CN110604800A - 一种戒酒解酒护肝植物饮品及制备方法 - Google Patents
一种戒酒解酒护肝植物饮品及制备方法 Download PDFInfo
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Abstract
本发明涉及一种戒酒解酒护肝植物饮品及制备方法,其原料包括附子、白术、党参、葛根、白菜子、猪肝粉、白茶、百合、甘草、蛹虫草、白果、黄精、水飞蓟素、罗汉果、黑桑葚、枳椇子、姜黄萃取物、圆酵母提取物份、二氢杨梅树皮素、醋酸菌,诸药配伍,共呈戒酒解酒、理气健脾之功。药理学试验表明,本申请的组合物可延长小鼠醉酒潜伏时间,缩短小鼠醉酒时间,降低肝内丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和丙二醛(MDA)水平,提高谷胱甘肽过氧化物酶(GSH‑PX)和乙醇脱氢酶(ADH)的活性,具有优异的解酒护肝效果,同时本发明对戒酒的也具有良好效果。
Description
技术领域
本申请涉及特膳食品技术领域,具体涉及一种戒酒解酒护肝植物饮品及制备方法。
背景技术
中国是酒类消费大国。适度饮酒能活血通络散寒,有益身体健康,但过度饮酒则会对 身体造成诸多伤害。过度饮酒除了会出现头晕头胀、呕吐、口干、胃出血等急性不适症状外,长期酗酒还会导致一些器质性变化,对肝脏和胃肠道的损伤尤为明显,如使干细胞发生脂肪变性、炎性坏死和纤维化,最终导致酒精性肝病,包括酒精性肝炎、酒精性脂肪肝、酒精性肝硬化、肝衰竭,最严重者可导致肝癌和胃癌等。
西医解酒主要采用利尿和对症处理的方法(如纳洛酮),这类药物对于急性酒精中毒有一定的疗效,但对于慢性酒精中毒引起的脏器组织病理改变——特别是对于肝损伤——则收效甚微。
中医解酒辨证论治,针对病人饮酒过量,损伤脏腑的病因病机,采取相应的治法,确定方药,较单纯的解酒药解酒效果更佳,且对于治疗长期过量饮酒导致的慢性中毒病证——特别是肝损伤——具有较好的效果。我国中药资源丰富,研究开发具有解酒护肝作用的中药组合物具有广阔的市场前景。
宋歌等,古代解酒方用药统计分析[J],时珍国医国药,2009,20(1):216~217,统计分析指出,酒方中常用解酒单味药主要有甘草、陈皮、葛根、茯苓、砂仁、人参、生姜、木香、白术、自蔻仁、半夏、丁香、神曲、葛花、黄连等,其中砂仁、白蔻仁、葛花、木香、
丁香共奏芳香化湿、解酒行气之效,人参、白术、茯苓有淡渗利湿、醒酒健脾之效,半夏、神曲、生姜、黄连配伍成解酒和胃、清热燥湿之效。另有葛根、陈皮、甘草可在解酒方中普遍适用。
章文炽等,枳葛饮解酒作用的实验观察[J],中国医院药学杂志,1994,14(3):137~ 137 公开了一种具有解酒作用的中药复方,其由枳椇子、葛根、枸杞和山楂按重量比 1∶1∶ ∶0.4 进行组方,在临床过程中该复方可以明显减轻醉酒症状。
CN103285252A 公开了一种解酒护肝口服液,其由葛根 5~15 份,枳椇子 5~15份,人参 0.5~5 份,白茅根 2~10 份,山楂 0~5 份,黄精 0~3 份,葛花 0~15 份,葡萄糖 3~ 20 份,木糖醇 1~10 份,L~阿拉伯糖 1~5 份,牛磺酸 0.2~1.0 份,谷氨酰胺 0~0.5 份, 抗性糊精 0~5 份,复合维生素 0~1 份,复合氨基酸 0~2 份制成。动物实验和临床初步测试表明该口服液具有一定的解酒保肝作用。
