CN114601906A - Jiulongqing enzyme probiotic oral liquid for treating digestive system diseases and preparation method and application thereof - Google Patents
Jiulongqing enzyme probiotic oral liquid for treating digestive system diseases and preparation method and application thereof Download PDFInfo
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Provides a JiuYeqing Changqing probiotic oral liquid for treating digestive system diseases and a preparation method thereof, the traditional Chinese medicine is selected from ginseng, largehead atractylodes rhizome, tuckahoe, liquorice, bitter orange, fingered citron, villous amomum fruit, tangerine peel, hawthorn, roasted malt, coastal glehnia root, fragrant solomonseal rhizome, dendrobium, golden thread, officinal magnolia bark, corydalis tuber, bletilla striata, angelica, medlar, bupleurum, white paeony root, coix seed, spreading hedyotis herb, glabrous sarcandra herb, red-rooted salvia root, common yam rhizome, lucid ganoderma, white hyacinth bean, heterophylly falsestarwort root, membranous milkvetch root and peach seed; compared with the corresponding optimization process, the optimum traditional decoction process optimized by multiple factors such as particle size, decoction time, extraction method and the like is found to have obvious changes in the contents of ginsenoside Rg1 and ammonium glycyrrhizinate analyzed, and is superior to the traditional decoction process. The method has the advantages of simple process, less loss of effective components, high leaching rate and the like.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a Jiulong qing enzyme probiotic oral liquid for treating digestive system diseases, and a preparation method and application thereof.
Background
Digestive diseases such as functional dyspepsia, gastroesophageal reflux disease, gastroduodenal ulcer, chronic gastritis (erosive and atrophic), gastric polyp, irritable bowel syndrome, chronic colitis, constipation, intestinal polyp, hepatitis, hepatic fibrosis, liver cirrhosis, fatty liver, cholecystitis, gastrointestinal hemorrhage, intestinal obstruction, acute pancreatitis and the like are common diseases and frequently encountered diseases in clinic. Because the traditional Chinese medicine is mostly chronic disease, the recurrence rate of the disease is high, the disease is lingering and difficult to heal, and the disease can be progressively developed, the treatment and the medicine taking time of the disease are long, the physical and mental health and the life quality of a patient are seriously affected, and complications such as insomnia, anxiety and the like are often generated. At present, two treatment schemes of traditional Chinese medicine and western medicine are available, the western medicine mainly aims at symptomatic treatment such as acid inhibition and stomach protection, gastrointestinal function regulation, gastrointestinal motility promotion, gastrointestinal mucosa protection, intestinal flora regulation, liver protection and the like, the traditional Chinese medicine considers that the spleen is mainly transported and transformed, and dyspepsia is always rooted in the spleen, so traditional Chinese medicines such as spleen strengthening, spleen transportation, dampness eliminating, diuresis and the like are often adopted to treat diseases related to digestion. These traditional Chinese medicines are complex in ingredients, but have diverse and integrated efficacies. Traditional Chinese medicine has unique action mechanism for treating digestive system diseases, and often has multiple effects at the same time, so that the traditional Chinese medicine is selected and favored by more and more families of patients. An oral traditional Chinese medicine scheme is formulated according to syndrome differentiation and treatment, and traditional Chinese medicine characteristic therapies such as acupoint application, ear acupoint pressing, acupoint catgut embedding, acupoint injection, acupuncture, packaging, intermediate frequency therapy and the like are supplemented, so that a better curative effect is achieved on treating the diseases.
Patients with chronic digestive system diseases such as functional dyspepsia, gastroesophageal reflux disease, chronic gastritis (erosive, atrophic), irritable bowel syndrome, chronic colitis, constipation, etc., and complications such as insomnia, anxiety, etc., often require long-term treatment. For the patients with the disease, western medicines have poor treatment effect, are easy to relapse, and have certain toxic and side effects, such as dizziness, sleepiness, dyspepsia and the like. The common sedative-hypnotic drugs can only be used for short-term treatment, have the defects of drug resistance, addiction and the like when being used for a long time, are easy to generate physiological and psychological dependence, can cause adverse reactions such as gait instability, memory impairment and the like, are easy to relapse after the drugs are stopped, and are limited in clinical use to a certain extent.
