ6〜17重量部、肉桂3〜14重量部、甘草3〜14重量部、生姜2〜14重量部及び大棗4〜8重量部を混合して熱水抽出した、雙和湯乳酸菌発酵物を含む二日酔い解消用組成物を提供する。
キグシを含む加味雙和湯の製造は、キグシ502 g、白芍薬468 g、熟地黄187 g、黄耆187 g、当帰187 g、センキュウ187 g、肉桂140 g、甘草140 g、生姜74 g及び大棗100 gを混合し、熱水抽出して雙和湯を調剤した。前記雙和湯原液10Lをガラス瓶(Pylex 19L)に投入して1M NaOHでpHを7.0に調整した後、121℃、1.5気圧下で15分間加圧滅菌した。
<2-1>乳酸菌分譲
韓国食品研究院(Korea Food Research Institute:KFRI)の食品微生物遺伝子銀行からラクトバチルス(Lactobacillus spp.)7種、韓国生命工学研究院の生物資源センター(Korean Collection for Type Cultures:KCTC)からラクトバチルス1種を分譲されて実験に利用した(表1参照)。
表1:発酵に用いられたラクトバチルス菌株
前記<2-1>で分譲された8種の菌株は、斜面培地と液体培地で継代培養して実験に利用した。具体的に、乳酸菌を斜面培地に接種して37℃のインキュベータで24時間培養した後、乳酸菌コロニーが形成されると、パラフィンフィルムで酸素を遮断して冷蔵室で保管した。このとき、乳酸菌活性が低下するか雑菌の汚染が案じられるので、乳酸菌コロニーを2〜3週に一回ずつ新しい斜面寒天培地に移した後、実験時に液体培地に接種して37℃のインキュベータで24時間培養した。
種菌培養に用いられた培地は、乳酸菌別にMRS培地(Becton Dickinson社、米国)、MRS+0.5%グルコース培地、MRS+0.5%ラクトース培地、M17培地(Becton Dickinson社、米国)又はAPT培地(Becton Dickinson社、米国)である。
雙和湯乳酸菌発酵物の製造は、白芍薬468 g、熟地黄187 g、黄耆187 g、当帰187 g、センキュウ187 g、肉桂140 g、甘草140 g、生姜74 g及び大棗100 gを混合し、熱水抽出して雙和湯を調剤した後、前記雙和湯原液10Lをガラス瓶(Pylex 19L)に投入して1M NaOHでpHを7.0に調整した。
引き続き、121℃、1.5気圧下で15分間加圧滅菌した後、常温まで冷却させて前記実施例<2-2>で予め培養した液体種菌を1%(v/v)にして接種した。37±1℃の恒温室で48時間のあいだ通気培養しながら液体発酵した。
本実験では(株)オリエント(韓国)から8週齢雄ラットを入手し、韓国韓医学研究院の動物室で2週間検疫・純化した後、それらのうち健常なラットを選んで実験に用いた。
ラットの群は、次のように分離した。先ず、純化期間中に健常であると判定されたラットの体重を測定した後、5 g間隔で区分して、平均体重に近いラットを108匹選択した。このように選択された108匹を、同じ体重のラットが各群に6匹ずつ含まれるように、順位化した体重と乱数を利用した無作為法で分配した。ラットの個体識別は、被毛の色素染色法と個体識別カード表示法で実施した。
実験Aは、二日酔い前の効能を調べる方法で、キグシを含む加味雙和湯及び雙和湯乳酸菌発酵物など試験物質(15 ml/kg)投与30分後、60%エタノールを10 ml/kg用量で経口投与した(表2参照)。エタノール投与2時間後、下大静脈から血液を採取し、次のようなアルコール脱水素酵素による酵素法で血中アルコールの含量を測定した。
ADH
エタノール+NAD+---->アセトアルデヒド+NADH+H+
生成されたNADHは、378nmでの吸光度増加で定量し、アルデヒドを捕獲する試薬及び緩衝液として1,3-ジアミノ-2-ヒドロキシプロパンを用いた。
その結果、血清内アルコールの含量が陰性対照群(267.8mg/dl)に比べSHT 9%、HST 25%、SMT 39%及びS164 26%ほど減少した(表3参照)。
表2:アルコール処理前、試験物質を処理した実験群
SHT;雙和湯投与群(Ssangwhatang)、
HST;キグシ投与群(Hovenia Semen)、
GMT;陽性対照群1、(「グッドモーニング」投与、高麗人参科学社)
CDT;陽性対照群2、(「コンディション」投与、C.J社)
YMT;陽性対照群3、(「黎明808」投与、グラミ社)、
SMT;雙和湯+30%キグシ投与群、
S164;ラクトバチルス・ファーメンタムを含む雙和湯発酵群。
