CL2013000782A1 - Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide. - Google Patents
Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide.Info
- Publication number
- CL2013000782A1 CL2013000782A1 CL2013000782A CL2013000782A CL2013000782A1 CL 2013000782 A1 CL2013000782 A1 CL 2013000782A1 CL 2013000782 A CL2013000782 A CL 2013000782A CL 2013000782 A CL2013000782 A CL 2013000782A CL 2013000782 A1 CL2013000782 A1 CL 2013000782A1
- Authority
- CL
- Chile
- Prior art keywords
- beta
- dementia
- bace
- senility
- ylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10178315 | 2010-09-22 | ||
| EP11157858 | 2011-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000782A1 true CL2013000782A1 (es) | 2013-08-09 |
Family
ID=45873470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000782A CL2013000782A1 (es) | 2010-09-22 | 2013-03-21 | Compuestos derivados de 4,7-dihidro-pirazolo (1,5-a) pirazin-6-ilamina, inhibidores de beta-secretasa (bace); composicion farmaceutica; y su uso en enfermedad de alzheimer, deterioro cognitivo lleve, senilidad, demencia, demencia asociada a derrame cerebral, parkinson o beta-amiloide. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8609660B2 (es) |
| EP (1) | EP2619207B1 (es) |
| JP (1) | JP5797756B2 (es) |
| KR (1) | KR101962216B1 (es) |
| CN (1) | CN103097389B (es) |
| AU (1) | AU2011306941B2 (es) |
| BR (1) | BR112013006353A2 (es) |
| CA (1) | CA2807904C (es) |
| CL (1) | CL2013000782A1 (es) |
| CO (1) | CO6660450A2 (es) |
| EA (1) | EA021723B1 (es) |
| ES (1) | ES2529641T3 (es) |
| HK (1) | HK1182391A1 (es) |
| IL (1) | IL225349A (es) |
| IN (1) | IN2013MN00782A (es) |
| MX (1) | MX2013003246A (es) |
| MY (1) | MY160138A (es) |
| NZ (1) | NZ606848A (es) |
| SG (1) | SG188338A1 (es) |
| WO (1) | WO2012038438A1 (es) |
| ZA (1) | ZA201302128B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| TW200902526A (en) | 2007-04-24 | 2009-01-16 | Shionogi & Amp Co Ltd | Aminodihydrothiazin derivative substituted with a cyclic group |
| NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体 |
| US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
| TWI537263B (zh) | 2010-06-09 | 2016-06-11 | 健生藥品公司 | 使用作為β－分泌酶抑制劑之５，６－二氫－２Ｈ－［１，４］－３－基－胺衍生物 |
| EP2634186A4 (en) | 2010-10-29 | 2014-03-26 | Shionogi & Co | naphthyridine |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| AU2011347377B2 (en) | 2010-12-22 | 2016-03-03 | Janssen Pharmaceutica Nv | 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE) |
| SG193342A1 (en) | 2011-03-09 | 2013-10-30 | Janssen Pharmaceutica Nv | 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
| WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| KR102082016B1 (ko) | 2011-06-27 | 2020-02-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 알츠하이머병을 나타내는 마이크로rna 바이오마커들 |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| EP3008066B1 (en) | 2013-06-12 | 2018-08-15 | Janssen Pharmaceutica N.V. | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| CA2911693C (en) | 2013-06-12 | 2021-08-24 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| EA032662B1 (ru) | 2013-06-12 | 2019-06-28 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) |