The intestinal flora is a collective term for a variety of microorganisms that colonize the gastrointestinal tract of healthy humans and animals, and that not only assume digestive and nutritional functions, but also play a role in both immunomodulation and neuromodulation. The intestinal flora is closely related to the functions of the digestive system, and the imbalance of the intestinal flora can cause a series of digestive tract diseases. At present, the methods for regulating the intestinal flora mainly comprise antibiotics, prebiotics (polysaccharides), probiotics, intestinal flora transplantation and the like. The broad sterilization spectrum and drug resistance of the antibiotics make the antibiotics unsuitable for long-term application; the prebiotic preparation of pure oligosaccharide has poor effect and does not have the inhibiting effect on conditional pathogenic bacteria and pathogenic bacteria; probiotic preparations tend to be ineffective due to harsh storage conditions and loss through the stomach. The transplantation of intestinal flora is further at risk of infection and death of multiple drug-resistant bacteria. More and more researches show that the traditional Chinese medicine has natural advantages in the aspect of long-term fine conditioning for regulating the intestinal flora.
The astragalus and the white atractylodes rhizome in the traditional Chinese medicines tonify spleen and qi, strengthen exterior and stop sweating; the dried orange peel is used for regulating qi and activating spleen; radish seed and hawthorn fruit can promote digestion; the scutellaria baicalensis and the ophiopogon root have the effects of relieving fever and promoting the secretion of saliva; the compatibility of the medicines achieves the curative effect of strengthening spleen and promoting digestion. Modern pharmacological studies show that the recipe has the function of regulating gastrointestinal motility, can inhibit gastrointestinal propulsion and relieve diarrhea; but also can restore the small intestine with reduced exercise to normal. Can reduce gastric secretion, lower pH value, and promote healing of gastrointestinal ulcer. Can improve pepsin activity and digestion and absorption functions. Can increase the number of erythrocytes, hemoglobin and reticulocytes, and promote hematopoiesis. In addition, the formula also has the effects of enhancing immunologic function, promoting metabolism, protecting liver, enhancing the function of pituitary-adrenal cortex system, resisting tumor and mutation, improving microcirculation, resisting platelet aggregation, delaying aging, resisting stress reaction and the like.
The traditional Chinese medicines for treating the digestive system diseases are numerous, but the research on the specific mechanism of the pleiotropic effects of the traditional Chinese medicines is few, so that the research on the mechanism of improving the digestion and treating the digestive system dysfunction of the medicines is carried out according to the physiological characteristics of human bodies and by combining the interpretation of the traditional Chinese medicines and the western medicines of the digestive system diseases, and the development of the traditional Chinese medicine composition which has comprehensive functions and can regulate the functions of the digestive system has important social significance and economic value.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a jiuzye changqing enzyme probiotic oral liquid for treating digestive system diseases.
Another objective of the present invention is to provide a method for preparing a jiu ye qing enzyme probiotic oral liquid for treating digestive system diseases, wherein the method of the prior art is improved by using water decoction to extract ginsenoside and ammonium glycyrrhizinate which are active ingredients of traditional Chinese medicines with large loss, and fat-soluble active substances are difficult to extract, and water-soluble impurities are difficult to remove, so that side reactions causing long-standing diseases are caused. The method has the advantages of simple process, less loss of effective components, high leaching rate and the like.
In order to achieve the purpose, the invention adopts the technical scheme that:
a Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
8-12 g of ginseng, 8-12 g of bighead atractylodes rhizome, 8-12 g of poria cocos, 6-10 g of liquorice, 8-12 g of fructus aurantii, 3-6 g of fingered citron, 3-6 g of fructus amomi, 3-6 g of dried orange peel, 3-6 g of hawthorn, 3-6 g of fried malt, 3-6 g of radix glehniae, 3-6 g of radix polygonati officinalis, 3-6 g of dendrobe, 3-6 g of coptis chinensis, 3-6 g of mangnolia officinalis, 8-12 g of rhizoma corydalis, 8-12 g of bletilla, 3-6 g of angelica sinensis, 8-12 g of medlar, 3-6 g of radix bupleuri, 3-6 g of radix paeoniae alba, 3-6 g of semen coicis, 3-6 g of oldenlandia diffusa, 3-6 g of glabrous sarcandra herb, 3-6 g of salvia miltiorrhiza, 3-6 g of Chinese yam, 3-6 g of lucid ganoderma, 3-6 g of white hyacinth bean, 3-6 g of radix pseudostellariae, 3-6 g of astragalus mongholicus, 8-12 g of peach kernel and 900ml-1100ml of water.
A Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
9-11 g of ginseng, 9-11 g of bighead atractylodes rhizome, 9-11 g of poria cocos, 7-9 g of liquorice, 9-11 g of fructus aurantii, 4-5 g of fingered citron, 4-5 g of fructus amomi, 4-5 g of dried orange peel, 4-5 g of hawthorn, 4-5 g of fried malt, 4-5 g of radix glehniae, 4-5 g of radix polygonati officinalis, 4-5 g of dendrobe, 4-5 g of coptis chinensis, 4-5 g of mangnolia officinalis, 9-11 g of rhizoma corydalis, 9-11 g of bletilla, 4-5 g of angelica sinensis, 9-11 g of medlar, 4-5 g of radix bupleuri, 4-5 g of radix paeoniae alba, 4-5 g of semen coicis, 4-5 g of oldenlandia diffusa, 4-5 g of glabrous sarcandra herb, 4-5 g of salvia miltiorrhiza, 4-5 g of Chinese yam, 4-5 g of lucid ganoderma, 4-5 g of white hyacinth bean, 4-5 g of radix pseudostellariae, 4-5 g of astragalus membranaceus, 9-11 g of peach kernel and 950-1050 ml of water.
A Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
10g of ginseng, 9g of bighead atractylodes rhizome, 11g of poria cocos, 7g of liquorice, 12g of fructus aurantii, 5g of fingered citron, 4g of fructus amomi, 3g of pericarpium citri reticulatae, 5g of hawthorn, 4g of fried malt, 3g of radix glehniae, 4g of radix polygonati officinalis, 5g of dendrobe, 4g of coptis chinensis, 3g of mangnolia officinalis, 11g of rhizoma corydalis, 8g of bletilla, 4g of angelica sinensis, 11g of medlar, 3g of radix bupleuri, 5g of radix paeoniae alba, 4g of semen coicis, 4g of oldenlandia diffusa, 5g of glabrous sarcandra herb, 3g of radix salviae miltiorrhizae, 3g of Chinese yam, 5g of lucid ganoderma, 4g of white hyacinth bean, 5g of radix pseudostellariae, 4g of astragalus membranaceus, 10g of peach kernel and 1000ml of water.
As a preferred embodiment of the oral liquid of the Changqing enzyme probiotic of the invention, the oral liquid comprises the following components in parts by weight:
10g of ginseng, 10g of tuckahoe, 6g of honey-fried licorice root, 12g of bighead atractylodes rhizome, 10g of dried orange peel, 10g of roasted malt, 9g of radix glehniae, 10g of polygonatum, 10g of dendrobium and 1000ml of water.
As a preferred embodiment of the present invention, the digestive system diseases include chronic gastritis, gastrointestinal dysfunction, intestinal flora imbalance, dyspepsia, atrophic gastritis, gastric ulcer, and gastric cancer lesion.
In the jiuzongqing enzyme probiotic oral liquid, the adopted traditional Chinese medicinal materials have the following effects and effects:
an important feature of the present invention is that the important composition is rich in nutrients, wherein
A, the efficacies of ginseng, tuckahoe and honey-fried licorice root are as follows: tonify middle-jiao and Qi. Can be used for treating stomach deficiency cold, and has effects in invigorating middle warmer, eliminating dampness, etc.
B, the efficacies of the white atractylodes rhizome, the dried orange peel and the roasted malt are as follows: promoting digestion, invigorating stomach, regulating qi-flowing, and eliminating dampness. It can be used for treating gastritis and dyspepsia, and has effects in relieving flatulence and activating qi-flowing.
C, the effects of radix glehniae, polygonatum odoratum and dendrobium: tonify stomach yin, promote the production of body fluid and quench thirst. Can be used for treating chronic gastroenteritis, gastric erosion, ulcer, and gastrointestinal mucosa injury.
The invention also provides a preparation method of the jiulong qing enzyme probiotic oral liquid for treating digestive system diseases, which comprises the following steps:
1. cleaning and selecting raw materials:
ginseng, largehead atractylodes rhizome, Indian buead, liquoric root, bitter orange, fingered citron, villous amomum fruit, tangerine peel, hawthorn fruit, fried malt, coastal glehnia root, fragrant solomonseal rhizome, dendrobium, golden thread, officinal magnolia bark, corydalis tuber, bletilla striata, Chinese angelica, medlar, Chinese thorowax root, white paeony root, coix seed, spreading hedyotis herb, glabrous sarcandra herb, danshen root, common yam rhizome, lucid ganoderma, white hyacinth bean, heterophylly falsestarwort root, membranous milkvetch root and peach seed are cleaned and sorted, worm-eaten, rat bite, rotten and deteriorated products, counterfeit products and inferior products are removed, and the Chinese medicinal decoction pieces which are not rotten and deteriorated are processed are adopted to meet the requirements specified by quality standards. The Chinese herbal pieces: the traditional Chinese medicine decoction pieces are prepared from traditional Chinese medicines according to the traditional Chinese medicine theory and the traditional Chinese medicine preparation method, and can be directly used as traditional Chinese medicines in traditional Chinese medicine clinical practice. The concept shows that the traditional Chinese medicine and the traditional Chinese medicine decoction pieces have no absolute limit, and the traditional Chinese medicine decoction pieces comprise part of traditional Chinese medicine slices (including sections, blocks and petals) processed by the production place, original-shape traditional Chinese medicine decoction pieces and decoction pieces which are cut (based on the processing of the production place) and processed by stir-frying. For the first two categories, the Chinese medicinal herbs should be regarded as herbs in management, and they are understood as decoction pieces in the prescription and preparation according to the theory of Chinese medicine. The concept of decoction pieces in the management meaning is understood as that the finished product which is prepared by further cutting and processing the pure medicinal materials processed by the production place according to the requirements of blending or preparation is called Chinese medicinal decoction pieces.
