MX366063B - Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5-a]pira zina como inhibidores de beta-secretasa (bace). - Google Patents

Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5-a]pira zina como inhibidores de beta-secretasa (bace).

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Publication number
MX366063B
MX366063B MX2015017155A MX2015017155A MX366063B MX 366063 B MX366063 B MX 366063B MX 2015017155 A MX2015017155 A MX 2015017155A MX 2015017155 A MX2015017155 A MX 2015017155A MX 366063 B MX366063 B MX 366063B
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Mexico
Prior art keywords
beta
dementia
secretase
bace
triazolo
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MX2015017155A
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English (en)
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MX2015017155A (es
Inventor
Henricus Jacobus Maria Gijsen
Daniel Oehlrich
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Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2015017155A publication Critical patent/MX2015017155A/es
Publication of MX366063B publication Critical patent/MX366063B/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

La presente invención se refiere a derivados novedosos de 6,7- dihidro[1,2,3]triazolo[1,5-a]pirazin-6-ilo bncomo inhibidores de beta-secretasa, también conocida como enzima de escisión amiloide del sitio beta, BACE, en particular BACE1 y/o BACE2 (en donde BACE1, también se conoce como Asp2 o memapsina2 y BACE2 también se conoce como Asp1, Memapsina 1 o DRAP); la invención también se dirige a composiciones farmacéuticas que comprenden dichos compuestos, a procesos para preparar dichos compuestos y composiciones y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los que participa la beta-secretasa, tales como la enfermedad de Alzheimer (AD), deficiencia cognitiva leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con accidente cerebrovascular, demencia asociada con enfermedad de Parkinson, demencia tipo Alzheimer, demencia asociada con beta-amiloide, degeneración macular relacionada con la edad, diabetes tipo 2 y otros trastornos metabólicos.
MX2015017155A 2013-06-12 2014-06-12 Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5-a]pira zina como inhibidores de beta-secretasa (bace). MX366063B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13171720 2013-06-12
PCT/EP2014/062286 WO2014198854A1 (en) 2013-06-12 2014-06-12 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace)

Publications (2)

Publication Number Publication Date
MX2015017155A MX2015017155A (es) 2016-03-16
MX366063B true MX366063B (es) 2019-06-26

Family

ID=48577637

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017155A MX366063B (es) 2013-06-12 2014-06-12 Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5-a]pira zina como inhibidores de beta-secretasa (bace).

Country Status (12)

Country Link
US (1) US9751886B2 (es)
EP (1) EP3008065B1 (es)
JP (1) JP6435321B2 (es)
KR (1) KR102243133B1 (es)
CN (1) CN105324383B (es)
AU (1) AU2014280125B2 (es)
BR (1) BR112015030597A2 (es)
CA (1) CA2911693C (es)
EA (1) EA028775B1 (es)
ES (1) ES2721073T3 (es)
MX (1) MX366063B (es)
WO (1) WO2014198854A1 (es)

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