CN104288652A 公开了一种具有解酒保健功效的中药组合物,主要由如下重量份的原料制备而成:附子 1~5 份、白术 3~9 份、党参 5~15 份、葛根 10~30 份、白菜子5~15 份、猪肝粉 5~15 份、白茶 10~35 份、百合 5~15 份、甘草 10~35 份,蛹虫草 5~25 份,白果5~20 份,黄精 5~35 份,水飞蓟素 5~25 份、罗汉果 20~50 份、黑桑葚10~30 份、枳椇子5~15 份、姜黄萃取物 1~5 份、圆酵母提取物 0.5~3 份、二氢杨梅树皮素 0.5~5 份、醋酸菌 0.5~5 份。动物实验表明该口服液具有一定的解酒保肝作用。
发明内容
本发明目的是为了解决现有问题,提供一种一种戒酒解酒护肝植物饮品及制备方法: 其原料由以下重量份组成:附子 1~5 份、白术 3~9 份、党参 5~15 份、葛根 10~30 份、白菜子 5~15 份、猪肝粉 5~15 份、白茶 10~35 份、百合 5~15 份、甘草 10~35 份,蛹虫草 5~25 份,白果 5~20 份,黄精 5~35 份,水飞蓟素 5~25 份、罗汉果 20~50 份、黑桑葚10~30 份、枳椇子 5~15 份、姜黄萃取物 1~5 份、圆酵母提取物 0.5~3 份、二氢杨梅树皮素 0.5~5 份、益生菌 1~10 份。
其制备方法为:
步骤(1):将以上各原料,加入 70~90%的乙醇水溶液,加热回流 3~5 次,每次 0.5~2 小时,过滤,合并滤液,得醇提取液;
步骤(2):向步骤(1)所得渣中加入水,煎煮提取 1~3 次,每次 0.5~2 小时,过滤,合并滤液,得水提取液;
步骤(3):将步骤(1)的醇提取液与步骤(2)的水提取液合并; 步骤(4):将益生菌,圆酵母提取物、二氢杨梅树皮素接种到步骤(3)的合并液中进行发酵,发酵的温度为 30~50℃,且发酵时间为 18~20 小时,发酵后得到发酵原液,发酵原液的 pH 值为 3.5~5.5。
步骤(5):将步骤(4)发酵原液采用频率为 30~40kHz 的超声波进行处理,经过10~ 20s,发酵结束后采用 0.45~0.85μm 的滤膜过滤,减压浓缩得到饮品浸膏;
步骤(6):将步骤(5)所得浸膏加入食品标准规定的可接受的辅料,按药剂学上的常规方法制成制剂,即得。
所述组合物为片剂、粉剂、颗粒剂、胶囊剂、丸剂或口服液。
所述的益生菌为干酪乳杆菌菌粉 5%~10%、酿酒酵母菌粉 5%~10%、植物乳杆菌菌粉4%~8%、嗜酸乳杆菌菌粉5%~10%、巴氏醋杆菌菌粉10%~15%、嗜热链球菌粉10%~ 20%、保加利亚乳杆菌粉 5%~10%、鼠李糖乳杆菌 5%~10%、醋酸杆菌粉15%~30%、麦芽汁发酵醋酸菌粉 10%~20%、速酿醋酸菌粉 5%~15%、木醋杆菌粉10%~20%、丙酸杆菌粉 7%~15%、粪肠球菌粉 8%~15%、纳豆枯草粉 6%~12%。
优选地,步骤(1)中所用的乙醇水溶液的浓度为 60%。
