BR112015030597A2 - derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace) - Google Patents

derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace)

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Publication number
BR112015030597A2
BR112015030597A2 BR112015030597A BR112015030597A BR112015030597A2 BR 112015030597 A2 BR112015030597 A2 BR 112015030597A2 BR 112015030597 A BR112015030597 A BR 112015030597A BR 112015030597 A BR112015030597 A BR 112015030597A BR 112015030597 A2 BR112015030597 A2 BR 112015030597A2
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Prior art keywords
beta
secretase
dementia
bace
triazolo
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BR112015030597A
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English (en)
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Oehlrich Daniel
Jacobus Maria Gijsen Henricus
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015030597A2 publication Critical patent/BR112015030597A2/pt

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

resumo patente de invenção: "derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace)". a presente invenção refere-se a novos derivados 6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazin-6-il como inibidores de beta-secretase, também conhecida como enzima de clivagem de amiloide de local beta, bace, em particular bace1 e/ou bace2 (em que bace1 também é conhecida como asp2, ou memapsina2, e bace2 também é conhecida como asp1, memapsina 1 ou drap). a invenção também é dirigida a composições farmacêuticas compreendendo tais compostos, a processos para a preparação de tais compostos e composições, e ao uso de tais compostos e composições para a prevenção e tratamento de distúrbios nos quais está envolvida a beta-secretase, como doença de alzheimer (ad), defeito cognitivo ligeiro, senilidade, demência, demência com corpos de lewy, síndrome de down, demência associada a derrame cerebral, demência associada à doença de parkinson, demência do tipo alzheimer, demência associada a beta-amiloide, degeneração macular relacionada à idade, diabetes do tipo 2 e outros distúrbios metabólicos.
BR112015030597A 2013-06-12 2014-06-12 derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace) BR112015030597A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13171720 2013-06-12
PCT/EP2014/062286 WO2014198854A1 (en) 2013-06-12 2014-06-12 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace)

Publications (1)

Publication Number Publication Date
BR112015030597A2 true BR112015030597A2 (pt) 2017-07-25

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BR112015030597A BR112015030597A2 (pt) 2013-06-12 2014-06-12 derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace)

Country Status (12)

Country Link
US (1) US9751886B2 (pt)
EP (1) EP3008065B1 (pt)
JP (1) JP6435321B2 (pt)
KR (1) KR102243133B1 (pt)
CN (1) CN105324383B (pt)
AU (1) AU2014280125B2 (pt)
BR (1) BR112015030597A2 (pt)
CA (1) CA2911693C (pt)
EA (1) EA028775B1 (pt)
ES (1) ES2721073T3 (pt)
MX (1) MX366063B (pt)
WO (1) WO2014198854A1 (pt)

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CN105324383A (zh) 2016-02-10
CA2911693C (en) 2021-08-24
EP3008065A1 (en) 2016-04-20
MX2015017155A (es) 2016-03-16
WO2014198854A1 (en) 2014-12-18
US20160130274A1 (en) 2016-05-12
AU2014280125A1 (en) 2015-11-12
EP3008065B1 (en) 2019-01-30
EA201592307A1 (ru) 2016-04-29
JP6435321B2 (ja) 2018-12-05
KR102243133B1 (ko) 2021-04-22
AU2014280125B2 (en) 2018-03-15
EA028775B1 (ru) 2017-12-29
US9751886B2 (en) 2017-09-05
JP2016520660A (ja) 2016-07-14
KR20160019893A (ko) 2016-02-22
CA2911693A1 (en) 2014-12-18
CN105324383B (zh) 2017-10-31
MX366063B (es) 2019-06-26

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