2. Feeding and soaking:
adding the raw materials into a rotary drum type medicine washing machine, grinding the raw materials into 60-mesh small particles after drying, sieving the small particles, placing the small particles in a multifunctional extraction tank, adding water for soaking, wherein the water-material ratio is 1: 5 (five kilograms of water is added into each kilogram of traditional Chinese medicine particles), and soaking for 4-6 hours;
3. heating and decocting:
soaking the Chinese medicinal materials, extracting with ethanol, adding 18 times of water, decocting for 3 times, and mixing filtrates.
4. Concentration and extraction:
moving the traditional Chinese medicine extracting solution to 5-10 ℃, standing for 24 hours, concentrating, centrifuging at high speed for 15min when the relative density is 1.25, rotating at 8000 r/min, discarding the precipitate to extract supernatant, gradually adding ethanol into the concentrated supernatant at the flow rate of 10L/min while stirring to gradually increase the ethanol content, extracting supernatant after the ethanol is adjusted to the specified ethanol content of 65%, distilling at 30 ℃ under reduced pressure, recovering ethanol, detecting after completion, and controlling according to pharmacopeia standards or enterprise internal control standards.
5. Blending and internal control indexes:
the relative density of the traditional Chinese medicine extracting solution reaches more than 1.2, glucose aqueous solution is required to be added for blending to adapt to the growth degree of probiotics, 100 times of glucose aqueous solution is added into every 1Kg of traditional Chinese medicine extracting solution, and internal control index test is required after sugar blending; pH is 6-7; ② the relative density is 1.01 to 1.03; adding sterile edible baking soda to reach pH less than 7 when the pH is more than 6, and heating and concentrating under reduced pressure until the relative density reaches 1.01-1.03 to adapt to the osmotic pressure of probiotic cells when the relative density is less than 1.01;
6. and (3) sterilization:
after the traditional Chinese medicine extracting solution is prepared to meet the internal control index, high-pressure steam sterilization is carried out again in high-pressure steam sterilization equipment under the sterilization condition of 121 ℃ and 0.12MPa for 40 minutes, the traditional Chinese medicine extracting solution is filtered into a fermentation tank after being sterilized and is cooled to 28-32 ℃ for inoculation;
6.1, using strains: brewers yeast, lactobacillus, acetobacter, geotrichum fruitatum and bifidobacterium. The strain source and the quality requirement are as follows:
wherein Geotrichum carpum is derived from the institute of northeast science, Lactobacillus, Acetobacter, Bifidobacterium, cerevisiae Fermentum, Geotrichum carpum (Saccharomyces cerevisiae CMCC (F)98007, Acetobacter GIM1.152 are all from the institute of microbiology of Chinese academy of sciences), Bifidobacterium ATCC25527, Lactobacillus H225005 are derived from the national center for classical collection of strains, Geotrichum carpum AS2.364 is derived from the institute of northeast science)
6.2, inoculation method, inoculation time and inoculation amount:
the inoculation tool is composed of an inoculation needle and a pressure injection device, the inoculation needle is installed on a fermentation tank, the needle head of the inoculation needle is closed, a plurality of liquid drainage holes penetrate through the space between the inner cavity wall of the needle tube and the outer wall of the needle tube, the pressure injection device can be an atomizing nozzle, when in use, the inoculation needle is inserted into the needle from the end part of a culture medium bag along the outer side wall of the culture medium along the length direction of the culture medium bag, the fermentation chamber is disinfected before inoculation, an ozone disinfection machine and an ultraviolet lamp are disinfected in the indoor air, and the disinfection is carried out for 28-32 minutes by opening; inoculating time, wherein the first inoculation is to sterilize and cool the culture solution to 20 ℃, inoculating a first probiotic, namely lactobacillus, adjusting the pH after monitoring that the colony density meets the requirement, inoculating beer yeast after 7-8h, inoculating acetobacter by detecting the alcohol production content, and finally adding 1/10 equivalent mould falling suspension of fruity ground; carrying out mixed fermentation at constant temperature for 48h, and then inoculating bifidobacterium longum under anaerobic condition; the inoculation amount is determined according to the fermentation amount, and the ratio of 20: 1, inoculating bifidobacterium to obtain a third-level mixed probiotic strain;
7. fermentation management:
firstly, controlling the temperature, controlling the indoor temperature from 1h to 24h after inoculation to be 37 ℃ (the temperature is the growth temperature of lactobacillus, and the growth of lactobacillus can not be slow when the temperature is reached), controlling the temperature in the tank to be 18-25 ℃ (the temperature is the optimal growth temperature of beer yeast) after the growth speed of lactobacillus reaches the peak value (the growth curve of the lactobacillus in figure 1) for 36 hours after 30 hours, controlling the indoor temperature to be 30-35 ℃ (the acetobacter starts to produce acid) after 60 hours to 72 hours after inoculation, and controlling the temperature in the tank to reach the standard temperature of 35 ℃ and the fermentation period to be 24 hours;
controlling humidity, namely controlling the indoor humidity to be about 38% from the beginning of fermentation to the success of fermentation until the fermentation liquor is stored, and keeping ventilation and drying;
strictly controlling the oxygen introduction amount in the tank, starting oxygen aeration from the inoculated part, stopping oxygen aeration from 68 hours, entering an apoptosis stage of mixed strain fermentation, and controlling oxygen control management for the growth fermentation period of the bifidobacterium 72 hours later;
detecting internal control indexes, namely detecting the pH value in the first step, sampling in a fermentation tank to detect the pH value and the residual sugar content when the fermentation period reaches 24 hours, wherein according to the fermentation requirement, the fermentation is normal when the pH value is 4.5 and the residual sugar content is lower than 1.2g/L in 72 hours, the pH value is 3.5-4 and the residual sugar content is 1g/L in 80 hours, and the fermentation is successful;
testing the density of the active probiotics, according to the growth speed of the normal fermentation probiotics, the viable count of the probiotics obtained by fermentation under the condition is 53.04 multiplied by 107cfu/mL, and the viable count can still reach more than 107cfu/mL after being stored for 4 weeks at 4 ℃.
8. And (3) disinfecting the container:
when the relative density of the fermented Jiuyangqing Changqing probiotic oral liquid is higher than 1.04, the Jiuyangqing Changqing probiotic oral liquid is subpackaged into 10 parts of 60mL oral liquid bottles made of low borosilicate glass tubes, the bottles are sealed by covers, sterilized and packaged to obtain finished products, and the bottles are required to be sterilized by high-temperature steam before canning.
Compared with the prior art, the invention has the following advantages and effects:
A. can regulate the secretion of gastrointestinal hormone related to digestion and neuropeptide related to appetite, and is also one of the pharmacodynamic mechanisms of promoting digestion and improving appetite;
B. can regulate the micro-ecology of the intestinal flora and improve the structure of the intestinal flora, and is an important basis for exerting the pleiotropic effect on the aspect of treating digestive system diseases;
C. can improve the general physical sign state of patients, and relieve symptoms such as anorexia and abnormal defecation;
D. can improve the activity of enzymes in intestinal tracts, promote digestion and absorption and further improve the nutritional level of organisms.
The application method of the medicine comprises the following steps: the oral treatment is carried out on a patient 3 times a day, the single-day oral dose of 180mL is taken for each treatment, and the treatment is continuously carried out for 6 weeks for one treatment course.
(1) The invention is a prescription for treating digestive system dysfunction and inflammation (mainly comprising various chronic gastritis, gastrointestinal dysfunction, intestinal flora imbalance, dyspepsia, atrophic gastritis, gastric ulcer and gastric cancer lesion) by integrating years of clinical treatment experience. The medicine has the advantages of simple components, short treatment course, obvious effect, difficult relapse, small toxic and side effects and the like.
(2) The traditional Chinese medicines adopted by the invention are compatible with each other, and probiotics are used for decomposing drug macromolecules into micromolecular active substances which are more beneficial to the absorption of human bodies, so that the synergistic treatment effect of the traditional Chinese medicines can be exerted, the components of the traditional Chinese medicine raw materials have the efficacy of mutual promotion and coordination of the drug effects, and the traditional Chinese medicine has good curative effect on digestive system dysfunction and inflammation through clinical verification.
