HK1182098A1 - 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) -(bace) 56--2h-[14]-3-- - Google Patents
5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) -(bace) 56--2h-[14]-3--Info
- Publication number
- HK1182098A1 HK1182098A1 HK13109367.1A HK13109367A HK1182098A1 HK 1182098 A1 HK1182098 A1 HK 1182098A1 HK 13109367 A HK13109367 A HK 13109367A HK 1182098 A1 HK1182098 A1 HK 1182098A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bace
- oxazin
- secretase
- dihydro
- inhibitors
- Prior art date
Links
- 101150058765 BACE1 gene Proteins 0.000 title 2
- COPFSXJBOSOUGF-UHFFFAOYSA-N 3,6-dihydro-2h-1,4-oxazin-5-amine Chemical class N=C1COCCN1 COPFSXJBOSOUGF-UHFFFAOYSA-N 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10165335 | 2010-06-09 | ||
EP11152314 | 2011-01-27 | ||
EP11157765 | 2011-03-10 | ||
EP11164999 | 2011-05-05 | ||
PCT/EP2011/059441 WO2011154431A1 (en) | 2010-06-09 | 2011-06-08 | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1182098A1 true HK1182098A1 (en) | 2013-11-22 |
Family
ID=44317911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13109367.1A HK1182098A1 (en) | 2010-06-09 | 2013-08-09 | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) -(bace) 56--2h-[14]-3-- |
Country Status (22)
Country | Link |
---|---|
US (2) | US20130109683A1 (es) |
EP (1) | EP2580200B1 (es) |
JP (1) | JP5711813B2 (es) |
KR (1) | KR101730937B1 (es) |
CN (1) | CN102933564B (es) |
AR (1) | AR081587A1 (es) |
AU (1) | AU2011263797B2 (es) |
BR (1) | BR112012031094A2 (es) |
CA (1) | CA2799640C (es) |
CL (1) | CL2012003428A1 (es) |
CO (1) | CO6602112A2 (es) |
DK (1) | DK2580200T3 (es) |
EA (1) | EA021240B1 (es) |
ES (1) | ES2607083T3 (es) |
HK (1) | HK1182098A1 (es) |
IL (1) | IL223423A (es) |
MX (1) | MX339640B (es) |
NZ (1) | NZ603427A (es) |
SG (1) | SG185651A1 (es) |
TW (1) | TWI537263B (es) |
WO (1) | WO2011154431A1 (es) |
ZA (1) | ZA201209297B (es) |
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EA032662B1 (ru) | 2013-06-12 | 2019-06-28 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) |
BR112015030678A8 (pt) | 2013-06-12 | 2020-01-07 | Janssen Pharmaceutica Nv | derivados 4-amino-6-fenil-5,6-di-hidroimidazo [1,5-a] pirazina como inibidores de beta-secretase (bace), composição farmacêutica, processo para preparação da mesma, e usos na fabricação de medicamentos |
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MX2014004479A (es) | 2011-10-13 | 2014-08-01 | Novartis Ag | Derivados de oxazina novedosos y su uso en el tratamiento de enfermedades. |
UA111749C2 (uk) | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
JP5989130B2 (ja) | 2011-12-06 | 2016-09-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 5−(3−アミノフェニル)−5−アルキル−5,6−ジヒドロ−2h−[1,4]オキサジン−3−アミン誘導体 |
EP2934539B1 (en) | 2012-12-20 | 2019-03-27 | Merck Sharp & Dohme Corp. | C5, c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors |
BR112015030678A8 (pt) | 2013-06-12 | 2020-01-07 | Janssen Pharmaceutica Nv | derivados 4-amino-6-fenil-5,6-di-hidroimidazo [1,5-a] pirazina como inibidores de beta-secretase (bace), composição farmacêutica, processo para preparação da mesma, e usos na fabricação de medicamentos |
CA2911693C (en) | 2013-06-12 | 2021-08-24 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
EA032662B1 (ru) | 2013-06-12 | 2019-06-28 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) |
ES2768823T3 (es) | 2014-12-18 | 2020-06-23 | Janssen Pharmaceutica Nv | Derivados de 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2H-pirrol-5-amina útiles como inhibidores de beta-secretasa |
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Also Published As
Publication number | Publication date |
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CN102933564A (zh) | 2013-02-13 |
TW201211037A (en) | 2012-03-16 |
EA201291435A1 (ru) | 2013-05-30 |
JP2013531645A (ja) | 2013-08-08 |
CA2799640A1 (en) | 2011-12-15 |
MX2012014368A (es) | 2013-01-22 |
BR112012031094A2 (pt) | 2016-10-25 |
IL223423A (en) | 2016-03-31 |
DK2580200T3 (en) | 2017-01-09 |
AU2011263797B2 (en) | 2014-06-05 |
MX339640B (es) | 2016-06-01 |
US20130109683A1 (en) | 2013-05-02 |
CO6602112A2 (es) | 2013-01-18 |
AR081587A1 (es) | 2012-10-03 |
AU2011263797A1 (en) | 2012-11-22 |
CL2012003428A1 (es) | 2013-04-01 |
ES2607083T3 (es) | 2017-03-29 |
TWI537263B (zh) | 2016-06-11 |
JP5711813B2 (ja) | 2015-05-07 |
US20160152581A1 (en) | 2016-06-02 |
NZ603427A (en) | 2013-08-30 |
KR101730937B1 (ko) | 2017-04-27 |
CN102933564B (zh) | 2015-07-22 |
EA021240B1 (ru) | 2015-05-29 |
US9828350B2 (en) | 2017-11-28 |
WO2011154431A1 (en) | 2011-12-15 |
EP2580200B1 (en) | 2016-09-14 |
CA2799640C (en) | 2018-10-16 |
ZA201209297B (en) | 2014-09-25 |
SG185651A1 (en) | 2012-12-28 |
EP2580200A1 (en) | 2013-04-17 |
KR20130119851A (ko) | 2013-11-01 |
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