CO6602112A2 - Derivados de 5.6- dhidro-2h -[1.4]oxazin-3-il amina utiles como inhibidores de la betasecretasa(bace) - Google Patents

Derivados de 5.6- dhidro-2h -[1.4]oxazin-3-il amina utiles como inhibidores de la betasecretasa(bace)

Info

Publication number
CO6602112A2
CO6602112A2 CO12217134A CO12217134A CO6602112A2 CO 6602112 A2 CO6602112 A2 CO 6602112A2 CO 12217134 A CO12217134 A CO 12217134A CO 12217134 A CO12217134 A CO 12217134A CO 6602112 A2 CO6602112 A2 CO 6602112A2
Authority
CO
Colombia
Prior art keywords
beta
bace
oxazin
dementia
compounds
Prior art date
Application number
CO12217134A
Other languages
English (en)
Inventor
Suarez Andres Avelino Trabanco
Frederik Jan Rita Rombouts
Gary Jhon Tresadern
Gool Michiel Luc Maria Van
Gregor James Macdonald
Lamenca Carolina Martinez
Henricus Jacobus Maria Gijsen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6602112A2 publication Critical patent/CO6602112A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados novedosos de 5,6-dihidro-2H-[1,4]oxazin-3-ilamina como inhibidores de la beta-secretasa, también conocida como enzima de escisión amiloide del sitio beta, BACE, BACE1, Asp2, o memapsina2. La invención también se refiere a composiciones farmacéuticas quecomprenden dichos compuestos, a procesos para la preparación de dichos compuestos y composiciones, y al uso de dichos compuestos y composiciones para la prevención y el tratamiento de trastornos en los cuales se encuentra involucrada la beta-secretasa, tal como la enfermedad de Alzheimer (EA), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy,Síndrome de Down, demencia asociada con el accidente cerebro vascular, demencia asociada con la enfermedad de Parkinson y demencia asociada con beta-amiloide.
CO12217134A 2010-06-09 2012-11-29 Derivados de 5.6- dhidro-2h -[1.4]oxazin-3-il amina utiles como inhibidores de la betasecretasa(bace) CO6602112A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10165335 2010-06-09
EP11152314 2011-01-27
EP11157765 2011-03-10
EP11164999 2011-05-05

Publications (1)

Publication Number Publication Date
CO6602112A2 true CO6602112A2 (es) 2013-01-18

Family

ID=44317911

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12217134A CO6602112A2 (es) 2010-06-09 2012-11-29 Derivados de 5.6- dhidro-2h -[1.4]oxazin-3-il amina utiles como inhibidores de la betasecretasa(bace)

Country Status (22)

Country Link
US (2) US20130109683A1 (es)
EP (1) EP2580200B1 (es)
JP (1) JP5711813B2 (es)
KR (1) KR101730937B1 (es)
CN (1) CN102933564B (es)
AR (1) AR081587A1 (es)
AU (1) AU2011263797B2 (es)
BR (1) BR112012031094A2 (es)
CA (1) CA2799640C (es)
CL (1) CL2012003428A1 (es)
CO (1) CO6602112A2 (es)
DK (1) DK2580200T3 (es)
EA (1) EA021240B1 (es)
ES (1) ES2607083T3 (es)
HK (1) HK1182098A1 (es)
IL (1) IL223423A (es)
MX (1) MX339640B (es)
NZ (1) NZ603427A (es)
SG (1) SG185651A1 (es)
TW (1) TWI537263B (es)
WO (1) WO2011154431A1 (es)
ZA (1) ZA201209297B (es)

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