MX347912B - Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace). - Google Patents
Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace).Info
- Publication number
- MX347912B MX347912B MX2013007294A MX2013007294A MX347912B MX 347912 B MX347912 B MX 347912B MX 2013007294 A MX2013007294 A MX 2013007294A MX 2013007294 A MX2013007294 A MX 2013007294A MX 347912 B MX347912 B MX 347912B
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- secretase
- dementia
- bace
- pyrazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a derivados novedosos de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina como inhibidores de beta-secretasa, conocida también como enzima de separación amiloide del sitio beta, BACE, BACE1, Asp2 o memapsina2; la invención está dirigida también a composiciones farmacéuticas que comprenden dichos compuestos, a procedimientos para preparar dichos compuestos y composiciones, y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los cuales la beta-secretasa está implicada, tal como en enfermedad de Alzheimer (AD), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, angiopatía amiloide cerebrovascular, demencia por infartos múltiples, síndrome de Down, demencia asociada con accidente cerebrovascular, demencia asociada con enfermedad de Parkinson o demencia asociada con beta-amiloide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10196568 | 2010-12-22 | ||
PCT/EP2011/073522 WO2012085038A1 (en) | 2010-12-22 | 2011-12-21 | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013007294A MX2013007294A (es) | 2013-08-26 |
MX347912B true MX347912B (es) | 2017-05-17 |
Family
ID=43923528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007294A MX347912B (es) | 2010-12-22 | 2011-12-21 | Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace). |
Country Status (20)
Country | Link |
---|---|
US (1) | US9840507B2 (es) |
EP (1) | EP2655376B1 (es) |
JP (1) | JP5834091B2 (es) |
KR (1) | KR101866987B1 (es) |
CN (1) | CN103403007B (es) |
AU (1) | AU2011347377B2 (es) |
BR (1) | BR112013015430A2 (es) |
CA (1) | CA2819175C (es) |
CO (1) | CO6721049A2 (es) |
EA (1) | EA022409B1 (es) |
ES (1) | ES2648143T3 (es) |
HK (1) | HK1189221A1 (es) |
IL (1) | IL227054A (es) |
MX (1) | MX347912B (es) |
MY (1) | MY170715A (es) |
NZ (1) | NZ610948A (es) |
SG (1) | SG191097A1 (es) |
UA (1) | UA109459C2 (es) |
WO (1) | WO2012085038A1 (es) |
ZA (1) | ZA201304646B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0617852A2 (pt) | 2005-10-25 | 2011-08-09 | Shionogi & Co | compostos derivados de aminodi-hidrotiazina assim como composições contendo os mesmos |
WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
EP2580200B1 (en) | 2010-06-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
EP2655376B1 (en) * | 2010-12-22 | 2017-08-23 | Janssen Pharmaceutica NV | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
MX338333B (es) | 2011-03-01 | 2016-04-11 | Janssen Pharmaceutica Nv | DERIVADOS DE 6,7-DIHIDRO-PIRAZOLO [1,5ª]PIRAZIN-4-ILAMINA UTILES COMO INHIBIDORES DE BETA-SECRETASA (BACE). |
CN103415521B (zh) | 2011-03-09 | 2016-01-06 | 詹森药业有限公司 | 用作β分泌酶(BACE)抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物 |
JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
WO2014198853A1 (en) * | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
CN105452251B (zh) * | 2013-06-12 | 2017-12-26 | 詹森药业有限公司 | 作为β‑分泌酶(BACE)抑制剂的4‑氨基‑6‑苯基‑5,6‑二氢咪唑并[1,5‑A]吡嗪‑3(2H)‑酮衍生物 |
US9751886B2 (en) | 2013-06-12 | 2017-09-05 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE) |
CN104016925B (zh) * | 2014-06-17 | 2016-03-30 | 遵义医学院 | 4-烷基咪唑-2-羧酸的合成方法 |
KR20170095881A (ko) | 2014-12-18 | 2017-08-23 | 얀센 파마슈티카 엔.브이. | 베타―세크레타제의 2,3,4,5―테트라히드로피리딘―6―아민 및 3,4―디히드로―2h―피롤―5―아민 화합물 억제제 |
JP6877423B2 (ja) * | 2015-11-09 | 2021-05-26 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | がんの処置において有用なジヒドロイミダゾピラジノン誘導体 |
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188389A (en) | 1978-11-03 | 1980-02-12 | Ayerst Mckenna & Harrison, Inc. | 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines |
TW224974B (es) | 1991-07-02 | 1994-06-11 | Hoffmann La Roche | |
