EA201291413A1 - Производные 3-амино-5,6-дигидро-1h-пиразин-2-она, применимые для лечения болезни альцгеймера и других форм деменции - Google Patents
Производные 3-амино-5,6-дигидро-1h-пиразин-2-она, применимые для лечения болезни альцгеймера и других форм деменцииInfo
- Publication number
- EA201291413A1 EA201291413A1 EA201291413A EA201291413A EA201291413A1 EA 201291413 A1 EA201291413 A1 EA 201291413A1 EA 201291413 A EA201291413 A EA 201291413A EA 201291413 A EA201291413 A EA 201291413A EA 201291413 A1 EA201291413 A1 EA 201291413A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disease
- dementia
- beta
- pyrazin
- dihydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение касается новых производных 3-амино-5,6-дигидро-1Н-пиразин-2-она как ингибиторов бета-секретазы, также известной как фермент расщепления бета-сайта амилоида, ВАСЕ, ВАСЕ1, Asp2 или мемапсин 2. Изобретение также касается фармацевтических композиций, содержащих такие соединения, способа получения таких соединений и композиций и применения таких соединений и композиций для профилактики и лечения заболеваний, в которые вовлечена бета-секретаза, таких как болезнь Альцгеймера (AD), умеренное когнитивное расстройство, старость, деменция, деменция с тельцами Леви, синдром Дауна, деменция, связанная с инсультом, деменция, связанная с болезнью Паркинсона, или деменция, связанная с бета-амилоидом.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10167542 | 2010-06-28 | ||
PCT/EP2011/060712 WO2012000933A1 (en) | 2010-06-28 | 2011-06-27 | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201291413A1 true EA201291413A1 (ru) | 2013-05-30 |
Family
ID=44534844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201291413A EA201291413A1 (ru) | 2010-06-28 | 2011-06-27 | Производные 3-амино-5,6-дигидро-1h-пиразин-2-она, применимые для лечения болезни альцгеймера и других форм деменции |
Country Status (14)
Country | Link |
---|---|
US (1) | US20130102618A1 (ru) |
EP (1) | EP2585440A1 (ru) |
JP (1) | JP2013529664A (ru) |
KR (1) | KR20130089231A (ru) |
CN (1) | CN102985412A (ru) |
AU (1) | AU2011273640A1 (ru) |
BR (1) | BR112012033291A2 (ru) |
CA (1) | CA2802380A1 (ru) |
EA (1) | EA201291413A1 (ru) |
IL (1) | IL223819A0 (ru) |
MX (1) | MX2012015170A (ru) |
NZ (1) | NZ603896A (ru) |
SG (1) | SG186408A1 (ru) |
WO (1) | WO2012000933A1 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103936690B (zh) | 2005-10-25 | 2016-06-08 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
KR20100017255A (ko) | 2007-04-24 | 2010-02-16 | 시오노기 앤드 컴파니, 리미티드 | 환식기로 치환된 아미노다이하이드로싸이아진 유도체 |
NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
US8703785B2 (en) | 2008-10-22 | 2014-04-22 | Shionogi & Co., Ltd. | 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity |
AU2010328975B2 (en) | 2009-12-11 | 2015-01-22 | Shionogi & Co. Ltd. | Oxazine derivative |
PE20121640A1 (es) * | 2009-12-31 | 2012-12-17 | Novartis Ag | Derivados de pirazina como inhibidores de bace |
ES2607083T3 (es) | 2010-06-09 | 2017-03-29 | Janssen Pharmaceutica, N.V. | Derivados de 5,6-dihidro-2H-[1,4]oxazin-3-ilamina útiles como inhibidores de beta-secretasa (BACE) |
AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
EA022409B1 (ru) | 2010-12-22 | 2015-12-30 | Янссен Фармацевтика Нв | Производные 5,6-дигидроимидазо[1,2-а]пиразин-8-иламина, пригодные в качестве ингибиторов бета-секретазы (васе) |
SG193342A1 (en) | 2011-03-09 | 2013-10-30 | Janssen Pharmaceutica Nv | 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
ES2721073T3 (es) | 2013-06-12 | 2019-07-26 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5 a]pirazina como inhibidores de beta-secretasa (BACE) |
ES2627633T3 (es) | 2013-06-12 | 2017-07-28 | Janssen Pharmaceutica N.V. | Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]piracin-3(2H)-ona como inhibidores de beta-secretasa (BACE) |
MX369629B (es) | 2013-06-12 | 2019-11-14 | Janssen Pharmaceutica Nv | Derivados de 4-a mino-6-fenil-5,6-dihidroimidazo[1,5 a]pirazina como inhibidores de beta-secretasa (bace). |
EP3233834B1 (en) | 2014-12-18 | 2019-11-13 | Janssen Pharmaceutica NV | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine derivatives useful as inhibitors of beta-secretase |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1678172E (pt) | 2003-10-15 | 2010-03-03 | Targacept Inc | Composições farmacêuticas e métodos para alívio da dor e tratamento de perturbações do sistema nervoso central |
WO2007114771A1 (en) * | 2006-04-05 | 2007-10-11 | Astrazeneca Ab | 2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR TREATING OR PREVENTING Aβ-RELATED PATHOLOGIES |
ES2400173T3 (es) * | 2008-01-28 | 2013-04-08 | Janssen Pharmaceutica Nv | Derivados de 6-sustituido-tio-2-amino-quinolina útiles como inhibidores de beta-secretasa (BACE) |
PE20121640A1 (es) * | 2009-12-31 | 2012-12-17 | Novartis Ag | Derivados de pirazina como inhibidores de bace |
-
2011
- 2011-06-27 JP JP2013517227A patent/JP2013529664A/ja not_active Withdrawn
- 2011-06-27 AU AU2011273640A patent/AU2011273640A1/en not_active Abandoned
- 2011-06-27 WO PCT/EP2011/060712 patent/WO2012000933A1/en active Application Filing
- 2011-06-27 US US13/806,214 patent/US20130102618A1/en not_active Abandoned
- 2011-06-27 KR KR1020137000987A patent/KR20130089231A/ko not_active Application Discontinuation
- 2011-06-27 EA EA201291413A patent/EA201291413A1/ru unknown
- 2011-06-27 EP EP11729962.8A patent/EP2585440A1/en not_active Withdrawn
- 2011-06-27 SG SG2012093753A patent/SG186408A1/en unknown
- 2011-06-27 NZ NZ603896A patent/NZ603896A/xx not_active IP Right Cessation
- 2011-06-27 CN CN2011800319793A patent/CN102985412A/zh active Pending
- 2011-06-27 CA CA2802380A patent/CA2802380A1/en not_active Abandoned
- 2011-06-27 BR BR112012033291A patent/BR112012033291A2/pt not_active IP Right Cessation
- 2011-06-27 MX MX2012015170A patent/MX2012015170A/es not_active Application Discontinuation
-
2012
- 2012-12-24 IL IL223819A patent/IL223819A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ603896A (en) | 2013-08-30 |
SG186408A1 (en) | 2013-01-30 |
EP2585440A1 (en) | 2013-05-01 |
US20130102618A1 (en) | 2013-04-25 |
WO2012000933A1 (en) | 2012-01-05 |
BR112012033291A2 (pt) | 2016-11-22 |
AU2011273640A1 (en) | 2012-12-20 |
CA2802380A1 (en) | 2012-01-05 |
KR20130089231A (ko) | 2013-08-09 |
MX2012015170A (es) | 2013-01-24 |
IL223819A0 (en) | 2013-03-05 |
JP2013529664A (ja) | 2013-07-22 |
CN102985412A (zh) | 2013-03-20 |
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