MX368326B - Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace). - Google Patents

Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace).

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Publication number
MX368326B
MX368326B MX2015017151A MX2015017151A MX368326B MX 368326 B MX368326 B MX 368326B MX 2015017151 A MX2015017151 A MX 2015017151A MX 2015017151 A MX2015017151 A MX 2015017151A MX 368326 B MX368326 B MX 368326B
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MX
Mexico
Prior art keywords
beta
dementia
secretase
dihydroimidazo
bace
Prior art date
Application number
MX2015017151A
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English (en)
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MX2015017151A (es
Inventor
Henricus Jacobus Maria Gijsen
Daniel Oehlrich
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2015017151A publication Critical patent/MX2015017151A/es
Publication of MX368326B publication Critical patent/MX368326B/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a novedosos derivados de 5,6-dihidroimidazo[1,5-a]pirazin-3(2H)-ona como inhibidores de beta-secretasa, también conocida como enzima de escisión amiloide del sitio beta, BACE, en particular BACE1 y/o BACE2 (en donde BACE1, también se conoce como Asp2 o memapsina2 y BACE2 también se conoce como Asp1, Memapsína 1 o DRAP); la invención también se dirige a composiciones farmacéuticas que comprenden dichos compuestos, a procesos para preparar dichos compuestos y composiciones y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los que participa la beta-secretasa, tales como la enfermedad de Alzheimer (AD), deficiencia cognitiva leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con accidente cerebrovascular, demencia asociada con enfermedad de Parkinson, demencia tipo Alzheimer, demencia asociada con beta-amiloide, degeneración macular relacionada con la edad, diabetes tipo 2 y otros trastornos metabólicos.
MX2015017151A 2013-06-12 2014-06-12 Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace). MX368326B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13171723 2013-06-12
PCT/EP2014/062283 WO2014198851A1 (en) 2013-06-12 2014-06-12 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace)

Publications (2)

Publication Number Publication Date
MX2015017151A MX2015017151A (es) 2016-03-16
MX368326B true MX368326B (es) 2019-09-27

Family

ID=48577639

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017151A MX368326B (es) 2013-06-12 2014-06-12 Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace).

Country Status (12)

Country Link
US (1) US9834559B2 (es)
EP (1) EP3008067B1 (es)
JP (1) JP6387402B2 (es)
KR (1) KR102243135B1 (es)
CN (1) CN105452251B (es)
AU (1) AU2014280122B2 (es)
BR (1) BR112015030498A2 (es)
CA (1) CA2912156C (es)
EA (1) EA032662B1 (es)
ES (1) ES2627633T3 (es)
MX (1) MX368326B (es)
WO (1) WO2014198851A1 (es)

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KR101730937B1 (ko) 2010-06-09 2017-04-27 얀센 파마슈티카 엔.브이. 베타-세크레타아제(ｂａｃｅ) 저해제로 유용한 5,6-디하이드로-2ｈ-[1,4]옥사진-3-일-아민 유도체
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WO2014198851A1 (en) 2014-12-18
CA2912156A1 (en) 2014-12-18
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