Drawings
FIG. 1 is a diagram: bacterial count of mixed lactic acid bacteria of multiple strains of LOGARITHM of LAB (logCFU/ml)
FIG. 2 is a diagram of: example 1 comparing the oral liquid before and after taking Wangzanyuan gastroscope picture of patient
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1:
a Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
11g of ginseng, 11g of bighead atractylodes rhizome, 11g of poria cocos, 9g of liquorice, 11g of fructus aurantii, 5g of fingered citron, 5g of fructus amomi, 5g of pericarpium citri reticulatae, 5g of hawthorn, 5g of fried malt, 5g of radix glehniae, 5g of radix polygonati officinalis, 5g of dendrobe, 5g of coptis chinensis, 5g of mangnolia officinalis, 11g of rhizoma corydalis, 11g of bletilla striata, 5g of angelica sinensis, 11g of medlar, 5g of radix bupleuri, 5g of radix paeoniae alba, 5g of semen coicis, 5g of oldenlandia diffusa, 5g of glabrous sarcandra herb, 5g of salvia miltiorrhiza, 5g of Chinese yam, 5g of lucid ganoderma, 5g of white hyacinth bean, 5g of radix pseudostellariae, 5g of astragalus membranaceus, 11g of peach kernels and 1050ml of water. The medicine prepared in the embodiment 1 of the invention is used clinically, and the use conditions are shown in the table 1
Example 2:
a Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
ginseng radix10g. Poria cocos (Schw.) wolf10g. Prepared licorice root6g. White atractylodes rhizome12g. Dried orange peel10g. Roasted malt10g. Radix Glehniae9g. Radix polygonati officinalis10g. Dendrobium nobile10g。
The medicine prepared in the embodiment 2 of the invention is used clinically, and the use condition is shown in the table 2.
Jiufangqing Changqing enzyme probiotics belongs to a traditional Chinese medicine prescription in the traditional Chinese medicine, and is prepared into a novel traditional Chinese medicine product for treating a series of digestive diseases by adopting probiotic fermentation and biotransformation. The traditional Chinese medicine composition is used for treating gastrointestinal chronic diseases such as gastritis, enteritis, hepatitis, pancreatitis and cholecystitis, the effective rate can reach more than 95 percent, and the cure rate is several times higher than that of the common traditional Chinese medicine decoction or western medicine product when the traditional Chinese medicine composition is taken according to requirements. The most prominent characteristics are quick effect, high curative effect, safety and no side effect. In 2020, the health care hospital performs comparison tests, and 10 patients, 6 men and 4 women, the age of 25-65 years and the average age of 45 years in a test group are treated by heating before meals, taking the Jiuyangqing Changqing enzyme probiotics for three times a day and 180ml once, and after two months of traditional Chinese medicine treatment, the adverse symptoms of the patients are completely eliminated, and after gastroscopy, doctors confirm that the symptoms are basically cured. 10 persons, 6 men and 4 women, 28-68 years old and 46 years old are selected as a control group, patients all have digestive tract diseases and most of stomach diseases, and a doctor selects the decoction of four and corresponding drug therapy for two months, so that most of patients are improved during the drug therapy, but 70% of patients relapse after two months. Most of the latter agreed to the use of traditional Chinese medicine, and administered with the Changqing enzyme prebiotic.
Case one: in age 42 years of Wangzhengyuan women, xi county, the patients feel gastric acid, stomachache, gastrectasia and sour regurgitation in 8 months in 2019, the symptoms are severe, and the patients go to hospitals to have gastroscopy genus reflux gastritis. The western medicines are used for treating the disease, the disease recurrences are frequent, the effect is not good, the traditional Chinese medicine is used for treating and taking the Jiuzongqing enzyme probiotics, the dosage is 180ml every three times a day, and after the traditional Chinese medicine is continuously taken for six weeks, the symptoms are relieved, the appetite is increased, and the digestion is good. After the administration is continued for two weeks, the patients are basically cured and the adverse symptoms are basically eliminated.
Case two: wen Shi Yi in Xishui county, 45 years old, patients often felt stomach discomfort and sometimes pain before examination. In 2020, gastroscopy in hospitals belongs to grade II gastric erosion, and because patients are used to treat diseases by familiar western medicines before, the patients do not recover, but have serious symptoms, and after the causes of diseases are found, Chinese medicine treatment is selected. The JiuYeqing enzyme probiotics is taken three times a day, 180ml is taken once, and the patients are basically cured after being continuously taken for two months. After six months, the patient is rechecked without recurrence symptom and has good physical condition.
The practice proves that the Jiuyangqing enzyme probiotics is a high-efficiency product of Chinese medicine technical innovation, and has the advantages of quick response, high curative effect, safety and no side effect on the treatment of gastropathy and hepatitis.
Conclusion of the experiment
Jiu Ye Qing Chang Qing enzyme probiotics belongs to the Chinese medicine prescription of traditional Chinese medicine and is prepared into a series of digestive series disease characteristic traditional Chinese medicine new products by adopting probiotic fermentation for biotransformation. The traditional Chinese medicine composition is used for treating gastrointestinal chronic diseases such as gastritis, enteritis, hepatitis, pancreatitis and cholecystitis, and has the effective rate of over 95 percent and the cure rate which is several times higher than that of the common traditional Chinese medicine decoction or western medicine product when being taken according to requirements. The most prominent characteristics are quick effect, high curative effect, safety and no side effect; can remarkably relieve intestinal flora regulating effect, and promote digestion and absorption of food.
