CO6751283A2 - Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina útiles cini inhibidores de beta-secretasa (bace) - Google Patents

Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina útiles cini inhibidores de beta-secretasa (bace)

Info

Publication number
CO6751283A2
CO6751283A2 CO13205187A CO13205187A CO6751283A2 CO 6751283 A2 CO6751283 A2 CO 6751283A2 CO 13205187 A CO13205187 A CO 13205187A CO 13205187 A CO13205187 A CO 13205187A CO 6751283 A2 CO6751283 A2 CO 6751283A2
Authority
CO
Colombia
Prior art keywords
beta
dementia
dihydropyrrolo
bace
pyrazin
Prior art date
Application number
CO13205187A
Other languages
English (en)
Inventor
Andres Avelino Trabanco-Suarez
Francisca Delgado-Jimenez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6751283A2 publication Critical patent/CO6751283A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina como inhibidores de beta-secretasa, conocida también como la enzima que escinde la proteína precursora de amiloide por el sitio beta, BACE, BACE1, Asp2 o memapsina 2. La invención también se refiere a composiciones farmacéuticas que comprenden tales compuestos, a procesos para preparar tales compuestos y composiciones, y al uso de tales compuestos y composiciones para prevenir y tratar trastornos en los que participa la beta-secreta, tales como la enfermedad de Alzheimer (EA), el deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con el accidente cerebrovascular, demencia asociada con la enfermedad de Parkinson o demencia asociada con beta-amiloides.
CO13205187A 2011-03-09 2013-08-29 Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina útiles cini inhibidores de beta-secretasa (bace) CO6751283A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11157418 2011-03-09

Publications (1)

Publication Number Publication Date
CO6751283A2 true CO6751283A2 (es) 2013-09-16

Family

ID=43833325

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13205187A CO6751283A2 (es) 2011-03-09 2013-08-29 Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina útiles cini inhibidores de beta-secretasa (bace)

Country Status (20)

Country Link
US (1) US9845326B2 (es)
EP (1) EP2683721B1 (es)
JP (1) JP5853035B2 (es)
KR (1) KR102012675B1 (es)
CN (1) CN103415521B (es)
AU (1) AU2012224632B2 (es)
BR (1) BR112013022917A2 (es)
CA (1) CA2825620C (es)
CL (1) CL2013002511A1 (es)
CO (1) CO6751283A2 (es)
EA (1) EA023824B1 (es)
ES (1) ES2534973T3 (es)
HK (1) HK1189223A1 (es)
IL (1) IL228239A (es)
MX (1) MX340031B (es)
MY (1) MY163346A (es)
SG (1) SG193342A1 (es)
UA (1) UA109687C2 (es)
WO (1) WO2012120023A1 (es)
ZA (1) ZA201306719B (es)

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CN107108582B (zh) 2014-12-18 2019-10-18 詹森药业有限公司 β-分泌酶的2，3，4，5-四氢吡啶-6-胺化合物抑制剂

Also Published As

Publication number Publication date
EP2683721A1 (en) 2014-01-15
SG193342A1 (en) 2013-10-30
US9845326B2 (en) 2017-12-19
CN103415521A (zh) 2013-11-27
MX340031B (es) 2016-06-21
KR20140019332A (ko) 2014-02-14
IL228239A (en) 2016-06-30
CA2825620C (en) 2019-04-23
CN103415521B (zh) 2016-01-06
JP5853035B2 (ja) 2016-02-09
MY163346A (en) 2017-09-15
ES2534973T3 (es) 2015-04-30
KR102012675B1 (ko) 2019-08-21
MX2013010280A (es) 2013-10-01
US20130345228A1 (en) 2013-12-26
HK1189223A1 (zh) 2014-05-30
ZA201306719B (en) 2015-04-29
JP2014507455A (ja) 2014-03-27
AU2012224632A1 (en) 2013-08-01
BR112013022917A2 (pt) 2016-12-06
EA023824B1 (ru) 2016-07-29
AU2012224632B2 (en) 2016-06-16
CL2013002511A1 (es) 2014-01-24
NZ615720A (en) 2014-08-29
EP2683721B1 (en) 2015-01-28
WO2012120023A1 (en) 2012-09-13
IL228239A0 (en) 2013-11-25
UA109687C2 (xx) 2015-09-25
CA2825620A1 (en) 2012-09-13
EA201391296A1 (ru) 2014-01-30

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