JP2002505684A (ja) | 1997-06-18 | 2002-02-19 | メルク エンド カンパニー インコーポレーテッド | α1aアドレナリン受容体拮抗薬 |
MXPA04010288A (es) * | 2002-04-19 | 2005-05-17 | Cellular Genomics Inc | Imidazo[1,2-a]pirazin-8-ilaminas, y metodos para su fabricacion y usos. |
WO2004026877A1 (en) * | 2002-09-23 | 2004-04-01 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
CA2510298A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Acyclic pyrazole compounds |
US7157460B2 (en) * | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
AU2004282201A1 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
EP1740573A1 (en) | 2004-04-22 | 2007-01-10 | Eli Lilly And Company | Amides as bace inhibitors |
AU2005264915A1 (en) | 2004-06-16 | 2006-01-26 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
TW200624426A (en) | 2004-09-21 | 2006-07-16 | Lilly Co Eli | BACE inhibitors |
EP2264036A1 (en) | 2005-01-14 | 2010-12-22 | Wyeth LLC (Formerly Known As Wyeth) | Amino-imidazolones for the inhibition of beta-secretase |
US20070005404A1 (en) | 2005-06-09 | 2007-01-04 | Drive Diagnostics Ltd. | System and method for providing driving insurance |
WO2006138265A2 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
WO2007005404A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
BRPI0617852A2 (pt) | 2005-10-25 | 2011-08-09 | Shionogi & Co | compostos derivados de aminodi-hidrotiazina assim como composições contendo os mesmos |
TW200804290A (en) | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
WO2007114771A1 (en) | 2006-04-05 | 2007-10-11 | Astrazeneca Ab | 2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR TREATING OR PREVENTING Aβ-RELATED PATHOLOGIES |
GB2443654A (en) | 2006-05-30 | 2008-05-14 | Matthew Emmerson Allen | System for detecting and testing drivers who show abnormal driving behaviour. |
US20080051420A1 (en) | 2006-06-14 | 2008-02-28 | Astrazeneca Ab | New Compounds 317 |
AU2008245082B8 (en) * | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
TW200902499A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
JP2011502122A (ja) | 2007-10-30 | 2011-01-20 | アリーナ ファーマシューティカルズ, インコーポレイテッド | ヒスタミンh3関連障害の治療のために有用なヒスタミンh3−レセプターの調節因子としてのビフェニル誘導体 |
CA2713998A1 (en) | 2008-01-28 | 2009-08-06 | Janssen Pharmaceutica N.V. | 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of.beta.-secretase (bace) |
US20090221612A1 (en) * | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
TWI431004B (zh) | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Bace抑制劑 |
WO2011002409A1 (en) | 2009-07-02 | 2011-01-06 | Astrazeneca Ab | 5h-pyrrolo[3,4-£>]pyrazin-7-amine derivatives inhibitors of beta-secretase |
AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
AR077328A1 (es) | 2009-07-24 | 2011-08-17 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos |
US8188079B2 (en) | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
US20120238557A1 (en) | 2009-11-13 | 2012-09-20 | Shionogi & Co., Ltd. | Aminothiazine or aminooxazine derivative having amino linker |
UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
JPWO2011077726A1 (ja) | 2009-12-24 | 2013-05-02 | 塩野義製薬株式会社 | 4−アミノ−1,3−チアジンまたはオキサジン誘導体 |
JP5600754B2 (ja) | 2009-12-31 | 2014-10-01 | ノバルティス アーゲー | ピラジン誘導体および神経障害の処置におけるそれらの使用 |
US20130079349A1 (en) | 2010-06-09 | 2013-03-28 | Janssen Pharmaceutica Nv | 5-amino-3,6-dihydro-1h-pyrazin-2-one derivatives useful as inhibitors of beta-secretase (bace) |
EP2580200B1 (en) | 2010-06-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
WO2012000933A1 (en) | 2010-06-28 | 2012-01-05 | Janssen Pharmaceutica Nv | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia |
ES2529641T3 (es) | 2010-09-22 | 2015-02-24 | Janssen Pharmaceutica, N.V. | Derivados de 4,7-dihidro-pirazolo[1,5-a]pirazin-6-ilamina útiles como inhibidores de beta-secretasa (BACE) |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
EP2655376B1 (en) | 2010-12-22 | 2017-08-23 | Janssen Pharmaceutica NV | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
JP2014505688A (ja) | 2011-01-12 | 2014-03-06 | ノバルティス アーゲー | オキサジン誘導体および神経障害の処置におけるその使用 |
JP2012147763A (ja) | 2011-01-17 | 2012-08-09 | Toshitaka Kobayashi | 乾物穿孔具 |
