CO6660450A2 - Derivados de 4,7-dihidro-pirazol[1,5-a]pirazin-6-ilamina útiles como inhibidoresde beta-secretasa (bace) - Google Patents

Derivados de 4,7-dihidro-pirazol[1,5-a]pirazin-6-ilamina útiles como inhibidoresde beta-secretasa (bace)

Info

Publication number
CO6660450A2
CO6660450A2 CO13055809A CO13055809A CO6660450A2 CO 6660450 A2 CO6660450 A2 CO 6660450A2 CO 13055809 A CO13055809 A CO 13055809A CO 13055809 A CO13055809 A CO 13055809A CO 6660450 A2 CO6660450 A2 CO 6660450A2
Authority
CO
Colombia
Prior art keywords
beta
bace
pyrazin
dihydro
dementia
Prior art date
Application number
CO13055809A
Other languages
English (en)
Inventor
Andres Avelino Trabanco-Suarez
Gary Jhon Tresadern
Francisca Delgado-Jimenez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6660450A2 publication Critical patent/CO6660450A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a derivados novedosos de 4,7-dihidro-pirazolo(1,5-a]pirazin-6-il-amina como inhibidores de betasecretasa, también conocida como la enzima de corte de amiloide en el sitio beta, BACE, BACE1, Asp2 o memapsin2; la invención también está dirigida a composiciones farmacéuticas que comprenden estos compuestos, a procedimientos para preparar estos compuestos y composiciones, y al uso de estos compuestos y composiciones para la prevención y tratamiento de trastornos en los que está implicada la beta-secretasa, tales como la enfermedad de Alzheimer (AD), deterioro cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada con derrame cerebral, demencia asociada con enfermedad de Parkinson o demencia asociada con beta-amiloide.
CO13055809A 2010-09-22 2013-03-20 Derivados de 4,7-dihidro-pirazol[1,5-a]pirazin-6-ilamina útiles como inhibidoresde beta-secretasa (bace) CO6660450A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10178315 2010-09-22
EP11157858 2011-03-11

Publications (1)

Publication Number Publication Date
CO6660450A2 true CO6660450A2 (es) 2013-04-30

Family

ID=45873470

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13055809A CO6660450A2 (es) 2010-09-22 2013-03-20 Derivados de 4,7-dihidro-pirazol[1,5-a]pirazin-6-ilamina útiles como inhibidoresde beta-secretasa (bace)

Country Status (21)

Country Link
US (1) US8609660B2 (es)
EP (1) EP2619207B1 (es)
JP (1) JP5797756B2 (es)
KR (1) KR101962216B1 (es)
CN (1) CN103097389B (es)
AU (1) AU2011306941B2 (es)
BR (1) BR112013006353A2 (es)
CA (1) CA2807904C (es)
CL (1) CL2013000782A1 (es)
CO (1) CO6660450A2 (es)
EA (1) EA021723B1 (es)
ES (1) ES2529641T3 (es)
HK (1) HK1182391A1 (es)
IL (1) IL225349A (es)
IN (1) IN2013MN00782A (es)
MX (1) MX2013003246A (es)
MY (1) MY160138A (es)
NZ (1) NZ606848A (es)
SG (1) SG188338A1 (es)
WO (1) WO2012038438A1 (es)
ZA (1) ZA201302128B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2628074C (en) 2005-10-25 2014-01-14 Shionogi & Co., Ltd. Aminodihydrothiazine derivative
KR20100017255A (ko) 2007-04-24 2010-02-16 시오노기 앤드 컴파니, 리미티드 환식기로 치환된 아미노다이하이드로싸이아진 유도체
WO2008133273A1 (ja) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
US8703785B2 (en) 2008-10-22 2014-04-22 Shionogi & Co., Ltd. 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
US8999980B2 (en) 2009-12-11 2015-04-07 Shionogi & Co., Ltd. Oxazine derivatives
CA2799640C (en) 2010-06-09 2018-10-16 Janssen Pharmaceutica Nv 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace)
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
EP2634186A4 (en) 2010-10-29 2014-03-26 Shionogi & Co naphthyridine
BR112013015430A2 (pt) 2010-12-22 2016-09-20 Janssen Pharmaceutica Nv derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace)
MX340031B (es) 2011-03-09 2016-06-21 Janssen Pharmaceutica Nv Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina utiles como inhibidores de beta-secretasa (bace).
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF
US9771617B2 (en) 2011-06-27 2017-09-26 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
CA2911693C (en) 2013-06-12 2021-08-24 Janssen Pharmaceutica Nv 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace)
AU2014280124B2 (en) 2013-06-12 2018-11-01 Janssen Pharmaceutica Nv 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (BACE)
US9834559B2 (en) 2013-06-12 2017-12-05 Janssen Pharmaceutica Nv 4-Amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2H)-one derivatives as inhibitors of beta-secretase (BACE)
MX2017008083A (es) 2014-12-18 2017-10-31 Janssen Pharmaceutica Nv Compuestos 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2h-pirrol-5-amina inhibidores de beta-secretasa.
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
CN108440320A (zh) * 2018-05-09 2018-08-24 上海凌凯医药科技有限公司 一种高手性选择性合成α-双取代α-氨基酸的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514043A (ja) 2002-12-20 2006-04-27 ファルマシア・コーポレーション マイトジェン活性化タンパク質キナーゼ−活性化タンパク質キナーゼ−２を阻害する化合物
AU2006259573A1 (en) * 2005-06-14 2006-12-28 Pharmacopeia, Inc. Heterocyclic aspartyl protease inhibitors, preparation and use thereof
TW200804290A (en) * 2005-11-15 2008-01-16 Astrazeneca Ab Compounds and uses thereof
WO2011002409A1 (en) 2009-07-02 2011-01-06 Astrazeneca Ab 5h-pyrrolo[3,4-£>]pyrazin-7-amine derivatives inhibitors of beta-secretase

Also Published As

Publication number Publication date
JP5797756B2 (ja) 2015-10-21
HK1182391A1 (zh) 2013-11-29
IL225349A0 (en) 2013-06-27
AU2011306941A1 (en) 2013-02-28
US20130190318A1 (en) 2013-07-25
CL2013000782A1 (es) 2013-08-09
CA2807904A1 (en) 2012-03-29
MX2013003246A (es) 2013-05-22
JP2013540740A (ja) 2013-11-07
IN2013MN00782A (es) 2015-06-12
EA021723B1 (ru) 2015-08-31
EP2619207A1 (en) 2013-07-31
EP2619207B1 (en) 2014-11-12
MY160138A (en) 2017-02-28
US8609660B2 (en) 2013-12-17
ZA201302128B (en) 2014-08-27
AU2011306941B2 (en) 2014-06-12
EA201390419A1 (ru) 2013-07-30
CN103097389A (zh) 2013-05-08
KR20130110161A (ko) 2013-10-08
CN103097389B (zh) 2015-10-14
SG188338A1 (en) 2013-04-30
ES2529641T3 (es) 2015-02-24
CA2807904C (en) 2018-09-11
NZ606848A (en) 2015-01-30
WO2012038438A1 (en) 2012-03-29
BR112013006353A2 (pt) 2024-01-16
KR101962216B1 (ko) 2019-03-26
IL225349A (en) 2016-07-31

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