WO2009069921A2 - Composition for alleviation of alcohol induced hangover comprising hovenia dulcis thunberg contained ssangwhatang - Google Patents
Composition for alleviation of alcohol induced hangover comprising hovenia dulcis thunberg contained ssangwhatang Download PDFInfo
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- WO2009069921A2 WO2009069921A2 PCT/KR2008/006920 KR2008006920W WO2009069921A2 WO 2009069921 A2 WO2009069921 A2 WO 2009069921A2 KR 2008006920 W KR2008006920 W KR 2008006920W WO 2009069921 A2 WO2009069921 A2 WO 2009069921A2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 206010019133 Hangover Diseases 0.000 title claims abstract description 19
- 244000010000 Hovenia dulcis Species 0.000 title claims description 4
- 235000008584 Hovenia dulcis Nutrition 0.000 title claims description 4
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- 241000186660 Lactobacillus Species 0.000 abstract description 48
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- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 2
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- FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 description 1
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- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- YXJHJCDOUFKMBG-BMZHGHOISA-M riboflavin sodium Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)[N-]C2=O YXJHJCDOUFKMBG-BMZHGHOISA-M 0.000 description 1
- 239000009536 samultang Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Definitions
- the present invention relates to a composition that alleviates alcohol induced hangover which comprises flavored Ssangwhatang including Hoveniae Semen(Hovenia dulcis Thunberg) or lactobacillus fermented Ssangwhatang as an effective ingredient.
- Ssangwhatang which is also known as Ssangwhasan, is described in the "weakness and fatigue” item of the “various disease” chapter of Dongeuibogam as a prescription for relief from fatigue. Ssangwhatang is obtained by adding Samultang (including
- Ssangwhatang is used by people who feel fatigued, people with blood disorders, people who feel weak after a serious illness, people lacking in energy, and people who has a lot of sweat.
- Ssangwhatang include medicinal herbs such as Paeoniae Radix
- Cinnamomi Ramulus activates functions of stomach and intestines, and is useful when digestive organs are cold to cause indigestion or when a belly is cold to cause a bellyache and diarrhea.
- Angelicae Gigantis Radix has been known for being effective in accelerating blood circulation, preventing cancer, reducing blood pressure, alleviation of pain and spasms, constipation relief through stimulation of large intestine movement, and removal of extravastated blood.
- Paeoniae Radix Alba mitigates excessive tension of nerves or muscles so as to stop the pain, nourishes blood, and alleviates pain.
- Rehmanniae Radix Preparat is effective in nourishing blood.
- Astragali Radix which has been used to supplement energy along with ginseng, stops cold sweats and cures swellings.
- Cnidii Rhizoma helps blood circulation and alleviates pain so that it is widely used in treatment of headaches. It also activates the function of the liver and bowels, and has a hematogenous function when it is used to cure anemia.
- Dried Zingiberis Rhizoma Crudus is used to treat indigestion, emesis and diarrhea and accelerate blood circulation.
- Jujubae Fructus strengthens the stomach and intestines, helps circulation of energy and blood, eases the stomach, protects the spleen, cures lack of energy, and harmonizes the properties of various drugs. Meanwhile, as for techniques to obtain effective medicines for humans by adding microorganisms to medicinal herbs and fermenting the resulting mixture, Korean Patent Registration No.
- the present inventors treated alcohol in a rat, and administered lactobacillus fermented Ssangwhatang or flavored Ssangwhatang including Hoveniae Semen of the present invention before and after hangover so as to confirm whether the hangover was relieved.
- Various embodiments of the present invention are directed at providing a composition to alleviate alcohol induced hangover that comprises flavored Ssangwhatang containg Hoveniae Semen or lactobacillus fermented Ssangwhatang as an effective ingredient.
- the present invention provides a composition for alleviation of alcohol induced hangover comprising flavored Ssangwhatang including Hoveniae Semen, wherein the flavored Ssangwhatang is produced by adding Hoveniae Semen to Ssanwhatang consisting of Paeoniae Radix Alba(Paeonia japonica), Rehmanniae Radix Preparat(Rehmannia glutinosa), Astragali Radix(Astragalus membranaceus), Angelicae Gigantis Radix(Angelica gigas), Cnidii Rhizoma(Cnidium officinale), Cinnamomi Ramulus(Cinnamonus cassia), Glycyrrhizae Radix(Glycyrrhiza uralensis), Zingiberis Rhizoma Crudus(Zingiber officinale) and Jujubae Fructus(Zizyphus
- the composition consists of Hoveniae Semen 10-15 parts by weight, Rehmanniae Radix Preparat 6-17 parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
- the present invention provides a composition for alleviation of alcohol induced hangover comprising lactobacillus fermented Ssangwhatang, wherein the fermented Ssangwhatang is produced by inoculating lactobacillus in hot water-extracted Ssangwhatang consisting of Paeoniae Radix Alba, Rehmanniae Radix Preparat, Astragali Radix, Angelicae Gigantis Radix, Cnidii Rhizoma, Cinnamomi Ramulus, Glycyrrhizae Radix, Zingiberis Rhizoma Crudus and Jujubae Fructus.
