JP5019612B2 - Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ - Google Patents

Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ Download PDF

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JP5019612B2
JP5019612B2 JP2007506357A JP2007506357A JP5019612B2 JP 5019612 B2 JP5019612 B2 JP 5019612B2 JP 2007506357 A JP2007506357 A JP 2007506357A JP 2007506357 A JP2007506357 A JP 2007506357A JP 5019612 B2 JP5019612 B2 JP 5019612B2
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JP2007531740A5 (https=
JP2007531740A (ja
Inventor
ジェレミー グリーン，
アンドリュー ミラー，
ユアン−ミゲル ヒメネス，
クレイグ マールへフカ，
ジンロン チャオ，
ジョン ジェイ． コート，
ウプル ケー． バンダラジ，
ホワイ ガオ，
スガンシニ ナンサクマー，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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JP2007506357A 2004-04-02 2005-04-04 Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ Expired - Fee Related JP5019612B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55904104P 2004-04-02 2004-04-02
US60/559,041 2004-04-02
PCT/US2005/011358 WO2005103050A2 (en) 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases

Publications (3)

Publication Number Publication Date
JP2007531740A JP2007531740A (ja) 2007-11-08
JP2007531740A5 JP2007531740A5 (https=) 2008-05-22
JP5019612B2 true JP5019612B2 (ja) 2012-09-05

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JP2007506357A Expired - Fee Related JP5019612B2 (ja) 2004-04-02 2005-04-04 Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ

Country Status (14)

Country Link
US (1) US7514448B2 (https=)
EP (1) EP1756108A2 (https=)
JP (1) JP5019612B2 (https=)
KR (1) KR20070002081A (https=)
CN (1) CN101014597A (https=)
AR (1) AR049333A1 (https=)
AU (1) AU2005236002A1 (https=)
CA (1) CA2561724A1 (https=)
IL (1) IL178414A0 (https=)
MX (1) MXPA06011328A (https=)
NO (1) NO20064976L (https=)
RU (1) RU2006138621A (https=)
TW (1) TW200604168A (https=)
WO (1) WO2005103050A2 (https=)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550361C (en) 2003-12-19 2014-04-29 Prabha Ibrahim Compounds and methods for development of ret modulators
JP4834840B2 (ja) 2004-01-06 2011-12-14 ノヴォ ノルディスク アー／エス ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用
US20080293716A1 (en) * 2004-01-30 2008-11-27 Smithkline Beecham Corporation Chemical Compounds
TWI372624B (en) * 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
MXPA06014415A (es) * 2004-06-24 2007-02-19 Shionogi & Co Compuestos de sulfonamida.
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