MX339640B - Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace). - Google Patents
Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace).Info
- Publication number
- MX339640B MX339640B MX2012014368A MX2012014368A MX339640B MX 339640 B MX339640 B MX 339640B MX 2012014368 A MX2012014368 A MX 2012014368A MX 2012014368 A MX2012014368 A MX 2012014368A MX 339640 B MX339640 B MX 339640B
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- secretase
- bace
- oxazin
- dihydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a derivados novedosos de 5, 6-dihidro-2H-[1, 4]oxazin-3-ilamina como inhibidores de la beta-secretasa, conocida también como enzima de escisión amiloide del sitio beta, BACE, BACE1, Asp2 o memapsina2; la invención se refiere también a composiciones farmacéuticas que comprenden dichos compuestos, a procedimientos para la preparación de dichos compuestos y composiciones, y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los cuales se encuentra involucrada la beta-secretasa, tales como en enfermedad de Alzheimer (EA), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con el accidente cerebrovascular, demencia asociada con la enfermedad de Parkinson o demencia asociada con beta-amiloide.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10165335 | 2010-06-09 | ||
EP11152314 | 2011-01-27 | ||
EP11157765 | 2011-03-10 | ||
EP11164999 | 2011-05-05 | ||
PCT/EP2011/059441 WO2011154431A1 (en) | 2010-06-09 | 2011-06-08 | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012014368A MX2012014368A (es) | 2013-01-22 |
MX339640B true MX339640B (es) | 2016-06-01 |
Family
ID=44317911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012014368A MX339640B (es) | 2010-06-09 | 2011-06-08 | Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace). |
Country Status (22)
Country | Link |
---|---|
US (2) | US20130109683A1 (es) |
EP (1) | EP2580200B1 (es) |
JP (1) | JP5711813B2 (es) |
KR (1) | KR101730937B1 (es) |
CN (1) | CN102933564B (es) |
AR (1) | AR081587A1 (es) |
AU (1) | AU2011263797B2 (es) |
BR (1) | BR112012031094A2 (es) |
CA (1) | CA2799640C (es) |
CL (1) | CL2012003428A1 (es) |
CO (1) | CO6602112A2 (es) |
DK (1) | DK2580200T3 (es) |
EA (1) | EA021240B1 (es) |
ES (1) | ES2607083T3 (es) |
HK (1) | HK1182098A1 (es) |
IL (1) | IL223423A (es) |
MX (1) | MX339640B (es) |
NZ (1) | NZ603427A (es) |
SG (1) | SG185651A1 (es) |
TW (1) | TWI537263B (es) |
WO (1) | WO2011154431A1 (es) |
ZA (1) | ZA201209297B (es) |
Families Citing this family (51)
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KR20100017255A (ko) | 2007-04-24 | 2010-02-16 | 시오노기 앤드 컴파니, 리미티드 | 환식기로 치환된 아미노다이하이드로싸이아진 유도체 |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
US8703785B2 (en) | 2008-10-22 | 2014-04-22 | Shionogi & Co., Ltd. | 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity |
UY32799A (es) | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
EP2485591B1 (en) | 2009-10-08 | 2016-03-23 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
CA2799640C (en) | 2010-06-09 | 2018-10-16 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
EP2634186A4 (en) | 2010-10-29 | 2014-03-26 | Shionogi & Co | naphthyridine |
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KR102012671B1 (ko) | 2011-03-01 | 2019-08-21 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(BACE)의 억제제로서 유용한 6,7-디하이드로-피라졸로[1,5-a]피라진-4-일아민 유도체 |
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US20160152581A1 (en) | 2016-06-02 |
SG185651A1 (en) | 2012-12-28 |
EP2580200B1 (en) | 2016-09-14 |
CN102933564B (zh) | 2015-07-22 |
EA021240B1 (ru) | 2015-05-29 |
ES2607083T3 (es) | 2017-03-29 |
CA2799640A1 (en) | 2011-12-15 |
IL223423A (en) | 2016-03-31 |
DK2580200T3 (en) | 2017-01-09 |
WO2011154431A1 (en) | 2011-12-15 |
AR081587A1 (es) | 2012-10-03 |
EA201291435A1 (ru) | 2013-05-30 |
KR101730937B1 (ko) | 2017-04-27 |
AU2011263797A1 (en) | 2012-11-22 |
EP2580200A1 (en) | 2013-04-17 |
TW201211037A (en) | 2012-03-16 |
KR20130119851A (ko) | 2013-11-01 |
HK1182098A1 (en) | 2013-11-22 |
ZA201209297B (en) | 2014-09-25 |
JP2013531645A (ja) | 2013-08-08 |
NZ603427A (en) | 2013-08-30 |
AU2011263797B2 (en) | 2014-06-05 |
TWI537263B (zh) | 2016-06-11 |
CN102933564A (zh) | 2013-02-13 |
CL2012003428A1 (es) | 2013-04-01 |
US20130109683A1 (en) | 2013-05-02 |
MX2012014368A (es) | 2013-01-22 |
BR112012031094A2 (pt) | 2016-10-25 |
JP5711813B2 (ja) | 2015-05-07 |
CO6602112A2 (es) | 2013-01-18 |
US9828350B2 (en) | 2017-11-28 |
CA2799640C (en) | 2018-10-16 |
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