MX339640B - Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace). - Google Patents

Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace).

Info

Publication number
MX339640B
MX339640B MX2012014368A MX2012014368A MX339640B MX 339640 B MX339640 B MX 339640B MX 2012014368 A MX2012014368 A MX 2012014368A MX 2012014368 A MX2012014368 A MX 2012014368A MX 339640 B MX339640 B MX 339640B
Authority
MX
Mexico
Prior art keywords
beta
secretase
bace
oxazin
dihydro
Prior art date
Application number
MX2012014368A
Other languages
English (en)
Other versions
MX2012014368A (es
Inventor
Frederik Jan Rita Rombouts
Henricus Jacobus Maria Gijsen
Andrés Avelino Trabanco-Suárez
Gregor James Macdonald
Gool Michiel Luc Maria Van
Gary John Tresadern
Lamenca Carolina Martinez
Original Assignee
Janssen Pharmaceutica Nv *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv * filed Critical Janssen Pharmaceutica Nv *
Publication of MX2012014368A publication Critical patent/MX2012014368A/es
Publication of MX339640B publication Critical patent/MX339640B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados novedosos de 5, 6-dihidro-2H-[1, 4]oxazin-3-ilamina como inhibidores de la beta-secretasa, conocida también como enzima de escisión amiloide del sitio beta, BACE, BACE1, Asp2 o memapsina2; la invención se refiere también a composiciones farmacéuticas que comprenden dichos compuestos, a procedimientos para la preparación de dichos compuestos y composiciones, y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los cuales se encuentra involucrada la beta-secretasa, tales como en enfermedad de Alzheimer (EA), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con el accidente cerebrovascular, demencia asociada con la enfermedad de Parkinson o demencia asociada con beta-amiloide.
MX2012014368A 2010-06-09 2011-06-08 Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace). MX339640B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10165335 2010-06-09
EP11152314 2011-01-27
EP11157765 2011-03-10
EP11164999 2011-05-05
PCT/EP2011/059441 WO2011154431A1 (en) 2010-06-09 2011-06-08 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace)

Publications (2)

Publication Number Publication Date
MX2012014368A MX2012014368A (es) 2013-01-22
MX339640B true MX339640B (es) 2016-06-01

Family

ID=44317911

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014368A MX339640B (es) 2010-06-09 2011-06-08 Derivados de 5, 6-dihidro-2h-[1, 4] oxazin-3-il-amina utiles como inhibidores de la beta-secretasa (bace).

Country Status (22)

Country Link
US (2) US20130109683A1 (es)
EP (1) EP2580200B1 (es)
JP (1) JP5711813B2 (es)
KR (1) KR101730937B1 (es)
CN (1) CN102933564B (es)
AR (1) AR081587A1 (es)
AU (1) AU2011263797B2 (es)
BR (1) BR112012031094A2 (es)
CA (1) CA2799640C (es)
CL (1) CL2012003428A1 (es)
CO (1) CO6602112A2 (es)
DK (1) DK2580200T3 (es)
EA (1) EA021240B1 (es)
ES (1) ES2607083T3 (es)
HK (1) HK1182098A1 (es)
IL (1) IL223423A (es)
MX (1) MX339640B (es)
NZ (1) NZ603427A (es)
SG (1) SG185651A1 (es)
TW (1) TWI537263B (es)
WO (1) WO2011154431A1 (es)
ZA (1) ZA201209297B (es)

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US20130109683A1 (en) 2013-05-02
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