- lactobacillus fermented Ssangwhatang wherein the fermented Ssangwhatang is produced by inoculating lactobacillus in hot water-extracted Ssangwhatang consisting of Paeoniae Radix Alba, Rehmanniae Radix Preparat, Astragali Radix, Angelicae Gigantis Radix, Cnidii Rh
- the composition consists of Rehmanniae Radix Preparat 6-17 parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
- the lactobacillus that can be used in preparation of fermented Ssangwhatang of the present invention may include Lactobacillus spp. bacterial strain.
- Lactobacillus fermentum as an inoculum source is seed cell-cultured and inoculated into an crude liquid of Ssangwhatang ranging from 0.1 to 10% (v/v).
- the inoculated solution is cultured with aeration in an incubated chamber, and fermented into liquid, thereby obtaining the lactobacillus fermented Ssangwhatang.
- the seed cell culture and fermentation are performed at an incubated temperature ranging from 20 0 C to 40 0 C, preferably from 30 0 C to 40 0 C, for l ⁇ 10 days, preferably for 1 ⁇ 5 days.
- the lactobacillus can be selected from the group consisting of
- Lactobacillus gasseri Lactobacillus casei, Lactobacillus acidophilus and Lactobacillus rhamnosus as well as Lactobacillus fermentum, which is not limited herein.
- the media can be selected from the group consisting of Man-Rogosa-Sharpe (MRS), lactose, M17 and APT media to be suitable for each lactobacillus, which is not limited herein.
- MRS Man-Rogosa-Sharpe
- lactose lactose
- M17 lactose
- APT APT media
- the present inventors performed a blood biochemical test after alcohol treatment. Specifically, before and after a rat is treated with alcohol, general Ssangwhatang, flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were administered. Then, blood of the rat was extracted to determine the content of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). As a result, it was shown that the increased activity of the above enzyme in treatment of alcohol was decreased by administration of flavored Ssangwhatang and lactobacillus fermented Ssangwhatang (see Tables 6 and 7). Therefore, the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang of the present invention have the effect to alleviate hangover when the rats are inoculated before and after treatment of alcohol.
- AST aspartate aminotransferase
- ALT alanine
- the composition of the present invention comprises flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang as an effective ingredient.
- the flavored Ssangwhatang including Hoveniae Semen and lactobacllus fermented Ssangwhatang can be orally administered in clinical medication, and can be used with general medicines for medical supplies.
- the pharmaceutical medicines include oral administration medicines such as tablets, rigid or soft capsules, liquid drugs, suspensions, which can be prepared using pharmaceutically acceptable carriers.
- the oral administration medicines can be prepared using excipients, binders, disintegrators, lubricants, solubilizers, suspending agents, preservatives or expanders.
- the dosage of the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang is determined depending on various factors such as condition, age, sex and complications of patients. Generally, the dosage ranges from 1 to 8 ml per adult lkg/day, preferably from 4 to 6 ml. One day dosage or 1/2, 1/3 or 1/4 dosage of the lactobacillus fermented Ssangwhatang per unit formulation can be administered one to six times per day. However, in the case of long-term intake, the dosage may be used in the above range or less, and/or more because the effective ingredient has no problem in stability.
- the present invention provides health foods to alleviate alcohol induced hangover that comprises the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang.
- the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang are used as food, they are added as they are, or used with other food or food ingredients, and may be used properly by a general method.
- the mixture amount of the effective ingredient can be determined depending on its usage (i.e. prevention, health or therapeutic treatment).
- the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang of the present invention can be added in an amount ranging from 5 to 30 wt%, preferably from 10 to 20wt%, based on the ingredient in preparation of food or beverages.
- the effective dosage of flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang in health foods can be used based on the effective dosage of the pharmaceutical composition.
- the effective dosage can be used in the above range or less, and/or more because the effective ingredient has no problem in stability. There is no specific limit for use with health foods.
- composition of the present invention is useful in alleviating alcohol induced hangover and reducing blood-alcohol concentration during alcohol intake when taken as a health food
- Example 1 Preparation of flavored Ssangwhatang Hoveniae Semen (502g), Paeoniae Radix Alba (468g), Rehmanniae Radix Preparat (187g), Astragali Radix (187g), Angelicae Gigantis Radix (187g), Cnidii Rhizoma (187g), Cinnamomi Ramulus (14Og), Glycyrrhizae Radix (14Og), Zingiberis Rhizoma Crudus (74g) and Jujubae Fructus (10Og) were mixed and hot water-extracted to obtain flavored Ssangwhatang including Hoveniae Semen.
- the eight types of bacterial strains provided in ⁇ 2-l> were sub- cultured in a slant culture medium and a liquid culture medium, and used in the experiment. Specifically, lactobacillus was inoculated in the slant culture medium, and cultured in an incubator of 37°C for 24 hours. When lactobacillus colonies were formed, oxygen was intercepted from the lactobacillus colonies by a paraffin film, and the lactobacillus colonies were kept in a cool chamber.
- lactobacillus colonies were transferred into a new agar slant culture medium every two to three weeks, inoculated into the liquid culture medium in the test, and cultured in the incubator of 37°C for 24 hours.