优选地,所述步骤(1)和步骤(2)各提取 2 次,每次各 1 小时。
所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 6~10 倍;步骤(2)中水的加入量为各原料总重量的 6~10 倍。
优选地,所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 8 倍;步骤(2)中水的加入量为各原料总重量的 8 倍。
所述的组合物在制备解酒护肝食品中的应用。
本申请所述组合物中各原料的药性及组方原则如下: 本申请组合物针对戒酒和解酒而设。
ADH(乙醇脱氢酶),是分解酒精的酶,ALDH(乙醛脱氢酶)是分解乙醛的酶,进入体内的酒精 80~90%都由肝脏中的 ADH(乙醇脱氢酶)和 ALDH(乙醛脱氢酶)来进行分解代谢; 体内 ADH(乙醇脱氢酶)和 ALDH(乙醛脱氢酶)不足时,会诱发脸红、酒精中毒等症状。醋酸菌发酵产生的 ADH 和 ALDH 可以快速解酒。
本发明中姜黄提取物,圆酵母提取物,可以帮助缓解酒后宿醉所产生的胃酸过多,恶心想吐等不适感,强化肝功能,加速酒精的代谢,提升体内的抗氧化能力;二氢杨梅树皮素实现解酒、醒酒及缓解醇中毒的功能。
酒属于本寒标热。当喝了酒以后,身体疏泄的力量加强,会发热,面部发红、出汗等。发热过去以后留给体内的是寒,表现出来的是为标、是热,留在体内的反而是一种阴寒的东西。一些人喝酒时间长了之后,就会发现他的脸色会变暗,脸色发暗的时候就说明我们体内的热走了,留下的是寒冷的东西,这种寒冷的东西恰恰就是我们继续想喝酒的原因。酒瘾只是留在我们体内的寒,我们感觉到不舒服。为了消除这种不舒服的寒,只能等 到下一次喝酒的时候,喝下酒去以后,他的标热又表现出来,此时血脉流通速度加快,疏泄的力量加强,这时候把这个寒又带得运转起来,我们人体对这种舒畅、通畅的感觉非常愉悦。
所以喝酒后再次喝酒的时候,寒又运转了,但是反复的喝酒、热散掉、寒停留在体内的过程中间,在体内就会留下越来越深的阴寒的东西。这种寒如果不把它消除掉的话,就会成为一个有瘾的瘾君子。
在喝酒之前用附子、白术、党参、葛根、白菜子、猪肝粉、白茶、百合、甘草、蛹虫草、白果、黄精、水飞蓟素、罗汉果、黑桑葚、枳椇子组合物的药物,用上一个阶段后,体内的寒依赖于附子、干姜,同时白术、党参、甘草属于调理脾胃的药物,就把体内的寒气拔出来、散掉。体内如果没有这种寒气的话,那么他就不会有瘾了。人脾胃功能的强弱、湿气的大小决定了酒量的大小;如果人体内没有寒、没有湿,那么对酒的运化能力也会加强。
本发明产品组合物注重在平时用,不仅能戒酒、解酒,而更侧重在喝完酒之后造成的这种阴寒停留在体内的危害通过本产品将阴寒解除掉。
本发明有益效果:
本发明组合物采用药食同源原料合理配比而成,组方合理,配伍得当,通过实验,可显著延长小鼠醉酒潜伏时间,缩短小鼠醉酒时间,降低血液中的乙醇含量,降低肝内丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和丙二醛(MDA)水平,提高谷胱甘肽过氧化物酶(GSH~PX)和乙醇脱氢酶(ADH)的活性,具有优异的解酒护肝效果。同时,本发明对戒酒的也具有良好效果。
具体实施方式
实施例 1
本实施例提供一种戒酒解酒护肝植物饮品及制备方法,其特征在于:其原料由以下重量份组成:附子 1 份、白术 3 份、党参 5 份、葛根 10 份、白菜子 5 份、猪肝粉 5 份、白茶 10份、百合 5 份、甘草 10 份,蛹虫草 5 份,白果 5 份,黄精 5 份,水飞蓟素 5 份、罗汉果 20份、黑桑葚 10 份、枳椇子 5 份、姜黄萃取物 1 份、圆酵母提取物 0.5 份、二氢杨梅树皮素0.5份、益生菌 1 份。其制备方法为:
步骤(1):将以上各原料,加入 70%的乙醇水溶液,加热回流 1 次,每次 0.5 小时,过滤,合并滤液,得醇提取液;
步骤(2):向步骤(1)所得渣中加入水,煎煮提取 1 次,每次 0.5 小时,过滤,合并滤液,得水提取液;
步骤(3):将步骤(1)的醇提取液与步骤(2)的水提取液合并; 步骤(4):将圆酵母提取物、二氢杨梅树皮素接种到步骤(3)的合并液中进行发酵,发酵的
温度为 30℃,且发酵时间为 18 小时,发酵后得到发酵原液,发酵原液的 pH 值为3.5。
步骤(5):将步骤(4)发酵原液采用频率为 30kHz 的超声波进行处理,经过 10s,发酵结束后采用 0.45μm 的滤膜过滤,减压浓缩得到饮品浸膏;
步骤(6):将步骤(5)所得浸膏加入食品标准规定的可接受的辅料,按药剂学上的常规方法制成制剂,即得。
所述组合物为片剂。
所述的益生菌为干酪乳杆菌菌粉 5%、酿酒酵母菌粉 5%、植物乳杆菌菌粉 4%、嗜酸乳杆菌菌粉 7%、巴氏醋杆菌菌粉 10%、嗜热链球菌粉 12%、保加利亚乳杆菌粉7%、鼠李糖乳杆菌 8%、醋酸杆菌粉 15%、麦芽汁发酵醋酸菌粉 13%、速酿醋酸菌粉11%、木醋杆菌粉 15%、丙酸杆菌粉 10%、粪肠球菌粉 10%、纳豆枯草粉 8%。
步骤(1)中所用的乙醇水溶液的浓度为 60%。
所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 6 倍;步骤(2)中水的加入量为各原料总重量的 6 倍。
所述的组合物在制备解酒护肝食品中的应用。 实施例 2
本发明提供一种戒酒解酒护肝植物饮品及制备方法,其原料由以下重量份组成:附子3份、白术 6 份、党参 10 份、葛根 20 份、白菜子 10 份、猪肝粉 10 份、白茶 20 份、百合10份、甘草 20 份,蛹虫草 15 份,白果 15 份,黄精 20 份,水飞蓟素 15 份、罗汉果 22份、黑桑葚 18 份、枳椇子 9 份、姜黄萃取物 2 份、圆酵母提取物 1.5 份、二氢杨梅树皮素 1.5 份、益生菌 5 份。
其制备方法为:
步骤(1):将以上除了圆酵母提取物、二氢杨梅树皮素的各原料,加入 80%的乙醇水溶液,加热回流 4 次,每次 1.5 小时,过滤,合并滤液,得醇提取液;
步骤(2):向步骤(1)所得渣中加入水,煎煮提取 2,每次 1 小时,过滤,合并滤液,得水提取液;
步骤(3):将步骤(1)的醇提取液与步骤(2)的水提取液合并;
步骤(4):将圆酵母提取物、二氢杨梅树皮素、醋酸菌接种到步骤(3)的合并液中进行发酵,发酵的温度为 40℃,且发酵时间为 19 小时,发酵后得到发酵原液,发酵原液的 pH值为 4.5;