US9242943B2 (en) | 2011-01-18 | 2016-01-26 | Siena Biotech S.P.A. | 1,4 oxazines as BACE1 and/or BACE2 inhibitors |
MX338333B (es) | 2011-03-01 | 2016-04-11 | Janssen Pharmaceutica Nv | DERIVADOS DE 6,7-DIHIDRO-PIRAZOLO [1,5ª]PIRAZIN-4-ILAMINA UTILES COMO INHIBIDORES DE BETA-SECRETASA (BACE). |
CN103415521B (zh) | 2011-03-09 | 2016-01-06 | 詹森药业有限公司 | 用作β分泌酶(BACE)抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物 |
JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
MX2014004479A (es) | 2011-10-13 | 2014-08-01 | Novartis Ag | Derivados de oxazina novedosos y su uso en el tratamiento de enfermedades. |
UA111749C2 (uk) | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
ES2582473T3 (es) | 2011-12-06 | 2016-09-13 | Janssen Pharmaceutica, N.V. | Derivados de 5-(3-aminofenil)-5-alquil-5,6-dihidro-2H-[1,4]oxazin-3-amina para el tratamiento de trastornos en que está implicada la beta-secretasa |
AU2013363151A1 (en) | 2012-12-20 | 2015-06-04 | Merck Sharp & Dohme Corp. | C5, C6 oxacyclic-fused iminothiazine dioxide compounds as BACE inhibitors |
CN105452251B (zh) | 2013-06-12 | 2017-12-26 | 詹森药业有限公司 | 作为β‑分泌酶(BACE)抑制剂的4‑氨基‑6‑苯基‑5,6‑二氢咪唑并[1,5‑A]吡嗪‑3(2H)‑酮衍生物 |
WO2014198853A1 (en) | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
US9751886B2 (en) | 2013-06-12 | 2017-09-05 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE) |
KR20170095881A (ko) | 2014-12-18 | 2017-08-23 | 얀센 파마슈티카 엔.브이. | 베타―세크레타제의 2,3,4,5―테트라히드로피리딘―6―아민 및 3,4―디히드로―2h―피롤―5―아민 화합물 억제제 |
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2011
- 2011-12-21 EP EP11804561.6A patent/EP2655376B1/en active Active
- 2011-12-21 CN CN201180068086.6A patent/CN103403007B/zh not_active Expired - Fee Related
- 2011-12-21 UA UAA201306422A patent/UA109459C2/ru unknown
- 2011-12-21 SG SG2013044730A patent/SG191097A1/en unknown
- 2011-12-21 KR KR1020137019224A patent/KR101866987B1/ko active IP Right Grant
- 2011-12-21 CA CA2819175A patent/CA2819175C/en active Active
- 2011-12-21 AU AU2011347377A patent/AU2011347377B2/en not_active Ceased
- 2011-12-21 US US13/995,523 patent/US9840507B2/en active Active
- 2011-12-21 ES ES11804561.6T patent/ES2648143T3/es active Active
- 2011-12-21 EA EA201390932A patent/EA022409B1/ru not_active IP Right Cessation
- 2011-12-21 BR BR112013015430A patent/BR112013015430A2/pt active Search and Examination
- 2011-12-21 WO PCT/EP2011/073522 patent/WO2012085038A1/en active Application Filing
- 2011-12-21 MX MX2013007294A patent/MX347912B/es active IP Right Grant
- 2011-12-21 NZ NZ610948A patent/NZ610948A/en not_active IP Right Cessation
- 2011-12-21 MY MYPI2013002076A patent/MY170715A/en unknown
- 2011-12-21 JP JP2013545343A patent/JP5834091B2/ja not_active Expired - Fee Related
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2013
- 2013-06-19 IL IL227054A patent/IL227054A/en active IP Right Grant
- 2013-06-21 ZA ZA2013/04646A patent/ZA201304646B/en unknown
- 2013-06-25 CO CO13150832A patent/CO6721049A2/es unknown
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2014
- 2014-03-04 HK HK14102157.9A patent/HK1189221A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR101866987B1 (ko) | 2018-07-19 |
MY170715A (en) | 2019-08-27 |
CA2819175A1 (en) | 2012-06-28 |
BR112013015430A2 (pt) | 2016-09-20 |
CN103403007A (zh) | 2013-11-20 |
AU2011347377B2 (en) | 2016-03-03 |
SG191097A1 (en) | 2013-08-30 |
CN103403007B (zh) | 2015-12-09 |
CA2819175C (en) | 2019-01-08 |
HK1189221A1 (zh) | 2014-05-30 |
IL227054A (en) | 2016-09-29 |
CO6721049A2 (es) | 2013-07-31 |
JP2014500293A (ja) | 2014-01-09 |
US9840507B2 (en) | 2017-12-12 |
JP5834091B2 (ja) | 2015-12-16 |
MX2013007294A (es) | 2013-08-26 |
EP2655376A1 (en) | 2013-10-30 |
NZ610948A (en) | 2014-06-27 |
US20130274266A1 (en) | 2013-10-17 |
UA109459C2 (xx) | 2015-08-25 |
EA201390932A1 (ru) | 2013-11-29 |
EA022409B1 (ru) | 2015-12-30 |
ES2648143T3 (es) | 2017-12-28 |
WO2012085038A1 (en) | 2012-06-28 |
ZA201304646B (en) | 2014-12-23 |
EP2655376B1 (en) | 2017-08-23 |
KR20130132556A (ko) | 2013-12-04 |
AU2011347377A1 (en) | 2013-06-13 |
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