| ES2768823T3 (es) | 2014-12-18 | 2020-06-23 | Janssen Pharmaceutica Nv | Derivados de 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2H-pirrol-5-amina útiles como inhibidores de beta-secretasa |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| CN108440320A (zh) * | 2018-05-09 | 2018-08-24 | 上海凌凯医药科技有限公司 | 一种高手性选择性合成α-双取代α-氨基酸的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003297431A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
| KR20080028881A (ko) * | 2005-06-14 | 2008-04-02 | 쉐링 코포레이션 | 헤테로사이클릭 아스파르틸 프로테아제 억제제, 이의제조방법 및 용도 |
| TW200804290A (en) * | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
| WO2011002409A1 (en) * | 2009-07-02 | 2011-01-06 | Astrazeneca Ab | 5h-pyrrolo[3,4-£>]pyrazin-7-amine derivatives inhibitors of beta-secretase |
-
2011
- 2011-09-20 NZ NZ606848A patent/NZ606848A/en not_active IP Right Cessation
- 2011-09-20 EA EA201390419A patent/EA021723B1/ru not_active IP Right Cessation
- 2011-09-20 SG SG2013015136A patent/SG188338A1/en unknown
- 2011-09-20 JP JP2013528719A patent/JP5797756B2/ja not_active Expired - Fee Related
- 2011-09-20 MY MYPI2013000589A patent/MY160138A/en unknown
- 2011-09-20 KR KR1020137007365A patent/KR101962216B1/ko active IP Right Grant
- 2011-09-20 BR BR112013006353A patent/BR112013006353A2/pt not_active IP Right Cessation
- 2011-09-20 CN CN201180045440.3A patent/CN103097389B/zh not_active Expired - Fee Related
- 2011-09-20 CA CA2807904A patent/CA2807904C/en not_active Expired - Fee Related
- 2011-09-20 US US13/825,139 patent/US8609660B2/en not_active Expired - Fee Related
- 2011-09-20 MX MX2013003246A patent/MX2013003246A/es active IP Right Grant
- 2011-09-20 IN IN782MUN2013 patent/IN2013MN00782A/en unknown
- 2011-09-20 AU AU2011306941A patent/AU2011306941B2/en not_active Ceased
- 2011-09-20 WO PCT/EP2011/066343 patent/WO2012038438A1/en active Application Filing
- 2011-09-20 EP EP11757886.4A patent/EP2619207B1/en active Active
- 2011-09-20 ES ES11757886.4T patent/ES2529641T3/es active Active
-
2013
- 2013-03-20 CO CO13055809A patent/CO6660450A2/es unknown
- 2013-03-20 ZA ZA2013/02128A patent/ZA201302128B/en unknown
- 2013-03-20 IL IL225349A patent/IL225349A/en active IP Right Grant
- 2013-03-21 CL CL2013000782A patent/CL2013000782A1/es unknown
- 2013-08-21 HK HK13109786.4A patent/HK1182391A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IN2013MN00782A (es) | 2015-06-12 |
| BR112013006353A2 (pt) | 2024-01-16 |
| EA201390419A1 (ru) | 2013-07-30 |
| NZ606848A (en) | 2015-01-30 |
| ZA201302128B (en) | 2014-08-27 |
| JP5797756B2 (ja) | 2015-10-21 |
| IL225349A0 (en) | 2013-06-27 |
| CA2807904C (en) | 2018-09-11 |
| AU2011306941A1 (en) | 2013-02-28 |
| MY160138A (en) | 2017-02-28 |
| CA2807904A1 (en) | 2012-03-29 |
| HK1182391A1 (zh) | 2013-11-29 |
| WO2012038438A1 (en) | 2012-03-29 |
| CN103097389B (zh) | 2015-10-14 |
| EP2619207B1 (en) | 2014-11-12 |
| JP2013540740A (ja) | 2013-11-07 |
| IL225349A (en) | 2016-07-31 |
| MX2013003246A (es) | 2013-05-22 |
| US8609660B2 (en) | 2013-12-17 |
| KR101962216B1 (ko) | 2019-03-26 |
| CO6660450A2 (es) | 2013-04-30 |
| SG188338A1 (en) | 2013-04-30 |
| CN103097389A (zh) | 2013-05-08 |
| US20130190318A1 (en) | 2013-07-25 |
| EA021723B1 (ru) | 2015-08-31 |
| AU2011306941B2 (en) | 2014-06-12 |
| EP2619207A1 (en) | 2013-07-31 |
| ES2529641T3 (es) | 2015-02-24 |
| KR20130110161A (ko) | 2013-10-08 |
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