MX2019005247A - Compuestos 4,4a,5,7-tetrahidro-3h-furo[3,4-b]piridinilicos. - Google Patents
Compuestos 4,4a,5,7-tetrahidro-3h-furo[3,4-b]piridinilicos.Info
- Publication number
- MX2019005247A MX2019005247A MX2019005247A MX2019005247A MX2019005247A MX 2019005247 A MX2019005247 A MX 2019005247A MX 2019005247 A MX2019005247 A MX 2019005247A MX 2019005247 A MX2019005247 A MX 2019005247A MX 2019005247 A MX2019005247 A MX 2019005247A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- dementia
- beta
- disease
- furo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a inhibidores de la enzima que escinde APP por el sitio beta, los cuales son compuestos 4,4a,5,7-tetrahidro-3H-furo[3,4-b]piridinilicos que tienen la estructura que se muestra en la Formula (I) [ver fórmula (I)] donde los radicales son como se definen en la memoria descriptiva; la invencion tambien se refiere a composiciones farmaceuticas que comprenden tales compuestos, a procesos para preparar tales compuestos y composiciones, y al uso de tales compuestos y composiciones para la prevencion y el tratamiento de trastornos en los que participa la enzima que escinde APP por el sitio beta, tales como la enfermedad de Alzheimer (EA), deterioro cognitivo leve, enfermedad de Alzheimer preclinica, senilidad, demencia, demencia con cuerpos de Lewy, sindrome de Down, demencia asociada con el accidente cerebrovascular, demencia asociada con la enfermedad de Parkinson y demencia asociada con beta-amiloides.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16197351 | 2016-11-04 | ||
EP17162307 | 2017-03-22 | ||
PCT/EP2017/078200 WO2018083247A1 (en) | 2016-11-04 | 2017-11-03 | 4,4a,5,7-tetrahydro-3h-furo[3,4-b]pyridinyl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019005247A true MX2019005247A (es) | 2019-06-24 |
Family
ID=60413151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005247A MX2019005247A (es) | 2016-11-04 | 2017-11-03 | Compuestos 4,4a,5,7-tetrahidro-3h-furo[3,4-b]piridinilicos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20200062773A1 (es) |
EP (1) | EP3535271A1 (es) |
JP (1) | JP2019532992A (es) |
KR (1) | KR20190075072A (es) |
CN (1) | CN109890828A (es) |
AU (1) | AU2017353510A1 (es) |
CA (1) | CA3039586A1 (es) |
MA (1) | MA46698A (es) |
MX (1) | MX2019005247A (es) |
WO (1) | WO2018083247A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR077277A1 (es) * | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
CA2894919A1 (en) * | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | C5,c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors, compositions, and their use |
CA2967164A1 (en) * | 2014-12-18 | 2016-06-23 | Janssen Pharmaceutica Nv | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase |
MA42604A (fr) * | 2015-08-12 | 2018-06-20 | H Lundbeck As | 2-amino-7a-phényl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridines comme inhibiteurs de bace1 |
-
2017
- 2017-11-03 MA MA046698A patent/MA46698A/fr unknown
- 2017-11-03 CA CA3039586A patent/CA3039586A1/en not_active Abandoned
- 2017-11-03 JP JP2019523091A patent/JP2019532992A/ja active Pending
- 2017-11-03 MX MX2019005247A patent/MX2019005247A/es unknown
- 2017-11-03 AU AU2017353510A patent/AU2017353510A1/en not_active Abandoned
- 2017-11-03 US US16/347,064 patent/US20200062773A1/en not_active Abandoned
- 2017-11-03 WO PCT/EP2017/078200 patent/WO2018083247A1/en unknown
- 2017-11-03 KR KR1020197011917A patent/KR20190075072A/ko unknown
- 2017-11-03 EP EP17801369.4A patent/EP3535271A1/en not_active Withdrawn
- 2017-11-03 CN CN201780067760.6A patent/CN109890828A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2018083247A1 (en) | 2018-05-11 |
US20200062773A1 (en) | 2020-02-27 |
EP3535271A1 (en) | 2019-09-11 |
MA46698A (fr) | 2021-04-07 |
KR20190075072A (ko) | 2019-06-28 |
AU2017353510A1 (en) | 2019-05-02 |
CA3039586A1 (en) | 2018-05-11 |
CN109890828A (zh) | 2019-06-14 |
JP2019532992A (ja) | 2019-11-14 |
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