MX347912B - Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace). - Google Patents

Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace).

Info

Publication number
MX347912B
MX347912B MX2013007294A MX2013007294A MX347912B MX 347912 B MX347912 B MX 347912B MX 2013007294 A MX2013007294 A MX 2013007294A MX 2013007294 A MX2013007294 A MX 2013007294A MX 347912 B MX347912 B MX 347912B
Authority
MX
Mexico
Prior art keywords
beta
secretase
dementia
bace
pyrazin
Prior art date
Application number
MX2013007294A
Other languages
English (en)
Other versions
MX2013007294A (es
Inventor
Henricus Jacobus Maria Gijsen
Andrés Avelino Trabanco-Suárez
Francisca Delgado-Jiménez
Ramiro Juan Antonio Vega
Gary John Tresadern
Daniel Oehlrich
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2013007294A publication Critical patent/MX2013007294A/es
Publication of MX347912B publication Critical patent/MX347912B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a derivados novedosos de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina como inhibidores de beta-secretasa, conocida también como enzima de separación amiloide del sitio beta, BACE, BACE1, Asp2 o memapsina2; la invención está dirigida también a composiciones farmacéuticas que comprenden dichos compuestos, a procedimientos para preparar dichos compuestos y composiciones, y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los cuales la beta-secretasa está implicada, tal como en enfermedad de Alzheimer (AD), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, angiopatía amiloide cerebrovascular, demencia por infartos múltiples, síndrome de Down, demencia asociada con accidente cerebrovascular, demencia asociada con enfermedad de Parkinson o demencia asociada con beta-amiloide.
MX2013007294A 2010-12-22 2011-12-21 Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace). MX347912B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10196568 2010-12-22
PCT/EP2011/073522 WO2012085038A1 (en) 2010-12-22 2011-12-21 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (2)

Publication Number Publication Date
MX2013007294A MX2013007294A (es) 2013-08-26
MX347912B true MX347912B (es) 2017-05-17

Family

ID=43923528

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007294A MX347912B (es) 2010-12-22 2011-12-21 Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace).

Country Status (19)

Country Link
US (1) US9840507B2 (es)
EP (1) EP2655376B1 (es)
JP (1) JP5834091B2 (es)
KR (1) KR101866987B1 (es)
CN (1) CN103403007B (es)
AU (1) AU2011347377B2 (es)
BR (1) BR112013015430A2 (es)
CA (1) CA2819175C (es)
CO (1) CO6721049A2 (es)
EA (1) EA022409B1 (es)
ES (1) ES2648143T3 (es)
IL (1) IL227054A (es)
MX (1) MX347912B (es)
MY (1) MY170715A (es)
NZ (1) NZ610948A (es)
SG (1) SG191097A1 (es)
UA (1) UA109459C2 (es)
WO (1) WO2012085038A1 (es)
ZA (1) ZA201304646B (es)

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Also Published As

Publication number Publication date
EP2655376B1 (en) 2017-08-23
IL227054A (en) 2016-09-29
ES2648143T3 (es) 2017-12-28
KR101866987B1 (ko) 2018-07-19
AU2011347377A1 (en) 2013-06-13
MX2013007294A (es) 2013-08-26
KR20130132556A (ko) 2013-12-04
US9840507B2 (en) 2017-12-12
MY170715A (en) 2019-08-27
UA109459C2 (xx) 2015-08-25
CN103403007B (zh) 2015-12-09
CA2819175C (en) 2019-01-08
CN103403007A (zh) 2013-11-20
CO6721049A2 (es) 2013-07-31
EA201390932A1 (ru) 2013-11-29
BR112013015430A2 (pt) 2016-09-20
CA2819175A1 (en) 2012-06-28
WO2012085038A1 (en) 2012-06-28
EP2655376A1 (en) 2013-10-30
EA022409B1 (ru) 2015-12-30
HK1189221A1 (zh) 2014-05-30
ZA201304646B (en) 2014-12-23
AU2011347377B2 (en) 2016-03-03
JP5834091B2 (ja) 2015-12-16
SG191097A1 (en) 2013-08-30
NZ610948A (en) 2014-06-27
JP2014500293A (ja) 2014-01-09
US20130274266A1 (en) 2013-10-17

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