- the culture medium used in seed cell culture includes a MRS culture medium (Becton Dickinson, U.S.A.), a MRS + 0.5% glucose culture medium, a MRS + 0.5% lactose culture medium, a M 17 culture medium (Becton Dickinson, U.S.A) or ATP culture medium (Becton
- Astragali Radix (187g), Angelicae Gigantis Radix (187g), Cnidii Rhizoma (187g), Cinnamomi Ramulus (140g), Glycyrrhizae Radix (140g), Zingiberis Rhizoma Crudus (74g) and Jujubae Fructus (10Og) were mixed and hot water-extracted to obtain flavored Ssangwhatang including Hoveniae Semen.
- the crude liquid of Ssangwhatang (10L) was added in a glass bottle (Pylex 19L), and its pH was adjusted to 7.0 with NaOH (IM).
- ⁇ 1-1> Group separation and animal identification The groups of rats were separated as follows. The weight of rats that were judged to be healthy during the purification period was measured, and divided at intervals of 5g, then 108 rats close to the average weight were selected. The 108 rats were distributed by a random method using random numbers and weights which are ranked so that 6 rats having the same weight were included in each group. The rats were identified by a pigment dyeing method of hair and an individual identification card display method.
- ⁇ l-2> Analysis of change in the serum-alcohol concentration. Experiment A was performed to find out the alleviation effect before hangover.
- test materials such as the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were administered
- 60% ethanol was orally administered with 10mt/kg (see Table 2).
- blood was collected from caudal vena cava, and the serum-alcohol content was determined by an enzyme method with the following alcohol dehydrogenase.
- NADH was quantified at 378nm of absorbance.
- l,3-diamino-2-hydroxypropane was used as a reagent and buffering solution to capture aldehyde.
- Experiment B was performed to find out the effect to alleviate hangover after drunkenness. 2 hours after oral administration of 60% ethanol lOmJ/kg, the test materials (15m(/kg) such as the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were orally administered. 2 hours after administration of the test materials, blood was collected from caudal vena cava, and the serum-alcohol content was analyzed using COBAS Integra 800(Roche Co., Switzerland) (see Table 4).
- the alcohol content in serum was decreased by SHT 13%, HST 9%, GMT 20%, CDT 18%, YMT 19%, SMT 29% and S164 34% in comparison with the negative control group (257.7 mg/dt) (see Table 5).
- the AST activity of the negative control group was 184.6 IU/L, which was increased further by 8% than in the normal group (170 IU/L), and which was decreased up to SHT 15%, GMT 21%, CDT 11%, YMT 16%, SMT 9% and S164 16% than in the negative control group.
- HST was increased by 1%.
- ALT was measured to be 63.8 IU/L in the normal group, and was increased to be 83.0 IU/L in alcohol treatment.
- the test material (15mVkg) administration group was decreased by SHT 27%, HST 20%, GMT 22%, CDT 30%, YMT 30%, SMT 23% and S164 27% less than in the negative control group.
- the LDH content was increased by 49% in alcohol treatment more than in the normal group.
- the test material was orally administered with 15m£/kg to the test animal treated with alcohol, the LDH content was decreased by SHT 10%, GMT 27%, CDT 10%, YMT 22%, SMT 12% and S164 18%.
- the LDH amount in serum was increased by HST 9% (see Table 6).
- Table 7 Blood biochemical examination for rats administered with the test materials after alcohol treatment.
- Examples 1 or 2 soybean oil (175. Omg), yellow beeswax (45. Omg), coconut palm oil (127.5mg), soybean phosphatide (21. Omg), gelatin
- the flavored Ssangwhatang or lactobacillus fermented Ssangwhatang obtained from Examples 1 or 2, corn starch (90. Omg), lactose (175. Omg), L-hydroxypropylcellulose (15. Omg), polyvinylpyrrolidone (5. Omg) and ethanol (proper amount) were mixed uniformly, and granulated by a wet granulation method. Stearic acid magnesium (1.8mg) was added to the granulation, and tableted so that one tablet may be 40mg.
- Preparation example 2 Preparation of health foods ⁇ 2-l> Preparation of capsules The flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (100. Omg) obtained from Examples 1 or 2, corn starch (83.2mg), lactose (175. Omg) and stearic acid magnesium (1.8mg) were mixed uniformly so that one capsule may be 360mg. ⁇ 2-2> Preparation of beverages
- the flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (2g) obtained from Examples 1 or 2 and lactose (Ig) were mixed, and filled in air-tight capsules to prepare powders.
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Abstract
A composition for alleviation of alcohol induced hangover comprises Ssangwhatang including Hoveniae Semen or lactobacillus fermented Ssangwhatang as an effective ingredient. Specifically, the composition comprises Ssangwhatang including Hoveniae Semen extracts or lactobacillus fermented Ssangwhatang prepared by inoculating, culturing and fermenting or lactobacillus. The composition is useful in alleviation of alcohol induced hangover and reducing blood-alcohol concentration during alcohol intake when taken as a health food.
Description
COMPOSITION FOR ALLEVIATION OF ALCOHOL INDUCED
HANGOVER COMPRISING HOVENIA DULCIS THUNBERG
CONTAINED SSANG WH ATANG
FIELD OF THE INVENTION
The present invention relates to a composition that alleviates alcohol induced hangover which comprises flavored Ssangwhatang including Hoveniae Semen(Hovenia dulcis Thunberg) or lactobacillus fermented Ssangwhatang as an effective ingredient.