步骤(5):将步骤(4)发酵原液采用频率为 35kHz 的超声波进行处理,经过 15s,发酵结束后采用 0.65μm 的滤膜过滤,减压浓缩得到饮品浸膏; 步骤(6):将步骤(5)所得浸膏加入食品标准上可接受的辅料,按药剂学上的常规方法制成制剂,即得。
所述解酒饮品为粉剂。
所述的益生菌为干酪乳杆菌菌粉 5%、酿酒酵母菌粉 6%、植物乳杆菌菌粉 5%、嗜酸乳杆菌菌粉 9%、巴氏醋杆菌菌粉 12%、嗜热链球菌粉 11%、保加利亚乳杆菌粉6%、鼠李糖乳杆菌 7%、醋酸杆菌粉 17%、麦芽汁发酵醋酸菌粉 15%、速酿醋酸菌粉13%、木醋杆菌粉 17%、丙酸杆菌粉 10%、粪肠球菌粉 10%、纳豆枯草粉 8%。
所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 8 倍;步骤(2)中水的加入量为各原料总重量的 8 倍。
所述的解酒饮品在制备解酒护肝食品中的应用。 实施例 3
本发明提供一种戒酒解酒护肝植物饮品及制备方法,其特征在于:其原料由以下重量份的原料组成:附子 5 份、白术 9 份、党参 15 份、葛根 30 份、白菜子 15 份、猪肝粉 15份、白茶 35 份、百合 15 份、甘草 35 份,蛹虫草 25 份,白果 20 份,黄精 35 份,水飞蓟素 25 份、罗汉果 50 份、黑桑葚 30 份、枳椇子 15 份、姜黄萃取物 5 份、圆酵母提取物3 份、二氢杨梅树皮素 5 份、益生菌 10 份。其制备方法为:
步骤(1):将以上除了圆酵母提取物、二氢杨梅树皮素的各原料,加入 90%的乙醇水溶液,加热回流 5 次,每次 2 小时,过滤,合并滤液,得醇提取液;
步骤(2):向步骤(1)所得渣中加入水,煎煮提取 3 次,每次 2 小时,过滤,合并滤液,得水提取液;
步骤(3):将步骤(1)的醇提取液与步骤(2)的水提取液合并;
步骤(4):将圆酵母提取物、二氢杨梅树皮素、醋酸菌接种到步骤(3)的合并液中进行发酵,发酵的温度为 50℃,且发酵时间为 20 小时,发酵后得到发酵原液,发酵原液的 pH值为 5.5;
步骤(5):将步骤(4)发酵原液采用频率为 40kHz 的超声波进行处理,经过 20s,发酵结束后采用 0.85μm 的滤膜过滤,减压浓缩得到饮品浸膏;
步骤(6):将步骤(5)所得浸膏加入食品标准上可接受的辅料,按药剂学上的常规方法制成制剂,即得。
所述解酒饮品为颗粒剂。
所述的益生菌为干酪乳杆菌菌粉 10%、酿酒酵母菌粉 10%、植物乳杆菌菌粉8%、嗜酸乳杆菌菌粉 10%、巴氏醋杆菌菌粉 15%、嗜热链球菌粉 20%、保加利亚乳杆菌粉 10%、鼠李糖乳杆菌 10%、醋酸杆菌粉 30%、麦芽汁发酵醋酸菌粉 20%、速酿醋酸菌粉 15%、木醋杆菌粉 20%、丙酸杆菌粉 15%、粪肠球菌粉 15%、纳豆枯草粉 12%。步骤(1)中乙醇水溶液的加入量为各原料总重量的 10 倍;步骤(2)中水的加入量为各原料总重量的 10 倍。 所述的解酒饮品在制备戒酒解酒护肝食品中的应用。
对比试验:将组合中的附子、白术、党参、二氢杨梅树皮素、醋酸菌去掉,其余同实施例 2.
