JP4799864B2 - サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン - Google Patents

サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン Download PDF

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Publication number
JP4799864B2
JP4799864B2 JP2004537904A JP2004537904A JP4799864B2 JP 4799864 B2 JP4799864 B2 JP 4799864B2 JP 2004537904 A JP2004537904 A JP 2004537904A JP 2004537904 A JP2004537904 A JP 2004537904A JP 4799864 B2 JP4799864 B2 JP 4799864B2
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compound
cancer
group
alkyl
diseases
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JP2006507253A5 (https=
JP2006507253A (ja
Inventor
カミル パルチ，
ティモシー ジェイ． グジ，
マイケル ピー． ドワイヤー，
ロナルド ジェイ． ドール，
ヴィヨール エム． ジリジャヴァラブハン，
アラン ケー． マラムス，
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004537904A 2002-09-23 2003-09-19 サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン Expired - Fee Related JP4799864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41299702P 2002-09-23 2002-09-23
US60/412,997 2002-09-23
PCT/US2003/029209 WO2004026877A1 (en) 2002-09-23 2003-09-19 Imidazopyrazines as cyclin dependent kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2006507253A JP2006507253A (ja) 2006-03-02
JP2006507253A5 JP2006507253A5 (https=) 2006-10-26
JP4799864B2 true JP4799864B2 (ja) 2011-10-26

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Family Applications (1)

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JP2004537904A Expired - Fee Related JP4799864B2 (ja) 2002-09-23 2003-09-19 サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン

Country Status (18)

Country Link
US (2) US6919341B2 (https=)
EP (1) EP1543008B1 (https=)
JP (1) JP4799864B2 (https=)
KR (1) KR20050057520A (https=)
CN (1) CN1694886A (https=)
AR (1) AR041347A1 (https=)
AT (1) ATE377600T1 (https=)
AU (1) AU2003272476B2 (https=)
CA (1) CA2499756C (https=)
DE (1) DE60317353T2 (https=)
ES (1) ES2293015T3 (https=)
MX (1) MXPA05003120A (https=)
MY (1) MY134589A (https=)
NZ (2) NZ538685A (https=)
PE (1) PE20050081A1 (https=)
TW (1) TW200413378A (https=)
WO (1) WO2004026877A1 (https=)
ZA (1) ZA200502375B (https=)

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US6919341B2 (en) 2005-07-19
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