DESCRIPTION OF THE RELATED ART
Ssangwhatang, which is also known as Ssangwhasan, is described in the "weakness and fatigue" item of the "various disease" chapter of Dongeuibogam as a prescription for relief from fatigue. Ssangwhatang is obtained by adding Samultang (including
Rehmanniae Radix Preparat, Paeoniae Radix Alba, Cnidii Rhizoma and
Angelicae Gigantis Radix) to Yijungtang (including ginseng,
Atractylodes and dried Zingiberis Rhizoma Crudus and Glycyrrhizae
Radix). Ssangwhatang is used by people who feel fatigued, people with blood disorders, people who feel weak after a serious illness, people lacking in energy, and people who has a lot of sweat.
Ssangwhatang include medicinal herbs such as Paeoniae Radix
Alba(Paeonia japonica), Rehmanniae Radix Preparat(Rehmannia glutinosa), Astragali Radix(Astragalus membranaceus), Angelicae Gigantis Radix(Angelica gigas), Cnidii Rhizoma(Cnidium officinale), i
Cinnamomi Ramulus(Cinnamonus cassia), Glycyrrhizae
Radix(Glycyrrhiza uralensis), Zingiberis Rhizoma Crudus(Zingiber officinale) and Jujubae Fructus(Zizyphus jujube), which are prepared as herb water for dosage. As for efficacy of the medicinal herbs, Cinnamomi Ramulus activates functions of stomach and intestines, and is useful when digestive organs are cold to cause indigestion or when a belly is cold to cause a bellyache and diarrhea. Angelicae Gigantis Radix has been known for being effective in accelerating blood circulation, preventing cancer, reducing blood pressure, alleviation of pain and spasms, constipation relief through stimulation of large intestine movement, and removal of extravastated blood.
Paeoniae Radix Alba mitigates excessive tension of nerves or muscles so as to stop the pain, nourishes blood, and alleviates pain. Rehmanniae Radix Preparat is effective in nourishing blood. Astragali Radix, which has been used to supplement energy along with ginseng, stops cold sweats and cures swellings.
Cnidii Rhizoma helps blood circulation and alleviates pain so that it is widely used in treatment of headaches. It also activates the function of the liver and bowels, and has a hematogenous function when it is used to cure anemia. Dried Zingiberis Rhizoma Crudus is used to treat indigestion, emesis and diarrhea and accelerate blood circulation. Jujubae Fructus strengthens the stomach and intestines, helps circulation of energy and blood, eases the stomach, protects the spleen, cures lack of energy, and harmonizes the properties of various drugs.
Meanwhile, as for techniques to obtain effective medicines for humans by adding microorganisms to medicinal herbs and fermenting the resulting mixture, Korean Patent Registration No. 185619 discloses a technique using lactobacillus, which is helpful for growth and has an agreeable flavor, from bath squeezed solution of medicinal herbs. The lactobacillus is then mixed, cultured and fermented, thereby obtaining the synergy effect of digestive functions. Also, Korean Patent Publication No. 2004-0078030 discloses a technique which selects grains and medicinal herbs, and ferments a combination of the mixture with fermented soybeans by a quick low temperature process, thereby maintaining the original properties of each ingredient and doubling the effectiveness. However, there are no known documents on how to ferment Ssangwhatang.
The present inventors treated alcohol in a rat, and administered lactobacillus fermented Ssangwhatang or flavored Ssangwhatang including Hoveniae Semen of the present invention before and after hangover so as to confirm whether the hangover was relieved.
SUMMARY OF THE INVENTION Various embodiments of the present invention are directed at providing a composition to alleviate alcohol induced hangover that comprises flavored Ssangwhatang containg Hoveniae Semen or lactobacillus fermented Ssangwhatang as an effective ingredient.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention provides a composition for alleviation of alcohol induced hangover comprising flavored Ssangwhatang including Hoveniae Semen, wherein the flavored Ssangwhatang is produced by adding Hoveniae Semen to Ssanwhatang consisting of Paeoniae Radix Alba(Paeonia japonica), Rehmanniae Radix Preparat(Rehmannia glutinosa), Astragali Radix(Astragalus membranaceus), Angelicae Gigantis Radix(Angelica gigas), Cnidii Rhizoma(Cnidium officinale), Cinnamomi Ramulus(Cinnamonus cassia), Glycyrrhizae Radix(Glycyrrhiza uralensis), Zingiberis Rhizoma Crudus(Zingiber officinale) and Jujubae Fructus(Zizyphus jujube), and extracting them with hot water. The composition consists of Hoveniae Semen 10-15 parts by weight, Rehmanniae Radix Preparat 6-17 parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
Also, the present invention provides a composition for alleviation of alcohol induced hangover comprising lactobacillus fermented Ssangwhatang, wherein the fermented Ssangwhatang is produced by inoculating lactobacillus in hot water-extracted Ssangwhatang consisting of Paeoniae Radix Alba, Rehmanniae Radix Preparat, Astragali Radix, Angelicae Gigantis Radix, Cnidii Rhizoma, Cinnamomi Ramulus, Glycyrrhizae Radix, Zingiberis Rhizoma Crudus and Jujubae Fructus. The composition consists of Rehmanniae Radix Preparat 6-17
parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
Preferably, the lactobacillus that can be used in preparation of fermented Ssangwhatang of the present invention may include Lactobacillus spp. bacterial strain. According to a preferred embodiment of the present invention, Lactobacillus fermentum as an inoculum source is seed cell-cultured and inoculated into an crude liquid of Ssangwhatang ranging from 0.1 to 10% (v/v). The inoculated solution is cultured with aeration in an incubated chamber, and fermented into liquid, thereby obtaining the lactobacillus fermented Ssangwhatang. The seed cell culture and fermentation are performed at an incubated temperature ranging from 200C to 400C, preferably from 300C to 400C, for l~10 days, preferably for 1~5 days.