a);投与量(Adimistration of the volume)
その結果、血清内アルコール含量が陰性対照群(257.7mg/dl)に比べSHT 13%、HST 9%、GMT 20%、CDT 18%、YMT 19%、SMT 29%及びS164 34%ほど減少した(表5参照)。
表4:アルコール処理後、試験物質を処理した実験群
表5:アルコール処理後、試験物質を投与したラットでアルコール分析
血液生化学的検査は、前記実験A及びBと同じ方法で実験した後、ラットの下大静脈から5 mlの血液を採取して室温で凝固させ、冷蔵庫内の遠心分離機(Avanti 30、Beckman社、米国)を用いて5000rpmで10分間遠心分離した。このうち血清を分離した後、生化学分析機(Advia 1650、Shimaz社、日本)を利用してAST(aspartate aminotransferase)、ALT(alanine aminotransferase)及びLDH(lactate dehydrogenase)の含量を測定した。
陰性対照群と試験物質投与群との間の統計学的有意差は、ダネットテスト(Dunnett test)により平均と標準偏差を求めて統計処理した(*p<0.05、**p<0.01)。
ALTは正常群で63.8 IU/Lと測定され、アルコール投与時に83.0 IU/Lに増加しており、陰性対照群に比べ試験物質(15 ml/kg)投与群でSHT 27%、HST 20%、GMT 22%、CDT 30%、YMT 30%、SMT 23%及びS164 27%それぞれ減少した。
LDH含量は、正常群に比べアルコール投与時49%増加した。アルコール処理された実験動物に試験物質を15 ml/kg経口投与時SHT 10%、GMT 27%、CDT 10%、YMT群 22%、SMT 12%及びS164 18%ほど減少した。HSTは、血清内LDH量が9%増加した(表6)。
前記の実験結果の分析によると、アルコール投与2時間後AST、ALT及びLDHの含量の変化は、アルコール投与による深刻な毒性の変化が観察されなかったが、加味雙和湯又は発酵雙和湯の投与時(15 ml/kg)に血液生化学肝毒性指標物質であるAST、ALT及びLDHの含量が減少する傾向が見られた。
表6:アルコール処理前、試験物質を投与したラットで血液生化学的検査
表7:アルコール処理後、試験物質を投与したラットで血液生化学的検査
エタノール及び試験物質単回経口投与に対する異常病変は観察されなかったが、アルコール投与による胃内出血が肉眼的に観察された。しかし、試験物質漢方製剤などを15 ml/kg投与時、アルコールによる胃内出血が減少する傾向が見られた。
<1-1>軟質カプセルの製造
実施例1又は2で製造された加味雙和湯又は雙和湯乳酸菌発酵物100.0 mg、大豆油175.0 mg、黄蝋45.0 mg、椰子硬化油127.5 mg、大豆燐脂質21.0 mg、ゼラチン212.0 mg、グリセリン(比重1.24)50.0 mg、D-ソルビトール76.0 mg、パラオキシ安息香酸メチル0.54 mg、パラオキシ安息香酸プロピル0.90 mg、メチルバニリン0.56 mg、黄色203号適量の成分が1カプセル中に含まれるように、薬局方製剤総則中軟質カプセルの製法に従って製造した。
実施例1又は2で製造された加味雙和湯又は雙和湯乳酸菌発酵物100.0 mg、トウモロコシ澱粉90.0 mg、乳糖175.0 mg、L-ヒドロキシプロピルセルロース15.0 mg、ポリビニルピロリドン5.0 mg及びエタノール適量の原料を均質に混合して湿式顆粒法で顆粒化し、ステアリン酸マグネシウム1.8 mgを加えて混合した後、1錠が400 mgになるように打錠した。
<2-1>カプセル剤の製造
実施例1又は2で製造された加味雙和湯又は雙和湯乳酸菌発酵物100.0 mg、トウモロコシ澱粉83.2 mg、乳糖175.0 mg及びステアリン酸マグネシウム1.8 mgの原料を均質に混合し、1カプセルに360 mgが含まれるように充填した。
実施例1又は2で製造された加味雙和湯又は雙和湯乳酸菌発酵物0.48〜1.28 mg、蜂蜜522 mg、チオクト酸アミド5 mg、ニコチン酸アミド10 mg、塩酸リボフラビンナトリウム3 mg、塩酸ピリドキシン2 mg、イノシトール30 mg、オロト酸50 mg及び水200 mlの組成及び含量にし、通常の方法を使用して飲料を製造した。
実施例1又は2で製造された加味雙和湯又は雙和湯乳酸菌発酵物2 g及び乳糖1 gを混合し、気密袋に充填して散剤を製造した。
Claims (8)