试验一:动物试验
实验材料:实验动物为昆明种成年 SPF 级健康小鼠,雄性,体重约 18~22g。56 度牛栏山二锅头,去离子水,乙醇脱氢酶(ADH)试剂盒,丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)试剂盒,丙二醛(MDA)试剂盒,谷胱甘肽过氧化物酶(GSH~PX)等。
受试物为按照制备例 2 制备的提取物混合物(即加入辅料之前的各原料的提取物的混合物);正常对照组给予生理盐水;阳性对照为海王金樽对照。
本发明组合物溶液的制备:将按照制备例 1 制备的提取物混合物(即加入辅料之前的各原料的提取物的混合物)溶解于去离子水中,制成 100mg/ml 的本申请的溶液。
海王金樽溶液的制备:将海王金樽片粉碎,溶解于去离子水中,制成 100mg/ml 的海王金樽溶液。
给食剂量:本申请的组合物的中等给食剂量(即中剂量)为 0.15ml/10g/天的上述组合物溶液,2 倍的中剂量为高剂量,0.5 倍的中剂量为低剂量。海王金樽对照组的给食剂量为0.15ml/10g/天的上述海王金樽溶液,对照组的给食剂量为 0.15ml/10g/天的上述对照组合物溶液。
试验例 1:小鼠醒酒试验
取 70 只昆明种小鼠,随机分成正常对照组、模型组、海王金樽对照组、对照组、本申请的高、中和低剂量组 3 组,共 7 组,每组各 20 只小鼠。实验前动物禁食不禁水 12 小时。正常对照组和模型组给予 0.15ml/10g 体重的生理盐水,高剂量组给予 0.3ml/10g 体重的上述本申请的组合物溶液,中剂量组给予 0.15ml/10g 体重的上述本申请的组合物溶液,低剂量组给予 0.06ml/10g 体重的上述本申请的组合物溶液,海王金樽对照组给予0.15ml/10g 体重的上述海王金樽溶液,对照组给予 0.15ml/10g 体重的上述对照组合物溶液。给药或给予生理盐水后 30 分钟后,正常对照组灌胃给予 0.15ml/10g 体重的生理盐水,其余各组灌胃给予 0.15ml/10g 体重的 56 度牛栏山二锅头。观察小鼠的活动状况和翻正反射情况。将小鼠背向下轻轻放在动物笼中,若小鼠保持背向下的姿势 30 秒以上,则认为翻正反射消失,即醉酒,醉酒后如果翻正反射恢复即为醒酒。记录每组小鼠的给酒时间、醉酒小鼠的只数、翻正反射消失时间以及翻正反射恢复时间。
按以下公式计算醉酒潜伏期和醉酒时间:
醉酒潜伏期(也称醉酒耐受时间)=翻正反射消失时间~给酒时间。醉酒时间=翻正反射恢复时间~翻正反射消失时间。
整个实验过程中未观察到小鼠死亡。实验指标采用 SPSS 软件中的 t 检验进行处理,数据以 X±S 表示,p<0.05 和 p<0.01 表示差异有统计学意义。
各组小鼠的醉酒例数、醉酒潜伏期和醉酒时间如下面的表 1 所示。表 1:各组小鼠的醉酒例数、醉酒潜伏期和醉酒时间(n=10, X±S)
组别 | 醉酒例数(只) | 醉酒潜伏期(min) | 醉酒时间(min) |
正常对照组 | 20 | —— | —— |
模型组 | 20 | 7.91±1.78 | 469.91±19.79 |
高剂量组 | 16 | 42.49±2.16** | 205.21±19.83 |
中剂量组 | 18 | 42.17±2.96** | 214.38±22.67 |
低剂量组 | 18 | 38.12±1.76** | 315.19±29.31 |
海王金樽对照组 | 20 | 22.17±2.49* | 315.76±33.14 |
注:*表示与模型组相比,p<0.05;**表示与模型组相比,p<0.01。
由表 1 中的结果可以看出,与模型组相比,本申请的组合物高、中和低剂量组均能显著缩短急性酒精中毒小鼠的醉酒时间(p<0.01),且能延长小鼠的醉酒潜伏期(p<0.01)并减少小鼠醉酒数量。在延长醉酒潜伏期和缩短醉酒时间方面,本申请的组合物高、中和低剂量组的效果优于海王金樽对照组。
试验二:人体戒酒试验
试验方法:将 100 位重度依赖饮酒的人士随机分为两组,每组 50 位。 其中一组服用本发明实施例 2 制备的戒酒解酒组合物;另外一组服用对比例 1。观察每组患者对酒精依赖性的改善状况。
用法用量:每人每次三片,一天二次,连续服用二个月。