Note that: firstly, the patent product can be put into use only after the quality is qualified through inspection and detection before leaving the factory.
Before the application of the product, a patient needs to be examined in a hospital or diagnosed in a Chinese and Western medicine, and the patient is proved to be suitable for conditioning and health preserving or treating digestive system diseases by using the product.
Before the product is used, the conditioning or the patient can see the instruction clearly, and the application range, the using method and the storage method are understood in detail.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and their concepts should be considered to be equivalent or modified within the technical scope of the present invention.
Claims (7)
1. A Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
8-12 g of ginseng, 8-12 g of bighead atractylodes rhizome, 8-12 g of poria cocos, 6-10 g of liquorice, 8-12 g of fructus aurantii, 3-6 g of fingered citron, 3-6 g of fructus amomi, 3-6 g of dried orange peel, 3-6 g of hawthorn, 3-6 g of fried malt, 3-6 g of radix glehniae, 3-6 g of radix polygonati officinalis, 3-6 g of dendrobe, 3-6 g of coptis chinensis, 3-6 g of mangnolia officinalis, 8-12 g of rhizoma corydalis, 8-12 g of bletilla, 3-6 g of angelica sinensis, 8-12 g of medlar, 3-6 g of radix bupleuri, 3-6 g of radix paeoniae alba, 3-6 g of semen coicis, 3-6 g of oldenlandia diffusa, 3-6 g of glabrous sarcandra herb, 3-6 g of salvia miltiorrhiza, 3-6 g of Chinese yam, 3-6 g of lucid ganoderma, 3-6 g of white hyacinth bean, 3-6 g of radix pseudostellariae, 3-6 g of astragalus mongholicus, 8-12 g of peach kernel and 900ml-1100ml of water.
2. A Changqing enzyme probiotic oral liquid for treating digestive system diseases comprises the following components in parts by weight:
10g of ginseng, 10g of tuckahoe, 6g of honey-fried licorice root, 12g of bighead atractylodes rhizome, 10g of dried orange peel, 10g of roasted malt, 9g of radix glehniae, 10g of polygonatum, 10g of dendrobium and 1000ml of water.
3. A process for producing the jiulong qingqing enzyme probiotic oral liquid for treating digestive system diseases according to claim 1 or 2, which comprises the steps of:
A. cleaning and selecting raw materials: ginseng, largehead atractylodes rhizome, Indian buead, liquoric root, bitter orange, finger citron, villous amomum fruit, tangerine peel, hawthorn fruit, fried malt, coastal glehnia root, fragrant solomonseal rhizome, dendrobium, golden thread, officinal magnolia bark, corydalis tuber, bletilla, Chinese angelica, medlar, Chinese thorowax root, white paeony root, coix seed, spreading hedyotis herb, glabrous sarcandra herb, danshen root, common yam rhizome, glossy ganoderma, white hyacinth bean, heterophylly falsestarwort root, membranous milkvetch root and peach seed;
B. feeding and soaking: adding the raw materials into a rotary drum type medicine washing machine, grinding the raw materials into 60-mesh small particles after drying, sieving the small particles, placing the small particles in a multifunctional extraction tank, adding water for soaking, wherein the water-material ratio is 1: 5 (five kilograms of water is added into each kilogram of traditional Chinese medicine particles), and soaking for 4-6 hours;
C. heating and decocting: soaking the Chinese medicinal materials, extracting with ethanol, adding 18 times of water, decocting for 3 times, and mixing filtrates;
D. concentration and extraction: standing the traditional Chinese medicine extract at 5-10 deg.C for 24 hr, concentrating, centrifuging at high speed for 15min when the relative density is 1.25, rotating at 8000 r/min, discarding the precipitate to extract supernatant, gradually adding ethanol into the concentrated supernatant at flow rate of 10L/min while stirring to gradually increase ethanol content, adjusting ethanol to specified ethanol content of 65%, extracting supernatant, distilling at 30 deg.C under reduced pressure, recovering ethanol, detecting, and controlling according to pharmacopeia standard or enterprise internal control standard;
E. blending and internal control indexes: the relative density of the traditional Chinese medicine extracting solution reaches more than 1.2, glucose aqueous solution is added for blending to adapt to the growth degree of probiotics, 100 times of the amount of the glucose aqueous solution is added into every 1Kg of the traditional Chinese medicine extracting solution, and internal control index testing is carried out after the sugar is added for blending; pH is 6-7; ② the relative density is 1.01 to 1.03; adding sterile edible baking soda to reach pH less than 7 when the pH is more than 6, and heating and concentrating under reduced pressure until the relative density reaches 1.01-1.03 to adapt to the osmotic pressure of probiotic cells when the relative density is less than 1.01;
F. and (3) sterilization: after the traditional Chinese medicine extracting solution is prepared to meet the internal control index, high-pressure steam sterilization is carried out again in high-pressure steam sterilization equipment under the sterilization condition of 121 ℃ and 0.12MPa for 40 minutes, the traditional Chinese medicine extracting solution is filtered into a fermentation tank after being sterilized and is cooled to 28-32 ℃ for inoculation;
G. fermentation management: strictly controlling the oxygen introduction amount in the tank, starting from inoculation, increasing oxygen, starting from 68 hours, stopping increasing oxygen, entering an apoptosis stage of mixed strain fermentation, and controlling oxygen for the growth fermentation period of the bifidobacteria after 72 hours;
H. and (3) disinfecting the container: when the relative density of the fermented Jiuyangqing Changqing probiotic oral liquid is higher than 1.04, the Jiuyangqing Changqing probiotic oral liquid is subpackaged into 10 parts of 60mL oral liquid bottles made of low borosilicate glass tubes, the bottles are sealed by covers, sterilized and packaged to obtain finished products, and the bottles are required to be sterilized by high-temperature steam before canning.