- 白芍薬、熟地黄、黄耆、当帰、センキュウ、肉桂、甘草、生姜及び大棗からなる雙和湯成分にキグシを混合して熱水抽出することにより製造される、キグシを含む加味雙和湯を含有する二日酔い解消用組成物。
- 白芍薬10重量部に対し、キグシ10〜15重量部、熟地黄6〜17重量部、黄耆6〜17重量部、当帰6〜17重量部、センキュウ6〜17重量部、肉桂3〜14重量部、甘草3〜14重量部、生姜2〜14重量部及び大棗4〜8重量部を混合することを特徴とする請求項1に記載の組成物。
- 前記組成物が、アルコール摂取前又は後に血液内のアルコール含量を低下させることを特徴とする請求項1又は2に記載の組成物。
- 白芍薬、熟地黄、黄耆、当帰、センキュウ、肉桂、甘草、生姜及び大棗を混合して熱水抽出した雙和湯に乳酸菌を接種して発酵させることにより製造されることを特徴とする、雙和湯乳酸菌発酵物を含む二日酔い解消用組成物。
- 白芍薬10重量部に対し、熟地黄6〜17重量部、黄耆6〜17重量部、当帰6〜17重量部、センキュウ6〜17重量部、肉桂3〜14重量部、甘草3〜14重量部、生姜2〜14重量部及び大棗4〜8重量部を混合することを特徴とする請求項4に記載の組成物。
- 乳酸菌が、ラクトバチルス・ファーメンタム(Lactobacillus fermentum)、ラクトバチルス・ガッセリー(Lactobacillus gasseri)、ラクトバチルス・カゼイ(Lactobacillus casei)、ラクトバチルス・アシドフィルス(Lactobacillus acidophilus)、ラクトバチルス・ラムノサス(Lactobacillus rhamnosus)からなる群より選択されることを特徴とする請求項4又は5に記載の組成物。
- 乳酸菌が、ラクトバチルス・ファーメンタムであることを特徴とする請求項4〜6のいずれか1項に記載の組成物。
- 前記組成物が、アルコール摂取前又は後に血液内のアルコール含量を低下させることを特徴とする請求項4〜7のいずれか1項に記載の組成物。
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PCT/KR2008/006920 WO2009069921A2 (en) | 2007-11-30 | 2008-11-24 | Composition for alleviation of alcohol induced hangover comprising hovenia dulcis thunberg contained ssangwhatang |
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KR102561015B1 (ko) * | 2016-06-29 | 2023-07-31 | 주식회사 농업회사법인비엔케어 | 프로폴리스를 이용한 숙취해소 음료 제조방법 |
CN106501434B (zh) * | 2016-12-30 | 2018-06-05 | 天津同仁堂集团股份有限公司 | 一种双和汤标准汤的hplc指纹图谱测定方法 |
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JP2019011279A (ja) * | 2017-06-30 | 2019-01-24 | 小林製薬株式会社 | 下痢抑制剤 |
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CN109222089A (zh) * | 2018-10-18 | 2019-01-18 | 上海梵怡生物科技有限公司 | 一种含米糠脂肪烷醇的解酒护肝组合物及制备方法 |
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CN111956774A (zh) * | 2020-09-01 | 2020-11-20 | 想象之上(北京)科技有限公司 | 一种天然本草健康饮品元气汤 |
KR102454128B1 (ko) * | 2021-10-29 | 2022-10-14 | (주)메디프레소 | 미생물의 세포벽 파괴 및 동결건조를 통해 유효성분의 함량 및 보존성을 향상시킨 캡슐 음료용 조성물의 제조방법 |
CN114514973B (zh) * | 2022-02-17 | 2023-09-05 | 华南农业大学 | 一种具有醒酒护肝功效的葛根复合发酵饮料的制备方法 |
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