试验结果:服用对比例制备的戒酒组合物的只有 10 人摆脱酒精依赖,有效率20%;服用本发明实施例 2 制备的戒酒组合物的 35 人摆脱酒精依赖,有效率 70%。
以上仅是本发明的优选实施方式,应当指出的是,上述优选实施方式不应视为对本发明的限制,本发明的保护范围应当以权利要求所限定的范围为准。对于本技术领域的普通技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (8)
1.一种戒酒解酒护肝植物饮品及制备方法,其特征在于:其原料由以下重量份组成:附子 1~
5 份、白术 3~9 份、党参 5~15 份、葛根 10~30 份、白菜子 5~15 份、猪肝粉 5~15 份、白茶 10~35 份、百合 5~15 份、甘草 10~35 份,蛹虫草 5~25 份,白果 5~20份,黄精 5~ 35 份,水飞蓟素 5~25 份、罗汉果 20~50 份、黑桑葚 10~30 份、枳椇子5~15 份、姜黄萃取物 1~5 份、圆酵母提取物 0.5~3 份、二氢杨梅树皮素 0.5~5 份,益生菌 1~10 份。其制备方法为:
步骤(1):将以上各原料,加入 70~90%的乙醇水溶液,加热回流 3~5 次,每次 0.5~2 小时,过滤,合并滤液,得醇提取液;
步骤(2):向步骤(1)所得渣中加入水,煎煮提取 1~3 次,每次 0.5~2 小时,过滤,合并滤液,得水提取液;
步骤(3):将步骤(1)的醇提取液与步骤(2)的水提取液合并;
步骤(4):将益生菌,圆酵母提取物、二氢杨梅树皮素接种到步骤(3)的合并液中进行发酵,发酵的温度为 30~50℃,且发酵时间为 18~20 小时,发酵后得到发酵原液,发酵原液的 pH 值为 3.5~5.5。
步骤(5):将步骤(4)发酵原液采用频率为 30~40kHz 的超声波进行处理,经过 10~20s, 发酵结束后采用 0.45~0.85μm 的滤膜过滤,减压浓缩得到饮品浸膏;
步骤(6):将步骤(5)所得浸膏加入食品标准规定的可接受的辅料,按药剂学上的常规方法 制成制剂,即得。
2.根据权利要求 1 所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,所述组合物为片剂、粉剂、颗粒剂、胶囊剂、丸剂或口服液。
3. 根据权利要求 1 所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,所述的益生菌为干酪乳杆菌菌粉 5%~10%、酿酒酵母菌粉 5%~10%、植物乳杆菌菌粉 4%~8%、嗜酸乳杆菌菌粉 5%~10%、巴氏醋杆菌菌粉 10%~15%、嗜热链球菌粉 10%~20%、保加利亚乳杆菌粉 5%~10%、鼠李糖乳杆菌 5%~10%、醋酸杆菌粉 15%~30%、麦芽汁发酵醋酸菌粉10%~20%、速酿醋酸菌粉 5%~15%、木醋杆菌粉 10%~20%、丙酸杆菌粉 7%~15%、粪肠球菌粉 8%~15%、纳豆枯草粉 6%~12%。
4. 根据权利要求 1 所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,步骤(1)中所用的乙醇水溶液的浓度为 60%。
5. 根据权利要求 1 所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,所述步骤(1)和步骤(2)各提取 2 次,每次各 1 小时。
6. 根据权利要求 1 所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 6~10 倍;步骤(2)中水的加入量为各原料总重量的6~10 倍。
7. 根据权利要求 1所述的戒酒解酒护肝植物饮品及制备方法,其特征在于,所述步骤(1)中乙醇水溶液的加入量为各原料总重量的 8 倍;步骤(2)中水的加入量为各原料总重量的 8 倍。
8. 根据权利要求 1~7中任一项所述的组合物在制备解酒护肝食品中的应用。
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CN115364128A (zh) * | 2022-10-21 | 2022-11-22 | 北京本草源生物科技有限公司 | 含锌组合物及其护肝酒、应用 |
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