The lactobacillus can be selected from the group consisting of
Lactobacillus gasseri, Lactobacillus casei, Lactobacillus acidophilus and Lactobacillus rhamnosus as well as Lactobacillus fermentum, which is not limited herein. The media can be selected from the group consisting of Man-Rogosa-Sharpe (MRS), lactose, M17 and APT media to be suitable for each lactobacillus, which is not limited herein. Also, Ssangwhatang can be directly prepared or used with a commercially available product.
In the preferred embodiment of the present invention, before and after a rat is treated with alcohol, general Ssangwhatang, flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang are administered to the rat in order to find out the degree of hangover alleviation. As a result, it is shown to reduce the alcohol content in serum by administration of flavored Ssangwhatang and lactobacillus fermented Ssangwhatang (see Tables 3 and 5).
The present inventors performed a blood biochemical test after alcohol treatment. Specifically, before and after a rat is treated with alcohol, general Ssangwhatang, flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were administered. Then, blood of the rat was extracted to determine the content of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). As a result, it was shown that the increased activity of the above enzyme in treatment of alcohol was decreased by administration of flavored Ssangwhatang and lactobacillus fermented Ssangwhatang (see Tables 6 and 7). Therefore, the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang of the present invention have the effect to alleviate hangover when the rats are inoculated before and after treatment of alcohol.
The composition of the present invention comprises flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang as an effective ingredient. The flavored Ssangwhatang including Hoveniae Semen and lactobacllus fermented Ssangwhatang
can be orally administered in clinical medication, and can be used with general medicines for medical supplies. Preferably, the pharmaceutical medicines include oral administration medicines such as tablets, rigid or soft capsules, liquid drugs, suspensions, which can be prepared using pharmaceutically acceptable carriers. For example, the oral administration medicines can be prepared using excipients, binders, disintegrators, lubricants, solubilizers, suspending agents, preservatives or expanders.
In the composition, the dosage of the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang is determined depending on various factors such as condition, age, sex and complications of patients. Generally, the dosage ranges from 1 to 8 ml per adult lkg/day, preferably from 4 to 6 ml. One day dosage or 1/2, 1/3 or 1/4 dosage of the lactobacillus fermented Ssangwhatang per unit formulation can be administered one to six times per day. However, in the case of long-term intake, the dosage may be used in the above range or less, and/or more because the effective ingredient has no problem in stability.
Also, the present invention provides health foods to alleviate alcohol induced hangover that comprises the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang.
When the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang are used as food, they are added as they are, or used with other food or food ingredients, and may be used properly by a general method. The mixture amount of
the effective ingredient can be determined depending on its usage (i.e. prevention, health or therapeutic treatment). Generally, the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang of the present invention can be added in an amount ranging from 5 to 30 wt%, preferably from 10 to 20wt%, based on the ingredient in preparation of food or beverages. The effective dosage of flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang in health foods can be used based on the effective dosage of the pharmaceutical composition. However, in the case of long-term intake for health and sanitation or health regulation, the effective dosage can be used in the above range or less, and/or more because the effective ingredient has no problem in stability. There is no specific limit for use with health foods.
ADVANTAGEOUS EFFECT
The composition of the present invention is useful in alleviating alcohol induced hangover and reducing blood-alcohol concentration during alcohol intake when taken as a health food
EXAMPLES
Hereinafter, the present invention will be described in more detail with experimental examples and preferred embodiments, which are given by way of illustration only, and thus are not limitative of the present invention. <Example 1> Preparation of flavored Ssangwhatang
Hoveniae Semen (502g), Paeoniae Radix Alba (468g), Rehmanniae Radix Preparat (187g), Astragali Radix (187g), Angelicae Gigantis Radix (187g), Cnidii Rhizoma (187g), Cinnamomi Ramulus (14Og), Glycyrrhizae Radix (14Og), Zingiberis Rhizoma Crudus (74g) and Jujubae Fructus (10Og) were mixed and hot water-extracted to obtain flavored Ssangwhatang including Hoveniae Semen. The crude liquid of Ssangwhatang (10L) was added in a glass bottle (Pylex 19L), and its pH was adjusted to 7.0 with NaOH (IM). The resulting mixture was pressure-sterilized at 121°C under 1.5 atm for 15 minutes. < Example 2> Preparation of lactobacillus fermented
Ssangwhatang
<2-l> Distribution of lactobacillus
Seven strains of Lactobacillus spp. were provided by Food
Microorganism Gene Bank of Korea Food Research Institute (KFRI), and one strain of lactobacillus spp. was provided by Korean Collection for Type Cultures (KCTC), and they were used in the experiment (see
Table 1)
Table 1: Strains of lactobacillus spp. used in fermentation
[Table 1]
<2-2> Seed cell culture
The eight types of bacterial strains provided in <2-l> were sub- cultured in a slant culture medium and a liquid culture medium, and used in the experiment. Specifically, lactobacillus was inoculated in the slant culture medium, and cultured in an incubator of 37°C for 24 hours. When lactobacillus colonies were formed, oxygen was intercepted from the lactobacillus colonies by a paraffin film, and the lactobacillus colonies were kept in a cool chamber. Since the activity of lactobacillus may be degraded or the lactobacillus colonies may be contaminated by various bacteria, the lactobacillus colonies were transferred into a new agar slant culture medium every two to three weeks, inoculated into the liquid culture medium in the test, and cultured in the incubator of 37°C for 24 hours.
