BR112012033291A2 - derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência - Google Patents
derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demênciaInfo
- Publication number
- BR112012033291A2 BR112012033291A2 BR112012033291A BR112012033291A BR112012033291A2 BR 112012033291 A2 BR112012033291 A2 BR 112012033291A2 BR 112012033291 A BR112012033291 A BR 112012033291A BR 112012033291 A BR112012033291 A BR 112012033291A BR 112012033291 A2 BR112012033291 A2 BR 112012033291A2
- Authority
- BR
- Brazil
- Prior art keywords
- dementia
- disease
- pyrazin
- alzheimer
- dihydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência. a presente invenção refere-se a novos derivados de 3-amino-5,6-di-hidro-1h-pirazin-2-ona como inibidores de betasecretase, também conhecida como enzima de clivagem de beta-sítio amiloide, bace, bace1, asp2, ou memapsin2. a invenção também se refere a composições farmacêuticas compreendendo os referidos compostos, a processos para preparar os referidos compostos e composições, e à aplicação dos referidos compostos e composições para a prevenção e para o tratamento de distúrbios nos quais beta-secretase está envolvida, tais como a doença de alzheimer (ad), disfunção cogntiva branda, senilidade, demência, demência com corpos de lewy, síndrome de down, demência associada com derrame, demência associada com a doença de parkinson ou demência associada com beta-amiloide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10167542 | 2010-06-28 | ||
PCT/EP2011/060712 WO2012000933A1 (en) | 2010-06-28 | 2011-06-27 | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012033291A2 true BR112012033291A2 (pt) | 2016-11-22 |
Family
ID=44534844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012033291A BR112012033291A2 (pt) | 2010-06-28 | 2011-06-27 | derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência |
Country Status (14)
Country | Link |
---|---|
US (1) | US20130102618A1 (pt) |
EP (1) | EP2585440A1 (pt) |
JP (1) | JP2013529664A (pt) |
KR (1) | KR20130089231A (pt) |
CN (1) | CN102985412A (pt) |
AU (1) | AU2011273640A1 (pt) |
BR (1) | BR112012033291A2 (pt) |
CA (1) | CA2802380A1 (pt) |
EA (1) | EA201291413A1 (pt) |
IL (1) | IL223819A0 (pt) |
MX (1) | MX2012015170A (pt) |
NZ (1) | NZ603896A (pt) |
SG (1) | SG186408A1 (pt) |
WO (1) | WO2012000933A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2628074C (en) | 2005-10-25 | 2014-01-14 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
CA2683887A1 (en) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group having inhibitory activity against production of amyloid beta protein |
JP5490692B2 (ja) | 2008-06-13 | 2014-05-14 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
EP2511268B2 (en) | 2009-12-11 | 2021-02-17 | Shionogi & Co., Ltd. | Oxazine derivative |
EA201200952A1 (ru) * | 2009-12-31 | 2013-02-28 | Новартис Аг | Производные пиразина и их применение для лечения неврологических нарушений |
WO2011154431A1 (en) | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
EP2634186A4 (en) | 2010-10-29 | 2014-03-26 | Shionogi & Co | naphthyridine |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
CN103403007B (zh) | 2010-12-22 | 2015-12-09 | 詹森药业有限公司 | 用作β-分泌酶(BACE)抑制剂的5,6-二氢-咪唑并[1,2-a]吡嗪-8-基胺衍生物 |
WO2012120023A1 (en) | 2011-03-09 | 2012-09-13 | Janssen Pharmaceutica Nv | 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
EP2703399A4 (en) | 2011-04-26 | 2014-10-15 | Shionogi & Co | OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
ES2721073T3 (es) | 2013-06-12 | 2019-07-26 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5 a]pirazina como inhibidores de beta-secretasa (BACE) |
CN105452251B (zh) | 2013-06-12 | 2017-12-26 | 詹森药业有限公司 | 作为β‑分泌酶(BACE)抑制剂的4‑氨基‑6‑苯基‑5,6‑二氢咪唑并[1,5‑A]吡嗪‑3(2H)‑酮衍生物 |
EP3008066B1 (en) | 2013-06-12 | 2018-08-15 | Janssen Pharmaceutica N.V. | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
EA031041B1 (ru) | 2014-12-18 | 2018-11-30 | Янссен Фармацевтика Нв | Соединения 2,3,4,5-тетрагидропиридин-6-амин и 3,4-дигидро-2h-пиррол-5-амин - ингибиторы бета-секретазы |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1678172T3 (da) | 2003-10-15 | 2010-04-06 | Targacept Inc | Azabicykliske forbindelser til lindring af smerte og behandling af sygdomme i centralnervesystemet |
US20090099217A1 (en) * | 2006-04-05 | 2009-04-16 | Astex Therapeutics Ltd. | 2-Aminopyrimidin-4-Ones And Their Use For Treating Or Preventing Alpha Beta-Related Pathologies |
US8076358B2 (en) * | 2008-01-28 | 2011-12-13 | Janssen Pharmaceutica Nv | 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
EA201200952A1 (ru) * | 2009-12-31 | 2013-02-28 | Новартис Аг | Производные пиразина и их применение для лечения неврологических нарушений |
-
2011
- 2011-06-27 NZ NZ603896A patent/NZ603896A/xx not_active IP Right Cessation
- 2011-06-27 JP JP2013517227A patent/JP2013529664A/ja not_active Withdrawn
- 2011-06-27 BR BR112012033291A patent/BR112012033291A2/pt not_active IP Right Cessation
- 2011-06-27 CN CN2011800319793A patent/CN102985412A/zh active Pending
- 2011-06-27 WO PCT/EP2011/060712 patent/WO2012000933A1/en active Application Filing
- 2011-06-27 EP EP11729962.8A patent/EP2585440A1/en not_active Withdrawn
- 2011-06-27 AU AU2011273640A patent/AU2011273640A1/en not_active Abandoned
- 2011-06-27 MX MX2012015170A patent/MX2012015170A/es not_active Application Discontinuation
- 2011-06-27 SG SG2012093753A patent/SG186408A1/en unknown
- 2011-06-27 CA CA2802380A patent/CA2802380A1/en not_active Abandoned
- 2011-06-27 EA EA201291413A patent/EA201291413A1/ru unknown
- 2011-06-27 KR KR1020137000987A patent/KR20130089231A/ko not_active Application Discontinuation
- 2011-06-27 US US13/806,214 patent/US20130102618A1/en not_active Abandoned
-
2012
- 2012-12-24 IL IL223819A patent/IL223819A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ603896A (en) | 2013-08-30 |
AU2011273640A1 (en) | 2012-12-20 |
KR20130089231A (ko) | 2013-08-09 |
IL223819A0 (en) | 2013-03-05 |
EP2585440A1 (en) | 2013-05-01 |
MX2012015170A (es) | 2013-01-24 |
CA2802380A1 (en) | 2012-01-05 |
EA201291413A1 (ru) | 2013-05-30 |
WO2012000933A1 (en) | 2012-01-05 |
US20130102618A1 (en) | 2013-04-25 |
JP2013529664A (ja) | 2013-07-22 |
CN102985412A (zh) | 2013-03-20 |
SG186408A1 (en) | 2013-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |