CL2013000782A1 - Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide. - Google Patents

Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide.

Info

Publication number
CL2013000782A1
CL2013000782A1 CL2013000782A CL2013000782A CL2013000782A1 CL 2013000782 A1 CL2013000782 A1 CL 2013000782A1 CL 2013000782 A CL2013000782 A CL 2013000782A CL 2013000782 A CL2013000782 A CL 2013000782A CL 2013000782 A1 CL2013000782 A1 CL 2013000782A1
Authority
CL
Chile
Prior art keywords
beta
dementia
bace
senility
ylamine
Prior art date
Application number
CL2013000782A
Other languages
English (en)
Inventor
Andres Avelino Trabanco-Suarez
Gary John Tresadern
Francisca Delgado-Jimenez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2013000782A1 publication Critical patent/CL2013000782A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CL2013000782A 2010-09-22 2013-03-21 Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide. CL2013000782A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10178315 2010-09-22
EP11157858 2011-03-11

Publications (1)

Publication Number Publication Date
CL2013000782A1 true CL2013000782A1 (es) 2013-08-09

Family

ID=45873470

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013000782A CL2013000782A1 (es) 2010-09-22 2013-03-21 Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide.

Country Status (21)

Country Link
US (1) US8609660B2 (es)
EP (1) EP2619207B1 (es)
JP (1) JP5797756B2 (es)
KR (1) KR101962216B1 (es)
CN (1) CN103097389B (es)
AU (1) AU2011306941B2 (es)
BR (1) BR112013006353A2 (es)
CA (1) CA2807904C (es)
CL (1) CL2013000782A1 (es)
CO (1) CO6660450A2 (es)
EA (1) EA021723B1 (es)
ES (1) ES2529641T3 (es)
HK (1) HK1182391A1 (es)
IL (1) IL225349A (es)
IN (1) IN2013MN00782A (es)
MX (1) MX2013003246A (es)
MY (1) MY160138A (es)
NZ (1) NZ606848A (es)
SG (1) SG188338A1 (es)
WO (1) WO2012038438A1 (es)
ZA (1) ZA201302128B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2572263T3 (es) 2005-10-25 2016-05-31 Shionogi & Co Derivados de dihidrooxazina y tetrahidropirimidina como inhibidores de BACE 1
EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
CN102834384A (zh) 2009-12-11 2012-12-19 盐野义制药株式会社 *嗪衍生物
BR112012031094A2 (pt) 2010-06-09 2016-10-25 Janssen Pharmaceutica Nv derivados de 5,6-di-hidro-2h-[1,4]oxazin-3-il-maina úteis como inibidores de beta-secretase (bace)
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
WO2012057248A1 (ja) 2010-10-29 2012-05-03 塩野義製薬株式会社 ナフチリジン誘導体
JP5834091B2 (ja) 2010-12-22 2015-12-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ ベータ−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な５，６−ジヒドロ−イミダゾ［１，２−ａ］ピラジン−８−イルアミン誘導体
CN103415521B (zh) 2011-03-09 2016-01-06 詹森药业有限公司 用作β分泌酶（BACE）抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF
CA2840196C (en) 2011-06-27 2022-09-20 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
KR102243135B1 (ko) 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체
EA028775B1 (ru) 2013-06-12 2017-12-29 Янссен Фармацевтика Нв Производные 4-амино-6-фенил-6,7-дигидро[1,2,3]триазоло[1,5-a]пиразина в качестве ингибиторов бета-секретазы (bace)
CN105283457B (zh) 2013-06-12 2018-09-18 詹森药业有限公司 作为β-分泌酶(BACE)抑制剂的4-氨基-6-苯基-5,6-二氢咪唑并[1,5-A]吡嗪衍生物
ES2768823T3 (es) 2014-12-18 2020-06-23 Janssen Pharmaceutica Nv Derivados de 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2H-pirrol-5-amina útiles como inhibidores de beta-secretasa
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
CN108440320A (zh) * 2018-05-09 2018-08-24 上海凌凯医药科技有限公司 一种高手性选择性合成α-双取代α-氨基酸的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003301226A1 (en) * 2002-12-20 2004-07-22 Pharmacia Corp Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
BRPI0612545A2 (pt) * 2005-06-14 2010-11-23 Schering Corp compostos inibidores de protease, composições farmacêuticas e uso dos mesmos
TW200804290A (en) * 2005-11-15 2008-01-16 Astrazeneca Ab Compounds and uses thereof
WO2011002409A1 (en) * 2009-07-02 2011-01-06 Astrazeneca Ab 5h-pyrrolo[3,4-£>]pyrazin-7-amine derivatives inhibitors of beta-secretase

Also Published As

Publication number Publication date
CA2807904A1 (en) 2012-03-29
CA2807904C (en) 2018-09-11
BR112013006353A2 (pt) 2024-01-16
ES2529641T3 (es) 2015-02-24
MY160138A (en) 2017-02-28
SG188338A1 (en) 2013-04-30
CO6660450A2 (es) 2013-04-30
NZ606848A (en) 2015-01-30
IL225349A0 (en) 2013-06-27
AU2011306941A1 (en) 2013-02-28
WO2012038438A1 (en) 2012-03-29
EA201390419A1 (ru) 2013-07-30
EP2619207A1 (en) 2013-07-31
AU2011306941B2 (en) 2014-06-12
CN103097389B (zh) 2015-10-14
JP2013540740A (ja) 2013-11-07
MX2013003246A (es) 2013-05-22
HK1182391A1 (zh) 2013-11-29
IL225349A (en) 2016-07-31
US8609660B2 (en) 2013-12-17
KR101962216B1 (ko) 2019-03-26
EP2619207B1 (en) 2014-11-12
US20130190318A1 (en) 2013-07-25
IN2013MN00782A (es) 2015-06-12
EA021723B1 (ru) 2015-08-31
CN103097389A (zh) 2013-05-08
KR20130110161A (ko) 2013-10-08
ZA201302128B (en) 2014-08-27
JP5797756B2 (ja) 2015-10-21

Similar Documents

Publication Publication Date Title
CL2013000782A1 (es) Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide.
IL269858A (en) Pyridone and aza-pyridone compounds, pharmaceutical composition and kits comprising the same and uses thereof
AP2011005672A0 (en) Pyrazolopyrimidines and their use for the treatment of CNS disorders.
EP2742155A4 (en) BIOMARKER FOR ALZHEIMER'S DISEASE AND / OR COGNITIVE LIGHT DISORDER, AND USE THEREOF
IL212339A (en) Pyrolobenzodiazepine derivatives and processes for their preparation
CL2014000343A1 (es) Procedimientos de preparacion de compuesto polimorfico derivado de pirazolo[3,4-d]pirimidina; sal del compuesto; composicion farmaceutica que lo comprende y su uso en el tratamiento de un trastorno asociado a mtor.
IL237761B (en) History of pyrrolo[2,3–d]pyrimidine for the treatment of viral infections and other diseases
CL2007003879A1 (es) Compuestos derivados de aril-carboxamida; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alzheimer, epilepsia y parkinson.
BRPI0814529A2 (pt) Derivados de 2-3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas alfa2c para o uso no tratamento de doenças do sistema nervoso periférico e central.
IL184694A0 (en) New polymorphous forms of rifazimin, processes for their production and use thereof in the medicinal
CL2012003427A1 (es) Compuestos derivados de 5-amino-3,6-dihidro-1h-pirazina-2-ona; y uso en el tratamiento de enfermedades tales como alzheimer, senilidad, demencia, entre otras.
IL201158A0 (en) Soild forms of pemetrexed , compositions comprising the same and processes for the preparation thereof
CL2007001731A1 (es) Compuestos derivados de imidazo[1,5-a]pirimidina; composicion farmaceutica; y uso para tratar o prevenir un trastorno asociado con el deterioro cognitivo, la enfermedad de alzheimer, demencia senil y demencia asociada con enfermedad de parkinson entre otras.
CL2007001732A1 (es) Compuestos derivados de imidazo[1,5-a]pirimidina; composicion farmaceutica; y uso para tratar o prevenir un trastorno asociado con el deterioro cognitivo, la enfermedad de alzheimer, demencia senil y demencia asociada con enfermedad de parkinson entre otras.
IL215732A0 (en) Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof
CL2007001042A1 (es) Compuestos derivados de tioxantina; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento de desordenes neuroinflamatorios como esclerosis multiple, parkinson, en desordenes ateroscleroticos, cardio- y cerebrovascular, des
WO2013059530A3 (en) Peptidomimetic macrocycles
FI20085213A (fi) Pigmenttipartikkelikoostumus, menetelmä sen valmistamiseksi sekä sen käyttö
IL220682A0 (en) 1h-quinazoline-2,4-diones, processes for their manufacture, and use thereof in the preparation of medicaments for treating conditions mediated by the ampa-receptor
HK1193100A1 (zh) 苯基- -氮雜-雙環 己- -基-甲酮及其作為藥物的用途
FR2908600B1 (fr) Capsicum microencapsule, procede pour sa preparation, et utilisation
IL206531A0 (en) Cyclic pyridyl-n-(1,3,4)-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
BR112013007230A2 (pt) ''processo de cristalização pulverizável,particulas sólidas e uso''.
BRPI0912687A2 (pt) uso de bactéria probiótica para o tratamento de hiperhomocisteinaemia
CL2014003325A1 (es) Compuestos derivados de difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos, inhibidores de bace 1; composicion farmaceutica; y su uso en el tratamiento de enfermedades con niveles elevados de beta-amiloide, tal como la enfermedad de alzheimer