The culture medium used in seed cell culture includes a MRS culture medium (Becton Dickinson, U.S.A.), a MRS + 0.5% glucose culture medium, a MRS + 0.5% lactose culture medium, a M 17 culture medium (Becton Dickinson, U.S.A) or ATP culture medium (Becton
Dickinson, U.S.A).
<2-3> Preparation of lactobacillus fermented Ssangwhatang Paeoniae Radix Alba (468g), Rehmanniae Radix Preparat (187g),
Astragali Radix (187g), Angelicae Gigantis Radix (187g), Cnidii Rhizoma (187g), Cinnamomi Ramulus (140g), Glycyrrhizae Radix (140g), Zingiberis Rhizoma Crudus (74g) and Jujubae Fructus (10Og) were mixed and hot water-extracted to obtain flavored Ssangwhatang
including Hoveniae Semen. The crude liquid of Ssangwhatang (10L) was added in a glass bottle (Pylex 19L), and its pH was adjusted to 7.0 with NaOH (IM).
The resulting mixture was pressure-sterilized at 121°C under 1.5 atm for 15 minutes, and cooled to a room temperature. The cooled mixture was inoculated with seed cell solution to l%(v/v) which was previously cultured in <2-2>. The resulting mixture was cultured with aeration in an incubated chamber of 37±1°C for 48 hours for liquid fermentation. Experimental Example 1> Confirmation of alleviation of alcohol induced hangover
8-week-old Sprague Dawley male rats obtained from Orientbio Inc.(Korea) were quarantined and purified in the animal laboratory of Korea Institute of Oriental Medicine for two weeks. Healthy rats were selected from those rats, and used in the experiment.
< 1-1> Group separation and animal identification The groups of rats were separated as follows. The weight of rats that were judged to be healthy during the purification period was measured, and divided at intervals of 5g, then 108 rats close to the average weight were selected. The 108 rats were distributed by a random method using random numbers and weights which are ranked so that 6 rats having the same weight were included in each group. The rats were identified by a pigment dyeing method of hair and an individual identification card display method. < l-2> Analysis of change in the serum-alcohol concentration.
Experiment A was performed to find out the alleviation effect before hangover. 30 minutes after the test materials (15mVkg) such as the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were administered, 60% ethanol was orally administered with 10mt/kg (see Table 2). 2 hours after administration of ethanol, blood was collected from caudal vena cava, and the serum-alcohol content was determined by an enzyme method with the following alcohol dehydrogenase.
ADH ethanol + NAD+ ■* acetaldehyde + NADH + H+
The generated NADH was quantified at 378nm of absorbance. l,3-diamino-2-hydroxypropane was used as a reagent and buffering solution to capture aldehyde.
As a result, the alcohol content in serum was decreased by SHT 9%, HST 25%, SMT 39% and S164 26% in comparison with the negative control group (267.8 mg/dt) (see Table 3).
Table 2: Experimental group treated with the test materials before alcohol treatment [Table 2]
NCT; Negative control group,
SHT; Ssangwhatang,
HST; Hovenia Semen,
GMT; Positive control group 1, (administration of "Good Morning", Korea
Ginseng Bio Science Co., LTD)
CDT; Positive control group 2, (administration of "Condition", CJ corporation)
YMT; Positive control group 3, (administration of "Yeomyung 808",
GLAMI Co., Ltd.),
SMT; Ssangwhatang + 30% Hovenia Semen
S164; Ssangwhatang fermented group including lactobacillus fermentum a); The volume of administration
Table 3: Alcohol analysis of rat administered with the test materials before alcohol treatment
[Table 3]
Experiment B was performed to find out the effect to alleviate hangover after drunkenness. 2 hours after oral administration of 60% ethanol lOmJ/kg, the test materials (15m(/kg) such as the flavored Ssangwhatang including Hoveniae Semen and lactobacillus fermented Ssangwhatang were orally administered. 2 hours after administration of the test materials, blood was collected from caudal vena cava, and the serum-alcohol content was analyzed using COBAS Integra 800(Roche Co., Switzerland) (see Table 4).
As a result, the alcohol content in serum was decreased by SHT 13%, HST 9%, GMT 20%, CDT 18%, YMT 19%, SMT 29% and S164 34% in comparison with the negative control group (257.7 mg/dt) (see Table 5).