4. The process for producing a Changqing enzyme probiotic oral liquid for the treatment of digestive system diseases according to claim 3, wherein step F employs the bacterial species: brewers yeast, lactobacillus, acetobacter, geotrichum fruitatum and bifidobacterium.
5. The process for producing a Changqing enzyme probiotic oral liquid for treating digestive system diseases according to claim 3, wherein the inoculation method, the inoculation time and the inoculation amount in step F: the inoculation tool is composed of an inoculation needle and a pressure injection device, the inoculation needle is arranged on a fermentation tank, the needle head of the inoculation needle is closed, a plurality of liquid drainage holes penetrate through the space between the inner cavity wall of the needle tube and the outer wall of the needle tube, the pressure injection device can be a spray nozzle, when the inoculation tool is used, the inoculation needle is inserted into the needle from the bagged end part of a culture medium along the outer side wall of the culture medium along the bagged length direction of the culture medium, before inoculation, the fermentation chamber is disinfected, indoor air is disinfected by an ozone disinfection machine and an ultraviolet lamp, and meanwhile, the disinfection is opened for 28-32 minutes; inoculating time, wherein the first inoculation is to sterilize and cool the culture solution to 20 ℃, inoculating a first probiotic, namely lactobacillus, adjusting the pH after monitoring that the colony density meets the requirement, inoculating beer yeast after 7-8h, inoculating acetobacter by detecting the alcohol production content, and finally adding 1/10 equivalent mould falling suspension of fruity ground; carrying out mixed fermentation at constant temperature for 48h, and then inoculating bifidobacterium longum under anaerobic condition; the inoculation amount is determined according to the fermentation amount, and the ratio of 20: 1 part of bifidobacteria are inoculated to obtain a third-level mixed probiotic strain.
6. The process for producing a Changqing enzyme probiotic oral liquid for treating digestive system diseases according to claim 3, wherein the temperature and humidity control of step F is specifically:
firstly, controlling the temperature, controlling the indoor temperature from 1h to 24h after inoculation to be 37 ℃ (the temperature is the growth temperature of lactobacillus, and the growth of lactobacillus can not be slow when the temperature is reached), controlling the temperature in the tank to be 18-25 ℃ (the temperature is the optimal growth temperature of beer yeast) after the growth speed of lactobacillus reaches the peak value (the growth curve of the lactobacillus in figure 1) for 36 hours after 30 hours, controlling the indoor temperature to be 30-35 ℃ (the acetobacter starts to produce acid) after 60 hours to 72 hours after inoculation, and controlling the temperature in the tank to reach the standard temperature of 35 ℃ and the fermentation period to be 24 hours;
controlling humidity, namely controlling the indoor humidity to be about 38% from the beginning of fermentation to the success of fermentation until the fermentation liquor is stored, and keeping ventilation and drying.
7. The process for producing a Changqing enzyme probiotic oral liquid for treating digestive system diseases according to claim 3, wherein the specific fermentation management of step G is: detecting an internal control index, namely detecting the pH value at the first time, sampling in a fermentation tank to detect the pH value and the residual sugar amount from the fermentation period to 24 hours, wherein according to the fermentation requirement, the fermentation is normal when the pH value is 4.5 at 72 hours and the residual sugar amount is lower than 1.2g/L, and the fermentation is successful when the pH value is 3.5-4 at 80 hours and the residual sugar amount is 1 g/L; the density of the active probiotics is detected, according to the growth speed of the normal fermentation probiotics, the viable count of the probiotics obtained by fermentation under the condition is 53.04 multiplied by 107cfu/mL, and the viable count can still reach more than 107cfu/mL after being stored for 4 weeks at 4 ℃.
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