Table 4: Experimental group treated with the test materials after alcohol treatment
Table 5: Alcohol analysis of rats administered with the test materials after alcohol treatment
[Table 4]
[Table 5]
< l-3> Blood biochemical examination
The same procedure as Experiments A and B was repeated for biochemical examination of blood. Blood (5m£) was collected from caudal vena cava, coagulated at a room temperature, and centrifuged at 5000rpm for 10 minutes using a centrifuge (Avanti 30, Beckman Coulter, Inc., U.S.A.). After separation of serum, the content of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) was measured using a biochemical analyzer (Advia 1650, Shimas Co., JAPAN).
A statistical significant difference between the negative control group and the test material administration group was obtained from the average and the standard deviation by Dunnett test (*p < 0.0.5, **p < 0.01).
As a result, in the alcohol intake test 30 minutes after administration of the test materials such as the flavored Ssangwhatang
including Hoveniae Semen and lactobacillus fermented Ssangwhatang, the AST activity of the negative control group was 184.6 IU/L, which was increased further by 8% than in the normal group (170 IU/L), and which was decreased up to SHT 15%, GMT 21%, CDT 11%, YMT 16%, SMT 9% and S164 16% than in the negative control group. However, HST was increased by 1%.
ALT was measured to be 63.8 IU/L in the normal group, and was increased to be 83.0 IU/L in alcohol treatment. The test material (15mVkg) administration group was decreased by SHT 27%, HST 20%, GMT 22%, CDT 30%, YMT 30%, SMT 23% and S164 27% less than in the negative control group.
The LDH content was increased by 49% in alcohol treatment more than in the normal group. When the test material was orally administered with 15m£/kg to the test animal treated with alcohol, the LDH content was decreased by SHT 10%, GMT 27%, CDT 10%, YMT 22%, SMT 12% and S164 18%. The LDH amount in serum was increased by HST 9% (see Table 6).
However, in the test including 2 hours of alcohol intake and 2 hours of test material administration, the content of AST, ALT and LDH was shown to have no change in all test groups (CON, NCT, SHT, HST, GMT, CDT, YMT, SMT and S164) (see Table 7).
According to the analysis of the above test result, 2 hours after alcohol treatment, there was no severe toxic change by alcohol treatment in the content change of AST, ALT and LDH. However, in administration of the flavored Ssangwhatang or the fermented
Ssangwhatang (15m{!/kg), the content of AST, ALT and LDH, blood biochemical hepatotoxic index materials, was shown to decrease.
Table 6: Blood biochemical examination for rats administered with the test materials before alcohol treatment
Table 7: Blood biochemical examination for rats administered with the test materials after alcohol treatment.
[Table 6]
<l-4> Autopsy findings
Although abnormal lesions were not observed in single-time oral administration of ethanol and the test materials, bleeding in the stomach by alcohol intake was observed with the naked eyes.
However, the bleeding in the stomach by alcohol intake was shown to decrease when the test materials were administered at a dosage of 15mtykg.
< Preparation Example 1> Preparation of pharmaceutical composition
< 1-1> Preparation of soft capsules
To one capsule were added the flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (100. Omg) obtained from
Examples 1 or 2, soybean oil (175. Omg), yellow beeswax (45. Omg), coconut palm oil (127.5mg), soybean phosphatide (21. Omg), gelatin
(212. Omg), glycerin (specific gravity 1.24) (50. Omg), di-sorbitol
(76. Omg), para-oxy benzoate methyl (0.54mg), para-oxy benzoate propyl (0.90mg), methyl vanillin (0.56mg), yellow No. 203 (proper amount) by a preparation method of soft capsules in general pharmaceutical provisions.
< l-2> Preparation of tablets
The flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (100. Omg) obtained from Examples 1 or 2, corn starch (90. Omg), lactose (175. Omg), L-hydroxypropylcellulose (15. Omg), polyvinylpyrrolidone (5. Omg) and ethanol (proper amount) were mixed uniformly, and granulated by a wet granulation method. Stearic acid magnesium (1.8mg) was added to the granulation, and tableted so that one tablet may be 40mg.
< Preparation example 2> Preparation of health foods <2-l> Preparation of capsules
The flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (100. Omg) obtained from Examples 1 or 2, corn starch (83.2mg), lactose (175. Omg) and stearic acid magnesium (1.8mg) were mixed uniformly so that one capsule may be 360mg. <2-2> Preparation of beverages
The flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (0.48mg~1.28mg) obtained from Examples 1 or 2, honey (522mg), thioctic acid amide (5mg), hydrochloric acid riboflavin sodium (3mg), hydrochloric acid pyridoxine (2mg), inositol (30mg), orotic acid (50mg) and water (200m() were mixed to prepare a beverage by a general method.
<2-3> Preparation of powders
The flavored Ssangwhatang or lactobacillus fermented Ssangwhatang (2g) obtained from Examples 1 or 2 and lactose (Ig) were mixed, and filled in air-tight capsules to prepare powders.
Claims
1. A composition for alleviation of alcohol induced hangover comprising flavored Ssangwhatang including Hoveniae Semen(Hovenia dulcis Thunberg), wherein the flavored Ssangwhatang is produced by adding Hoveniae Semen to Ssanwhatang consisting of Paeoniae Radix Alba(Paeonia japonica), Rehmanniae Radix Preparat(Rehmannia glutinosa), Astragali Radix(Astragalus membranaceus), Angelicae Gigantis Radix(Angelica gigas), Cnidii Rhizoma(Cnidium officinale), Cinnamomi Ramulus(Cinnamonus cassia), Glycyrrhizae Radix(Glycyrrhiza uralensis), Zingiberis Rhizoma Crudus(Zingiber officinale) and Jujubae Fructus(Zizyphus jujube), and extracting them with hot water.
2. The composition according to claim 1, wherein the composition consists of Hoveniae Semen 10-15 parts by weight, Rehmanniae Radix Preparat 6-17 parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
3. The composition according to claim 1, wherein the composition lowers the alcohol content in blood when it is administered before and after alcohol intake.
4. The composition according to claim 1, wherein the composition is provided in the form of health foods.
5. A composition for alleviation of alcohol induced hangover comprising iactobacillus fermented Ssangwhatang, wherein the fermented Ssangwhatang is produced by inoculating Iactobacillus in hot water-extracted Ssangwhatang consisting of Paeoniae Radix Alba, Rehmanniae Radix Preparat, Astragali Radix, Angelicae Gigantis Radix, Cnidii Rhizoma, Cinnamomi Ramulus, Glycyrrhizae Radix, Zingiberis Rhizoma Crudus and Jujubae Fructus.
6. The composition according to claim 5, wherein the composition consists of Rehmanniae Radix Preparat 6-17 parts by weight, Astragali Radix 6-17 parts by weight, Angelicae Gigantis Radix 6-17 parts by weight, Cnidii Rhizoma 6-17 parts by weight, Cinnamomi Ramulus 3-14 parts by weight, Glycyrrhizae Radix 3-14 parts by weight, Zingiberis Rhizoma Crudus 2-14, and Jujubae Fructus 4-8 parts by weight, based on Paeoniae Radix Alba 10 parts by weight.
7. The composition according to claim 5, wherein the
Iactobacillus is selected from the group consisting of Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus casei, Lactobacillus acidophilus and Lactobacillus rhamnosus.
8. The composition according to claim 5, wherein the Iactobacillus is Lactobacillus fermentum.
9. The composition according to claim 5, wherein the composition lowers the alcohol content in blood when it is administered before and after alcohol intake.
10. The composition according to claim 5, wherein the composition is provided in the form of health foods.
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| JP2010535873A JP5340302B2 (en) | 2007-11-30 | 2008-11-24 | A composition for relieving hangover, containing Kamisuwato containing Kigushi as an active ingredient |
| CN2008801183939A CN101878035B (en) | 2007-11-30 | 2008-11-24 | Composition for alleviation of alcohol induced hangover comprising hovenia dulcis thunberg contained ssangwhatang |
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| KR10-2007-0123513 | 2007-11-30 | ||
| KR1020070123513A KR101040721B1 (en) | 2007-11-30 | 2007-11-30 | Composition for alleviation of alcohol-induced hangover comprising Hovenia dulcis Thunberg contained Ssangwhatang |
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| JP2011136907A (en) * | 2009-12-25 | 2011-07-14 | Kirin Holdings Co Ltd | Endurance-enhancing agent |
| JP2012001511A (en) * | 2010-06-18 | 2012-01-05 | Nitto Yakuhin Kogyo Kk | Composition for degrading glycoside |
| JP2012246280A (en) * | 2011-05-31 | 2012-12-13 | Kirin Holdings Co Ltd | Agent reducing oxygen consumption and energy consumption |
| CN106924706A (en) * | 2017-05-02 | 2017-07-07 | 福建南少林药业有限公司 | A kind of promoting digestion and protecting liver electuary and preparation method thereof |
| CN114514973A (en) * | 2022-02-17 | 2022-05-20 | 华南农业大学 | Preparation method of radix puerariae compound fermented beverage with sobering and liver protecting effects |
| EP3858370A4 (en) * | 2018-09-28 | 2022-09-07 | Kolmar BNH Co., Ltd | Composition for alleviating fatigue or enhancing exercise capability comprising angelica gigas extract, cnidii rhizoma extract, and paeonia japonica extract |
| US12029770B2 (en) | 2018-09-28 | 2024-07-09 | Kolmar Bnh Co., Ltd | Composition for alleviating fatigue or enhancing exercise capability comprising Angelica gigas extract, Cnidium officinale extract, and Paeonia lactiflora extract |
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| KR101016606B1 (en) * | 2009-12-07 | 2011-02-21 | 주식회사 엔유씨전자 | Food composition for eliminating hangover comprising essentially of ferments from fruit of hovenia dulcis thunb |
| KR101252639B1 (en) * | 2010-06-23 | 2013-04-09 | 한국 한의학 연구원 | Composition for Prevention or Treatment of Osteoporosis Comprising Ssanghwatang and Fermentation Product Thereof with Lactic Acid Bacteria |
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| JP3442031B2 (en) * | 2000-06-02 | 2003-09-02 | 株式会社東洋新薬 | healthy food |
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| JP5340302B2 (en) | 2013-11-13 |
| WO2009069921A3 (en) | 2009-08-13 |
| KR20090056385A (en) | 2009-06-03 |
| KR101040721B1 (en) | 2011-06-10 |
| JP2011505354A (en) | 2011-02-24 |
| CN101878035A (en) | 2010-11-03 |
| CN101878035B (en) | 2012-11-28 |
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